Medicine and Health Sciences Commons^™

Effect Of Twin Screw Granulator Process Parameters On Granule Attributes, Haosheng Xu, Ridade Sayin, James Litster

The Summer Undergraduate Research Fellowship (SURF) Symposium

Twin screw wet granulation has been considered as an efficient and effective technique of manufacturing granules (agglomerates made up of small particles) and has been widely applied in pharmaceutical industry. However, narrow granule size distributions are difficult to achieve. This study aims to elucidate the effect of process parameters such as liquid feed rate and screw configuration on the granule attributes through granule characterization. The methods used are sieve analysis (for size distribution), liquid distribution (determining the dye concentration in the granules) and density and porosity (percentage gas volume in the granule) analyses. A sieve shaker is used to divide …

Constructing Representative Social Networks For Disease Simulation, Tao Yang, Mario Ventresca

The Summer Undergraduate Research Fellowship (SURF) Symposium

Diseases spread mechanisms have been questioned and studied for many years. The ability to make predictions about an epidemic could enable scientists to evaluate inoculation/ isolation plans, control the mortality rate, and prevent the future course of an outbreak. Accurate predictions, however, are extremely hard to make and requires interdisciplinary solutions from epidemiology, sociology, statistics, graph theory, and Computer Science. For making the prediction, currently few network analysis platforms written in C++ are designed and optimized. The research is aimed to address this gap by exploring methods of constructing social contact network, simulating disease spreading, and proposing mitigation strategies for …

Synthesis And Biological Study Of Adenylyl Cyclase Inhibitors, Siyuan Sun, Zhishi Ye, Mingji Dai

The Summer Undergraduate Research Fellowship (SURF) Symposium

Adenylyl cyclases (AC) is a critical family of enzymes which modulates the dynamic cellular level of cAMP, cyclic adenosine monophosphate. The study of cAMP showed that it is indispensable for the signal transduction cascades during many physiological processes, such as immune responses and metabolism which highly relate to cancers. Previous studies of AC inhibitors have been limited due to a lack of isoform-selective small molecule modulators. Selectivity of the molecules is imperative to the activation of only the desired AC inhibitor. The design of the described project was to test the structure activity relationship (SAR) by synthesizing a class of …

Electrochemical Investigations Of Benzanthrone, Antonio Trevino, Kefa Karimu Onchoke

Undergraduate Research Conference

No abstract provided.

A Day In My Life With Partial Lobe Damage, Ashley Dutton

Undergraduate Research Conference

No abstract provided.

Libraries Respond To Mobile Ubiquity: Research And Assessment Of Mobile Device Usage Trends For Academic And Medical Libraries, Megan M. Hurst, Eleanor I. Cook, J. Michael Lindsay, Martha F. Earl

Charleston Library Conference

The authors consider trends in mobile device usage for the Internet as a whole, for EBSCO Discovery Service across all client libraries, and at two specific libraries: Preston Medical Library, serving the University of Tennessee (UT) Graduate School of Medicine and UT Medical Center, and the Joyner Library at East Carolina University, serving students and faculty on the main campus. Librarians at Preston Medical Library conducted a survey to determine which mobile devices, platforms, and apps were used by their patrons in 2012. East Carolina University piloted an iPad and e-reader lending program in 2010–2011. The results of each are …

16th Annual Pacific Research Day Abstracts, University Of The Pacific

Excellence Day

No abstract provided.

Agenda (Pdf), School Of Dentistry

LSU School of Dentistry Research Day

No abstract provided.

Effectiveness Of Multiple Recruitment Strategies For A Large Clinical Trial With Learner Teen Drivers, Julia Lockyer, Megan Fisher-Thiel, Allison Curry, Jessica Mirman, Flaura Winston, James Massey, Dennis Durbin

Research Day

Many studies do not achieve their goal for participant enrollment (Mapstone, Elbourne, & Roberts, 2002).

• Longitudinal studies with teen drivers are rare, in part due to the difficulty with recruitment and attrition as well as necessarily strict inclusion criteria (Lee et al., 2011; McCartt, Farmer, 7 Jenness, 2010).• The sources used for recruitment can be a determining factor in the effectiveness of the overall enrollment rates.

• A community-based randomized controlled trial required recruitment of a large number of participants, 512 parent-teen dyads, in a short period of time. This is a post-hoc analysis of the most effective forms …

Get The Right Fit: Strategies For Navigating Author Rights And Access, Skye Bickett, Stephanie Ferretti

Research Day

Supporting research at PCOM is one of the core missions of the PCOM Library. Librarians have been leaders in the movement for expanded sharing of scholarship. Scholarly publishing is undergoing fundamental transformations and the PCOM Library wants to help you understand how these changes impact your scholarly endeavors. Here are some resources and ideas that can assist faculty, staff, and students with scholarly publishing and data management.

Phytochemicals Added To The Feed Of Ovariectomized Adult Rats Increase Brown Adipose Activity, Colette N. Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzel, Emily England, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile

Research Day

Background: Brown adipose tissue (BAT) uncouples respiration, using lipids as an energy source while dissipating heat. Increases in BAT activity are protective against obesity, thus compounds that increase BAT activation may help prevent weight gain. Resveratrol (R) increases BAT activity by upregulating thermogenic genes. As phytochemicals have synergistic properties, our research strategy has included investigation of the efficacy of relatively low concentrations of phytochemical blends on BAT activation. Methods: Previously, we showed that R combined with genistein (G) and quercetin (Q) reduced weight gain in aged ovariectomized (OVX) female rats. In the current study, OVX rats were fed diets containing …

Nutri One-On-One: Improving Patients’ Metabolic Profile With One-On-One Nutritional Coaching, Jennifer King, Jeffrey E. Harris, David Kuo, Farzaneh Daghigh

Research Day

Introduction: More than one-third of U.S. adults (35.7%) are obese. Some of the leading causes of death are due to complications of chronic conditions related to metabolic disorders and obesity. One on one health coaching will assist people in adopting healthy lifestyle behaviors that prevent and control diseases through phases of effective goal setting, motivational interviewing, and collaboration with health care providers.

Objectives: This study’s aim was to positively influence patients’ nutritional habits and lifestyle through a brief one on one coaching session. The effects of one on one nutritional education are analyzed through goal setting, motivational lessons, and follow-up …

Social Problem-Solving Orientation And Ptsd Symptoms In Adults With Lqts Who Experienced Cardiac Events, Elizabeth A. Waldron, Stephanie H. Felgoise, Katherine L. Corvi

Research Day

Long QT Syndrome (LQTS) is a genetic condition affecting 1:2500, predisposing individuals to cardiac arrhythmias (Ellis et al., 2009). Life threatening symptoms are unpredictable though physical exertion, emotional upset, and sleep are known triggers. Severity of symptoms and psychological factors predict development of PTSD symptoms for other cardiac diseases (Whitehead et al., 2006). Effects of LQTS-related events have not been studied. Individuals with PTSD show poorer problem solving compared to those without PTSD (Sutherland & Bryant, 2008). Problem orientation is comprised of the cognitive-emotional schemas reflective of the approaches towards problem-solving ability, general life appraisals, and beliefs (D’Zurilla et al., …

Ponatinib-Induced Adverse Effects: Thrombocytopenia, Pancreatitis And Hepatoxicity-- A Case Report, Saba Hasan, Crystal Fedorkiv, Naba Rahman, Jennifer Andres

Research Day

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease that generates from malignant transformation of pluripotent hematopoietic stem cells. First line treatment for CML is the tyrosine kinase inhibitor (TKI), imatinib. For patients resistant or intolerant to imatinib, other TKIs, dasatinib, nilotinib, and ponatinib, are approved treatments. Patients who are resistant or intolerant to other agents are started on ponatinib as a last line option. Common adverse events of ponatinib are hypertension, dry skin, rash, abdominal pain, constipation, and nausea. More serious adverse effects include cardiovascular effects, fluid retention, pancreatitis, severe myelosuppression, and hepatotoxicity. Treatment for these adverse effects can …

Insulin Pump Class: Back To The Basics Of Pump Therapy, Sara Wilson Reece, Cheryl Williams

Research Day

Insulin pump therapy is a common mechanism for insulin delivery in Type 1 diabetes mellitus as well as in some patients with Type 2 diabetes mellitus. At the Longstreet Clinic, approximately 3% of patients on insulin therapy utilize insulin pumps. After several patients on insulin pump therapy experienced severe hypoglycemic episodes while driving, the need for review of insulin pump survival skills were identified. The insulin pump class which was conducted in a small group setting reviewed all of the necessary survival skills for effective insulin pump therapy. Pre- and post-class hemoglobin A1c values and emergency room visits as well …

Mitoquinone (Mitoq) Exerts Antioxidant Effects Independent Of Mitochondrial Targeted Effects In Phorbol-12-Myristate-13-Acetate (Pma) Or N-Formyl-L-Methiony-L-Leucyl-L-Phenylalanine (Fmlp) Stimulated Polymorphonuclear Leukocyte (Pmn) Superoxide (So) Release, Matthew Lepera, D. Pesikan, J. Voeun, Kerry-Anne Perkins, Qian Chen, Robert J. Barsotti, Lindon H. Young

Research Day

MitoQ is a mitochondrial-targeted coenzyme Q antioxidant analog that dose-dependently restored cardiac function and reduced infarct size in isolated perfused rat hearts subjected to ischemia reperfusion (I/R). Moreover, mitoQ also dose-dependently attenuated PMA stimulated PMN superoxide (SO) release at the same concentration (10uM) as the cardioprotective dose. NADPH oxidase is the principle source of PMN SO release. We speculate that mitoQ may exert antioxidant effects independent of the mitochondria. Therefore, we hypothesized that inhibition of mitoQ on PMN-SO release will be similar as other coenzyme Q analogs: coenzyme Q1 and decylubiquinone without affecting cell viability. SO release was measured spectrophotometrically …

Gp91ds-Tat, A Selective Nadph Oxidase Peptide Inhibitor, Increases Blood Nitric Oxide (No) Bioavailability In Bind Limb Ischemia And Reperfusion (I/R), Sydney Walker, Tyler Galbreath, Qian Chen, Robert J. Barsotti, H. Patel, William Chau, Lindon H. Young

Research Day

I/R injury induces cell death and organ dysfunction in part due to a burst of reactive oxygen species that occurs upon the reintroduction of oxygen into the ischemic area, leading to endothelial dysfunction: decreased blood NO and increased hydrogen peroxide (H2O2 ) levels. We’ve previously shown in isolated rat hearts subjected to I/R injury, gp91ds-tat attenuated cardiac contractile dysfunction and reduced infarct size compared to controls presumably by the inhibition of NADPH oxidase induced superoxide release. Superoxide can quench NO via the formation of peroxynitrite and also be converted to H2O2 in blood. We attempted to confirm this hypothesis using …

Modeling Mglur1 Mediated Synaptic Depression In Cerebellar Purkinje Cells, Yizhen Su, Huo Lu

Research Day

In our previous study, we have successfully simulated mGluR1 mediated sEPSP based on experimental and is associated with parallel fiber – Purkinje cell LTD [1, 2, 3]. Recent studies have shown that the mGluR1 mediated sEPSP is generated by calcium signaling through the TRPC channel which is crucial in cerebellar LTD induction [4]. Behavior study using mutant mice that lack this type of LTD has shown no motor learning impairment [5]. We hypothesize that cerebellar TRPC mediated synaptic depression shifts the excitatory and inhibitory balance to down regulate ongoing simple-spike activity. To test our hypothesis we modified our previous model …

Anterior Cervical Foraminotomy: Short Term Outcomes In Patients With Isolated Cervical Radiculopathy, Howard Eisenbrock, Mark Rivkin, Amir R. Dehdashti

Research Day

Intro: Anterior cervical foraminotomy (ACF) is a novel approach involving direct decompression of nerve from an offending agent without fusion. Historically, several anterior and posterior approaches were utilized to treat cervical radiculopathy. Anterior cervical discectomy necessitates fusion and is subject to adjacent segment disease as well as loss of ROM. Posterior laminoforaminotomy seldom allows for removal of disc fragment and is associated with higher postoperative pain.

Methods: Between May 2010 and March 2013, 16 patients with one or two level cervical spondylosis with radiculopathy without myelopathy who failed conservative therapies such as anti-inflammatory medications, physical therapy or injections underwent anterior …

Kyphotic Progression After Thoracolumbar Burst Fractures Treated Conservatively, With Mis, Or Via Open Approach, Mark Rivkin, Howard Eisenbrock

Research Day

Management of thoracolumbar burst fractures (AO A3) without neurological deficit is subject to debate in the literature. While TLICS provides guidance for injuries necessitating intervention, it makes little mention of best surgical approaches. Furthermore, intact patients with suspected posterior ligamentous complex injury (TLICS 4) compose an additional level of management uncertainty. Present study examined outcomes for TL burst fractures in neurologically intact patients with suspected disruption of the PLC treated with bracing, MIS, or open fixation and fusion.

A Program Evaluation Of A Housing With Services Project For Low-Income Adults In Portland, Oregon, Jack A. Phillips, Paula C. Carder, Diana White

Student Research Symposium

Reducing hospital use and connecting individuals to local available services and supports are key features of the Affordable Care Act. Adult residents of public housing tend to experience worse health outcomes than other adults. Poor self-rated health and high rates of emergency department use and hospitalization among these residents have prompted efforts to improve health outcomes. Even among residents living independently, prior research indicates that health and social disparities can be effectively addressed through coordinated care and improved access to health and social services.

Cedar Sinai Park—a nonprofit residential care organization located in Portland, Oregon—will implement a demonstration project attempting …

Using Radiation Therapy For Mesothelioma, Samira Rezaei

Student Research Symposium

This poster details research that shows that patients who suffer from mesothelioma cancer and choose Immune Therapy treatment have a longer survival rate in comparison with other methods of treatment.

The Globalization Of Maternal Healthcare In Western Africa, Maura T. Magistrali

Celebration

Maternal healthcare is one of the most important global issues in today’s world, reflected in its inclusion in the Millennium Development Goals. Globalization, through increased acceleration and movement, has improved maternal healthcare in Western Africa, as observed through the spread of Westernized medicines and treatments and improved technology in prenatal and obstetric care. Another remarkable effect of globalization is the hybridity manifested in both women’s healthcare choices and in the pluralistic training of midwives. However, the same forces of movement and exchange can also bring negative consequences, visible through health-access inequalities, brain drain, and the exploitation West African countries.

Human Disease - Unintended Globalization, Christopher J. Dellana

Celebration

Before man was exchanging goods and ideas, he was exchanging germs. As such, the spread of infectious disease constitutes the first truly global phenomenon and, therefore, marks the beginnings—primitive though they may have been—of what today we have finally termed ‘globalization.’ The global spread of disease, then, proves that globalization is not new and that its origins were the result of a different narrative than the ones we read from globalization theorists; it further demonstrates that the modern conception of the phenomenon is only now so well recognized because the accelerated and efficient processes that inform its daily activities have …

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

The Facts And Fiction About The Use Of Sign Language With Young Children, Naomi Greenblat

Undergraduate Research Symposium

In this study we sought to determine how parents and caregivers perceived the use of sign language with young children. We asked participants Likert scale questions concerning their agreement with various statements about sign language. The participants were asked questions about using sign language for communication, expressing emotion, advancing intelligence, and promoting pro-social behavior. We also asked participants open ended questions about what they had previously heard about sign language use, their thoughts about using sign language, and if they had every purchased or used materials to teach a child sign language. The responses show that on average most participants …

History Of Women And Alternative Medicine, Megan Eineke

Undergraduate Research Symposium

Alternative medicine has been used all over the world for centuries. From meditation to hydrotherapy, both men and women practice these modalities. Alternative medicine is an important part of the history of medicine and women have played a crucial role in traditional medical and other healing-related careers. This research project examines health activism among feminists and how that has played a role in what alternative medicine has become today. Information gathered from journals, articles, books, and biographies will be used to create a timeline to share how and when specific events and women influenced the reemergence of alternative medicine and …

Localization And Expression Level Of Vascular Endothelial Growth Factor After Partial Hepatectomy Of Wky Rats, Adam Kronebusch, Tyler Koonst

Undergraduate Research Symposium

Inflammation and fibrosis are indicative of liver regeneration following injury and chronic liver diseases, such as cirrhosis and hepatocellular carcinoma. The formation of new vasculature via the process of angiogenesis is vital to the pathological progression of liver regeneration and these diseases. Thus, inhibiting the process of angiogenesis could have the potential to stop or slow the progression of chronic liver diseases. Vascular endothelial growth factor (VEGF) is the most potent and specific growth factor for initiating the process of angiogenesis, making it a prime target to inhibit angiogenesis. Bevacizumab is an antibody that binds to VEGF, inhibiting it from …

Comparing Perceptions Of Motivation To Change: Clinicians Versus Their Substance-Abuse Clients, Arthur Tabrizi

Graduate Research Symposium (2010 - 2017)

Although some clients enter treatment voluntarily to seek intervention for their substance abuse problems, most enter under coercive external pressures that may be perceived by clinicians as less influenced by addressing substance abuse than by appeasing mandates from the judicial system, family, or employers. Little research has examined and compared how clinicians assess clients’ extrinsic and intrinsic motivation to change as opposed to how the clients assess themselves. A congruency between the two parties’ assessments may inform the quality of the therapeutic relationship and facilitate an effective treatment plan. Using the Circumstance, Motivation, and Readiness Scales (CMR) and availability sampling …

Acceptability Of Sexting In Same-Sex Relationships, Carly Shadid, Katherine M. Hertlein, Sarah M. Steelman

Graduate Research Symposium (2010 - 2017)

For individuals who identify as part of the LGB community, the Internet can be seen as a tool to take control of their lives, may promote self-esteem, and foster a sense of belonging. The purpose of the study was to learn about sexting practices on college campuses. It builds on the existing body of knowledge by attending specifically to sexting rather than the previous literature about engagement in sexual behavior online (see, for example, Daneback, Cooper, & Månsson, 2005). Findings indicated that sexting is viewed as more acceptable in same sex relationships as compared to heterosexual relationships.