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2021

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Articles 3631 - 3660 of 3840

Full-Text Articles in Medicine and Health Sciences

Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay Jan 2021

Clinical Course Of Covid-19 Disease In Immunosuppressed Renal Transplant Patients, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Esma Seda Çeti̇n, Ahmed Bi̇lal Genç, Necatti̇n Firat, Mehmet Köroğlu, Gürkan Muratdaği, Yakup Tomak, Kezban Özmen Süner, Ömer Faruk Ateş, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: We aimed to identify clinical settings of renal transplant patients with COVID-19. Materials and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information was documented. Results: Twenty patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 days and 4.5 ± 2.0 months, …

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Cerebral Hemodynamic Alterations In Patients With Covid-19, Ali̇ Riza Sonkaya, Bi̇lgi̇n Öztürk, Ömer Karadaş Jan 2021

Cerebral Hemodynamic Alterations In Patients With Covid-19, Ali̇ Riza Sonkaya, Bi̇lgi̇n Öztürk, Ömer Karadaş

Turkish Journal of Medical Sciences

Background/aim: Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19. Materials and methods: The sample of this study included 20 patients hospitalized in our clinic diagnosed with Covid-19 via PCR modality and 20 healthy volunteers of similar age and sex. Bilateral middle cerebral arteries were investigated with transcranial Doppler ultrasonography. Basal cerebral blood flow velocities and vasomotor reactivity rates were determined and statistically compared. Results: When patient and control groups …

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Characteristics And Outcomes Of Critically Ill Patients With Covid-19 In Sakarya, Turkey: Asingle Centre Cohort Study, Havva Kocayi̇ği̇t, Kezban Özmen Süner, Yakup Tomak, Gürkan Demi̇r, İbrahi̇m Kocayi̇ği̇t, Selçuk Yaylaci, Yusuf Aydemi̇r, Mehmet Köroğlu, Oğuz Karabay, Mehmet Hali̇l Öztürk, Ali̇ Fuat Erdem Jan 2021

Characteristics And Outcomes Of Critically Ill Patients With Covid-19 In Sakarya, Turkey: Asingle Centre Cohort Study, Havva Kocayi̇ği̇t, Kezban Özmen Süner, Yakup Tomak, Gürkan Demi̇r, İbrahi̇m Kocayi̇ği̇t, Selçuk Yaylaci, Yusuf Aydemi̇r, Mehmet Köroğlu, Oğuz Karabay, Mehmet Hali̇l Öztürk, Ali̇ Fuat Erdem

Turkish Journal of Medical Sciences

Background/aim: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Turkey on March 10, 2020 and the number of the patients are increasing day by day. Coronavirus disease 2019 (Covid-19) has high mortality rates in intensive care units (ICUs). We aimed to describe the demographic characteristics, comorbidities, treatment protocols, and clinical outcomes among the critically ill patients admitted to the ICU of our hospital. Materials and methods: This cohort study included 103 consecutive patients who had laboratory confirmed Covid-19 and admitted to ICU of Sakarya University Training and Research Hospital between March 19 and April 13, 2020. The …

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The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü Jan 2021

The Predictive And Diagnostic Accuracy Of Long Pentraxin-3 In Covid-19 Pneumonia, Ahmed Bi̇lal Genç, Selçuk Yaylaci, Hamad Dhei̇r, Ahmed Ci̇had Genç, Kubi̇lay İşsever, Deni̇z Çeki̇ç, Havva Kocayi̇ği̇t, Erdem Çokluk, Alper Karacan, Mehmet Ramazan Şekeroğlu, Hande Toptan, Ertuğrul Güçlü

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and methods: This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients. Results: Of 88 patients with COVID-19, 59 (67%) were discharged with …

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Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş Jan 2021

Factors Affecting Mortality In Geriatric Patients Hospitalized With Covid-19, Rabi̇a Bağ Soytaş, Damla Ünal, Pinar Arman, Veysel Suzan, Tuğçe Emi̇roğlu Gedi̇k, Günay Can, Bora Korkmazer, Ridvan Karaali̇, Şermi̇n Börekçi̇, Mert Ahmet Kuşkucu, Hakan Yavuzer, Ülev Deni̇z Erdi̇nçler, Alper Döventaş

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19). Materials and methods: This is a retrospective study of patients 65 years old or older with COVID-19 who were hospitalized in İstanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital, between March 11 and May 28, 2020. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records. We used univariate and multivariate logistic regression methods to explore the risk factors for in-hospital death. Results: A total of 218 patients (112 men, 106 women) …

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The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu Jan 2021

The Necessity Of Treating Asymptomatic Bacteriuria With Antibiotics In The Perioperativeperiod Of Joint Arthroplasty: A Metaanalysis., Sayed Abdulla Jami, Jian Dang Shi, Zhanwen Zhou, Chang Hao Liu

Turkish Journal of Medical Sciences

Background/aim: Oral antibiotics are usually used to treat asymptomatic bacteriuria during the perioperative period of joint replacement. However, there is no unified conclusion as to whether asymptomatic bacteriuria causes infection around joint prostheses, and the efficacy of antibiotics is unknown. Materials and methods: We systematically searched PubMed, CNKI, Ovid, Cochrane Library, EMBASE, manual research, and references of relevant articles up to January 1, 2020, to identify and compare observational studies. The Cochrane systematic review method was used, and Review Manager 5.3 software was used for analysis. Results: Nine articles were included in the analysis, involving 29,844 cases of joint arthroplasty …

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Sural Nerve Harvest For Infants: Integrated With Information Based On Anatomicaldissections, Mustafa Büyükmumcu, Anil Di̇dem Aydin Kabakçi, Duygu Akin Saygin, Mehmet Tuğrul Yilmaz, Muzaffer Şeker Jan 2021

Sural Nerve Harvest For Infants: Integrated With Information Based On Anatomicaldissections, Mustafa Büyükmumcu, Anil Di̇dem Aydin Kabakçi, Duygu Akin Saygin, Mehmet Tuğrul Yilmaz, Muzaffer Şeker

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study was to determine the course and possible variations of the sural nerve with all anatomical details in human fetal cadavers. Materials and methods: This study was performed on 60 fetal cadavers. Formation type and level of the sural nerve was detected. Results: According to trimesters, it was determined that the mean transverse and vertical distance between the lowest point of the LM and the SN varied between 1.1 and 2.9 mm and 1.54 and 3.58 mm, respectively. Type 2 was the most common seen type of sural nerve (35.83%). It was determined that …

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Identification Of Novel Tubb1 Variants In Patients With Macrothrombocytopenia, Zi̇hni̇ Onur Çalişkaner, Abdullah Abdul Waheed, Merve Tuzlakoğlu Öztürk, Yeşi̇m Oymak, Uygar Hali̇s Tazebay, Mehmet Nejat Akar, Ayten Kandi̇lci̇, Di̇dem Özkan Jan 2021

Identification Of Novel Tubb1 Variants In Patients With Macrothrombocytopenia, Zi̇hni̇ Onur Çalişkaner, Abdullah Abdul Waheed, Merve Tuzlakoğlu Öztürk, Yeşi̇m Oymak, Uygar Hali̇s Tazebay, Mehmet Nejat Akar, Ayten Kandi̇lci̇, Di̇dem Özkan

Turkish Journal of Medical Sciences

Background/aim: Macrothrombocytopenia is an autosomal-dominant disorder characterized by increased platelet size and a decreased number of circulating platelets. The membrane skeleton and the link between actin filaments of the skeleton and microtubules, which consist of alpha and beta tubulin [including the tubulin beta-1 chain (TUBB1)] heterodimers, are important for normal platelet morphology, and defects in these systems are associated with macrothrombocytopenia. Materials and methods: In this study, we sequenced the exons of the TUBB1 gene using DNA isolated from the peripheral blood samples of healthy controls (n = 47) and patients with macrothrombocytopenia (n = 37) from Turkey. The TUBB1 …

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Reliability And Validity Of The National Institutes Of Health Chronic Prostatitis Symptomindex Questionnaire In The Turkish Population, Alper Coşkun, Utku Can, Fati̇h Tarhan, Övünç Kavukoğlu, Kami̇l Fehmi̇ Narter Jan 2021

Reliability And Validity Of The National Institutes Of Health Chronic Prostatitis Symptomindex Questionnaire In The Turkish Population, Alper Coşkun, Utku Can, Fati̇h Tarhan, Övünç Kavukoğlu, Kami̇l Fehmi̇ Narter

Turkish Journal of Medical Sciences

Background/aim: To develop the first Turkish version of the National Institutes of Health Chronic Prostatitis Symptom Index (NIHCPSI) questionnaire and to investigate its validity and reliability in men with chronic prostatitis/chronic pelvic pain syndrome (CP/ CPPS) and healthy controls. Material and methods: A total of 204 patients, 116 CP/CPPS and a control group which consisted of 88 healthy individuals were included in this prospective study. The NIH-CPSI form was first translated into Turkish and later on back into English. Using the Turkish version of the NIH CPSI, 40 patients completed the same questionnaires twice at 2-week intervals for test-retest concordance. …

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Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan Jan 2021

Retrospective Analysis Of The Effect Of Breast Surgery On Body Posture In Patients Withearly-Stage Breast Cancer After Cancer Treatment (Venus Study)(Breast Cancer And Body Posture), Özgür Tanriverdi̇, Ahmet Ozan Çeti̇n, Ali̇ Alkan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to determine whether breast surgery changes body posture in patients with early-stage breast cancer. Materials and methods: Study variables include age, side and localization of the tumor in the breast, applied breast surgery, axillary interference, pathological tumor size, axillary lymph node metastasis, body mass index, bone density, adjuvant therapies, and histological type. Thoracic kyphosis angle due to the anatomically affected primary region to detect changes in body posture and Cobb's method were used to measure this. Results: There was a statistically significant difference in the mean Cobb's angle between the follow-up times of …

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Angiographic Prostatic Arterial Anatomy In A Turkish Population With Benign Prostatichyperplasia, Fatma Gonca Eldem, Firat Atak, Osman Öcal, Ali̇ Cansu Bozaci, Ahmet Güdeloğlu, Bora Peyni̇rci̇oğlu Jan 2021

Angiographic Prostatic Arterial Anatomy In A Turkish Population With Benign Prostatichyperplasia, Fatma Gonca Eldem, Firat Atak, Osman Öcal, Ali̇ Cansu Bozaci, Ahmet Güdeloğlu, Bora Peyni̇rci̇oğlu

Turkish Journal of Medical Sciences

Background/aim: Prostatic artery embolization (PAE) is a minimally invasive effective method in the treatment of benign prostatic hyperplasia (BPH). The procedure is technically challenging, as pelvic vascular anatomy is highly prone to variations and the identification of the prostatic artery (PA) is the most time-consuming step, which can lead to increased procedure times. The aim of this study was to categorize the anatomic variations in the prostatic supply in patients with BPH treated with PAE. Materials and methods: The digital subtraction angiography findings of 68 PAE procedures were reviewed retrospectively and the age, PA origin, number, and procedure of the …

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Pattern Of Systemic Antibiotic Use And Potential Drug Interactions: Evaluations Through Apoint Prevalence Study In Ankara University Hospitals, İrem Akdemi̇r Kalkan, Güle Çinar, Aysel Pehli̇vanli, Fati̇h Ürkmez, İzel Ezgi̇ Topaloğlu, Büşra Akyol, Arzu Beşi̇kci̇, Alpay Azap, Kemal Osman Memi̇koğlu Jan 2021

Pattern Of Systemic Antibiotic Use And Potential Drug Interactions: Evaluations Through Apoint Prevalence Study In Ankara University Hospitals, İrem Akdemi̇r Kalkan, Güle Çinar, Aysel Pehli̇vanli, Fati̇h Ürkmez, İzel Ezgi̇ Topaloğlu, Büşra Akyol, Arzu Beşi̇kci̇, Alpay Azap, Kemal Osman Memi̇koğlu

Turkish Journal of Medical Sciences

Background/aim: Most of the hospitalized patients are on a number of drugs for comorbidities and/or to prevent nosocomial infections. This necessitates a careful consideration of drug interactions not only to avoid possible toxicities but also to reach the highest efficiency with drug treatment. We aimed to investigate drug interactions related to systemic antibiotic use and compare three different databases to check for drug interactions while characterizing the main differences between medical and surgical departments. Materials and methods: This point prevalence study covered data on 927 orders for patients hospitalized between June 3 and 10, 2018 in Ankara University Hospitals. Systemic …

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Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan Jan 2021

Risk Factors For Evisceration In Gynecological Oncology Surgeries, Fati̇h Kiliç, Günsu Ki̇myon Cömert, Mehmet Ünsal, İsmet Çi̇ğdem Kiliç, Caner Çakir, Di̇lek Yüksel, Mustafa Alper Karalök, Osman Türkmen, Ahmet Taner Turan

Turkish Journal of Medical Sciences

Background/aim: To investigate the risk factors for evisceration in a gynecological oncology population. The secondary aim was to evaluate the impact of evisceration on survival. Materials and methods: Inclusion criteria consisted of having had an elective surgery performed through a xiphoidopubic incision in our institution and having a gynecological malignancy based on pathology. A total of 198 patients were evaluated, 54 with evisceration and 144 without evisceration. Due to the widely varied prognosis of female genital cancers, the survival was analyzed on a homogenized group, including only 62 patients with primary advanced stage epithelial ovarian-tubal-peritoneal cancer. Results: The preoperative factors …

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Fatigue And Its Relationship With Disease-Related Factors In Patients With Systemicsclerosis: A Cross-Sectional Study, Hazal Yakut, Sevgi̇ Özalevli̇, Ahmet Meri̇h Bi̇rli̇k Jan 2021

Fatigue And Its Relationship With Disease-Related Factors In Patients With Systemicsclerosis: A Cross-Sectional Study, Hazal Yakut, Sevgi̇ Özalevli̇, Ahmet Meri̇h Bi̇rli̇k

Turkish Journal of Medical Sciences

Background/aim: Fatigue is very common symptom in patients with systemic sclerosis (SSc) and adversely affects health-related quality of life and the ability to perform daily living activities. This study aimed to determine the severity of fatigue, and its related factors, in patients with SSc. Materials and methods: A total of 35 patients with SSc (6 males and 29 females, mean age of 50.71 ± 10.09 years) and 35 healthy control subjects (8 males and 27 females, mean age of 54.14 ± 9.51 years) were included in this study. The Fatigue Impact Scale for fatigue, Modified Medical Research Council Scale for …

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Frailty Is Associated With Poor Sleep Quality In The Oldest Old, Çağatay Çavuşoğlu, Olgun Deni̇z, Rana Tuna Doğrul, Süheyla Çöteli̇, Ali̇ Öncül, Muhammet Cemal Kizilarslanoğlu, Berna Göker Jan 2021

Frailty Is Associated With Poor Sleep Quality In The Oldest Old, Çağatay Çavuşoğlu, Olgun Deni̇z, Rana Tuna Doğrul, Süheyla Çöteli̇, Ali̇ Öncül, Muhammet Cemal Kizilarslanoğlu, Berna Göker

Turkish Journal of Medical Sciences

Background/aim: Sleep disorders and frailty increase with advancing age, along with physical disabilities, cognitive dysfunction, mood disorders, and social vulnerability. Thus, the study objective was to evaluate the relationship between frailty and sleep quality in the oldest old patients. Materials and methods: In this study, 100 patients aged ≥ 80 years were assessed using comprehensive geriatric assessment (CGA) including basic activities of daily living (ADL), instrumental ADL, handgrip strength, the Geriatric Depression Scale-15, the MiniMental State Examination, and the Mini-Nutritional Assessment-Short Form. The sleep quality and frailty status of the patients were evaluated using the Pittsburgh Sleep Quality Index (PSQI) …

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Emergency Department Extracorporeal Membrane Oxygenation May Also Includenoncardiac Arrest Patients, Yunus Emre Özlüer, Mücahi̇t Avci̇l, Duygu Ege, Kezban Şeker Yaşar Jan 2021

Emergency Department Extracorporeal Membrane Oxygenation May Also Includenoncardiac Arrest Patients, Yunus Emre Özlüer, Mücahi̇t Avci̇l, Duygu Ege, Kezban Şeker Yaşar

Turkish Journal of Medical Sciences

Background/aim: The primary purpose of this study is to report the experience on the extracorporeal membrane oxygenation (ECMO) process for patients in the critical care unit (CCU) of an emergency department of a tertiary hospital in Turkey, from cannulation to decannulation, including follow-up procedures. Materials and methods: This retrospective and observational study included eight patients who received ECMO from January 2018 to January 2020. We evaluated the demographics, indications for ECMO, laboratory values, Respiratory ECMO Survival Prediction, Survival After Veno-Arterial ECMO and ECMO net scores, the management process, and patient outcomes. Blood gas analyses done after the first hour of …

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Interobserver And Intermethod Variability In Data Interpretation Of Breast Strainelastography In Suspicious Breast Lesions, Hale Turnaoğlu, Kemal Murat Haberal, Serdar Arslan, Meri̇ç Yavuz Çolak, Funda Ulu Öztürk, Ni̇hal Uslu Jan 2021

Interobserver And Intermethod Variability In Data Interpretation Of Breast Strainelastography In Suspicious Breast Lesions, Hale Turnaoğlu, Kemal Murat Haberal, Serdar Arslan, Meri̇ç Yavuz Çolak, Funda Ulu Öztürk, Ni̇hal Uslu

Turkish Journal of Medical Sciences

Background/aim: Strain elastography has the disadvantage of being operator-dependent. Interobserver variability is observed during image acquisition and interpretation. This study aimed to analyze the interobserver and intermethod variability of strain elastography in image interpretation and evaluate the diagnostic performance combining elasticity score and strain ratio with ultrasonography. Materials and methods: A retrospective study was conducted on 70 breast lesions evaluated with B-mode ultrasonography and strain elastography. B-mode ultrasonography findings, elasticity scores, and strain ratio values were evaluated using static images by two radiologists. BI-RADS assessment of the lesions and the decision of both observers as to whether the biopsy was …

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Early Detection Breast Cancer: Role Of Circulating Plasma Mirna-21 Expression As Apotential Screening Biomarker, Muhammad Noor Diansyah, Ami Ashariati Prayogo, Made Putra Sedana, Merlyna Savitri, Pradana Zaky Romadhon, Putu Niken Ayu Amrita, Andi Yasmin Wijaya, Winona May Hendrata, Ugroseno Yudho Bintoro Jan 2021

Early Detection Breast Cancer: Role Of Circulating Plasma Mirna-21 Expression As Apotential Screening Biomarker, Muhammad Noor Diansyah, Ami Ashariati Prayogo, Made Putra Sedana, Merlyna Savitri, Pradana Zaky Romadhon, Putu Niken Ayu Amrita, Andi Yasmin Wijaya, Winona May Hendrata, Ugroseno Yudho Bintoro

Turkish Journal of Medical Sciences

Aim: To explore the potential of the circulating plasma miRNA-21 as an early detection biomarker by comparing early-stage breast cancer (BG) and healthy control (HG) in Indonesian population. Materials and methods: The enlisted patients were 26 adult female early-stage breast cancer patients (stage 1A, 1B, 2A, and 2B) of Airlangga University Hospital from August 2019 to October 2019. Sixteen volunteers were recruited as matching healthy subjects. MiRNA-21 expression was quantified by plasma qRT-PCR. Data analysis performed using IBM SPSS Statistics v.24 (IBM Corp., Armonk, NY, USA). MiRNA-21 cut-off, sensitivity, and specificity were analyzed using receiver operating characteristic (ROC) curve. Results: …

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Retrospective Evaluation Of 377 Patients With Penetrating Foreign Body Injuries: Auniversity Hospital Experience (A Present Case Of Missed Sponge Foreign Body Injury), Anil Murat Öztürk, Omar Aljasim, Gamze Şanlidağ, Meltem Taşbakan Jan 2021

Retrospective Evaluation Of 377 Patients With Penetrating Foreign Body Injuries: Auniversity Hospital Experience (A Present Case Of Missed Sponge Foreign Body Injury), Anil Murat Öztürk, Omar Aljasim, Gamze Şanlidağ, Meltem Taşbakan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to retrospectively analyse patients with foreign body (FB) injuries in our hospital and to present a patient with missed penetrating sponge FB injury. Materials and methods: This study lasted 12 years (2008-2020) and reviewed all patients with FB injuries who were admitted to the emergency department (ED) of our hospital. Along with our overall results, we present a case with missed penetrating sponge FB injury in detail. Results: Approximately 377 patients were included in the study (age: 28.3 ± 18.3 years, m/f: 229/148). The foot (n = 148, 39.3%) and the hand (n = 143, 37.9%) …

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The Effect Of Measurement Area Size On The Reliability Of Myocardial Iron Load Measurementin Cardiac Magnetic Resonance Imaging Examinations Of Thalassemia Patients, İbrahi̇m Önder Yeni̇çeri̇, Fati̇h Mehmet Azik, Funda Di̇nç Eli̇bol Jan 2021

The Effect Of Measurement Area Size On The Reliability Of Myocardial Iron Load Measurementin Cardiac Magnetic Resonance Imaging Examinations Of Thalassemia Patients, İbrahi̇m Önder Yeni̇çeri̇, Fati̇h Mehmet Azik, Funda Di̇nç Eli̇bol

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the intraobserver and interobserver reliability of cardiac T2* MRI measurements in different region of interest (ROI) sizes. Materials and methods: Cardiac T2* MRIs of 24 thalassemia major patients were evaluated. Two different ROI sizes were used for measurement. In the first measurement, an ROI approximately 5 mm in diameter was used in the interventricular septal myocardium. In the other method, the whole ventricular septal myocardium was used as the measurement. The intraobserver and interobserver variabilities were assessed with the intraclass correlation coefficient (ICC). Results: The measurement of the first observer, the …

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Evaluation Of Cardiac Functions After Catheter Ablation Of Atrioventricular Nodal Reentranttachycardia, Ahmet Çağri Aykan, Can Yücel Karabay, Mustafa Yildiz Jan 2021

Evaluation Of Cardiac Functions After Catheter Ablation Of Atrioventricular Nodal Reentranttachycardia, Ahmet Çağri Aykan, Can Yücel Karabay, Mustafa Yildiz

Turkish Journal of Medical Sciences

Background/aim: Radiofrequency catheter ablation (RFA) is the most effective method of supraventricular tachycardia therapy. Recurrent supraventricular tachycardia causes systolic dysfunction and dilated cardiomyopathy. The aim of this study was to evaluate the long-term alterations of atrial and ventricular functions after RFAof typical atrioventricular nodal reentrant tachycardia (AVNRT). Materials and methods: This cross-sectional study included 55 consecutive patients with symptomatic drug-resistant AVNRT who had had an invasive electrophysiology study and RFA. Speckle-tracking-based echocardiographic assessment was performed shortly before and 1 year after the operation. Left ventricle (LV) and right ventricle (RV) peak systolic strain (PSS) and atrial strain measurements were performed. …

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A Practical Method Of Drug Provocation Testing To Prove Tolerance To Alternative Drugs Indrug Hypersensitivity, Ebru Damadoğlu, Özge Öztürk Aktaş, Gül Karakaya, Ali̇ Fuat Kalyoncu Jan 2021

A Practical Method Of Drug Provocation Testing To Prove Tolerance To Alternative Drugs Indrug Hypersensitivity, Ebru Damadoğlu, Özge Öztürk Aktaş, Gül Karakaya, Ali̇ Fuat Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Drug provocation tests (DPTs) are the gold standard method performed at the end of a stepwise approach in a drug allergy workup. Drug provocation tests are administered as a single drug on a test day. Testing more than one drug in a day is a feasible option and could be a safe and time- and manpower-saving procedure in well-selected patients. The aim of the present study was to investigate the efficacy and safety of performing a DPT with two or three alternative drugs in one test day (Hacettepe method). Materials and methods: Adult patients who were admitted with drug …

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Risk Factors Predicting The Development Of Diabetes Mellitus And Metabolic Syndromefollowing Gestational Diabetes Mellitus, Bülent Can, Sema Çi̇ftçi̇, Gülşah Yeni̇dünya Yalin, Nevi̇n Di̇nççağ Jan 2021

Risk Factors Predicting The Development Of Diabetes Mellitus And Metabolic Syndromefollowing Gestational Diabetes Mellitus, Bülent Can, Sema Çi̇ftçi̇, Gülşah Yeni̇dünya Yalin, Nevi̇n Di̇nççağ

Turkish Journal of Medical Sciences

Background/aim: To determine risk factors associated with the development of insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in gestational diabetes mellitus (GDM) patients 10 years after giving birth. Materials and methods: Medical records of patients with former GDM were screened. Eligible patients were invited to the hospital to obtain information about their present health status. Patients with pregestational diabetes and patients with multiple pregnancies were excluded. A total of 67 women formed the study group. American Diabetes Association (ADA) and International Diabetes Federation (IDF) criteria were used to define T2DM and MetS, respectively. Results: A total …

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A Comparison Of Rates And Severity Of Chronic Kidney Disease In Deceased-Donor Andliving-Donor Liver Transplant Recipients: Times Matter, Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesi̇mi̇ Meci̇t, Glen E. Leverson, David Foley, Joshua D. Mezrich, Turan Kanmaz, Oya Münevver Andaçoğlu, Anthony M. D'Alessandro, Koray Sadik Acarli, Münci̇ Kalayoğlu, Luis A. Fernandez Jan 2021

A Comparison Of Rates And Severity Of Chronic Kidney Disease In Deceased-Donor Andliving-Donor Liver Transplant Recipients: Times Matter, Yücel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesi̇mi̇ Meci̇t, Glen E. Leverson, David Foley, Joshua D. Mezrich, Turan Kanmaz, Oya Münevver Andaçoğlu, Anthony M. D'Alessandro, Koray Sadik Acarli, Münci̇ Kalayoğlu, Luis A. Fernandez

Turkish Journal of Medical Sciences

Background/aim: The progression of chronic kidney disease (CKD) in recipients of living-donor liver transplant (LDLT) compared to deceased-donor liver transplant (DDLT) has not been studied in the literature. We hypothesize that CKD stage progression in LDLT recipients is reduced compared to that of their DDLT counterparts. Materials and methods: A retrospective study was undertaken including 999 adult, single-organ, primary liver transplant recipients (218 LDLT and 781 DDLT) at 2 centers between January 2003 and December 2012, in which CKD progression and regression were evaluated within the first 3 years after transplantation. Results: Waiting time from evaluation to transplantation was significantly …

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Which Scoring System Is Better In Association With Exercise Capacity And Health Status Innoncystic Fibrosis Bronchiectasis Patients?, Yelda Varol, Hülya Doğan Şahi̇n, Ni̇met Aksel, Ali̇ Kadri̇ Çirak Jan 2021

Which Scoring System Is Better In Association With Exercise Capacity And Health Status Innoncystic Fibrosis Bronchiectasis Patients?, Yelda Varol, Hülya Doğan Şahi̇n, Ni̇met Aksel, Ali̇ Kadri̇ Çirak

Turkish Journal of Medical Sciences

Background/aim: Two different scoring systems were developed to determine the severity of bronchiectasis: FACED scoring and the bronchiectasis severity index (BSI). In this study, we aim to compare these 2 scoring systems according to the 6-min walking distance test and a disease-specific health status questionnaire in patients with noncystic fibrosis bronchiectasis (NCFB). Materials and methods: Smoking history, emergency and hospital admissions, and body mass index were obtained from NCFB patients admitted to our hospitals' pulmonary rehabilitation unit between 2013 and 2018. Detailed pulmonary function tests were performed for all participants. Dyspnea perceptions were determined according to the mMRC dyspnea scale. …

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Factors Influencing Anterior/Low Anterior Resection Syndrome After Rectal Or Sigmoidresections, Sami̇ Benli̇, Tahsi̇n Çolak, Mehmet Özgür Türkmenoğlu Jan 2021

Factors Influencing Anterior/Low Anterior Resection Syndrome After Rectal Or Sigmoidresections, Sami̇ Benli̇, Tahsi̇n Çolak, Mehmet Özgür Türkmenoğlu

Turkish Journal of Medical Sciences

Background/aim: Sphincter-preserving surgery is one of the main goals in the treatment of rectal cancer because it improves the quality of life (QoL). However, some patients may experience disrupted symptoms called anterior or low anterior resection syndrome (LARS). This study was designed to evaluate the frequency and influencing factors of LARS in patients who underwent sigmoid or rectal resection. Materials and methods: In this retrospective, clinical study, patients who underwent rectal or sigmoid resection and anastomosis due to any benign and malignant reasons were evaluated in terms of LARS between January 2010 and November 2019 at Medical Faculty Hospital of …

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Role Of Mir-33a, Mir-203b, Mir361-3p, And Mir-424 In Hepatocellular Carcinoma, Burhanetti̇n Yalçinkaya, Esra Güzel Tanoğlu, Di̇dem Taşteki̇n, Sadretti̇n Pençe Jan 2021

Role Of Mir-33a, Mir-203b, Mir361-3p, And Mir-424 In Hepatocellular Carcinoma, Burhanetti̇n Yalçinkaya, Esra Güzel Tanoğlu, Di̇dem Taşteki̇n, Sadretti̇n Pençe

Turkish Journal of Medical Sciences

Background/aim: Hepatocellular carcinoma (HCC) is one of the most aggressive cancer types. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that function posttranscriptionally. miRNA deregulation was observed in the development and progression of HCC. In this study, we aimed to investigate the expression levels of four miRNAs (mir-33a, mir-203b, mir361-3p, and mir-424) in HCC patients in comparison to healthy individuals. Materials and methods: Venous blood samples were collected from both HCC patients and healthy individuals. In order to determine the relative expression levels of mir-33a, mir-203b, mir361-3p, and hsa-mir-424 in HCC patients, probe-based quantitative real time PCR (qRT-PCR) was performed. The …

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Characteristics And Mortality Determinants Of Covid-19 Patients Undergoinghemodialysis, Savaş Si̇pahi̇, Hamad Dhei̇r, Aysel Toçoğlu, Meli̇ke Bektaş, Seyyi̇d Bi̇lal Açikgöz, Ahmed Ci̇had Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay Jan 2021

Characteristics And Mortality Determinants Of Covid-19 Patients Undergoinghemodialysis, Savaş Si̇pahi̇, Hamad Dhei̇r, Aysel Toçoğlu, Meli̇ke Bektaş, Seyyi̇d Bi̇lal Açikgöz, Ahmed Ci̇had Genç, Fuldem Mutlu, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19 infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis. Materials and methods: Forty-two patients over 18 years of age who underwent a maintenance hemodialysis program at our unit, who tested positive for COVID-19 by PCR from nasopharyngeal swabs, and/or who were observed to have disease-related signs in their CTs were included in the study. Results: In this study, 23 of …

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Basal And Pentagastrin-Stimulated Calcitonin Cut-Off Values In Diagnosis Of Preoperativemedullary Thyroid Cancer, Emi̇ne Kartal Baykan, Mehmet Erdoğan Jan 2021

Basal And Pentagastrin-Stimulated Calcitonin Cut-Off Values In Diagnosis Of Preoperativemedullary Thyroid Cancer, Emi̇ne Kartal Baykan, Mehmet Erdoğan

Turkish Journal of Medical Sciences

Background/aim: Medullary thyroid cancer (MTC) originates from parafollicular cells (C cell) and produces calcitonin (CT). Basal serum CT was used in the diagnosis and treatment of MTC. If basal CT level is 100 pg/mL or higher, it is likely to have MTC, but if basal CT level is below 10 pg/mL, the probability of developing thyroid disease is low. In cases with basal CT level between 10-100 pg/mL, pentagastrin-stimulated (PS) CT level is studied to evaluate MTC and C cell hyperplasia (CHH). This study aimed to determine cut-off value for basal and PS peak CT level for diagnosis of MTC. …

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Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül Jan 2021

Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül

Turkish Journal of Medical Sciences

Background/aim: It is believed that radiotherapy has important effects on oxidant/antioxidant systems. Oxidative stress occurs when the balance between oxidant formation and antioxidant defense is disrupted in favor of oxidants. The aim of this study was to determine the biochemical changes in saliva pre- and postradiotherapy in head-neck radiotherapy patients and to find out the effects of radiation on glutathione (GSH), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels in saliva. Materials and methods: This study included 16 patients undergoing head-neck radiotherapy in Atatürk University Research Hospital. The levels of GSH, GSH-Px, and MDA were measured in saliva samples taken from …

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