Medicine and Health Sciences Commons^™

Neuroprotective Action Of Cycloheximide Involves Induction Of Bcl-2 And Antioxidant Pathways, Katsutoshi Furukawa, Steven Estus, Weiming Fu, Robert J. Mark, Mark P. Mattson

Sanders-Brown Center on Aging Faculty Publications

The ability of the protein synthesis inhibitor cycloheximide (CHX) to prevent neuronal death in different paradigms has been interpreted to indicate that the cell death process requires synthesis of “killer” proteins. On the other hand, data indicate that neurotrophic factors protect neurons in the same death paradigms by inducing expression of neuroprotective gene products. We now provide evidence that in embryonic rat hippocampal cell cultures, CHX protects neurons against oxidative insults by a mechanism involving induction of neuroprotective gene products including the antiapoptotic gene bcl-2 and antioxidant enzymes. Neuronal survival after exposure to glutamate, FeSO₄, and amyloid β-peptide …

Pug Mill Operator Killed After Entanglement, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

On November 19, 1996, a 25-­year­-old female pug mill operator at a brick manufacturing plant was killed after her clothing became caught in a rotating shaft. She was strangled as the rotating shaft tightened her clothing around her neck, restricting her airway. In order to prevent similar incidents from occurring, FACE investigators recommend:

• Machines with rotating parts should have guards to prevent worker contact
• Employers should designate a competent person to conduct regular safety inspections and coordinate routine safety and injury prevention meetings
• Employers should provide a kill switch (panic bar) within reach of the pug mill that stops the …

Individual Differences In Response To Novelty, Amphetamine-Induced Activity And Drug Discrimination In Rats, Rick A. Bevins, J. E. Klebaur, M. T. Bardo

Department of Psychology: Faculty Publications

Rats mere pre-tested in several individual difference screens - novelty-induced activity, novelty-induced place preference, novel-object interaction, and amphetamine-induced activity. Rats that were more sensitive to the locomotor effects of amphetamine were more active in an inescapable novel environment and displayed a greater preference for a novel environment. All animals were then trained to discriminate amphetamine (1 mg/kg) from saline in a two-bar discrimination procedure using food-maintained responding. After acquisition of the discrimination (mean =37 trials), two amphetamine generalization tests (0.0625,0.125,0.25,0.5, 1.0 and 2.0 mg/kg) were conducted. In the second generalization test, rats that were more sensitive to the activating effect …

Converging Evidence For One-Trial Context Fear Conditioning With An Immediate Shock: Importance Of Shock Potency, Rick A. Bevins, Janice E. Mcphee, Anthony S. Rauhut, John J.B. Ayres

Department of Psychology: Faculty Publications

In a sample of 208 Holtzman-descended albino rats, we found evidence with 4 measures of conditioning (freezing, defecation, side crossing, and nose crossing) that a single 2-s, 1.0-mA immediate shock could condition fear to a context (Experiments 1, 2, and 4). When we reduced the shock intensity to 0.5 mA, we obtained a complete immediate-shock conditioning deficit according to all measures in Experiment 3 and to all but the defecation measure in Experiment 4. Results suggest two conclusions: (a) Differences in shock potency between laboratories may help explain discrepant findings about whether immediate shock supports contextual conditioning; (b) theories of …

Influence Of Information Related To Child Physical Abuse On Professional Ratings Of Adjustment And Prognosis, Virginia M. Deroma, David J. Hansen, Amy C. Tishelman, Peter D'Amico

Department of Psychology: Faculty Publications

The study investigates the influence of access to information of a history of physical maltreatment on the evaluative responding of social service and clinical psychology professionals. Written vignettes were used in a 2 × 2 × 2 factorial design to manipulate the: (a) presence/absence of abuse history; (b) presence/absence of behavior problems; and (c) gender of the child. Professionals rated children presented in 12 case vignettes along five treatment-related dimensions: (a) overall adjustment; (b) predicted 6 month temporal stability of behavior; (c) likelihood of treatment referral; (d) expected home intervention success; and (e) expected school intervention success. Four dimensions related …

Predictors Of Social Physique Anxiety In Elite Female Youth Athletes, Jeffrey J. Martin, Hermann J. Engels, John C. Wirth, Kari L. Smith

Kinesiology, Health and Sport Studies

The purpose of this study was to examine predictors of social physique anxiety (SPA). SPA, self-esteem, body-esteem, public body consciousness (PBC) and percent body fat (%BF) were assessed with elite female youth athletes (N = 68) competing in either figure skating, soccer or gymnastics. Stepwise multiple regression analyses, controlling for BF%, accounted for 59% of the variance in SPA. Self-esteem entered first, and BF%, followed by body-esteem and PBC. The psychological variables accounted for 57% of the variance with self-esteem contributing the most (R square change = 45%). Contrary to previous research, BF% did not significantly contribute to SPA. …

Assessment Of Nonverbal Cognitive Processes In Children With Attention Deficit Hyperactivity Disorder, Jacqueline J. Head

Faculty Publications - Doctor of Psychology (PsyD) Program

This study reviewed the literature on ADHD/ADD including a survey of the disorder, current clinical interventions and, diagnostic techniques. Data was collected comparing three groups of children (control, ADHD, ADD) on a newly developed nonverbal assessment test, the Leiter-R. The findings show that the Leiter-R resulted in significant differences in scores between the control group and the ADHD and ADD groups on twelve of the twenty subtests. This demonstrates the efficacy of the Leiter-R as an assessment tool for ADHD and ADD. Based on these findings the following tentative recommendations were proposed to assist children with ADHD and ADD. Children …

Special Maneuver For Removal Of An Impacted Bronchial Foreign Body At Thoracotomy, Saima H. Khan, Asad Mian, Qaisar M. Khan, Naeem-Uz-Zafar Khan

Department of Emergency Medicine

Tracheobronchial foreign body aspiration is a common, but often unobserved event in children. A delay in diagnosis can lead to difficulty in removal of the aspirated object. The present case report highlights a special intraoperative maneuver at thoracotomy that was adopted to remove an impacted foreign body that could not be removed at bronchoscopy.

Jefferson Alumni Bulletin – Volume Xlvi, Number 2, March 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 2, March 1997

Urology, Page 4

Report from the Alumni Trustees, Page 8

Student Notebook from 1831-33 Returns to Jefferson, Page 9

Named Professorships at Jeff, Page 10

Where the Alumni Are: A Map, Page 12

Why Does Melanoma Vaccine Work? An Answer, Page 14

Jefferson’s First Combined Kidney/Pancreas Transplant, Page 15

Dr. Shaedler is Honored for 29 Years of Teaching, Page 16

Percutaneous Removal Of Biliary Stone From Anomalous Right Hepatic Duct, T Ul Haq, M Y. Sheikh, C K. Jadun, M N. Ahmad, Y H. Husen

Department of Radiology

No abstract provided.

Profile And Risk Factors For Congenital Heart Disease, I Hassan, A A. Haleem, Z A. Bhutta

Department of Paediatrics and Child Health

Congenital heart disease is an important cause of infant mortality and disability. The frequency, spectrum and contributory risk factors for significant cardiovascular malformations among live-births was retrospectively evaluated at the Aga Khan University Hospital. Of a total of 8331 live births between July, 1987 and December, 1992 34 babies were diagnosed to have congenital heart disease in the neonatal period giving a prevalence of 4 per 1000 live births. Ventricular septal defects was the most common (n = 10, 29%) abnormality. Eight cases had associated chromosomal abnormality, the most common being Trisomy 21. Maternal abortions, still-births, consanguinity and diabetes mellitus …

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Winter, 1997 edition of the ALHeLa newsletter - Synapse.

Contents include:

• President's column
• Alabama Health Libraries association - 1997 Executive Committee
• Alabama Health Libraries Association - Executive Committee Meeting
• Proposal to establish an Ad Hoc Committee on the recruitment and training of medical librarians in Alabama
• MASA manual - Information at your fingertips
• Reports on SC/MLA 1996 key events
• Librarian's Image - James Pat Craig
• Leadership Image - Mary Edith Walker
• Mergers & Managed Care - Rourke & Ellis
• Effective communication skills - David Armbruster
• Issues in Information Malpractice - Marianne Puckett
• MLA and NNLM/SEA update

Drift Macroalgal Abundance In Seagrass Beds: Investigating Large-Scale Associations With Physical And Biotic Attributes, Susan S. Bell, Margaret O. Hall

Integrative Biology Faculty and Staff Publications

The relationship between a suite of physical and biological factors and drift macroalgal abundance was examined in 12 seagrass sites spanning a distance of over 50 km within Tampa Bay, Florida, USA. Field sampling was conducted in December 1991, and drift algal abundance was determined by recording algal percent cover from 25 quadrants at each site. Additionally, drift macroalgae were collected from gridded plots and dry weight biomass measured. Sediment characteristics and seagrass biomass, shoot density, blade length and percent cover at each site were also determined. Likewise, position of site within Tampa Bay was categorized by spatial coordinates. Step-wise …

Transgenic Mice Which Overexpress Nerve Growth Factor, Kathryn M. Albers, Brian M. Davis

Neuroscience Faculty Patents

Transgenic mice that express increased levels of nerve growth factor (NGF) in the epidermis and other stratified, keratinized epithelium. The nerve growth factor expressing transgenic mice are useful in the study of neurodegenerative disorders of the brain such as Parkinson's syndrome and Alzheimer's disease and for testing for drug candidates for the treatment of these diseases.

Sterically Stabilized Ph-Sensitive Liposomes. Intracellular Delivery Of Aqueous Contents And Prolonged Circulation In Vivo, Vladimir A. Slepushkin, Sérgio Simões, Paul Dazin, Mary S. Newman, Luke S. Guo, Maria C. Pedroso De Lima, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Liposomes that destabilize at mildly acidic pH are efficient tools for delivering water-soluble drugs into the cell cytoplasm. However, their use in vivo is limited because of their rapid uptake from circulation by the reticuloendothelial system. Lipid-anchored polyethylene glycol (PEG-PE) prolongs the circulation time of liposomes by steric stabilization. We have found that addition of PEG-PE to the membrane of pH-sensitive liposomes composed of cholesteryl hemisuccinate (CHEMS) and dioleoylphosphatidylethanolamine (DOPE) confers steric stability to these vesicles. This modification significantly decreases the pH-dependent release of a charged water-soluble fluorophore, calcein, from liposomes suspended in buffer or cell culture medium. However, the …

Ua25/2 Connections, Wku Human Resources

WKU Administration Documents

Newsletter created by WKU Human Resources for the faculty and staff of WKU regarding personnel issues and benefits.

Research To Practice: Responding To The Needs Of Youth With Disabilities Who Are Runaway Or Homeless, Sheila Fesko, David Temelini

Research to Practice Series, Institute for Community Inclusion

Results from a national survey of Family Youth and Service Bureau-funded agencies regarding their knowledge of the needs of youth with disabilities who are runaways, homeless, or at risk for running away.

Where Do Elderly Veterans Obtain Care For Acute Myocardial Infarction: Department Of Veterans Affairs Or Medicare?, S M. Wright, J Daley, E S. Fisher, G E. Thibault

Dartmouth Scholarship

To examine Department of Veterans Affairs (VA) and Medicare hospitalizations for elderly veterans with acute myocardial infarction (AMI), their use of cardiac procedures in both systems, and patient mortality. DATA SOURCES: Merging of inpatient discharge abstracts obtained from VA Patient Treatment Files (PTF) and Medicare MedPAR Part A files. A retrospective cohort study of male veterans 65 years or older who were prior users of the VA medical system (veteran-users) and who were initially admitted to a VA or Medicare hospital with a primary diagnosis of AMI at some time from January 1, 1988 through December 31, 1990 (N = …

Prenatal Cocaine Exposure And Mother–Infant Interaction: Implications For Occupational Therapy Intervention, Heather Miller-Kuhaneck

Occupational Therapy Faculty Publications

The literature from multiple disciplines on in utero cocaine exposure and mother–infant interaction and attachment was examined for possible relationships and implications for occupational therapists. Maternal cocaine use and neurobehavioral deficits in neonates prenatally exposed to cocaine may result in interactional difficulties between mother and infant. Knowledge of child development, sensory regulation, and infant cues will enable therapists to assist the mother in creating positive interactive experiences between herself and her child.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Résumé, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Rénovation Générale De Produits De Métal, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Réusinage De Produits De Métal, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Unités Mobiles De Sablage Au Jet, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Impact De L'Utilisation Des Pistolets De Soudage Pourvus D'Une Buse D'Aspiration Sur L'Activation Musculaire Des Membres Supérieurs, La Perception Psychophysique Et La Qualité Des Assemblages Soudés, Yves Beauchamp, Denis Marchand, Michel Galopin, Marc Thomas

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Outils De Collecte De Données, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Marquage Du Granit, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

La Surveillance Biologique De L'Exposition Mixte En Milieu De Travail. Développement De Modèles En Vue De L'Interprétation Des Données De Surveillance Biologique De L'Exposition, Robert Tardif, Jules Brodeur

Rapports de recherche scientifique

No abstract provided.

Les Indicateurs De Lésions En Santé Et Sécurité Du Travail Au Québec : Analyse Par Profession En 1991, Patrice Duguay

Rapports de recherche scientifique

No abstract provided.

Choix D'Abrasifs, Acceptabilité Des Substituts De La Silice Et Adoption De Mesures Préventives Lors Du Sablage Au Jet : Grande Entreprise Manufacturière Et Construction, Mario Roy, Lucie Fortier, Anne-Marie Robert, Danielle Giroux

Rapports de recherche scientifique

No abstract provided.

Évaluation Biomécanique De Stratégies Distinguant Les Travailleurs Experts Et Novices, Micheline Gagnon, Alain Delisle

Rapports de recherche scientifique

No abstract provided.