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Full-Text Articles in Medicine and Health Sciences

Interprofessional Healthcare Education, Research And Practice, James Ballard, Maria Gabriela Castro, Mary Lynn English, Andrea Pfeifle, Melody Ann Ryan, Ted Hodgson Oct 2014

Interprofessional Healthcare Education, Research And Practice, James Ballard, Maria Gabriela Castro, Mary Lynn English, Andrea Pfeifle, Melody Ann Ryan, Ted Hodgson

JCIPE Conference

Background

• What we ‘know’

– Literature identifies demonstrated change in attitudes as a result of learning with, about and from each other (Barr, et.al., 2000)

– Similar experiences at UK

• Less understood:

– What if students are required to participate if the primary motivation of the experience is not IPE?

– What does the process of interprofessional development look like?

• Relevant vectors for IPE

– Clinical is idea

– Consider global health as an appropriate context


Study Of The Impact Of Interprofessional Education On The Advanced Pharmacy Practice Experiences Of Jefferson School Of Pharmacy Students, Caitlin Brown, Bs, Pharmd Candidate 2015, Elena Umland, Pharmd, Carolyn Giordano, Phd Oct 2014

Study Of The Impact Of Interprofessional Education On The Advanced Pharmacy Practice Experiences Of Jefferson School Of Pharmacy Students, Caitlin Brown, Bs, Pharmd Candidate 2015, Elena Umland, Pharmd, Carolyn Giordano, Phd

JCIPE Conference

Purpose

• To evaluate the impact of interprofessional education (IPE) in the first three years of pharmacy school

•This was investigated by looking at students’ preparedness for and degree of interprofessional collaboration in the final year of advanced pharmacy practice experiences (APPEs)


Health Mentors' Evaluation Of Program Impact And Student Effectiveness, Edwin Lim, Pharmd Candidate 2015, Carolyn Giordano, Phd, Lauren Collins, Md, Elena Umland, Pharmd Oct 2014

Health Mentors' Evaluation Of Program Impact And Student Effectiveness, Edwin Lim, Pharmd Candidate 2015, Carolyn Giordano, Phd, Lauren Collins, Md, Elena Umland, Pharmd

JCIPE Conference

Background

• Previous research studies have focused on student perceptions regarding interprofessional education (IPE)1

• This pilot study evaluated the Health Mentor’s (HM) perspective relative to the program’s success


Hearing From Our Health Mentors: Impact Of A Longitudinal Interprofessional Education Program, Ashley Baronner, Bs, Msii, Lauren Collins, Md, Carolyn Giordano, Phd, Edwin Lim, Pharmd Candidate 2015 Oct 2014

Hearing From Our Health Mentors: Impact Of A Longitudinal Interprofessional Education Program, Ashley Baronner, Bs, Msii, Lauren Collins, Md, Carolyn Giordano, Phd, Edwin Lim, Pharmd Candidate 2015

JCIPE Conference

Introduction

Mixed-methods study to evaluate the perspectives of the Health Mentors in the Jefferson Health Mentors Program (JHMP) relative to impact of program

Correlate these responses to the Interprofessional Education Collaborative’s (IPEC) Competencies

  • Values/Ethics
  • Roles/Responsibilities
  • Interprofessional Communication
  • Team and Teamwork


The Role Of The Rn In An Interprofessional Primary Health Care Team, Elizabeth T. Speakman, Edd, Rn, Anef, Fnap, Laura Wood, Dnp, Ms, Rn, Janice Smolowitz, Edd, Dnp, Rn, Anp-Bc, Danuta Wojnar, Phd, Mn, Med, Ibclc, Faan, Ellen-Marie Whelan, Phd, Rn, Crnp, Faan, Suzan Ulrich, Drph, Rn, Cnm, Facnm, Carolyn Hayes, Phd, Rn, Nea-Bc Oct 2014

The Role Of The Rn In An Interprofessional Primary Health Care Team, Elizabeth T. Speakman, Edd, Rn, Anef, Fnap, Laura Wood, Dnp, Ms, Rn, Janice Smolowitz, Edd, Dnp, Rn, Anp-Bc, Danuta Wojnar, Phd, Mn, Med, Ibclc, Faan, Ellen-Marie Whelan, Phd, Rn, Crnp, Faan, Suzan Ulrich, Drph, Rn, Cnm, Facnm, Carolyn Hayes, Phd, Rn, Nea-Bc

JCIPE Conference

OBJECTIVE OF THE PROJECT

To understand the role of RN as a member of the interprofessional health care team in primary care and its effect on patient care outcomes, cost and effectiveness and provider satisfaction.


Advancing Interprofessional Education And Collaborative Practice (Ipecp) In Graduate Medical Education, Dewitt Baldwin Jr., Joanne Schwartzberg, Nicholas Yaghmour Oct 2014

Advancing Interprofessional Education And Collaborative Practice (Ipecp) In Graduate Medical Education, Dewitt Baldwin Jr., Joanne Schwartzberg, Nicholas Yaghmour

JCIPE Conference

No abstract provided.


What? So What? Now What? Student Reflections On Ipe And Collaborative Practice, Lauren Collins, Md, Claire Sokas, Msiii, Elizabeth T. Speakman, Edd, Rn, Elena Umland, Pharmd, Christine Jerback, Md, Vibin Roy, Sokha Koeuth Oct 2014

What? So What? Now What? Student Reflections On Ipe And Collaborative Practice, Lauren Collins, Md, Claire Sokas, Msiii, Elizabeth T. Speakman, Edd, Rn, Elena Umland, Pharmd, Christine Jerback, Md, Vibin Roy, Sokha Koeuth

JCIPE Conference

Outline

Background

• Description of Health Mentors Program (HMP)

• Purpose of Study

Methods

• Description of Analysis

Results

• Themes and Sub-themes

Conclusions


Seniors Assisting In Geriatric Education (Sage): Reynolds Program Addresses The Lack Of Training In Geriatrics And Provides A Model For Interprofessional Education, Sandra Marquez Hall, Yolanda Pitts-Lane Oct 2014

Seniors Assisting In Geriatric Education (Sage): Reynolds Program Addresses The Lack Of Training In Geriatrics And Provides A Model For Interprofessional Education, Sandra Marquez Hall, Yolanda Pitts-Lane

JCIPE Conference

Reynolds IGET-IT Program

• DW Reynolds Mission for geriatric education: “Improving the quality of life of America’s growing elderly population through better training of physicians in geriatrics.”

• Seniors Assisting in Geriatric Education (SAGE) Program addressed the lack of geriatric skills training through the implementation of a senior mentor program for (medical) health professions students.


Ensuring The Continuum Of Interprofessional Education And Collaborative Practice In The Post Graduate Training Years, Joanne Schwartzberg, Dewitt Baldwin Jr., Nicholas Yaghmour Oct 2014

Ensuring The Continuum Of Interprofessional Education And Collaborative Practice In The Post Graduate Training Years, Joanne Schwartzberg, Dewitt Baldwin Jr., Nicholas Yaghmour

JCIPE Conference

Changing Expectations About Residency Training in Teamwork and Team-based Care

ACGME- 2002 – Six Competencies

  • Required Self-Report and Description

ACGME- 2013 – “Milestones”

  • Specialty specific, graduated IPECP competencies

“New Accreditation System” 2013-2014

  • Mandated Assessment of IPECP competencies 2X/yr.


The Use Of Standardized Patient Simulation For Interprofessional Teaching Of Palliative Care Communication Skills, Ksenia G. Zukowsky, Phd, Nnp-Bc, Kathleen Black, Phd, Rnc, Laura Roettger, Msn, Pnp-Bc, Michael Spear, Md, Msedl Oct 2014

The Use Of Standardized Patient Simulation For Interprofessional Teaching Of Palliative Care Communication Skills, Ksenia G. Zukowsky, Phd, Nnp-Bc, Kathleen Black, Phd, Rnc, Laura Roettger, Msn, Pnp-Bc, Michael Spear, Md, Msedl

JCIPE Conference

The Use of Standardized Patient Simulation for Interprofessional Teaching of Palliative Care Communication Skills

• Children who receive palliative care services are affected by illnesses that are different in nature and number from those that typically affect adult recipients.

• Interdisciplinary/Interprofessional teams are the norm:

• Special knowledge of pediatric developmental, psychological, social and spiritual dimensions round out the comprehensive palliative care of pediatric patients.

• Even symptom management requires unique assessment tools.

• http://www2.aap.org/sections/palliative/


Developing An Open Educational Resource For Interprofessional Education (Ipe)., Susanne P. Boyle, Matthew Ramirez, Lynn Sheridan Oct 2014

Developing An Open Educational Resource For Interprofessional Education (Ipe)., Susanne P. Boyle, Matthew Ramirez, Lynn Sheridan

JCIPE Conference

Jisc

Aims

» The development of an online, digitally rich IPE resource which supports an IPE learning experience.

» Employs family narratives, authentic voices and cultural insights to help students visualise and identify with the patient and client scenarios.

» Sharing of the IPE open educational resource (OER) via Jorum.

» Supports HEI sector efficiency and capacity building by the development of a quality IPE Open Educational Resource (OER) which may be adopted, adapted and re-purposed.


Ipe/Ipc: Some Big Issues Theoretical And Methodological, John H.V. Gilbert, C.M., Phd., Fcahs Oct 2014

Ipe/Ipc: Some Big Issues Theoretical And Methodological, John H.V. Gilbert, C.M., Phd., Fcahs

JCIPE Conference

John H.V. Gilbert, C.M., PhD, FCAHS

Principal & Professor Emeritus

College of Health Disciplines

University of British Columbia

Co-Chair, Canadian Interprofessional Health Collaborative

Adjunct Professor, Dalhousie University

Dr. John Gilbert is founding Principal & Professor Emeritus, College of Health Disciplines, University of British Columbia where he was also founding Director of the School of Audiology and Speech Sciences, and Director of the School of Rehabilitation Sciences.

His many honors include a Fulbright Scholarship; Medical Research Council of Canada Post-Doctoral Scholarship; the Outstanding Alumnus Award of the School of Liberal Arts, Purdue University; a UBC Isaac Killam-Walton Outstanding Teaching Award; The …


It's Time We Become A Learning Team, Barbara F. Brandt, Phd Oct 2014

It's Time We Become A Learning Team, Barbara F. Brandt, Phd

JCIPE Conference

Barbara F. Brandt, PhD

Director, National Center for Interprofessional

Practice and Education

Associate Vice President for Education

University of Minnesota Academic Health Center

Professor, Pharmaceutical Care and Health System

Barbara Brandt is one of the nation’s foremost experts in interprofessional practice and education and a leading force in the creation of the National Center for Interprofessional Practice and Education housed at the University of Minnesota. As center director, Dr. Brandt is responsible for engaging leaders and experts across the country in this ground-breaking effort to improve health by realigning health professions education and care delivery. Dr. Brandt and her colleague, …


Using Graph Visualization To Look At The Trajectories Of Events That Lead To Readmission, Abbas Shojaee, Isuru Ranasinghe, Sudhakar Nuti, Shu-Xia Li, Harlan Krumholz Sep 2014

Using Graph Visualization To Look At The Trajectories Of Events That Lead To Readmission, Abbas Shojaee, Isuru Ranasinghe, Sudhakar Nuti, Shu-Xia Li, Harlan Krumholz

Yale Day of Data

Information on specific sequence of healthcare utilization events in heart failure patients may be useful for identifying distinct subpopulations of patients with HF. Knowledge of patient trajectories may help to improve prediction of future readmission which can be used to tailor management to the individual needs of the patient.

This research introduces a new approach to mining administrative and clinical datasets by incorporating graph networks to identify & visualize the trajectories of sequences of events.


Using Graphs To Characterize Nationwide Physician Referral Networks, Ding Tong, Shu-Xia Li, Isuru Ranasinghe, Sudhakar Nuti, Hongyu Zhao, Harlan Krumholz Sep 2014

Using Graphs To Characterize Nationwide Physician Referral Networks, Ding Tong, Shu-Xia Li, Isuru Ranasinghe, Sudhakar Nuti, Hongyu Zhao, Harlan Krumholz

Yale Day of Data

AIM:

Evaluating physician referral network characteristics can help to understand how physicians and hospitals interact to provide patient services within the US healthcare system and ultimately how this may influence patient outcomes.

METHOD:

We used the 2012-2013 national Physician Referral data from the Centers for Medicare & Medicaid Services (CMS), which consists of 73,071,804 pairs of referrals from one health provider to another in calendar year 2012 and the first two quarters of year 2013 within 30 days of care. These referrals are from 642,144 national-wide physicians and 4,811 hospitals. We obtained information for each provider, physician or hospital, from …


International Occupational Health Research On An "Invisible" Workforce, Martin D. Slade, Rafael Lefkowitz Sep 2014

International Occupational Health Research On An "Invisible" Workforce, Martin D. Slade, Rafael Lefkowitz

Yale Day of Data

There are many professions in which employees are located in remote locations. International maritime workers make up one such occupation. They are a vulnerable, underserved and neglected population of approximately 1.2 million people with high rates of disease and injury. During their typical nine month deployments, they live in relative isolation with no health care professional on board. To understand the root causes of disease and injury among this remote workforce, strategies to collect information, analyze data, and report results and recommendations have been developed. These strategies, which include gathering of data through an alliance of companies involved in seafaring, …


Beyond Original Intent – The Use Of A Corporation’S Administrative Databases For Academic Research, Martin D. Slade, Linda Cantley, Baylah Tessier-Sherman, Deron Galusha, Michael Mctague Sep 2014

Beyond Original Intent – The Use Of A Corporation’S Administrative Databases For Academic Research, Martin D. Slade, Linda Cantley, Baylah Tessier-Sherman, Deron Galusha, Michael Mctague

Yale Day of Data

Large corporations maintain a variety of administrative databases as part of their normal operations. These databases, created for distinct functions by separate organizational entities, are generally independent. For instance, a company’s Human Resources organization typically maintains a database containing information such as demographics, job and salary history, and employee status for all employees.. The environmental, health and safety department maintains information regarding work-place exposures and exposure levels for various agents within each job as well as injury and illness surveillance records. The medical department maintains occupational health information including audiometric and pulmonary function test results. As many large corporations are …


Applying Novel Tree-Based Frameworks To Big Data For Classification Of Heart Failure Patients And Prediction Of Clinical Responses, Yan Zhang, Nicholas Downing, Emily Bucholz, Suganthi Balasubramanian, Shu-Xia Li, Tara Liptak, Harlan Krumholz, Mark Gerstein Sep 2014

Applying Novel Tree-Based Frameworks To Big Data For Classification Of Heart Failure Patients And Prediction Of Clinical Responses, Yan Zhang, Nicholas Downing, Emily Bucholz, Suganthi Balasubramanian, Shu-Xia Li, Tara Liptak, Harlan Krumholz, Mark Gerstein

Yale Day of Data

Over 5 million Americans suffer from heart failure, a condition with a 5-year survival that eclipses all cancers apart from that of lung cancer. Conventional understanding of heart failure is simplistic: it is viewed as a single syndrome, despite real heterogeneity. In addition, models predicting outcomes focus on dichotomous results, like 30-day readmission. A novel approach to classification of heart failure may improve our ability to target interventions, improve patient experiences, and predict outcomes.

The Healthcare Cost and Utilization Project is a family of administrative claims databases that describes patient demographics, comorbidities, procedures, acute care utilization and outcomes, such as …


The Yoda Project: Developing Methods For Sharing Clinical Trial Data, Jessica Ritchie, Harlan Krumholz, Joseph Ross, Cary Gross, Beth Hodshon Sep 2014

The Yoda Project: Developing Methods For Sharing Clinical Trial Data, Jessica Ritchie, Harlan Krumholz, Joseph Ross, Cary Gross, Beth Hodshon

Yale Day of Data

Abstract

Data sharing and data transparency are becoming the new standard in clinical research to ensure that patients and clinicians possess all necessary information about a drug or device when making treatment decisions. The Yale University Open Data Access (YODA) Project developed a model to facilitate access to participant-level clinical research data to promote independent analysis by external investigators. The YODA Project is currently collaborating with Medtronic, Inc. and Janssen, the pharmaceutical companies of Johnson & Johnson, to facilitate access to their clinical trial program data by external investigators in a manner that is aligned with the following principles: advance …


Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix Sep 2014

Stratified Meta-Analysis To Examine Data Biases In Lung Cancer Studies Of Refinery Workers, Sherman Selix

Yale Day of Data

Petroleum refineries employ a variety of workers who historically experienced different potentials for asbestos exposure depending on job tasks. Associations between petroleum refinery work and lung cancer related to occupational asbestos exposure have been quantified among various locations, corporations, and time periods. To combine the data from several individual refinery studies and examine an overall effect, a systematic review and stratified meta-analysis was employed. Using set search terms among four databases, 112 potential publications were identified, of which 29 qualified for meta-analysis. Risk estimates and confidence intervals were extracted from these publications to construct four separate datasets. Inverse variance weighting …


The Capus Project-Innovative Solutions For Hiv/Aids Linkage To Care, Melanie Gwynn, Jamila Ealey, Kate Racoff Musgrove Sep 2014

The Capus Project-Innovative Solutions For Hiv/Aids Linkage To Care, Melanie Gwynn, Jamila Ealey, Kate Racoff Musgrove

9th Annual Rural HIV Research & Training Conference (2014-2019) (Archived)

“The CAPUS Project-Innovative Solutions for HIV/AIDS Linkage to Care”

Objectives: 1) Expand knowledge of the current linkage to care landscape within Georgia; 2) Identify essential components of the Resource Hub to enhance linkage to care efforts throughout Georgia; and 3)Promote effective use of the Resource Hub to facilitate HIV/AIDS linkage to care within highly impacted communities


Your Life With Type Ii Diabetes: The Relationship Between Overall Health With And Without Diabetes, Cory Brandt, Jessika Jackson, Helen W. Bland Sep 2014

Your Life With Type Ii Diabetes: The Relationship Between Overall Health With And Without Diabetes, Cory Brandt, Jessika Jackson, Helen W. Bland

GS4 Student Scholars Symposium

The purpose of this study is to assess the behavior of patients with Type 2 Diabetes and their ability to maintain a healthy and unassisted lifestyle. Research has shown showed that adults, especially older adults, with T2D will live a less healthy and more assisted lifestyle. In the United States it’s estimated that 25.6 million adults have T2D and another 79 million are at beginning stages of T2D (Kanaya, Gregorich, & Grossman, 2012). There are numerous health behaviors that can affect the risk of having T2D (Basha & Sunnarao, 2012). The instrument used in this study was a 17-question behavioral …


Parental Feeding Behavior: Influences On Elementary Children's Health, Cydni Martin, Jennifer Paquin, Helen W. Bland Sep 2014

Parental Feeding Behavior: Influences On Elementary Children's Health, Cydni Martin, Jennifer Paquin, Helen W. Bland

GS4 Student Scholars Symposium

The purpose of this study was to assess the nutrition and physical activity of children. The hypothesis was that parental feeding styles will influence the healthy eating habits and physical activity among children. Childhood obesity has been called one of the most serious public health challenges of the 21st century (World Health Organization, n.d). In the past 30 years, childhood obesity has more than doubled in children and tripled in adolescents (Centers for Disease Control and Prevention, 2013). The research design used was a quantitative, descriptive, non-experimental, self-reported study in which a 27-question survey measured the parents’ child feeding behavior …


Exploring The Effect Of Solution Speciation On Crystallization Outcome, David M. Harvey, Arjun Kalra, Tonglei Li Aug 2014

Exploring The Effect Of Solution Speciation On Crystallization Outcome, David M. Harvey, Arjun Kalra, Tonglei Li

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the field of pharmaceuticals, the crystallization process significantly impacts the purity, morphology and polymorphism of active pharmaceutical ingredients (API), all of which are important in drug development. Polymorphism is the existence of more than one solid-state form of the same chemical entity. Tolfenamic acid (TFA), a Non-Steroid Anti-inflammatory drug (NSAID), has been shown to exhibit a unique physical phenomenon called concomitant polymorphism, whereby two polymorphs crystallize from the solution simultaneously. From previous work, it has been established that solution speciation i.e. the presence of monomers or dimers of TFA in solution is concentration and temperature dependent. This study correlates …


Cellular Uptake Of Drug Nanocrystals, Alexandra R. Seybold, Tonglei Li, Yan Chen Aug 2014

Cellular Uptake Of Drug Nanocrystals, Alexandra R. Seybold, Tonglei Li, Yan Chen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Systemic toxicity and poor solubility of existing chemotherapeutic drugs piqued an interest in the use of nanocrystals for chemotherapy. To increase cytotoxicity, surface coating of nanocrystals is of interest to enhance tumor targeting and reduce treatment toxicity. As such, we tested in this project various coated paclitaxel nanocrystals on cancer cells for determining the efficacy of surface coating. An IC50 assay was chosen to determine the cytotoxicity of surface-coated paclitaxel nanocrystals; the lower the IC50 value, the higher the efficacy of the drug. Using the Sulforhodamine B method, paclitaxel, paclitaxel nanocrystals, and polymer coated paclitaxel nanocrystals were tested …


Using Collagen Binding Poly(N-Isopropylacrylamide) Nanoparticles To Prevent Intravascular Platelet Adhesion And Activation, Anna E. Searle, Alyssa Panitch, James Mcmasters Aug 2014

Using Collagen Binding Poly(N-Isopropylacrylamide) Nanoparticles To Prevent Intravascular Platelet Adhesion And Activation, Anna E. Searle, Alyssa Panitch, James Mcmasters

The Summer Undergraduate Research Fellowship (SURF) Symposium

Balloon angioplasty, the most prevalent non-surgical treatment for Atherosclerosis, damages the endothelial layer of the artery, baring an underlying collagenous layer, which causes platelet adhesion and activation and eventual thrombosis and intimal hyperplasia. Previous work in our lab has used a collagen-binding peptidoglycan, dermatan-sulfate-SILY (DS-SILY), that has been shown to bind to type I collagen and prevent platelet adhesion and activation. Our goal is to fabricate nanoparticle-SILY by cross-linking SILY to a poly(N-isopropylacrylamide) (NIPAm) nanoparticle instead of a DS backbone, while retaining the SILY’s high collagen binding affinity and platelet inhibition capacity observed in DS-SILY. Using a biotin-streptavidin assay, we …


Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, Ms, Marc Mendonca, Keith Stantz, Phd Aug 2014

Validating Hemoglobin Saturation And Dissolved Oxygen In Tumors Using The Oxylab Probe And Photoacoustic Imaging, Jenna Burnett, Justin Sick, Ms, Marc Mendonca, Keith Stantz, Phd

The Summer Undergraduate Research Fellowship (SURF) Symposium

The goal of this experiment is to validate the relationship between hemoglobin saturation (SaO2) and partial pressure of dissolved oxygen (pO2) in breast tumors in mice using photoacoustic computed tomographic (PCT) imaging and OxyLite probe, respectively. In its simplest form, the relationship is described by the dissociation curve, or Hill’s equation, for hemoglobin, and is modeled as a sigmoidal curve that is a function of two parameters – the Hill coefficient, n, and the net association constant of HbO2, K (or pO2 at 50% SaO2). First, a calibration study to validate …


Tissue Engineering: Applications In Developmental Toxicology, Stephanie N. Thiede, Nimisha Bajaj, Kevin Buno, Sherry L. Voytik-Harbin Aug 2014

Tissue Engineering: Applications In Developmental Toxicology, Stephanie N. Thiede, Nimisha Bajaj, Kevin Buno, Sherry L. Voytik-Harbin

The Summer Undergraduate Research Fellowship (SURF) Symposium

In vivo toxicology assays are expensive, low-throughput, and often not predictive of a human response. Three-dimensional in vitro human cell-based tissue systems incorporating cell-cell and cell-matrix interactions have promise to provide high-throughput, physiologically-relevant information on the mechanism of the toxin and a more accurate assessment of the toxicity of a chemical before progression to human trials. Quantification of the disruption of vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells, can serve as an appropriate indicator of developmental toxicity since vasculogenesis is critical to the early development of the circulatory system. The current routinely used in vitro …


Three Dimensional Quantification Of Angiotensin Ii-Induced Murine Abdominal Aortic Aneurysms Using High Frequency Ultrasound, Amelia R. Adelsperger, Alexa A. Yrineo, Hilary D. Schroeder, Ashley Nicole Blaize, Katherine E. Wilson, Evan H. Phillips, Frederick W. Damen, Craig J. Goergen Aug 2014

Three Dimensional Quantification Of Angiotensin Ii-Induced Murine Abdominal Aortic Aneurysms Using High Frequency Ultrasound, Amelia R. Adelsperger, Alexa A. Yrineo, Hilary D. Schroeder, Ashley Nicole Blaize, Katherine E. Wilson, Evan H. Phillips, Frederick W. Damen, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Abdominal aortic aneurysms (AAAs), a localized dilation of the vessel wall of 50% or more above normal, claims approximately 14,000 U.S. lives yearly due to aortic rupture. This commonly asymptomatic disease can only be treated by endovascular stent grafts or invasive surgery, usually after the AAA diameter reaches 5 cm. Because these treatment methods carry serious risk, stem cell therapy is being explored in order to provide a low risk option for managing smaller AAAs. To determine if stem cell therapy, once administered, could stabilize or reduce AAA growth, baseline 3D ultrasound measurements in a control group were first needed. …


Formation Of Lactalbumin Nanoparticles By Desolvation Method, Menglu Gao, Jozef Kokini, Luis Fernando Maldonado-Mejia Aug 2014

Formation Of Lactalbumin Nanoparticles By Desolvation Method, Menglu Gao, Jozef Kokini, Luis Fernando Maldonado-Mejia

The Summer Undergraduate Research Fellowship (SURF) Symposium

Protein nanoparticles are ideal carriers for bioactive compounds such as nutraceuticals and drugs because they are biodegradable, less immunogenic and non-toxic and can be nanoparticulated. This study focuses on the desolvation method to form lactalbumin protein nanoparticles. Lactalbumin is soluble in water and insoluble in many organic solvents. Different solvent/non-solvent ratios are evaluated in this research project for the effect they have on the size, PDI and stability of protein nanoparticles. Different methods including sonication and centrifugation were used and compared in terms of their effectiveness to produce small nanoparticles during fabrication of the nanoparticles. Data collected including protein nanoparticles …