Medicine and Health Sciences Commons^™

Neurological Comorbidities In Hispanic Skin Cancer Patients In South Texas: A Five-Year Retrospective Study, Jared Hensley, Russell Wiggins, Blake Martin, Hunter M. Butler, Kevin Garcia Valdez, Chloe Harris, Kelsey Potter-Baker

Research Symposium

Background: Skin cancer is highly prevalent in the South Texas region due to a combination of increased UVB exposure, occupational hazards, and lack of access to preventative screening. Unfortunately, several studies have suggested that skin cancer diagnosis may be linked with an increased risk of neurodegenerative conditions, such as Alzheimer’s Disease. For example, it was recently suggested that amyloid beta plaques may have a role in melanoma metastasis. Here, we seek to evaluate the role of skin cancer incidence and the degree and severity of neurological comorbidities, with a particular focus on the Hispanic patient population. We anticipate that a …

The Link Between Depression And Bone Fractures In The Rio Grande Valley, Blake Martin, Hunter M. Butler, Russell Wiggins, Jared Hensley, Kevin Garcia Valdez, Kelsey Potter-Baker, Chloe Harris

Research Symposium

Background: The prevalence of depression has increased throughout the twenty-first century, with depression experiencing a spike in recent years due to the COVID-19 pandemic. Recent evidence has suggested that depression may be linked with changes in bone health such as fractures which may then worsen the existing depression. In this study, we sought to evaluate the relationship between depression and bone health directly in the patient population in the Rio Grande Valley, an area that is medically underserved. Specifically, we sought to determine how a history of depression was related to bone fracture frequency in our target population. We hypothesized …

Quantifying Incidence Of Early Onset Neurodegenerative Disease Post Traumatic Brain Injury In The Rio Grande Valley, A Retrospective Chart Review, Russell W. Wiggins, Jared Hensley, Hunter M. Butler, Blake Martin, Kevin Garcia Valdez, Chloe Harris, Kelsey Potter-Baker

Research Symposium

Background: Researchers have previously established evidence of early onset neurodegenerative disease (NDD) in certain patient populations post traumatic brain injury (TBI). The Rio Grande Valley (RGV) is a region in South Texas which has some of the largest health disparities in the United States. This retrospective chart review aims to quantify the difference in onset of NDD in patients with and without history of TBI within the RGV from that of the broader American population in order to determine the extent at which early onset NDD may be mitigated with appropriate intervention.

Methods: A retrospective chart review was conducted using …

Correlation Between Lecture Engagement And Academic Performance In The Utrgv School Of Medicine, Chloe Harris, Kelsey Potter-Baker, Blake Martin, Jared Hensley, Hunter Butler, Kevin Garcia Valdez, Russell Wiggins

Research Symposium

Introduction: The landscape of medical education has witnessed significant changes in recent years, marked by a decline in both in-person lecture attendance and online lecture viewership. This trend is particularly notable in the post-COVID-19 era and raises important questions about the relationship between lecture engagement and academic performance among medical students. Our study seeks to investigate the correlation between lecture viewership and course performance, with a specific focus on the unique context of the UTRGV School of Medicine. Our primary objectives were to (1) evaluate the correlation between lecture viewership and academic performance and (2) examine the relationship between lecture …

Healthcare For Undocumented People In America, Richard Pazer

Graduate Student Research Symposium

Millions of undocumented people live in America and roughly a million have entered every year since 2021. This is a hot-button issue in mainstream politics for a variety of reasons. However, there is an issue that tends to get overlooked which is their health care. In most states, undocumented people do not qualify for healthcare coverage of any kind. This leaves them reliant on EMTALA and emergency departments (ED). Through an examination of the various state and federal policies that pertain to undocumented people’s healthcare coverage, we can see that these people are in desperate need of assistance. It becomes …

Measurement And Imaging Of Intra Matrix Igg Diffusion, Riya Debbarma, Antonio C. F. Dos Santos, Diana Milena Ramiez Gutierrez, Fernanda M. Da Cunha, Michael Ladisch

Graduate Industrial Research Symposium

Bovine IgG diffusion measurement by tracking the movement of the protein over time in an in-vitro matrix is motivated by the large number of protein/peptide therapeutics currently under various stages of development in the pharmaceutical industry. Many of these therapeutics are monoclonal antibodies (IgG type proteins) that are candidates for subcutaneous, intra-vitreous and intra-articular administration depending on the target of the therapeutic. Hyaluronic acid (HA) is a major constituent and determines the key attributes of the subcutaneous environment, vitreous humor of the eye and synovial fluid of the knee joint. HA exhibits varying molecular weight at these anatomic locations thereby …

Characterization Of Biological Particles Using An Integrated Hyperspectral Imaging And Machine Learning, Kaeul Lim, Arezoo Ardekani

Graduate Industrial Research Symposium

Hyperspectral imaging (HSI) is a promising modality in medicine with many potential applications. This study focuses on developing a label-free lipid nanoparticle characterization method using a convolutional neural network (CNN) analysis of HSI images. The HSI data, hypercube, consists of a series of images acquired at different wavelengths for the same field of view, providing continuous spectra information for each pixel. Three distinct liposome samples were collected for analysis. Advanced image preprocessing and classification methods for HSI data were developed to differentiate liposomes based on their material compositions. Our machine learning-based classification method was able to distinguish different liposome types …

Sepsis Treatment: Reinforced Sequential Decision-Making For Saving Lives, Dipesh Tamboli, Jiayu Chen, Kiran Pranesh Jotheeswaran, Denny Yu, Vaneet Aggarwal

Graduate Industrial Research Symposium

Sepsis, a life-threatening condition triggered by the body's exaggerated response to infection, demands urgent intervention to prevent severe complications. Existing machine learning methods for managing sepsis struggle in offline scenarios, exhibiting suboptimal performance with survival rates below 50%. Our project introduces the "PosNegDM: Reinforcement Learning with Positive and Negative Demonstrations for Sequential Decision-Making" framework utilizing an innovative transformer-based model and a feedback reinforcer to replicate expert actions while considering individual patient characteristics. A mortality classifier with 96.7% accuracy guides treatment decisions towards positive outcomes. The PosNegDM framework significantly improves patient survival, saving 97.39% of patients and outperforming established machine learning …

Cocaine Induced Qt Prolongation, Jian Garcia Cruz, Alberto Pena, Julio Perez Rodriguez, Diana Othon Martinez, Roy Kondapavuluru

Research Symposium

Introduction:The Q-T interval represents ventricular repolarization of the heart. Prolongation of this interval is called Long QT syndrome (LQTS) and can lead to deadly arrythmias such as Torsades de Pointes. (1) According to the AHA, a Q-T interval is prolonged when it is >450ms in males and >460ms in females. LQTS has different etiologies (not limited to, but including): idiopathic, congenital, electrolyte abnormalities, and drug-induced. (2) However, recreational drugs such as cocaine may often be overlooked by some. A study by Magnano et al. found that cocaine can increase a QTc interval by 23 points (+/- 25) (P

Case …

Chasing Incessant Urinary Tract Infections Results In An Intriguing Case Of Myeloma Kidney., Jessica Marcela Daza, Eunbee Cho, Shakirat Ganiyu, Celia Patricia Daza, Cesar Gutierrez

Research Symposium

Background: Light chain cast nephropathy, formerly known as myeloma kidney, is the primary cause of renal failure in multiple myeloma (MM). At the time of presentation, about 50% of patients had kidney involvement, strongly associated with higher mortality rates.

Case presentation: A 68-year-old white female with a history of osteoarthritis on chronic NSAIDs and recurrent UTIs, proteinuria treated with long-term antibiotics, presented to the Emergency Department with the chief complaint of lightheadedness, described as episodic, accompanied by gait instability, polyuria, polydipsia, back pain, and constipation. Negative for urinary symptoms or weight loss. Medical records obtained from Primary Care Physician proven …

Chemical-Induced Pancreatitis In A Peritoneal Dialysis Patient At South Texas: A Case Report, Elimar Gonzalez Morales, Yareli L. Durazo Gonzalez, Jose Gomez Casanovas, Andres Suarez, Khairiya Haj-Yahya, Victor Tran

Research Symposium

Introduction: Acute pancreatitis is the leading cause of gastrointestinal-related hospitalization in the United States. Pancreatitis is often linked to excessive alcohol consumption or gallstones, accounting for 80% of all cases. However, in some cases, it can be drug-induced acute pancreatitis (DIP) or via chemical injury. Icodextrin (Extraneal) is a high-molecular-weight glucose polymer developed as an alternative osmotic agent to dextrose in peritoneal dialysis (PD). It is regarded as biocompatible due to its iso-osmolarity, making it generally safe and well-tolerated. While rare, cases have been reported associating icodextrin with pancreatitis; nevertheless, specific rates of icodextrin-induced pancreatitis are unknown. In this case, …

Case Of Rosai Dorfman Disease In A Patient With Newly Diagnosed Hodgkin Lymphoma, Liza Salloum, Jennifer Rojas Huen, Ricardo Serna, Alisha Valdez

Research Symposium

Background: Rosai Dorfman Disease (RDD, also known as sinus histiocytosis with massive lymphadenopathy) is a rare non-Langerhans cell histiocytosis, classified into nodal (classic) and extranodal disease. Most patients present with non-tender cervical lymphadenopathy, although other sites including the inguinal and axillary regions have been reported. Extranodal disease (~43% of cases) can involve any organ system. RDD is more common in children, but cases have been reported in patients in their 70s. The prognosis of nodal RDD can correlate with the number of nodal groups involved. Many cases can be managed only with observation, although surgery, chemotherapy, corticosteroids, and immunomodulators have …

Characterization Of Anti-Cancer Properties Of Fungal Metabolite Ophiobolin A, Asma Syed, Rozena Shirvani, Maximiliano Arath Morales, Shizue Mito, Alexander Kornienko, Xiaoqian Fang

Research Symposium

Background: Ophiobolin A (Oph A) is a secondary metabolite and a phytotoxin produced by the pathogenic fungi Cochliobolus heterostrophus that causes “southern corn leaf blight” disease in maize via modulation of the calcium binding protein calmodulin. Numerous studies have found antiproliferative effects of Ophiobolin A against a variety of cells including bacteria and various cancers including melanoma, glioma and leukemia. Recent studies have shown that OphA induces paraptosis-like cell death in glioblastoma multiforme (GBM) cells via vacuolization of the cytoplasm and enlargement of the mitochondria and endoplasmic reticulum. Notably, unlike apoptosis, paraptosis cell death lacks DNA fragmentation and activation …

Baclofen Induced Excessive Perspiration; A Case Report, Othman Farahneh, Lois C. Akpati, Miguel Alvarez Silva

Research Symposium

This case report highlights an unexpected side effect of Baclofen, a well-known medication, excessive sweating, a rare occurrence not typically associated with the drug. The patient, a 63-year-old woman, experienced persistent sweating despite initial attributions to postmenopausal symptoms and subsequent medication adjustments. Extensive testing revealed an association between Baclofen use and the symptoms, which resolved upon discontinuation of the drug.

The significance of this case lies in drawing attention to the underreported side effects of excessive sweating linked to Baclofen, emphasizing the importance of considering medication-related effects even with established drugs. The report urges increased awareness among healthcare professionals, addressing …

Birth Defect Trends Within Texas Public Health Region 11, 2000-2019: An Analysis Of Texas Department Of State Health Services Public Data., Miguel A. Lopez, Jonathan M. Hebert, Padmanabhan Rengasamy

Research Symposium

South Texas is a predominantly Hispanic region with high rates of chronic illness, poor healthcare access, and a history of birth defect clusters. Between 1986 and 1991, 47 cases of anencephaly in Cameron County were linked to elevated fumonisins in the region’s corn-based diet, prompting a series of ongoing public health efforts. This paper aims to identify changes in prevalence for CNS defects, in addition to cardiac, circulatory, gastrointestinal, and genitourinary defects in South Texas within the last two decades. Public data on 20 birth defects from the Texas Department of State Health Services were obtained for decades 2000-2010 and …

Assessing The Reliability, Internal Consistency, And Sensitivity Of A Nutrition Knowledge Questionnaire For Four-Year-Old Pre-K Children, Lin Wang, Karla Cortez, Brenda Rodriguez, Joseph Reyes, Moises Cisneros, Elizabeth Alanis, Zasha Romero, Lisa Michelle Belzer Salinas, Juan López Alvarenga, Roberto Treviño-Peña

Research Symposium

Introduction: Assessing nutrition knowledge in four-year-olds, a developmental stage marked by limited attention spans and varying comprehension abilities, is challenging with traditional methods. A reliable test is pivotal for establishing a foundation for future health interventions. We evaluated a 13-question nutrition and healthy habits test in Pre-K4 children to assess reliability and sensitivity to detect differences.

Methods: Calculations included Cronbach's alpha, kappa coefficient, McNemar analysis by item, and Bland-Altman plots for test-retest differences. Mixed model regression assessed the questionnaire's sensitivity by sex and association with age. Item response theory (IRT) models were employed, generating latent abilities for students and individual …

An Unusual Presentation Of The Severe Hypothyroidism Presenting As Shortness Of Breath, Shreel H. Patel, Kashif Ali, Eunbee Cho, Fatimah Bello, Andres Suarez Parraga, Alcibiades Fleires

Research Symposium

Background: Hypothyroidism is defined as failure of the thyroid gland to produce sufficient thyroid hormone to meet the metabolic demands of the body. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. It may occur as a result of primary gland failure or insufficient thyroid gland stimulation by the hypothalamus or pituitary gland. Primary gland failure can result from the congenital abnormalities, autoimmune destruction, iodine deficiency, and infiltrative diseases. Patients can clinically present with weight gain, cold intolerance, depression, muscle fatigue, poor concentration, and menstrual irregularities. The best laboratory test for the thyroid assessment is serum …

Assessing Gait Metrics For Early Parkinson's Disease Prediction: A Preliminary Analysis Of Underfit Models, Daniel Salinas, Gerardo Medellin, Katherine Bolado, Tomas Gomez, Kelsey Potter-Baker, Nawaz Khan Abdul Hack, Ramu Vadukapuram

Research Symposium

Background: Parkinson's Disease (PD) is characterized by both motor and non-motor symptoms, and its diagnosis primarily relies on clinical presentation. There is a growing need for diagnostic tools to identify the early signs of PD, particularly the initial motor impairments often manifested as gait abnormalities. Here we seek to present preliminary findings to address this need. Our study focuses on using Machine Learning techniques (ML) to predict the PD clinical stage most efficiently and accurately. Specifically, we have sought to evaluate how spatiotemporal characteristics and other locomotor performance variables obtained on a walkway system can be utilized to identify the …

A True Bloody Emergency: An Unusual Case Of Thrombotic Thrombocytopenic Purpura, Joshua M. Ninan

Research Symposium

Background: Thrombotic thrombocytopenic purpura (TTP) is a primary thrombotic microangiopathy that is classically characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA). Although rare with an annual incidence of 3.7 cases per one million adults, it is considered a true hematological emergency due to its fatality rate of almost 100% if appropriate treatment is not initiated immediately. This makes it vitally important to identify and treat patients with TTP, a task that becomes unusually challenging in the absence of the disorder’s other characteristically diagnostic clinical features such as mucosal bleeding, fever, or presence of schistocytes.

Case Presentation: A 30-year-old gentleman with …

Circular Gene Mapping Of Identified Amr Genes In Multi-Drug Resistant Escherichia Coli Isolated From Potable Water, Shikha Sharma, Abhishek Chauhan, Tanu Jindal, Vivek Narayan Singh, Anuj Ranjan

Research Symposium

Background: Escherichia coli is a Gram-negative & facultative anaerobe bacterium ubiquitously found in all environments. It is a waterborne and foodborne pathogen associated with many diarrhoea and GI tract diseases inclusive of UTIs in humans. The rise in the number of bacteria resistant to antimicrobial drugs has a major impact on disease control efforts. Antibiotic-resistant bacteria can be found in a variety of water sources. As a result, the objective of the current study is to construct a circular AMR gene map based on the assessment of the antibiotic susceptibility profiling of E. coli isolated from twenty various potable water …

Assessment Of Mucin 13 (Muc13) As An Imaging Target For Guiding Colorectal Cancer Treatment: A Pathway Towards Theranostic Development, Ryan P. Coll, Aiko Yamaguchi, Jianbo Wang, Xiaoxia Wen, Denise Hernandez, Subhash C. Chauhan, H. Charles Manning

Research Symposium

Background: A theranostic strategy combining diagnostic imaging and targeted therapy in a single regimen is proposed for improved management and treatment of colorectal cancer (CRC). Increased specificity in detection by the noninvasive imaging technique positron emission tomography (PET) can be achieved by radiolabeling antibodies (Abs) designed to target tumor-associated antigens with increased expression post-translational modifications present in cancer cells. In this study, an Ab designed to target the transmembrane glycoprotein mucin 13 (MUC13) was radiolabeled with the positron-emitting radionuclide zirconium-89 (⁸⁹Zr) for PET imaging of a xenograft mouse model of CRC. Specified uptake of this radioimmunoconjugate was observed …

Antibody Mediated Targeted Drug Delivery Approach For Pancreatic Tumors, Nirnoy Dan, Saini Setua, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

Research Symposium

Background: Pancreatic ductal adenocarcinomas, originating from the epithelial cell lining of ducts, account for approximately 95% of tumors in this category, showcasing a survival rate of less than 5-7%. Unfortunately, little progress has been seen in the outcomes of patients with PDAC as tumor develops high desmoplasia and chemo-resistance to chemotherapeutic drugs, such as gemcitabine (Gem). The therapies are unable to penetrate to the fibrotic tumors leading to insufficient availability of the therapeutic drugs at the tumor site. We and others have shown that MUC13 is aberrantly expressed in pancreatic tumors but not in normal pancreas, which makes MUC13 as …

Distraction Culture: The Origin Story Of Notification Stress, Benedicte Kalonda

Symposium of Student Scholars

Long gone are the days when procrastination was the sole culprit of poor productivity through the chronic delay of task completion, which has also been linked to a range of stress-related health problems (e.g., headaches, digestive issues, and insomnia). Today’s culture has given rise to the phenomenon of pre-crastination, whereby a technological notification demands and receives immediate attention despite its level of urgency. This propensity to abandon flow and groove is becoming normalized, and the public health impact is currently unknown.

These notifications, a seemingly benign cost of technological advances, are setting the stage for a new level of stressor …

Creating A Positive Environment For A Better Tomorrow: Culture And Climate, Kiawana Kennedy

National Youth Advocacy & Resilience Conference

Do you want resources and strategies for creating a positive climate and culture? This presentation is specifically designed for K-12 educators who are looking for ways to support positive climate and culture, Help your students develop their social-awareness, self-awareness, self-management, relationship, and responsible decision-making skills with the thousands of resources and tools through PBS LearningMedia.

An Evaluation Of The Combination Of Metformin And Y15 For The Treatment Of Platinum-Resistant Ovarian Cancer, Manuel A. Duarte, Krystal Garcia, Marco A. Arriaga, Arkene Levy, Sue Anne Chew

Research Symposium

Background: Ovarian cancer is the fifth leading cause of cancer mortality among women. This high mortality rate is linked to the development of resistance to first-line chemotherapy with platinum compounds which has been attributed in part to increased activity of focal adhesion kinase (FAK). The anti-diabetic drug Metformin was previously shown to inhibit the proliferation and migration of ovarian cancer cells and thus, the combination of a FAK inhibitor, Y15, and Metformin may be a promising treatment for platinum-resistant ovarian cancer (PROC). The objective of this study was to evaluate the combination of Y15 and Metformin on PROC cell viability …

Alteration Of The Interferon Alpha Signaling Pathway Significantly Affects Alzheimer's Disease Pathology In App/Ps1 Mouse Model., Ranjit Kumar Das, Nirakar Sahoo, Chun Xu, Hansapani Rodrigo, Michael Paul Murphy, Upal Roy, Deepa Roy

Research Symposium

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 …

A Rare Encounter: Extracranial Meningioma Mimicking Musculoskeletal Neoplasms, Liza Salloum, Jennifer Rojas Huen, Ricardo Serna, Andrew Kolodziej

Research Symposium

Background: Meningiomas are the most common primary brain tumor in adults. While commonly encountered intracranially, 2% manifest extracranially. Although usually benign, 10% of meningiomas can become malignant. Despite their relatively high incidence, they are often difficult to diagnose due to long asymptomatic periods, often diagnosed after mass effect symptoms occur. This case explores the intricacies of diagnosing and managing an extracranial meningioma that mimicked musculoskeletal neoplasms.

Case Presentation: A 70-year-old female, with a history of hypertension and dyslipidemia, presented with diplopia, blurry vision, and intermittent right orbital pain. A recent CT had identified a slow-growing right temporal mass, yet she …

Advanced Neuroimaging Findings In A Patient With Neurotoxin-Exposure Related Parkinson’S Disease: A Case Report, Kevin A. Garcia Valdez, Blake Martin, Jared Hensley, Hunter M. Butler, Russel W. Wiggins, Daniel Salinas, Chloe Harris, Nawaz Hack, Kelsey Baker

Research Symposium

Background: Neurotoxin exposure has been linked to a variety of neurological conditions and diseases. This is likely because many neurotoxins (natural and synthetic) can cross the blood brain barrier and impact the structure and function of neuronal cells and pathways. In particular, neurotoxin exposure has had a strong association with development of Parkinson’s Disease (PD), with the Department of Veteran’s affairs acknowledging the link in 2010. Here, we seek to understand if patients with PD and a history of neurotoxin-exposure demonstrate a different disease pathophysiology. Specifically, we want to evaluate microstructural changes in the brain in patients with PD and …

Addressing Educational Disparities To Improve Health In The Rio Grande Valley, Ronald A. Shaju, Alex Zuo

Research Symposium

Background. The Rio Grande Valley (RGV) has emerged as a United States region facing great hardships regarding health, with the region identified in the work with the highest rates of diabetes and obesity among the diverse mix of people that inhabit it. This extensive public health research shall seek to delve deeply into the relationships between educational disparities and health outcomes in the RGV population, as this might serve as a pivotal point for breaking down health disparities in the RGV. This comprehensive public health research endeavor seeks to delve deeply into that complicated relationship between educational disparities and the …

A Potential Role Of Urinary P75ecd As A Biomarker For Amyotrophic Lateral Sclerosis In An American Cohort, Swati Dhasmana, Anupam Dhasmana, Sheema Khan, Acharan S. Narula, Murali Yallapu, Subhash Chauhan

Research Symposium

Background: Neurological disorders present a unique complexity compared to other diseases, involving multiple risk factors, causes, treatments, and outcomes. These disorders often exhibit various molecular and morphological changes indicative of disruptions in cellular plasticity and resilience. The pathogenesis of many neurological disorders remains unclear, necessitating ongoing investigations. Amyotrophic lateral sclerosis (ALS) exemplifies an idiopathic and fatal neurodegenerative disease marked by the degeneration of upper and lower motor neurons. The average life expectancy post-diagnosis is a mere 36 months, primarily attributed to respiratory muscle denervation.The persistent challenges in ALS clinical trials and the absence of effective therapeutic options have intensified interest …