Medicine and Health Sciences Commons^™

Adolescent Opioid Use And Prefrontal Cortex Development - A Systematic Review, Jonathan Perumpail, Liam Kerrick, Shreya Kadi

Rowan-Virtua Research Day

Adolescence represents a critical period of neurodevelopment characterized by ongoing maturation of the prefrontal cortex (PFC), a brain region essential for executive function, impulse control, and behavioral regulation. Exposure to opioids during this vulnerable window may disrupt neural development and lead to long-term consequences. This review synthesizes current preclinical and human evidence examining the effects of adolescent opioid exposure on PFC development. Across rodent models, opioid exposure is associated with impaired synaptogenesis, altered dopaminergic signaling, and dysregulation of the prefrontal-mesolimbic circuits involved in decision making. Human studies showed reduced functional connectivity and white matter changes in those with opioid use …

Challenges Of Weight Management In A Transgender Woman Veteran, Emily Sarett, Wilmington Va Medical Center

Rowan-Virtua Research Day

Case Report

Title: Challenges of Weight Management in a Transgender Woman Veteran

Authors/Institutions: Emily Sarett, OMS-II1; Heather Dixon, PharmD2

Abstract:

Introduction: Obesity is a growing concern among transgender individuals, influenced by hormone therapy and social determinants of health. Bariatric surgery is effective, but weight regain is common and understudied in this population. Case: A transgender woman with prior sleeve gastrectomy presented with weight regain despite multiple pharmacologic trials. Her Gender-affirming hormone therapy included estrogen and androgen suppression. Results: Following the initiation of tirzepatide, the patient achieved clinically meaningful weight loss (8.4% total body weight reduction) with normalization of hemoglobin A1c …

Feasibility Of 90-Day Follow Up For Patients With Intracerebral Hemorrhage: Early Data From A Neuro Icu Sleep Quality And Delirium Study, Sierra Triolo, Bethany C. Young, Mikel Shea Ehntholt, Anuoluwapo Fadare, Jamie R. Feinour, Jennifer A. Jond, Jonathan Perumpail, Kevin Eaise, Lily Roessler, Shay Lynn Greco, Vanessa Salasky

Rowan-Virtua Research Day

Background. Neuro intensive care unit (ICU) patients often experience sleep deprivation due to serial neurologic assessments, among other factors. Subjective sleep disturbance has been associated with increased delirium risk in patients with intracerebral hemorrhage (ICH).¹ However, relationships between specific sleep features, delirium and subsequent outcomes in neurocritically ill patients have not been studied.¹ Additionally, ICH-related clinical research has not historically been conducted at Virtua Our Lady of Lourdes (VOLOL) Hospital. This study aimed to assess feasibility of obtaining quantitative sleep data, delirium assessments, and 90-day functional outcomes in neurocritical care patients with ICH.

Hypothesis. We hypothesized that 90-day …

Hormonal Contraceptives And Menstrual Symptom Severity Among Women With Elevated Cardiovascular Disease Risk: Global And Daily Assessment, Maria Cox, Danielle Arigo, Gabrielle M. Salvatore

Rowan-Virtua Research Day

Hormonal contraceptive (HC) use is primarily for pregnancy prevention and may reduce menstrual symptoms in some individuals, though evidence is inconsistent. The aim of the study was to examine differences in symptom presence and severity among 64 menstruating women with ≥1 CVD risk factor (e.g., hypertension), including HC users (20.63%) and non-users (79.37%; sample M_age= 31.88 ± 9.89, M_bmi= 31.79 ± 7.6). Participants completed the global Premenstrual Screening Tool at baseline and then reported the presence and severity of 16 menstrual symptoms (1=Not Present to 4 = Severe) in end-of-day surveys over 45 days. In a …

Blinded By Relapse: A Rare Case Of Bilateral Vision Loss From Leukemic Meningeal Infiltration, Aun A. Bangash, Tejaswini Swamy, Chloe C. Harris, Victoria Parada

Research Symposium

Background: Acute lymphoblastic leukemia (ALL) accounts for 20% of adult leukemias, with outcomes improving through modern systemic and CNS-directed therapies. Leukemic meningeal relapse, defined as infiltration of the meninges and detected by cerebrospinal fluid cytology, is reported in 4–7% of adult ALL patients and remains a devastating complication despite CNS prophylaxis. CNS involvement typically presents with nonspecific symptoms such as headache, nausea, or cranial neuropathies; isolated, abrupt vision loss is rare. With a median survival of less than six months if untreated, timely recognition is critical. We present a case of intracranial hypertension with bilateral vision loss due to leukemic …

Evaluating The Impact Of Evidence-Based Education On The Utilization Of Preoperative Gastric Ultrasound For Patients On Glp-1 Agonists, Rachel K. Gibbons, Wesley Johnson, Rachel Cartillar

Create@State

Abstract

Patients taking glucagon-like peptide-1 (GLP-1) receptor agonists have a 30.5% higher prevalence of retained gastric contents at the time of surgery despite being held according to ASA and AANA recommendations, highlighting the need for enhanced preoperative assessment to reduce aspiration risk (Sen et al., 2024; Willson et al., 2024). Although an effective, noninvasive tool for assessing gastric contents and reducing the risk of pulmonary aspiration, gastric ultrasound remains underutilized in anesthesia practice (Pan et al., 2024). This evidence-based project evaluated whether an educational intervention could improve anesthesia providers’ knowledge, attitudes, and readiness to adopt point-of-care gastric ultrasound (POC-GUS) into …

Agenda (Pdf), School Of Allied Health Professions

School of Allied Health Professions Research Day

No abstract provided.

Implementing A School Nurse-Facilitated Communication And Tracking Bundle To Improve Vision Care Follow-Up Rates, Natalie Autumn Johnston

ONU Student Research Colloquium

Abstract

Problem: Children’s cognitive, physical, and social development are influenced by vision. This means that early interventions in school-aged children are critical. While school-based vision screenings are standardized and effective in identifying visual deficits, post-screening follow-up rates with eyecare professionals remain low. This trend is especially prevalent in underserved school districts, perpetuating systemic healthcare gaps.

Purpose: The purpose of this study is to evaluate whether the rates of follow-up eye care among school-aged students who fail vision screening will improve following the implementation of school nurse facilitated follow-up communication and referral tracking bundle.

Methods: This study will …

Behavioral Effects Of Cocaine After Activation Of Cb1 Cannabinoid Receptors In Male And Female Mice, Cade Baughman, Jejun Lee, Jessica Acheampong, Jihoon Choi, Sarah Seeley, Manoranjan Dsouza

ONU Student Research Colloquium

The goal of this study was to assess the behavioral effects of cocaine following activation of CB1 cannabinoid receptors in male and female mice. This study was undertaken because recently published data suggest sex-dependent behavioral differences after CB1 receptor activation. However, the sex-dependent effects of CB1 receptor activation on the rewarding and psychomotor effects of cocaine have not been systematically evaluated. This study aimed to address this gap in knowledge. The study will use adult male and female C57BL6 mice. CB1 receptors will be activated using synthetic cannabinoid WIN 55212. Behavioral effects assessed after CB1 receptor activation will include both …

Effects Of Limb Dominance On Dopaminergic Neurodegeneration In A 6-Ohda Rat Model Of Parkinson’S Disease Assessed By Immunoblotting, Jasin Aziz Porshia, Deanna Chaialee, Dipesh Pokharel, Kala Venkiteswaran, Thyagarajan Subramanian, Dilshan Beligala

ONU Student Research Colloquium

Effects of Limb Dominance on Dopaminergic Neurodegeneration in a 6-OHDA Rat Model of Parkinson’s Disease Assessed by Immunoblotting

Jasin Porshia^a , Deanna Chaialee^a , Dipesh Pokharel^b,c , Kala Venkiteswaran^{b, c, d} , Thyagarajan Subramanian^{b, c, d}, Dilshan Beligala^a

^aDepartment of Biological Sciences, Ohio Northern University, Ada, OH, USA

^bDepartment of Neurosciences and Psychiatry, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

^cDepartment of Neurology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

^dDepartment of Neurology, Howard University, Washington, DC, …

A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics produce rapid, long-lasting antidepressant effects. Psychedelics may also exert anxiolytic effects and be useful in treating more complex psychiatric conditions, such as PTSD. However, less is known about the impact of these agents on PTSD-related symptoms. Thus, we aimed to determine whether a single administration of psilocybin could reverse PTSD-like sequelae induced by stress-enhanced fear learning in rats. Sprague-Dawley rats were placed in Context A (circular, white conditioning box) and exposed to several uncontrollable footshocks (Stress) or no footshocks (No Stress). The next day, the rats were placed in Context B (square conditioning box with clear …

Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics have demonstrated rapid, long-lasting antidepressant effects. However, psychedelics often produce unfavorable psychoactive effects that could worsen existing psychological distress. Thus, we compared the effects of psilocybin and the related tryptamine, norbaeocystin, on anxiety-like behavior in male and female rats. In Experiment 1, rats were treated with 1 mg/kg psilocybin (PSIL), 1 mg/kg norbaeocystin (NOR), or vehicle 30 min before a 5-min trial on an elevated plus maze (EPM) or in an open field test (OFT). On the EPM, PSIL led to decreased open arm time and fewer arm entries in males and females. NOR led to …

Abstract Book (Pdf), Lsu Health School Of Medicine

Medicine Research Day

No abstract provided.

Does Improved Reaction Time Correlate With Improvements In Sport Performance? A 10-Week Smart Reaction Training Intervention In Division Ii Collegiate Football Athletes, Caleb M. Forst, Christopher C. Mayer

Research & Creative Achievement Day

Introduction: Neurocognitive reaction time plays a critical role in football performance by influencing perceptual processing speed, decision-making, and motor execution. Slower reaction time has been associated with increased injury risk and reduced neuromuscular control, yet limited longitudinal research exists within Division II collegiate football populations. This study examined whether a 10-week smart reaction training program improves reaction time and whether these improvements are associated with performance outcomes, measured by the number of accurate hits. Methods: Thirty-one athletes from the Winona State Football team began the intervention and were divided into position groups (QB, WR, DL, OL); 19 completed the study. …

Fifteen Years Of The Abc-Ahp-Ncnpr Botanical Adulterants Prevention Program: What Have We Learned?, Stefan Gafner, Roy Upton, Mark Blumenthal, Ikhlas Khan

Oxford ICSB

Initiated in 2011, the Botanical Adulterants Prevention Program (BAPP) was created as a partnership between the American Botanical Council, the 2American Herbal Pharmacopoeia (AHP), and the National Center for Natural Products Research (NCNPR) at the University of Mississippi to educate the herbal dietary supplement industry, regulators, and scientists in academia about adulteration of botanical ingredients. The ultimate goal of the Program was to improve the authenticity and quality of herbal dietary supplements to the consumer. Since its inception, the Program has published 100 peer-reviewed documents. Despite herbal ingredient suppliers’ and dietary supplement manufacturers’ implementation of changes in quality control specifications, …

Gamification As A Strategy For Interprofessional Learning, Chisom S. Enebechi, Aislinn M. Dorko

Research & Creative Achievement Day

Background: A Community-based, student-led clinic provides free health services to underserved areas, bringing together students from allied health disciplines to promote interprofessional collaboration and health promotion. Previous orientation sessions were lecture-based with a team-building activity providing limited opportunities for active learning. To address this, a gamified orientation activity was developed using realistic, scenario-based cases designed to exemplify common community health situations. Purpose: This quality improvement project aims to evaluate whether gamification improves students' perceived ability to communicate, collaborate, and understand roles and responsibilities when delivering team-based care. Methods: The project was guided by Bandura's Social Learning Theory and implemented using …

Multi-Omics Systems-Guided Insights Of Withanolide And Other Bioactives Contributions To Anti-Stress And Endurance Outcomes In Withania Somnifera, Deepak Mundkinajeddu

Oxford ICSB

Conventional Ashwagandha standardization is largely focused on total withanolide quantification, without insights on the functional contribution of other phytochemical fractions. In this discovery-driven development program, orthogonal array–based model combined with predictive transcriptomics was used to delineate the relative biological roles of withanolide and other bioactive components within Withania somnifera extracts. Validated animal models showed that withanolide-enriched fractions significantly reduced serum cortisol (p< 0.05), while other bioactive-enriched fractions significantly increased run-time to exhaustion (p< 0.05), confirming anti-stress and endurance mechanisms. By linking the phytochemical profile with predicted biological pathway activity, the composition of the extract is rationally optimized for the development of a standardized extract (Ashwa.30), designed to deliver both anti-stress and endurance benefits at a dose of 30 mg. Clinical evaluation of the Ashwagandha extract demonstrated significant reductions in perceived stress scores and circulating cortisol levels, alongside measurable improvements in endurance parameters compared to placebo (p< 0.05), confirming translational alignment from preclinical discovery to human outcomes. Untargeted metabolomic profiling revealed enrichment of glycine and serine metabolism, methionine metabolism, phenylalanine and tyrosine metabolism, and homocysteine degradation pathways. These integrated metabolic changes worked together to improve energy production, support mitochondrial repair, maintain antioxidant balance, and help reset the body’s stress response system. This work presents a systems-biology–based approach to holistic Ashwagandha standardization, integrating withanolides and complementary bioactivities. It establishes a precision-driven framework for clinically validated adaptogenic efficacy.

Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu

Oxford ICSB

The Amaryllidaceae family is well known for its rich diversity of alkaloids, including lycorine- and galantamine-type structures with potent cholinesterase inhibitory properties. In this study, we investigated the phytochemical composition and cholinesterase inhibitory activity of alkaloids isolated from Narcissus poeticus L., a species native to the botanically rich Auvergne region of France. Phytochemical analysis and bioguided fractionation of bulb extracts led to the identification of three known alkaloids, pseudolycorine, norgalantamine, and 2-O-(3’-hydroxybutanoyl)-lycorine, as well as a newly characterized tetrahydroquinoline derivative, poeticine A. The inhibitory activities of these compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assessed using both a standard …

Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen

Oxford ICSB

Ashwagandha (Withania somnifera) is a widely consumed botanical supplement recognized for its anti-inflammatory, antioxidant, and anti-aging properties. Despite its extensive use, limited information exists on how its complex chemical composition changes during gastrointestinal digestion. An untargeted UPLC-MS/MS-based metabolomics approach enables analysis of discrete changes in complex mixtures. Previous in vitro studies of W. somnifera relied on simulated gastric and intestinal models composed primarily of buffers and digestive enzymes. This study advances those methods by incorporating bile salts and phospholipids under fasted and fed conditions to better simulate physiological digestion of aqueous and ethanolic extracts of W. somnifera root and leaf. …

Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir

Oxford ICSB

Ashwagandha (Withania somnifera) is an adaptogenic shrub valued for its roots, which support systemic health. Increasing use has raised safety concerns about adulteration and hepatotoxicity. The roots of ashwagandha are primarily preferred for systemic health, while the leaves were traditionally reserved for topical applications to treat joint inflammation and promote wound healing.  Although generally considered safe, ashwagandha supplements have been linked to drug-induced liver injury, including cholestasis, jaundice, and pruritus. Reports from various organizations like LARB in the Netherlands indicate a rise in liver toxicity cases, possibly due to cytotoxic withafrin A and DNA-damaging withanone. A major concern is widespread …

Advancements In Botanical Toxicology, Characterization, And Regulatory Frameworks, Paula Brown

Oxford ICSB

No abstract provided.

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift

Oxford ICSB

Peer-reviewed literature provides limited toxicological data on the consumption of naturally derived kratom extracts. Given the increasing use of kratom products, understanding their safety profile is critical for public health and regulatory decision-making. To address this gap, we conducted a rodent toxicology assessment and a controlled human clinical study. Human Clinical Study: Healthy male and female participants consumed specified kratom extracts daily for 14 consecutive days under controlled conditions. Clinical observations and biochemical markers were monitored throughout the study. Rodent Toxicology Study: Equivalent extract doses were administered to rodents for 90 days to evaluate subchronic exposure. Assessments included body weight, …

Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer

Research & Creative Achievement Day

Introduction: To manage player health, minimize injury, and optimize performance in NCAA Division II soccer, this study analyzed positional demands using GPS technology. The findings provide insights into enhancing training plans and recovery based on specific positions. Methods: NCAA Division II female soccer players were tracked during sixteen in-season competitions using 10 Hz GPS wearable technology. Players were grouped into tactical roles including Wing Backs (WB), Center Backs (CB), Defensive Midfielders (6), Attacking Midfielders (10), and Forwards (9). Key metrics analyzed included Total Distance (TD), Total Sprint Distance (TSD), and Distance per Minute (D/M). Results: Forwards (9) and attacking midfielders …

Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp

Research & Creative Achievement Day

The Business of Healthcare in Paris is a faculty-led study-away program that unites business, nursing, and other healthcare students in an immersive experience of global healthcare systems. The primary design of this course is around interprofessional learning that integrates coursework and cultural experiences from within the Midwest United States (US) and France. Students begin the course by visiting healthcare facilities and small alternative-therapy businesses in the US, gaining initial exposure to diverse care environments. They then travel to Paris and surrounding areas to explore comparable sites, including hospitals, an art therapy center, a residential rehabilitation facility, and small businesses providing …

Public Health Book Club, Ashia Meister, James W. Durst, Ameila Beyer, Kelly K. Freymiller, Julia I. Kunz, Jaci M. Winchell, Josephine M. Sandquist, Chloe F. Sand

Research & Creative Achievement Day

Introduction: This project describes the development and implementation of a book club focused on population health topics to promote learning, discussion, and community engagement. A public library is a safe space to host book club meetings due to its non-intimidating environment. All members of the community are welcome to participate. A book club was hosted on campus for members of the nursing cohort to attend. With a focus on public health, these book clubs build awareness, critical thinking, and community engagement around population health issues. Purpose: The promotion of a book club can improve health literacy in the community by …

Health Education For Caregivers Of Individuals With Intellectual And Developmental Disability (Idd), Madison M. Conlin, Jack Lux, Megan Hesse, Sadie Olson, Violet Nelson, Christina Chao, Anna Peterson, Johanna Shubert

Research & Creative Achievement Day

Background: Winona State University nursing students partner with Home and Community Options (HCO) during their population health clinical experience. HCO’s mission is to “empower and support people with developmental disabilities,” with a vision of ensuring that all individuals thrive and are valued members of their communities (Home and Community Options, n.d.). The Healthcare Director at HCO identified a need for additional staff education related to common health conditions affecting individuals with intellectual and developmental disabilities (IDD), including arthritis, diabetes, and depression or other mental health concerns. In response to this identified need, nursing students developed evidence-based educational strategies to enhance …

A Collaborative Approach To Strengthening Behavioral Strategies To The Arcadia School District, Mallory Arndt, Sada Stanley, Ariana Huntington, Erin Janiszewski, Syndey Graf, Josie Becker, Bailey Ripley, Dana Jones, Gabby Rinowski, Luke Garner, Hailey Schliep

Research & Creative Achievement Day

The School District of Arcadia is lacking mental health resources due to budget cuts from state and federal levels. Mental health needs have become a rising concern in recent years. With that, the guidance counselors, who traditionally supported students' emotional regulation and behavioral needs, became increasingly occupied with Academic and Career Planning requirements, leaving them with limited time to address students' mental health needs. To help address this need, Winona State University nursing students partnered with the district's guidance counselors to develop supplemental emotional management and decision-making skills-building videos that counselors could use during busy periods to support students' coping …

Natural Products As Multi Drug-Multi Target Therapeutics - From The Pharmacological Proof To New Approaches For Quantitative Quality Control, Olaf Kelber

Oxford ICSB

In the two decades since the mode of action of herbal medicinal products has been characterized as the Multi Target action of Multi Drug combinations [1,2, 3], the body of evidence supporting the general applicability of this principle to herbal health products has been exponentially increasing.  Key studies describing this principle, based on a wide range of pharmacological models, have been conducted in STW 5 and STW 5-II, herbal combinations used in the treatment of disturbances of the gut-brain interaction (DGBIs) as e.g. upset stomach and irritable bowel syndrome [2, 4]. They allow to characterize the contribution of each combination …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …