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Information Interface - Volume 22, Issue 3 - May/June 1997, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

Ua66/14/1 Student Nurse, Vol. 1, Issue 2, Wku Nursing

WKU Administration Documents

Newsletter created by WKU Nursing.

Selecting Subjects For Participation In Clinical Research: An Empirical Inquiry And Ethical Analysis, Charles Weijer

Philosophy Publications

Procedures for the selection of subjects for participation in randomized clinical trials--usually formalized as eligibility criteria in the study protocol--have both scientific and ethical implications. In this thesis, I undertake an examination of eligibility criteria at three stages in the genesis and dissemination of medical knowledge: clinical trial protocol, interpretation by investigators, and reporting of study results.

In the first chapter, ethical issues in subject selection are reviewed and the main study questions are presented. In the second chapter, the results of an examination of eligibility criteria in two sets of clinical trials, one sponsored by the NSABP, the other …

Genetic Markers And Duodenal Ulcer, Anjum Shahid, Sarwar J. Zuberi, Anwar Ali Siddiqui, Muhamined A. Waqar Muhamined A. Waqar Muhamined A. Waqar

Department of Biological & Biomedical Sciences

Serum pepsinogen, ui-antitrypsin (ui-AT) and blood groups were studied as genetic markets in 32 patients with endoscopically proven duodenal ulcer and 44 control subjects with no family history of ulcer disease. Serum pepsinogen was detennined by the modified method of Edward et al7, a1-AT by single radial hnmunodiffusion8 (RID) and phenotyping was carried out by isoelectric focusing (IEF)9. Duodenal ulcer patients with hyper- pepsinogenemia (28%) and low serum ui-AT (35%) had a dominant blood group 0, lower mean age, an early onset of disease, a higher frequency of gastrointestinal (CI) bleeding and ulcer perforation. These parameters were found considerably different …

Farmer Killed When Tractor Turns Over, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 56-year-old farmer was killed when the tricycle tractor he was operating on a hillside overturned. He had been going up and down the hill to bring loads of dirt in the tractor's front-end loader in order to bury a calf. The hillside was relatively steep, and the ground was wet from recent rains. As he attempted to turn with the loader filled and raised, the tractor rolled over several times, crushing the victim. He died at the scene. In order to prevent similar incidents, the FACE investigator recommends:

• Older tractors should be retrofitted with rollover protective structures (ROPS) and …

Sawmill Worker Killed By Circular Saw, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Other

A 32-year-old laborer (the victim) at a sawmill died as a result of injuries received when he lost his balance and fell onto the log carriage directly in front of the 56-inch circular saw. He had been using a cane hook to turn the logs for repeated passes through the saw. After hooking a log, he somehow lost his balance and fell backward onto the carriage; the saw cut him from his shoulders through his midsection. A co-worker (the sawyer) was present, but had been facing another direction and did not see the victim fall. When the sawyer turned around …

Tuberculous Hepatic Artery Aneurysm: Multimodality Imaging, Y A. Husen, M U. Islam, I H. Rizvi

Department of Radiology

No abstract provided.

Human Immunodeficiency Virus Type 1 Infection Of Cells And Tissues From The Upper And Lower Human Female Reproductive Tract, Alexandra L. Howell, Robert D. Edkins, Sherry E. Rier, Grant R. Yeaman, Judy E. Stern, Michael W. Fanger, Charles R. Wira

Dartmouth Scholarship

Viable tissue sections and isolated cell cultures from the human fallopian tube, uterus, cervix, and vaginal mucosa were examined for susceptibility to infection with human immunodeficiency virus type 1 (HIV-1). We examined infectivity by using the monocytotropic strain HIV-1_JR-FLand several primary isolates of HIV-1 obtained from infected neonates. HIV-1 infection was measured by p24 production in short-term culture and by immunofluorescence detection of HIV-1 Nef and p24 proteins by laser scanning confocal microscopy. Three-color immunofluorescence was used to phenotype HIV-infected cells within tissue sections from each site. Our findings indicate that epithelial, stromal, and dendritic cells and cells …

Hallucinations, Peter J. Whitehouse, Marian B. Patterson, Milton E. Strauss, David S. Geldmacher, James L. Mack, Grover C. Gilmore, Elizabeth Koss

Faculty Scholarship

No abstract provided.

Cationic Liposome-Mediated Expression Of Hiv-Regulated Luciferase And Diphtheria Toxin A Genes In Hela Cells Infected With Or Expressing Hiv, Krystyna Konopka, Gail S. Harrison, Philip L. Felgner, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

HIV-regulated expression of the diphtheria toxin A fragment gene (HIV-DT-A) is a potential gene therapy approach to AIDS. Since cationic liposomes are safe and non-immunogenic for in vivo gene delivery, we examined whether LipofectAMINE or DMRIE reagent could mediate the transfection of HIV-DT-A (pTHA43) or the HIV-regulated luciferase gene (pLUCA43) into HIV-infected or uninfected HeLa cells. pLUCA43 was expressed at a 103-fold higher level in HeLa/LAV cells than in uninfected HeLa cells, while the extent of expression of RSV-regulated luciferase was the same in both cell lines. Co-transfection of HeLa cells with pTHA43 and the proviral HIV clone, HXBΔBgl, resulted …

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Many different disorders can be treated using these compounds, including diseases or disorders of the central …

Logger Killed During Tree Felling, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Tractors/Logging

A 61-year-old male logger was killed when he was hit by the tree he was felling. On the day of the incident, he was working on a steep mountainside with his son and another logger. At approximately 10 am, the victim was felling a tree approximately 14 inches in diameter. As viewed from the bottom of the hill, a small tree about 6 inches in diameter stood about 6 feet to the right of the tree that was being felled. Lying on the ground directly behind those two vertical trees was a log 4-5 inches in diameter; it lay perpendicular …

Mid-Atlantic Ethics Committee Newsletter, Spring 1997

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Beat Newsletter, College Of Medicine

The Beat Newsletter

This is the April,1997 edition of the Frederick P. Whiddon College of Medicine's newsletter - The Beat.

Contents include:

• Novel treatment strategies for sickle cell disease
• Congratulations...
• Researchers Agreeing on process of researching science and religion
• Wellcome visiting professor in basic sciences
• Glusman honored for outstanding leadership
• Renowned researcher delivers Frazer lecture
• "Match Day" results
• Clikas Honored for planting of "The Trees of Hippocrates"
• Former USA professor Alden Dudley, M.D. presents Toren lecture
• COM Biostatistics and Epidemiology Core Unit Research Support Service

Center For Psychology Studies Newsletter - Spring 1997, Nova Southeastern University

Center for Psychological Studies Newsletter

No abstract provided.

Enhancing Compliance With Allergic Rhinitis Therapy, Beth Wofford, Deborah S. Zeitlin

Scholarship and Professional Work – COPHS

Allergic rhinitis is one of the most common chronic conditions in the US, surpassing even heart disease. Over $1 billion is spent annually for over-the-counter (OTC) and prescription medications. In addition, allergic rhinitis causes an estimated annual loss of $639 million related to lost work days and diminished work performance.

If not effectively treated, allergic rhinitis may lead to potential complications such as otitis media, sinusitis, facial and dental abnormalities, hearing loss, poor speech development, and recurrent upper respiratory tract infections. Ineffective treatment often the result of intentional or unintentional noncompliance and inadequate patient education. Therefore, it is imperative that …

Ua61/1 Wku Nursing Class 1997, Wku Nursing

WKU Administration Documents

Members of the 1997 nursing class: Donna Blakely, Donna Brown, Debbie Browning, Roger Burch, Tammy Childress, Pamela Cleveland, Rayner England, Traci Groce, Jennifer Holt, Dana Joiner, Patricia Keen, LaDonna Killebrew, Heather Nason, Mesha Pendley, Katina Reece, Stephanie Reynolds, Stacey Rouse, Teresa Rowlett, Holli Scott, Kristi Staples, Peggy Swann, Kevin Taylor and Heather Woodard.

Ua66/14/4 Kentucky Partnership Newsletter, Vol. Iv, No. 2, Kentucky Partnership For Farm Family Health & Safety

University Organizations

Newsletter created by and about the Kentucky Partnership for Farm Family Health & Safety.

Nsu Going Back May Be The Best Way Of Getting Ahead Courses, Seminars, Workshops, Conferences Spring 1997, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

Changes In Ankle Joint Proprioception Resulting From Strips Of Athletic Tape Applied Over The Skin, Guy G. Simoneau, Rebecca M. Degner, Cindi A. Kramper, Kent H. Kittleson

Physical Therapy Faculty Research and Publications

Athletic trainers, physical therapists, and other rehabilitation professionals stress the importance of proprioceptive reeducation during the rehabilitation process following an injury." 2 It is believed that an injury such as an inversion ankle sprain, for example, results in a reduction of proprioceptive function that may lead to future reinjuries. 3 One suggested palliative method to supplement a deficit in proprioceptive function at the ankle is the use of external support such as taping and braces.47 The tape or brace is believed to provide increased mechanical support as well as increased proprioception.

Nsu Going Back May Be The Best Way Of Getting Ahead Courses, Seminars, Workshops, Conferences Spring 1997, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice College Archive

No abstract provided.

Conception D'Un Étançonnement Adapté Au Milieu Urbain : Phase 1, André Lan, Jean Arteau, Martin Tremblay, Serge Gamelin, Jean-Marc Dugré

Rapports de recherche scientifique

No abstract provided.

Immunophenotypic Analysis Of Non-Hodgkin's Lymphoma, Suhail Muzaffar, Shahid Pervez, Farrukh Aijaz, Syed Abdul Aziz, Sheema H. Hasan

Department of Pathology and Laboratory Medicine

One hundred and three cases of Non-Hodgkin’s lymphoma were evaluated immunohistochemically using a panel of monoclonal antibodies which includes leucocyte common antigen (LCA), CD45R (Pan-B marker), L-26 (CD 20-Pan-B marker) and UCHL-1 (Pan-T marker). Of the total 63 cases (61.17%) showed a B-cell phenotype while 40(38.83%) were of T-cell origin. Most B-cell neoplasms belonged to intermediate (79.36%) or high grade (15.87%) according to the international Working Formulation (WF). Most T- cell lymphomas were of either intermediate (52.5%) or high grade (32.5%) neoplasms. Some T-cell neoplasms presented as specific clinicopathological entities like lymphomatoid granulomatosis (2 cases), mycosis fungoides (1 case) and …

Classification And Immunophenotyping Of Acute Leukemias: A Prospective Study., Shahid Pervez, M. Khurshid

Department of Pathology and Laboratory Medicine

Over a period of 3-1/2 years, 86 cases of acute leukemia were analyzed by immunohistochemical (IHC) means on ficoll separated cytospin preparations of peripheral blood and/or bone marrow samples. Antibodies included in the panel were specific against Tdt, HLA-DR, CD19/CD2O/CD22, CALLA (CD1O), CD2, CD11C as well as against Ig heavy chains. Of 86 cases analyzed, 48 cases were of ALL, (25 of common pre-B ALL, 15 of pre-B/NULL and 8 of T ALL phenotype), twenty-four (24) out of 86 cases were of non­lymphoblastic (AML/AMML) type. In six cases, there was suggestion of a mixed lineage, while in 8 cases there …

Dissection Of A Circadian Oscillation Into Discrete Domains, Martha W. Merrow, Norman Y. Garceau, Jay C. Dunlap

Dartmouth Scholarship

The circadian oscillator in Neurospora is a negative feedback loop involving as principal players the products of the frequency (frq) locus. frq encodes multiple forms of its protein product FRQ, which act to depress the amounts of frq transcript. In this scheme there are two discrete and separable steps to the circadian cycle, negative feedback itself (repression) in which FRQ acts to decrease the levels of its own transcript, and recovery from repression (derepression) in which frq transcript levels return to peak amounts. By introducing an exogenously regulatable frq transgene into a frq loss-of-function strain (frq^{9 …}

Paying For Suffering: The Problem Of Human Experimentation, Larry I. Palmer

Faculty Publications

No abstract provided.

Dental Implant Drill Guide System, J. Bruce Bavitz

College of Dentistry: Faculty Publications

A method for imbedding a dental implant includes the initial step of casting a model of the patient's jaw and teeth in the vicinity of the implant site. A pilot hole is drilled in the implant site of the model, correlating to the ideal angle and location of the implant in the patient's jaw. A guide rod is provided for forming a guide hole in a stent, with a generally cylindrical shaft and a screw portion mounted at the lower end of the shaft. The screw portion is threaded into the pilot hole with the upper portion of the guide …

Sch 48973: A Potent, Broad-Spectrum, Antienterovirus Compound., Peter J. Buontempo, Stuart Cox, Jacquelyn Wright-Minogue, Jason L. Demartino, Angela M. Skelton, Eric Ferrari, Randi Albin, Edward J. Rozhon, V. Girijavallabhan, John F. Modlin, John F. O'Connell

Dartmouth Scholarship

SCH 48973 is a novel molecule with potent, selective, antienterovirus activity. In assays of the cytopathic effect against five picornaviruses, SCH 48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH 48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The antiviral activity of SCH 48973 is derived from its specific interaction with viral capsid, as confirmed by competition binding studies. The affinity constant (Ki) for SCH 48973 binding to poliovirus was 8.85 x 10(-8) M. In kinetic studies, a maximum of approximately …

Anti-Idiotype Monoclonal Antibody 1a7 And Use For The Treatment Of Melanoma And Small Cell Carcinoma, Malaya Chatterjee, Kenneth A. Foon

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention relates isolation of anti-idiotypic antibody 1A7 raised against anti-GD2 mAb 14G2a and its use for the treatment of melanoma and small cell carcinoma. The antibody may be used as a substitute for isolated purified GD2 antigen in any appropriate application.

Ureteroscopic Lithotripsy., Demetrius H. Bagley

Department of Urology Faculty Papers

There is a wide array of endoscopic lithotriptors presently available. Each of these has its own advantages and disadvantages. No single lithotriptor is suitable for all applications and none can meet the goal of fragmenting all calculi while remaining harmless to tissue.