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Articles 3571 - 3600 of 11648
Full-Text Articles in Medicine and Health Sciences
Gene Expression Analysis Of Atypical Fibroxanthoma Patients Reveals New Insights Into The Tumor Microenvironment, Nia Gyongyosi, Aya Al-Nazal, Shehbeel Arif
Gene Expression Analysis Of Atypical Fibroxanthoma Patients Reveals New Insights Into The Tumor Microenvironment, Nia Gyongyosi, Aya Al-Nazal, Shehbeel Arif
Tower Health Research Day
No abstract provided.
Language Learning Disabilities: Adolescents Receiving Psychological Therapy In Addition To Speech Language Therapy, Katelyn Grace Mcnair, Catherine L. Cotton Phd.
Language Learning Disabilities: Adolescents Receiving Psychological Therapy In Addition To Speech Language Therapy, Katelyn Grace Mcnair, Catherine L. Cotton Phd.
Undergraduate Research Conference
Specific learning disabilities are among the most common disability categories, in which students receive special education and/or related services in schools, according to the National Center for Education Statistics (2023). Research has shown an increase of understanding in the areas of reading, writing, and spelling in individuals with learning disabilities. More recently, Ghiasi, Sedrpoushan, Abedi, Soltani (2022), noted students with learning disabilities have a lower level of achievement, motivation, self-esteem, and a high level of depression. Advances in language literacy remediation, may not be enough to overcome factors such as decreased self-esteem and fear of failure (Wolter, DiLollo, Apel, 2006). …
Disparities In Speech-Language Pathology As A Result Of Race, Lindsie Moseley, Catherine Cotton
Disparities In Speech-Language Pathology As A Result Of Race, Lindsie Moseley, Catherine Cotton
Undergraduate Research Conference
For all children to receive fair and proper speech-language services, it is vital to grasp a better understanding of how disparities in these services might impact clients. It is vital to identify the role race plays so clients of various racial backgrounds can be provided with equitable treatment, regardless of their racial identity (Robinson & Norton, 2019). Research has revealed noticeable discrepancies between racial groups including the quality, time frame of discharge, and overall results of treatment, among children of minority- or majority-racial groups (Riccardi & Lundine, 2022). If speech language pathologists remain unaware of these discrepancies, they will be …
Comparison Of Infectious Complications In Patients Undergoing Transperineal Biopsy With And Without Antibiotic Prophylaxis, Steven Leonard, Emma Helstrom, Olutiwa Akinsola, Kristen R. Scarpato, Andres Correa
Comparison Of Infectious Complications In Patients Undergoing Transperineal Biopsy With And Without Antibiotic Prophylaxis, Steven Leonard, Emma Helstrom, Olutiwa Akinsola, Kristen R. Scarpato, Andres Correa
Tower Health Research Day
No abstract provided.
Hgs-3 The Influence Of A Tandem Cycling Program In The Community On Physical And Functional Health, Therapeutic Bonds, And Quality Of Life For Individuals And Care Partners Coping With Parkinson’S Disease, Leila Djerdjour, Jennifer L. Trilk
Hgs-3 The Influence Of A Tandem Cycling Program In The Community On Physical And Functional Health, Therapeutic Bonds, And Quality Of Life For Individuals And Care Partners Coping With Parkinson’S Disease, Leila Djerdjour, Jennifer L. Trilk
SC Upstate Research Symposium
Purpose Statement: Several studies have shown that aerobic exercise can have a positive impact on alleviating symptoms experienced by individuals with Parkinson's disease (PD). Despite this evidence, the potential benefits of exercise for both PD patients and their care partners (PD dyad) remain unexplored. This research project investigates the effectiveness, therapeutic collaborations, and physical outcomes of a virtual reality (VR) tandem cycling program specifically designed for PD dyads.
Methods: Following approval from the Prisma Health Institutional Review Board, individuals with PD were identified and screened by clinical neurologists. The pre-testing measures for PD dyads (N=9) included emotional and cognitive status …
Hhp-3 Comparing Fitness Data Of Cadets In South Carolina To The General Population: A Pilot Study, Justen Chatman, Ming-Chi Sung, Matthew Brisebois
Hhp-3 Comparing Fitness Data Of Cadets In South Carolina To The General Population: A Pilot Study, Justen Chatman, Ming-Chi Sung, Matthew Brisebois
SC Upstate Research Symposium
BACKGROUND: To prepare for physically challenging environments, it is expected that military personnel achieve higher levels of physical fitness than the general population. The recent COVID-19 pandemic impacted physical activity levels among many of America’s youth, and thus, new recruits may be entering military service with lower fitness levels. It is also unknown how fitness levels of army cadets in upstate South Carolina compare to the general population. Therefore, the purpose of this pilot study was to compare anthropometric and fitness variables of army cadets from upstate South Carolina to data from the general population. METHODS: A sample of 22 …
Hhp-8 Barriers And Facilitators To Regular Physical Activity And Healthy Eating Behaviors In Schools: Perspectives Of South Carolina School Personnel, Logan J. Camp-Spivey, Susan D. Newman, Robert N. Stevens, Michelle Nichols
Hhp-8 Barriers And Facilitators To Regular Physical Activity And Healthy Eating Behaviors In Schools: Perspectives Of South Carolina School Personnel, Logan J. Camp-Spivey, Susan D. Newman, Robert N. Stevens, Michelle Nichols
SC Upstate Research Symposium
Background: In South Carolina (SC), 42% of youth are overweight or obese. Two sets of modifiable behaviors contributing to obesity are physical activity (PA) and dietary habits. School-based interventions have successfully improved these behaviors. The purpose of this study was to identify SC public school personnel perspectives on the most common barriers and facilitators to regular PA and healthy eating behaviors in schools.
Methods: A needs assessment survey was conducted with school personnel statewide. There were 17 questions on the survey that addressed: (1) demographic information about participants’ educational backgrounds, (2) barriers to regular PA and healthy eating behaviors in …
A Case Of “Neptune’S Fix Elixir” - The Dangerous Consequences Of Unregulated Use Of Tianeptine In Over-The-Counter Products, Priscilla Lozano, Maya Qutob Do, Eduardo Espiridion
A Case Of “Neptune’S Fix Elixir” - The Dangerous Consequences Of Unregulated Use Of Tianeptine In Over-The-Counter Products, Priscilla Lozano, Maya Qutob Do, Eduardo Espiridion
Tower Health Research Day
No abstract provided.
A Delayed Diagnosis Of Common Variable Immunodeficiency In A Patient With Chronic Enteropathy, Tahminah Kausar, Shefali Amin, Devi Parvathy Jyothi Ramachandran Nair, Raesham Bukhari, Mahmood Danishwar, Nimesh Khanal, Benjamin J. Lloyd
A Delayed Diagnosis Of Common Variable Immunodeficiency In A Patient With Chronic Enteropathy, Tahminah Kausar, Shefali Amin, Devi Parvathy Jyothi Ramachandran Nair, Raesham Bukhari, Mahmood Danishwar, Nimesh Khanal, Benjamin J. Lloyd
Tower Health Research Day
No abstract provided.
Unraveling A Rare Complication Of Perirectal Abscess In A Patient With Decompensated Alcoholic Cirrhosis, Tahminah Kausar, Mahmood Danishwar, Raesham Bukhari, Devi Parvathy Jyothi Ramachandran Nair, Benjamin J. Lloyd
Unraveling A Rare Complication Of Perirectal Abscess In A Patient With Decompensated Alcoholic Cirrhosis, Tahminah Kausar, Mahmood Danishwar, Raesham Bukhari, Devi Parvathy Jyothi Ramachandran Nair, Benjamin J. Lloyd
Tower Health Research Day
No abstract provided.
Restoring Effective Sleep Time In Post Cardiac Surgery Patients: A Quality Improvement Project, Brooke Watts Bsn, Rn
Restoring Effective Sleep Time In Post Cardiac Surgery Patients: A Quality Improvement Project, Brooke Watts Bsn, Rn
Epsilon Sigma at-Large Research Conference
Purpose: Restoring Effective Sleep Time in Post Cardiac Surgery Patients: A Quality Improvement Project
Brooke Watts, BSN, RN, DNP Student, Murray State University
Dr. Kristin Reid, DNP, APRN, ACNS-BC, DNP Program Director/Assistant Professor Murray State University
Aims: This quality improvement project was developed using DNP project guidelines provided through Murray State University and was designed to improve sleep in hospitalized cardiac surgery patients.
Processes: IRB approval was obtained from the healthcare institution and academic institution. This two-phase quality improvement project was designed to analyze the effects of a change in normalized hospital routines on self-reported sleep in post-cardiac surgery patients. …
Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara
Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara
Epsilon Sigma at-Large Research Conference
Trauma informed care nursing education is crucial. Trauma informed care is a method of providing health care which understands the likelihood of past and present traumatic events in patients and families. The experience of past or present trauma often led to chronic diseases, substance abuse disorder, fragmented health care, fears surrounding health care, chronic stress, and other negative health consequences. The purpose of this project is to increase licensed nurses’ awareness and ability to practice trauma informed care in clinical practice, as well as promote policy initiation within the health care facilities. Method planning integrated the Knowledge to Action Cycle. …
Will The Implementation Of Nurse Competency Days Improve Knowledge And Satisfaction In Nursing Staff Of A Community Health Center?, Christina Morton
Will The Implementation Of Nurse Competency Days Improve Knowledge And Satisfaction In Nursing Staff Of A Community Health Center?, Christina Morton
Epsilon Sigma at-Large Research Conference
Background: Nursing competencies are important for quality of care, patient safety, and identifying gaps in knowledge and skills. Patient harm has been linked to a lack of competency and insufficient policy and procedures.
Purpose: The purpose of this quality improvement project was to achieve standardization of nursing competencies within nurse-led clinics.
Aims: The aims of this project were to validate select competency days and determine the satisfaction of the competency days by the participants. The second aim of this project was to develop an electronic tracking form. A third aim was to develop and present a policy and procedure …
The Effects Of Age, Employment, Marriage, And Education On Academic Motivation In Undergraduate Nursing Students, Jessica Hamm Msn Rn Phd Student
The Effects Of Age, Employment, Marriage, And Education On Academic Motivation In Undergraduate Nursing Students, Jessica Hamm Msn Rn Phd Student
Epsilon Sigma at-Large Research Conference
The Effects of Age, Employment, Marriage, and Education on Academic Motivation in Undergraduate Nursing Students
Purpose: The amount of research on non-cognitive variables affecting motivation is limited in nursing students. By using Self-Determination Theory, faculty can determine what motivates students to learn which will allow the creation of a learning environment that promotes student achievement.
Aim: To determine the effect age, marriage status, employment, and education level have on academic motivation in nursing students in the third semester of a baccalaureate nursing program within the framework of Self-Determination Theory.
Method: A descriptive correlational design was used to identify the effect …
Comparisons Of Using Alcohol, Coping Strategies, Anxiety, And Depression Between Usa And Taiwanese College Students, Pi-Ming Yeh Associate Professor, Cheng-Huei Chiao Professor, Jennchang Liou Professor
Comparisons Of Using Alcohol, Coping Strategies, Anxiety, And Depression Between Usa And Taiwanese College Students, Pi-Ming Yeh Associate Professor, Cheng-Huei Chiao Professor, Jennchang Liou Professor
Epsilon Sigma at-Large Research Conference
Purpose: In this study, we compared United States (US) and Taiwanese college students’ using alcohol, coping strategies, anxiety, and depression.
Research Questions:
1. What were the differences in demographic characteristics, using alcohol, coping strategies, anxiety, and depression between US and Taiwanese college students?
2. What were the relationships between US and Taiwanese college students’ using alcohol, coping strategies, anxiety, and depression?
3. How much of US and Taiwanese college students’ anxiety and depression were predicted by their use of alcohol, coping strategies?
Methods: Four hundred and one US and 180 Taiwanese college students were recruited in this study. This was …
Quacking For Noggin: Farm Animal Assisted Therapy For The Traumatic Brain Injury Survivors, Alex Sargsyan
Quacking For Noggin: Farm Animal Assisted Therapy For The Traumatic Brain Injury Survivors, Alex Sargsyan
Epsilon Sigma at-Large Research Conference
The Aim
The aim of this study was to examine the effects of Animal Assisted Therapies with Farm Animals (AATF) with domesticated ducks on depression, anxiety, and self-efficacy in patients with traumatic brain injury (TBI) . Furthermore, the following hypothesis was tested:
Engaging in AATF with domesticated ducks will be associated with decrease in depression, anxiety, and an increase in self-efficacy.
Methods
The study examined the effects of AATF on anxiety and depression among patients with TBI. Time series quasi-experimental design structure was utilized. At the beginning of the study participants received Hospital Anxiety and Depression Survey (HADS) and General …
Integration Of Mental Health And Enabling Services In A Rural School-Based Setting: An Evidence-Based Initiative, Kim Ferguson, Teresa Carnevale
Integration Of Mental Health And Enabling Services In A Rural School-Based Setting: An Evidence-Based Initiative, Kim Ferguson, Teresa Carnevale
Epsilon Sigma at-Large Research Conference
The Rural Expansion Program for At-risk Communities to Promote Health Outcomes through the Integration of Mental health and Enabling services in an Existing Primary Care School-Based Setting (REACH ME) program was established to increase access to mental health services at two existing school-based health centers (SBHC) in rural Hancock County, TN. These SBHCs are among the most unique in the nation, holding designations as federally funded qualified health centers - proving primary care services in a geographically isolated, rural, and medically underserved area. The aim of the project is increasing the number of patients receiving mental health and enabling services …
Nursing Burnout: The Impact Of Fatigue On Patient Outcomes, Leah Mccloud, Kera F. Putnam, Dylan Zeller, Pressley Davis
Nursing Burnout: The Impact Of Fatigue On Patient Outcomes, Leah Mccloud, Kera F. Putnam, Dylan Zeller, Pressley Davis
Epsilon Sigma at-Large Research Conference
Introduction & Background: Nursing burnout is caused by high stress that leads to lack of motivation. Our goal is to review the literature to evaluate the impact of nurse burnout on nursing care.
Purpose Statement & Research Question: The purpose of this literature review was to find the impact on nursing care in response to nursing burnout.
Literature Review: These articles were derived from a variety of databases, including PubMed, JSTOR and CINHAL from the last 5 years by entering search criteria such as: “nursing burnout impact on patient care,” “nursing burnout”, “registered nurses”, “effects of burnout”, “consequences”, “turnover,” “nursing …
Health Literacy And Diabetes Outcomes In Adults With Type 2 Diabetes In Southwest Virginia, Casandra Reyes Arellano
Health Literacy And Diabetes Outcomes In Adults With Type 2 Diabetes In Southwest Virginia, Casandra Reyes Arellano
Epsilon Sigma at-Large Research Conference
Purpose: To determine if a quality improvement project involving individualized, one-on-one Diabetes education will improve health literacy and Diabetes outcomes in adults with Type 2 Diabetes in a rural primary care clinic. Diabetes is a chronic condition affecting the United States with 9.6% of Virginia’s population living with Diabetes.
Aims: To improve patient’s Diabetes literacy scores, BMI, and Hemoglobin A1c levels through Diabetes education.
Processes: There are pre- and post-education phases. Data to be collected at the end of both phases consist of DNT15 scores, BMI, and A1c. In the pre-education phase, BMI was obtained, DNT15 was administered, and Diabetes …
Implementation Of Provider-Made Follow-Up Appointments For Depression In Primary Care, Rebecca Vaughn
Implementation Of Provider-Made Follow-Up Appointments For Depression In Primary Care, Rebecca Vaughn
Epsilon Sigma at-Large Research Conference
Implementation of provider-made follow-up appointments for depression in primary care
Rebecca Vaughn
College of Nursing, East Tennessee State University; Whitson Hester School of Nursing, Tennessee Technological University
Author Note
Rebecca Vaughn https://orcid.org/0009-0007-0731-3316 College of Nursing, East Tennessee State University
There are no conflicts of interest to disclose.
Corresponding concerning this manuscript should be addressed to Rebecca Vaughn
108 Reed Mill Lane Monroe TN 38573
Abstract
Depression is a common condition diagnosed and managed in primary care.
Follow-up is inconsistent and low in these settings, creating a gap in care that
impacts management, adherence to treatment, and patient outcomes. The …
Best Practice: Peripheral Iv Flushing And Catheter Changes, Adrianna Fransman, Joseph Callahan, Madelyn Liudahl, Anna Dewitt
Best Practice: Peripheral Iv Flushing And Catheter Changes, Adrianna Fransman, Joseph Callahan, Madelyn Liudahl, Anna Dewitt
Celebration of Research
A literature review between August 2023 and November 2023 took a closer look into antibiotic peripheral intravenous line flushing and tubing changes. Ten articles were reviewed: five relating to antibiotic line flushing and five relating to peripheral intravenous catheter changes. This review aimed to determine the best and most effective practices related to PIV antibiotic flushing and peripheral intravenous catheter replacement which in turn decreases the risk of infection, injury, and medication errors, along with increased medication efficacy. The evidence for interventions that promote the most effective outcomes in patients with peripheral intravenous lines is presented.
Clinical Relevance Of Adolescent Ocp Use And Depression Risk, Rachael Shafer, Kaitlyn Waldner, Anne Reuter
Clinical Relevance Of Adolescent Ocp Use And Depression Risk, Rachael Shafer, Kaitlyn Waldner, Anne Reuter
Celebration of Research
Prevalence of depression within the United States has risen significantly in recent years.1 Depression in females has increased by 12 percent compared to 3.8 percent in males between 2009 and 2019.3 Hormonal contraceptives are widely used by women throughout the world and often started as early as menarche. Traditionally intended to prevent unwanted pregnancies, contraceptives are frequently used in the symptom management of menorrhagia and dysmenorrhea in females.2 Oral contraceptive pills (OCP) are a popular choice for adolescents due to their ease of use, formulation varieties, and ability to be used long-term. Considering the widespread use, the adverse effects can …
Peer Support Breastfeeding Programs, Charli Bomgaars, Madison Blankespoor, Owen Kolste, Grace Twelmeyer, Macay Van't Hul
Peer Support Breastfeeding Programs, Charli Bomgaars, Madison Blankespoor, Owen Kolste, Grace Twelmeyer, Macay Van't Hul
Celebration of Research
Research and analysis were done between August 2023 - November 2023 to explore the use of peer-support programs for anticipated and active breastfeeding women. Ten research reports were utilized to explore peer-supporting breastfeeding programs' use and potential success. The goal was to determine if peer support breastfeeding programs were impactful on breastfeeding mothers associated with Spencer Hospital. We present the benefits of peer support breastfeeding groups and their influence on maternal perceptions of breastfeeding, maternal confidence in sustaining breastfeeding, and the ability of mothers to achieve their breastfeeding goals.
Phun With Phages: Discovering Novel Bacteriophages In The Soil, Julia Kutz, Ryan Dodds, Logan Dykstra, Taylor M. Rentschler, Emma Steinhardt, Megan Vangarven, Jacie Vanderwaal, Shayler Vangelder, Byron Noordewier, Sara S. Tolsma
Phun With Phages: Discovering Novel Bacteriophages In The Soil, Julia Kutz, Ryan Dodds, Logan Dykstra, Taylor M. Rentschler, Emma Steinhardt, Megan Vangarven, Jacie Vanderwaal, Shayler Vangelder, Byron Noordewier, Sara S. Tolsma
Celebration of Research
We used three bacterial hosts: Mycobacterium smegmatis, Microbacterium foliorum, and Gordonia terrae, to isolate novel bacteriophages from soil samples. We named these phages, created high titer lysates, and purified their DNA genomes. We have archived the high titer lysates at Northwestern College and the University of Pittsburgh. The genomes of three of our phages were sequences at the University of Pittsburgh and we will be sequencing the remaining genomes this summer. Additionally, we are planning to image our phages with transmission electron microscopy at the University of Iowa or Nebraska yet this semester.
Cost-Effective And Efficient Screening Guidelines For Diagnosing Non-Alcoholic Fatty Liver Disease, Emma Montenegro, Katelyn Ten Pas, Connor Van Peursem, Chelsea Thurm
Cost-Effective And Efficient Screening Guidelines For Diagnosing Non-Alcoholic Fatty Liver Disease, Emma Montenegro, Katelyn Ten Pas, Connor Van Peursem, Chelsea Thurm
Celebration of Research
A literature review was conducted between the months of August 2023-November 2023 to research current guidelines for non-alcoholic fatty liver disease (NAFLD) that were both cost effective and efficient in the adult population. The purpose of this review was to provide current guidelines that could be applied in practice to screen Promise Community Health Center’s patients for the presence of NAFLD. In the review we provide guideline recommendations that are both cost effective and efficient for Promise to apply to their adult population.
Association Between Carpal Tunnel Syndrome And Amyloid Heart Disease May Assist With Early Detection And Reduced Morbidity And Mortality, Kayla Nachbar, Nicole Kirk, Jaclyn Freese
Association Between Carpal Tunnel Syndrome And Amyloid Heart Disease May Assist With Early Detection And Reduced Morbidity And Mortality, Kayla Nachbar, Nicole Kirk, Jaclyn Freese
Celebration of Research
Carpal tunnel syndrome may help identify more systemic issues than previously thought. Multiple research studies establish an association between carpal tunnel syndrome and heart disease, most specifically cardiac amyloidosis. This link is of importance as it requires alternative treatment choices to extend life expectancy for those diagnosed with the disease. Based on this analysis of multiple studies, there may be an indication for a screening criterion in those with carpal tunnel syndrome to identify a previously illusive disease before it progresses. History and certain clinical features may add to the utility of this finding to be applied as a screening …
A Shift Towards Informed Decision Making: Hormonal Contraception Versus Natural Cycle Tracking, Lauren Jurrens, Sydnee Isom, Deann Jelsma
A Shift Towards Informed Decision Making: Hormonal Contraception Versus Natural Cycle Tracking, Lauren Jurrens, Sydnee Isom, Deann Jelsma
Celebration of Research
Females participating in the wide array of birth control options are continuing to expand. With that, more females are expressing concerns about potential adverse drug reactions and side effects of hormonal birth control. While general side effects do occur, the risks for venous thromboembolism (VTE) vary depending on the hormone taken, and cancer risks are minimal to even nonexistent.3,4,7,15 Yet, many females are turning to natural cycle tracking to avoid synthetic hormones, common side effects, and potential poor health outcomes. Both options can provide comparable efficacy when used appropriately. Therefore, providers must be knowledgeable in all contraception options to …
Muscle Activation Frequency Relationship With Cost Of Transport At Increasing Walking Speed Reveals Interplay Of Both Active And Passive Dynamics, Grace Van Namen
Muscle Activation Frequency Relationship With Cost Of Transport At Increasing Walking Speed Reveals Interplay Of Both Active And Passive Dynamics, Grace Van Namen
Celebration of Research
The purpose of this study was to examine the correlation between metabolic cost and muscle activity, with a focus on frequency of EMG signals during walking at different speeds. The findings will be valuable in rehabilitating individuals who suffer from gait-related disorders. Nine participants were recruited. In the first session of data collection, each participant performed a ten-meter walk test determining their average walking speed. Using these average walking speeds, six more speeds were subsequently established during the second session. In the second session, subjects walked for four minutes at each of the six speeds while EMG data was collected …
The Impact Of Blood Flow Restriction On Heart Rate And Muscle Activation, Janaya Battles, Rajat Singh, Daniel Swier
The Impact Of Blood Flow Restriction On Heart Rate And Muscle Activation, Janaya Battles, Rajat Singh, Daniel Swier
Celebration of Research
Blood Flow Restriction (BFR) is a rehabilitation technique used in physical therapy to improve muscle growth in patients. The technique involves using blood cuffs on the limbs to occlude blood flow within the muscles, thus limiting the buildup of muscle growth inhibitors. The current literature provides information regarding these aspects but is limited in providing information regarding the impact of BFR on neural muscular coordination. Therefore, the purpose of this study was to determine how various pressure levels of the BFR cuffs can impact the muscle activation of the restrained muscles and heart rate. Our results have shown that a …
Pediatric Perceived Pain In Emergency Department Settings, Emma Jenness, Ana Dekruyter, Jackson Henry, Emily Miller
Pediatric Perceived Pain In Emergency Department Settings, Emma Jenness, Ana Dekruyter, Jackson Henry, Emily Miller
Celebration of Research
A literature review between September 2023-November 2023 examined the numerous nonpharmacological interventions employed in the Emergency Department setting to reduce perceived pain in the pediatric population during painful procedures. This review explored
current research for decreasing perceived pain for children using nonpharmacologic methods and to suggest evidence-based practices that meet the needs of the patient. We suggest several nonpharmacologic interventions that assist in decreasing pain during painful procedures in the Emergency Department setting for the pediatric population.