Expanding Natural Product Diversity Through Biotransformation, Emerson Queiroz

Oxford ICSB

Over the past decade, natural product research has undergone a methodological revolution [1]. Modern approaches now integrate advanced metabolite profiling techniques for compound annotation and prioritization, together with high-resolution chromatographic methods that enable seamless transition from analytical to preparative scales [2]. These tools have facilitated the detection and identification of minor bioactive constituents. Nevertheless, plant extracts typically contain abundant common scaffolds with limited relevance for drug discovery. In this context, enzymatic biotransformation emerges as a promising strategy to enhance chemical diversity and unlock new structural space. Two complementary biotechnological approaches have been developed: enzymatic transformation using fungal secretomes (crude extracellular …

Sudden Cardiac Arrest & Newly Diagnosed Arrhythmogenic Cardiomyopathy In A High School Athlete, Jacob Rolfes, Brent Holtgrewe, Mike Tzianos

2026 Student Academic Showcase

A high school soccer player experienced sudden cardiac arrest during competition and required immediate CPR and AED use. Following resuscitation, physicians ruled out commotio cordis and identified findings consistent with arrhythmogenic cardiomyopathy, supported by a prolonged T-wave on EKG while all other laboratory and catheterization results were normal. The athlete later received an ICD and pacemaker, prompting significant physical, emotional, and lifestyle adjustments. This capstone project examines the emergency response, the role of trained medical personnel at sporting events, and the implications of early cardiac screening for adolescent athletes. Through consented family interviews, structured questionnaires, and case-based data collection, the …

Longitudinal Fueling Status Of High School Female Athletes, Kaylee Turner, Abigail Rickermann

2026 Student Academic Showcase

Low energy availability (LEA) is a clinically significant concern in adolescent female athletes due to its impact on growth and development, bone health, hormonal function, performance, recovery, and cognitive outcomes. Despite established associations, a clear longitudinal understanding of how LEA relates to injury and illness rates across an academic year remains limited, representing a clinical gap in athletic training and sports medicine literature. The purpose of this capstone project was to develop a comprehensive Institutional Review Board (IRB) protocol to support a future longitudinal investigation examining LEA and its relationship to injury and illness incidence in high school female athletes. …

Effectiveness Of Rule Modification And Contact Exposure Reduction In Adolescent Contact Sports, Alex Martin

2026 Student Academic Showcase

Clinical Question: In adolescent athletes participating in contact sports, does rule modification or contact restriction reduce sport-related concussion incidence compared with standard full-contact rules? Background: Sport-related concussion remains a major concern in youth athletics. Structural prevention strategies, such as limiting contact exposure, have been proposed as effective approaches, though their comparative effectiveness remains under review. Methods: A critically appraised topic (CAT) was conducted using Google Scholar to identify peer-reviewed studies from the past 15 years examining rule modification or contact restriction as primary prevention strategies. Six high-quality studies met inclusion criteria, including one meta-analysis, one systematic review, prospective cohort studies, …

Understanding The Impact Of Therapeutic Recreation On Patient Outcomes, Faith Atkins, Emma Jones

2026 Student Academic Showcase

This exploratory project examines the role of Therapeutic Recreation (TR) in improving overall well-being and quality of life for individuals across diverse populations. The purpose of this project is to analyze how leisure-based interventions can be adapted to meet the physical, cognitive, emotional, and social needs of patients in various settings. By synthesizing current research and professional practices, this project highlights how TR contributes to rehabilitation, identity rebuilding, and long-term wellness. The project focuses on how recreational therapists use individualized, evidence-based approaches to help patients re-engage in meaningful activities following injury, illness, or disability. It also explores the impact of …

Clinical Evaluation And Rehabilitation Of A Complex Non-Contact Knee Injury In A Collegiate Athlete, Shelby Pritt

2026 Student Academic Showcase

This case follows the rehabilitation of a 22-year-old collegiate lacrosse player recovering from a complex knee injury. During the initial evaluation, the athlete presented with pain, swelling, and limited active range of motion, secondary to pain. The rehabilitation protocol used a combination of ACL, MCL, and meniscus standardized rehabilitation parameters. The primary goal of rehabilitation was to safely return the athlete play the following season. This case highlights the importance of knee health and the role of preventative exercise programs in reducing injury risks. This case covers the rehabilitation of a complex right knee injury primarily focusing on a complete …

Treating Depression With L-Methylfolate: A Review Of Evidence, Marianna G. Pettit

Epsilon Sigma at-Large Research Conference

Abstract

Introduction & Background: Depressive disorders have many different causes. Folate deficiency can sometimes be behind these disorders, due to this vitamin’s role in neurotransmitter synthesis. Some research suggests that supplementing with an active form of folate improves depressive symptoms with and without antidepressant use. Purpose Statement Question: For individuals with depressive disorders, does supplementation with L-methylfolate (LMF) reduce symptoms of depressive disorders with or without use of an antidepressant? Literature Review: A manual literature search for sources published within the past 7 years revealed 557 documents from four different databases. Key search words included, “depression,” “treatment,” …

A Historical Analysis Of The Development Of Prenatal Care In The U. S., Kristen Montgomery Phd, Cnm, Aprn, Shelby Greene Bsn, Rn, Lauren Griffin Bsn, Rn, Destiny Lewis Bsn, Rn, Lauryn Lewis Bsn, Rn, Bryleigh Newberry Bsn, Rn, Brittany Scott Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: This paper examines the historical development of prenatal care in the United States, tracing its evolution from informal, home—based management to structured, evidence-based systems that are central to maternal and fetal health.

Aims: The specific aim of this project was to determine how prenatal care evolved in the United States.

Methods: A historical methods approach was used. Historical documents were reviewed using PubMed, CINAHL, and Google Scholar to find relevant resources. Relevant articles were reviewed by the research team and analyzed for components regarding the development of prenatal care. All members of the research team reviewed the articles and …

Nurse-To-Patient Ratios In Adult Medical-Surgical Units, Kayleigh A. Runion, Emily G. Barnette, Maddison K. Wood, Jeremy Walker

Epsilon Sigma at-Large Research Conference

Nurse-to-patient ratios in adult medical-surgical floors vary across healthcare settings and have been linked to patient safety and quality outcomes. Nurse-to-patient ratios of 1 to 6 or greater are most common in practice settings, despite the growing evidence that higher nurse workloads are associated with increased mortality, longer length of stay, higher readmission rates, mistakes, and miscommunication in nursing care. The purpose of this evidence-based practice project is to examine whether applying safer nurse-to-patient ratios, 1 to 4 instead of 1 to 6 or higher, improves patient safety outcomes. Using the Johns Hopkins Evidenced-Based Practice Model, a project was put …

Does Time Matter? Comparing 8- And 12-Hour Registered Nurse Shifts., Ava P. King, Abby L. Goodall, Cheryl L. Goodall, Makayla B. Ramsey, Imari K. Golden

Epsilon Sigma at-Large Research Conference

This project analyzes the effect that registered nurse's shift length has on patient outcomes and quality of care. The research specifically explores a well-debated healthcare issue; are 12-hour shifts associated with poor patient care due to fatigue? By comparing errors made in 12-hour and 8-hour shift lengths of registered nurses, it can be determined if a trend can be seen in declining patient care. Not only will this research shed light on nurses' fatigue and burnout, but it will also showcase the patient dangers associated with overworking. Overall, the goal is to bring awareness using statistical data that explains why …

Historical Development Of Vaccines And The Public's Response, Kristen Montgomery, Samantha Prince Bsn, Rn, Melissa Ealey Bsn, Rn, Jarrad Morelock Bsn, Rn, Shelby Johnson Bsn, Rn, Kokeshia Crosby Bsn, Rn, Stephanies Himes Bsn, Rn, Theresia Hinton Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Vaccines, which have become one of the most important medical accomplishments in the prevention of communicable diseases, have a history that dates to the use of variolation as early as the 11th century. The purpose of this study is to explore the historical development of vaccines and to determine the characteristics that emerged when new vaccines were developed.

Aims: The specific aim of this study is to understand if all vaccines have been received about the same by the general public or if there are certain different or diverse characteristics associated with the introduction of different vaccines.

Methods: A …

A Systematic Literature Review On Alternative Treatment Modalities In Adults With Treatment Resistant Depression, Brian Miller

Epsilon Sigma at-Large Research Conference

Abstract

            Currently, Psychiatric Mental Health Nurse Practitioners (PMHNPs) often defer to electroconvulsive therapy (ECT) for individuals with TRD who fail to achieve resolution of their disorder. However, many individuals do not meet criteria for ECT or decline the treatment due to side effects and associated risks. To synthesize potential alternative treatments and address the current gap in literature that does not include first-line preferred electroconvulsive therapy (ECT), a systematic literature review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA 2020). Databases searched for this review included the Cumulative Index to Nursing and Allied Health Literature …

The Impact Of Social Interaction On Patient Well-Being With Transition Into Long-Term Care Settings: A Review Of Interventions For Improved Patient Outcomes, Helen Whitney Harmon

Epsilon Sigma at-Large Research Conference

Abstract

Purpose: When individual patients are transitioned from home or acute care settings to more long-term care environments such as skilled nursing units or assisted living facilities, the residents are at an increased risk of experiencing loneliness, which is linked to depression, anxiety, and increasing cognitive decline, and other detrimental outcomes.

Aims: Combinations of peer-reviewed qualitative and quantitative research studies were analyzed to determine what factors contributed to changes in patient well-being, mental health and overall quality of life during these transitions.

Methods: One article focusing on preventable healthcare transitions in patient population was able to link higher medical acuity …

Does Mandated Paid Maternity Leave Affect Postpartum Depression?, Amaya S. Hall, Shay Y. Bullwinkel, Loran M. Hurley, Sara Cook

Epsilon Sigma at-Large Research Conference

This project analyzes the effects that paid maternity leave has on postpartum depression. Upon reviewing multiple studies, it has been demonstrated that unpaid maternity leave is associated with postpartum depression. Throughout researching postpartum depression rates, it has been proven to be much higher in unpaid leave compared to paid maternity leave. Mothers that have the burden of staying home with their infants and having to juggle time off work, without being compensated, are at an increased risk of experiencing postpartum depression. It has been shown that when a mother is able to focus on her child and her healing after …

The Role Of Nurses In Robotic-Assisted Surgery, Tehya Wiedemeier, Gretchen Faith Grambow, Ella Froehlich, Whitney Anna Holmes

Epsilon Sigma at-Large Research Conference

The research examines the evolving role of nurses in robotic-assisted surgery. As the technology advances, the nursing role is expanding beyond the traditional responsibilities. The method of literature review for this study was completed through deductive content analysis based off three data bases called Science Direct, PubMed (Medline), and Scopus. Current research is working towards trying to bring educational awareness to the role of nurses within the robotic surgery environment and what new skills they will have to acquire.  For nurses to successfully fit into the role of assisting within robotic surgery, they will need to obtain a higher level …

Mindfulness-Based Therapy For The Treatment Of Anxiety In Adolescents, Alicia Lemaster

Epsilon Sigma at-Large Research Conference

Abstract

Adolescent anxiety disorders represent a significant and growing public health concern, with increasing prevalence and associated functional impairment. Traditional treatments, including cognitive behavioral therapy (CBT) and pharmacologic interventions, are effective but often limited by barriers such as access, stigma, and adherence. Mindfulness-based interventions (MBIs) have emerged as a promising alternative or adjunctive approach to address anxiety symptoms in adolescents. The purpose of this literature review is to evaluate the effectiveness of structured mindfulness-based therapy programs in reducing anxiety symptoms among adolescents compared to usual care. A systematic literature search was conducted using databases including PubMed, CINAHL, and PsycINFO, focusing …

Improving Glp-1 Ra Initiation In Primary Care Through A Paper-Based Clinical Decision Support Tool, Carissa R. Bowery, Karen Carver

Epsilon Sigma at-Large Research Conference

Title: Improving GLP-1 RA Initiation in Primary Care Through a Paper-Based Clinical Decision Support Tool

Authors: Carissa R. Bowery, MSN, FNP-C; East Tennessee State University College of Nursing. Karen M. Carver, PhD, APRN, FNP-C; East Tennessee State University College of Nursing

This quality improvement project focuses on improving evidence-based pharmacologic management of adults with type 2 diabetes mellitus (T2DM) and obesity through implementation of a paper-based clinical decision support (CDS) tool in primary care. The aim is to increase initiation of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among eligible patients and improve provider adherence to current clinical guidelines.

Processes: This …

A Systematic Literature Review Examining Suicide Risk Factors In Older Adults, Carolyn Bivens

Epsilon Sigma at-Large Research Conference

Introduction & Background: Suicide in older adults is a increasingly prevalent tragedy worldwide, and rates in North America have uniquely increased over the past two decades. The context of the cultural environment of North America and population-specific factors in the elderly must be explored to protect this vulnerable group.

Purpose Statement Question: In older adults living in North America, what experiences and risk factors influence the development and severity of suicidal thoughts and behaviors?

Literature Review: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart guided the search of the Cumulative Index to Nursing and Allied Health Literature …

Postpartum Psychosis Risk In Women With Bipolar Disorder, Rachel R. Lay

Epsilon Sigma at-Large Research Conference

Psychiatric relapse and postpartum psychosis pose vital psychological threats to women with bipolar disorder. The phase after delivery implies a great number of biological, psychological, and social alterations that might predispose to mood fluctuations and extreme psycho-psychiatric behavior. A systematic literature review assessed the recent literature on postpartum relapse risk, contributors, and maternal outcomes in women with bipolar disorder. Systematic search of three electronic databases, CINAHL, PubMed, and PsycINFO, revealed 168 studies dating back to 2022. Title and abstract screening of 124 articles was carried out after elimination of duplicates and other eligibility criteria. Eighteen articles were full-text reviewed, and …

Adolescent Depression, Telepsychiatry, And Access, Dustin Strickland

Epsilon Sigma at-Large Research Conference

Adolescent depression is prevalent, undertreated, and associated with long-term morbidity if left untreated. Several structural barriers impede timely access to specialty mental health care in this age group. Telepsychiatry, including therapist delivered videoconference psychotherapy and internet delivered cognitive behavioral therapies (ICBT) have been developed to expand access and continuity of care for adolescents. This modality, however, has not been thoroughly evaluated to determine the effectiveness of telepsychiatry in improving access to services and its ability to reduce depressive symptoms in adolescence. A structured literature review identified six primary studies and four complementary systematic reviews evaluating this topic. Randomized trials show …

Hazard Vs Risk: Scientific Considerations On The Eu Clp Approach To Mocs And Whole Essential Oil Classification With Tea Tree Essential Oil As An Illustrative Example, Cecile Bascoul, Dakota Carter, Joseph Dawson, Tim Valentiner, Russell J. Osguthorpe

Oxford ICSB

The ongoing revision of the EU Classification, Labelling and Packaging (CLP) Regulation represents a critical development for the essential oil industry. A provisional derogation has been introduced for plant-derived, non-chemically modified Multi-Constituent Substances (MOCS), including essential oils, following sustained advocacy efforts. However, the European Commission is required to deliver, by the end of 2029, a scientific report reassessing the validity of this derogation based on scientifically and regulatorily accepted safety evaluation approaches. In the absence of such a derogation, essential oils could be classified solely on the basis of individual constituents exceeding regulatory thresholds, irrespective of the whole oil safety …

Building The Nursing Leadership Pipeline: Outcomes Of A Statewide Emerging Nurse Leader Fellowhip, Kathleen Kinser Dnp, Aprn, Belinda J. Fleming Phd, Christie Manasco Phd, Monaco M. Briggs Edd, Yan Cao Phd, Jennifer Hitt Phd

Epsilon Sigma at-Large Research Conference

Healthcare systems increasingly require skilled nurse leaders to address workforce shortages, quality improvement demands, and complex care environments. However, many nurses transition into leadership roles without formal preparation. In this quality improvement project, nurse scientists Kathleen Kinser DNP; Belinda Fleming, PhD; and Christie Manasco, PhD, from the Tennessee Center for Nursing Advancement (TCNA) evaluated outcomes of the Emerging Nurse Leader Fellowship developed to strengthen foundational leadership competencies among novice nurse leaders. Guided by transformational leadership theory, the fellowship was a statewide, cohort-based, instructor-led, asynchronous online program emphasizing practical leadership development and application in clinical settings. Two cohorts participated and completed …

Mycotoxin Trends In Cannabis Flower And Concentrates In The United States, Kyle Boyar, Yasha Kahn, Michael Esposito, Sukhikh Pavel

Oxford ICSB

Mycotoxins are toxic fungal metabolites that may pose potential health risks in cannabis products, yet limited data exists on their prevalence in regulated markets. This study analyzed multi-state compliance testing data for cannabis flower and concentrates across eleven U.S. states to evaluate detection and failure rates for aflatoxins (B1, B2, G1, and G2) and ochratoxin A. Ochratoxin A was the most frequently detected mycotoxin in both flower and concentrates; however, detections rarely exceeded regulatory action limits, with overall failure rates remaining low at 0.016% for flower and 0.017% for concentrates. After excluding outlier laboratories with unusually high detection rates, true …

Canndor Herbarium: A Comprehensive Herbarium Resource For Cannabis Identity, Diversity, And Botanical Research, Nick Batora, Laura Klein, Kerin Law, Eleanor Kuntz

Oxford ICSB

Decades of cannabis prohibition have created major gaps in our understanding of cannabis biology, especially with regard to the genomic, phenotypic, and germplasm resources that are standard in other agriculturally and medicinally important crops. Herbarium collections, which serve as archival specimens that preserve plant material for long term study, are no exception. Although herbarium specimens are meant to document plant diversity, most collections contain only a narrow sampling of cannabis and do not reflect the extensive variation present in commerce or this species at large. To address this need, the Canndor Herbarium was established in 2016 as the first dedicated …

Association Of Self-Efficacy, Preceptor Teaching, And Role Modeling With Practice Preparedness In Student Nurse Practitioners, Quinton Carroll, Pi-Ming Yeh, Jean Croce Hemphill, Melessia Webb, Alex Sargsyan

Epsilon Sigma at-Large Research Conference

Purpose: Final-semester student nurse practitioners (SNPs) often report unpreparedness for practice. Little is known about which preceptor characteristics prepare students for practice. The purpose of this study was to examine whether final-semester SNPs' practice preparedness is associated with their self-efficacy and most significant preceptor’s clinical teaching effectiveness and role modeling.

Aim: To identify which student and preceptor factors are associated with and predict SNP preparedness.

Methods: Cross-sectional correlational study of final-semester SNPs (N = 83). Participants completed the New Nurse Practitioners’ Practice Preparedness Survey, New General Self-Efficacy Scale, Cleveland Clinic Teaching Effectiveness Instrument, and Role Model Apperception Tool. Analysis …

Real World Fertility: From Participatory Research To Clinical Trial, Belinda Tan, Azure Grant, Ayla Barmmer

Oxford ICSB

Nutritional supplements are widely popular for female reproductive health, but their ingredients are typically studied in isolation in the laboratory. Finished products make claims based on these isolated studies, creating a gap in which impact of multi-nutrient formulas in the real world are not investigated, largely due to high research costs. Decentralized clinical research methods are modernizing clinical trials, leading to affordable, efficient evidence generation in large representative populations. Utilizing a decentralized research platform, we tested the hypothesis that specific supplement protocols would be associated with improved female health and fertility in a real world cohort. We present a novel …

Implementing The Abcdef Bundle In A Rural Critical Care, Kayla Hubbard

Epsilon Sigma at-Large Research Conference

Patients admitted to the critical care unit are at risk of debilitating adverse outcomes including Delirium, Post intensive care syndrome (PICS), debility, wounds, depression, and both mental and physical impairments. Complications related to ICU care can easily be combatted by using a multidisciplinary approach. The ABCDEF bundle serves to incorporate all aspects of a critically ill patients care in a simple, easy to follow bundle focusing on assessment of pain (A), both spontaneous awakening ang breathing trials (B), choice of sedation/analgesic (C), delirium (D), early mobility (E), and family involvement (F). A quality improvement project was designed and piloted in …

A Historical Study Of The Nursing Role, Kristen Montgomery, Jessica Aranda Bsn, Rn, Amanda Dalton Bsn, Rn, Machea Scott Bsn, Rn, Lisa Desantis Bsn, Rn, Halle Hilton Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Historically, nurses have been at the bedside simply following the direction of physicians, but much has changed since then.

Aims: The purpose of this study is to examine how the roles of nurses have changed over the decades, from pre-professional caregiving to advanced practice. This study focuses on the birth of nursing as a profession, the direct experiences of nurses from different generations, the shift in physician-directed care to collaborative care, how nurses interpret the impact of major healthcare transformations on their role, and the emergence and development of the nurse practitioner role.

Methods: The study was conducted using …

Frankincense (Boswellia Spp.) Essential Oils: Chemistry-Driven Authentication, Chemotype Discovery, And Sustainability Insights Across My Published Studies, Prabodh Satyal

Oxford ICSB

Frankincense, which comes from the oleo-gum resins of Boswellia species, is one of the most important botanicals in global trade. However, its essential oils often face issues like variations in chemical makeup, mislabeling, and adulteration. This presentation summarizes findings from ten peer-reviewed studies conducted between 2016 and 2023. These studies create a chemistry-based framework for authenticating frankincense and ensuring sustainable sourcing.  Research on various Boswellia species, including B. sacra, B. carteri, B. papyrifera, B. frereana, B. occulta, B. ogadensis, and B. rivae, shows strong patterns in volatile profiles at both the species and tree levels. This supports distinguishing between species …

Using Path Analysis To Examine The Psychological Well-Being Model For U.S. College Students, Pi-Ming Yeh, Cheng-Huei Chiao, Gavin Waters

Epsilon Sigma at-Large Research Conference

Background: College students’ psychological well-being and mental health issues are very important in this society. Little is known about a comprehensive psychological well-being model for college students.

Purpose: The purpose of this study was using Path Analysis to examine the Development of Personality and Psychological Well-Being Model among US college students.

Methods: This was a cross sectional, descriptive design. The 481 participants were recruited from nursing and business college students in the United States. After IRB approval, the trained researchers explained this study to college students. After agreeing to participate, they signed an informed consent form. Upon completion of a …