Medicine and Health Sciences Commons^™

Distribution Of Sphaeriid Clams In Lake Erie Twenty-Five Years After Invasion Of Dreissena, Michael Keller

Undergraduate Research Posters 2015

Clams in the family Sphaeriidae are widespread native mollusk species that are often overlooked. The distribution of these organisms in Lake Erie has not been examined in the 25 years since the initial invasion of the zebra mussel, Dreissena polymorpha. Carr and Hiltunen identified 10 species of Sphaeriidae in Western Lake Erie in 1961, of which Pisidium casertanum, P. compressum, P. nitidum, Sphaerium corneum, and S. striatinum and Musculium transversum, contributed 89.7% of all fingernail and pea clams sampled and were considered common. Four other species were reported as rare. Our research examines whether the distribution of Sphaeriid clams in …

Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter

Undergraduate Research Posters 2015

In order to obtain a tangible basis for vaccine targets, it is crucial to understand the role of proteins at the site of invasion. In previous study, 27 novel rhoptry proteins were identified by MudPIT analysis and immunoelectron microscopy. In this investigation, the conservation of rhoptry genes between Plasmodium yoelii and Plasmodium falciparum was assessed. From the previously identified rhoptry genes, 14 were investigated with the orthologues/paralogues of the Plasmodium falciparum, Plasmodium yoelii, Plasmodium chabaudi, and Plasmodium berghei. Also, primers designed for the 14 Plasmodium yoelli rhoptry genes were used to test DNA amplification with the PCR. Amplification of Plasmodium …

Optimizing The Design And Potency Of Diterpenic Acid Derivatives To Improve Cell Membrane Permeability And Hsp27 Targeting Characteristics, Aicha Quamine

Undergraduate Research Posters 2015

Heat shock protein 27 (Hsp27) acts as a protective protein allowing it to play an integral role in aiding cancer cell resistance. Stress-induced Hsp 27 overexpression aids in the stabilization of partially denatured proteins to establish protein refolding resulting in thermotolerance, inhibition of apoptosis, cytoprotection, etc. As a result of rapid proliferation and general instability, cancer cells exhibit increased dependency on the support of Hsp 27 and it’s chaperone proteins, therefore generating an ideal target for anticancer therapy. Copalic acid, a clerodane diterpenoid, has already been confirmed in effective chaperone inhibition and antiproliferative synergistic effect. We hypothesize that by optimizing …

Characterization Of The Detailed Interaction Interface Between T. Brucei Telomere Proteins Trf And Tif2, Jennifer Kungle, John Sabljic, Tia Nikova

Undergraduate Research Posters 2015

The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. T. brucei switches its variant surface glycoproteins (VSGs) inside the mammalian host, evading the host immune response. VSGs are expressed monoallelically from subtelomeric expression sites, and telomere proteins regulate VSGs. We previously found that telomere protein TbTIF2 interacts with TbTRF (TTAGGG-repeat binding factor) and plays important roles in VSG switching regulation. TbTRF maintains the telomere terminal structure. TbTIF2 is essential for subtelomeric integrity and suppresses VSG switching by inhibiting subtelomeric gene conversion. Depletion of TbTIF2 decreases TbTRF protein level. We hypothesize that TbTRF-TbTIF2 interaction is …

Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie

Undergraduate Research Posters 2015

Deleterious effects of some methods used to harness energy from the environment today have garnered the exploration of safer and more reliable options, specifically solar energy conversion. Current solar cell technology has yielded quantum efficiencies commonly in the range of 10-20% but is limited by extensive processing methods, high cost, and need for rare materials. However, bio-derived solar cells containing Photosystem I (PSI) address these problems as PSI is highly abundant, very efficient, and low-cost. PSI acts as a biomolecular photodiode through rapid photoexcited charge separation, making it very promising for use as an integral element in solar cells. To …

Development Of A Gc-Ms Method For Investigation Mouse Plasma Amino Acid Levels And Their Significance To The Circadian Clock, Kylin Emhoff

Undergraduate Research Posters 2015

An extraction procedure and gas chromatography mass spectrometry (GC-MS) method was developed for quantitation of plasma amino acids. The experimental workflow included extraction of amino acids from plasma, followed by derivatization protocol for GC-MS compatibility. Automated Mass spectral Deconvolution and Identification System (AMDIS) and laboratory developed library was used for compound identification. Levels of plasma amino acids were calculated based on one point calibration with non-physiological amino acid L-norvaline as internal standard. The assay was applied to obtain and monitor levels of plasma amino acids to study the effect of feeding restriction on the circadian clock in mice. The circadian …

Autonomic Nervous System Response To Interpersonal Exclusion In Borderline Personality Disorder, Ilona Ponomariova, Brock Bodenbender, Khadeja Najjar, Elizabeth Golias

Undergraduate Research Posters 2015

Intense emotional reactions to interpersonal rejection reflect the core of Borderline Personality Disorder (BPD). These reactions supported by the autonomic nervous system (ANS), which has been linked to neural regions that undergird emotional experience and regulation that are affected among individuals with BPD. Despite such links, relatively few studies have examined ANS functioning among BPD populations. The few studies that have primarily focused on the independent activity of the two sympathetic (SNS) and parasympathetic (PNS) ANS branches during resting states or in response to emotion evocative films, rather than to interpersonal rejection. The present study overcomes the above noted gaps …

Children's Mercy Hospital Annual Report 2014, Children's Mercy Hospital

Children's Mercy Annual Reports

Annual report for The Children's Mercy Hospital in Kansas City MO, a pediatric medical center.

Prostate Cancer And Afro-Caribbean Men: Experiences, Perceptions, And Beliefs, Harold E. Taitt Jr.

2010-2016 Archived Posters

The incidence of prostate cancer is high among men of African descent. Research questions in this phenomenological study considered the perceptions and beliefs of Afro-Caribbean men. Participants conveyed low disease awareness, but believed that early diagnosis increased survival chances. Findings revealed strategies to help reduce mortality from the disease.

Understanding Distinctive Beliefs And Perceptions About Depression Among Haitian Men, Darlyne Richardson

2010-2016 Archived Posters

This is a quantitative analysis exploring the relationship between levels of depression in Haitian men as related to restrictive emotionality, self-­reliance, subjective masculine stress, spiritual well-­being, and length of time in the United States. The data were obtained from demographic questionnaires and surveys among 90 Haitian men residing in the United States.

The Relationship Of Mental Health Agency Productivity Standards With Marriage And Family Therapist Job Satisfaction And Turnover Intent, Gilbert E. Franco

2010-2016 Archived Posters

A quantitative study investigated how productivity standards were related to self-­efficacy, job satisfaction, and marriage and family therapist (MFT) turnover intent. The results show that productivity standards predict turnover intent, mediated by job self-­efficacy and job satisfaction. It was found that productivity predicts job satisfaction, mediated by job self-­efficacy.

Knowledge, Attitudes, Beliefs, And Behaviors Of Diabetes Among Afro-Caribbeans Living Near Brooklyn, Sophia I. Allen

2010-2016 Archived Posters

Literature has found Afro-Caribbeans with diabetes have a negative perception of medical professionals. Using a cross-sectional design, Afro-Caribbeans with type 2 diabetes were recruited across 7 churches to determine whether shared knowledge and beliefs about diabetes screening and complications exist and whether they would attend a workshop at their church.

Oral Health And The Elderly Talking Points, American Dental Association

Action for Dental Health

No abstract provided.

Vital Signs, Winter 2015, Boonshoft School Of Medicine

Vital Signs

A sixty page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

The Scoop, Vol. 1 Issue 10, January 2015, Health Sciences Library

Volume 1

Latest news and events from the Health Sciences Library in our monthly newsletter for January 2015.

Visionary Fall 2015, College Of Optometry

Visionary

No abstract provided.

Jane Case-Smith, Edd, Otr/L, Faota

OJOT Sponsor Profiles

No abstract provided.

Fmic Annual Report 2015 | English, French Medical Institute For Mothers And Children

French Medical Institute for Mothers and Children (FMIC) Archives

No abstract provided.

Insulin Patch Pumps In Type 2 Diabetes, Cristin Altendorf

Physician Assistant Scholarly Project Posters

• DM is a leading cause of death in Americans

• A HbA1c above 6.5% is diagnostic for DM because it is at this level the patient is at risk for retinopathy and other microvascular disease

• The purpose of this study is to determine alternative methods of maintaining tighter control on HbA1c to lessen the effects of type II diabetes.

Oral Immunotherapy In Ige-Mediated Cow’S Milk Protein Allergy, Jody Bauer

Physician Assistant Scholarly Project Posters

Cow’s milk allergy prevalence in children has been increasing significantly over the last several decades. The diagnosis of a cow’s milk allergy (CMA) can occur through several methods such as signs and symptoms, double blind oral food challenge, skin prick testing, IgE and IgG4 serum levels. Currently, there are no treatments beyond strict allergen avoidance. The patient’s quality of life is impacted with the fear of inadvertent exposure resulting in allergic reactions that may be life threatening. Recent studies have explored desensitization to CM using oral immunotherapy (OIT), subcutaneous immunotherapy, and sublingual immunotherapy (SLIT). Research has found that desensitization will …

Alpha Lipoic Acid: A Potential Therapeutic Option For Painful Peripheral Neuropathies, Jessica Curcio

Physician Assistant Scholarly Project Posters

• Peripheral neuropathy (PN) is a major public health concern.

• There are many etiologies for PN including injury, infection, toxicity, genetics, metabolic disease and nutritional deficiencies.

• Alpha lipoic acid (ALA), also known as thioctic acid, is a potent antioxidant and cofactor in many cellular metabolic processes.

• Oxidative damage plays a significant role in the pathogenesis of both diabetic peripheral neuropathy (DPN) and chemotherapy induced peripheral neuropathy (CIPN).

• Because of the antioxidant capability ALA has been studied for its potential benefit in preventing and treating PN

Pfapa: A Periodic Febrile Syndrome Afflicting Children, Jessica Lahti

Physician Assistant Scholarly Project Posters

• Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA).

• Auto-inflammatory disorder occurring in affected children every 3-8 weeks.

• Onset around age 2; lasting into second decade of life.

• A current pathophysiologic theory is PFAPA is a disorder of the innate immune system involving interleukins, chemoattractants, and cytokines that stimulating the inflammatory response causing symptoms associated with PFAPA.

• Early diagnosis of PFAPA may help prevent the unnecessary use of antibiotics.

• Biomarker CD64, galectin-3 and the MPV may be useful in the diagnosis of PFAPA along with other laboratory values during the febrile attack period …

Adolescent Idiopathic Scoliosis: Comparing And Contrasting Operative Versus Non-Operative Treatment Abstract, Ethan Morris

Physician Assistant Scholarly Project Posters

• Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis. It affects 2-4 percent of adolescents aged 10-16 years. Although most adolescents diagnosed with scoliosis will not develop clinical symptoms, ten percent will progress and require medical intervention due to the potential for rib deformity and respiratory compromise as well as significant emotional distress due to aesthetic changes in appearance. Primary care providers should be prepared to evaluate and recommend treatment when idiopathic scoliosis is discovered or addressed by the patient. Three major factors that determine whether scoliosis will progress are patient gender, magnitude of curve on presentation, …

Implementing Animal Therapy Into Current Medicinal Practices, Jenna Schiefelbein

Physician Assistant Scholarly Project Posters

• The purpose of this study was to explore an unconventional intervention of medicine; specifically the integration of animals into current healthcare practices.

• The review of literature evaluated the implementation of animal therapy in medicine, both in the past and present.

• It was demonstrated that incorporating animal-assistance therapy into modern day medicine had a positive correlation with overall patient health, pain control, and disposition.

Does Pharmacogenetics Play A Role In The Treatment Of Type Ii Diabetes Mellitus?, Lucas N. Vanemelen

Physician Assistant Scholarly Project Posters

• Type 2 diabetes mellitus (T2DM) is a disease commonly presented in the family practice setting. Current therapies include one or multiple medications. Until recently, providers have used algorithms and medical expertise to control T2DM.

• Pharmacogenomics is a branch of pharmacology dealing with genetic variation on a medication response in an individual patient to discover medication compatibility, efficacy or toxicity.

• Analysis of genetic factors are still being discovered; however, this growing field may change the way medications are being prescribed for diabetes. This analysis investigated if pharmacogenetics is a useful tool for prescribing diabetic medications to T2DM patients. …

Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection Antibiotic Prophylaxis Treatment Compared With Alternative Treatment Options, Heather Watkins

Physician Assistant Scholarly Project Posters

• Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection, known as PANDAS, is a clinical diagnosis made after a child develops Obsessive Compulsive Disorder and/or ticks after a Streptococcal Pharyngitis. Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcal Infection is diagnosed in children 3 years of age until 14 years of age. The purpose of this study is to determine if antibiotics versus selective serotonin reuptake inhibitor with cognitive behavior therapy versus prophylaxis with antibiotics should be used in the treatment of children who develops PANDAS. The review of literature will explore studies that compare current treatment options with new research …

The Da Vinci Robotic Surgical Systems In Atrial Septal Defect Repair, Coronary Artery Bypass Graft And Mitral Valve Repair, Randy Yergenson

Physician Assistant Scholarly Project Posters

Historically, these cardiac interventions have been performed using partial or complete open sternotomy.
1. Coronary artery bypass grafting (CABG)
2. Atrial septal defect (ASD) repair,
3. Mitral valve repair and/or replacement

In 2000, the Federal Food and Drug Administration approved the use of the da Vinci Robotic Surgical System. Less invasive surgical option.

Current Intimate Partner Violence Screening Practices Of Maternity Nurses In A Hospital Setting, Lina Garrard

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Expression Of The Nkcc2a Cotransporter In Mouse Central Nervous System, Katherine E. Fahy, James B. Lucot, Hayo Castrop, Mauricio Di Fulvio

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Na-K-2Cl cotransporter 2A (NKCC2A), also known as the bumetanide-sensitive cotransporter 1 (BSC1), transports Na+, K+ and Cl- with a stoichiometry of 1:1:2. NKCC2A is considered a kidney specific cotransporter. It is abundantly expressed in apical membrane of the tubular cells in the thick ascending limb of the loop of Henle (TALH) and in the macula densa. However, NKCC2 has also been found at low levels in different cells, including insulin-secreting ones. This secondary active transporter uses the energy stored in the electrochemical gradients of Na and K maintained by the Na/K-ATPase located on the basolateral membrane of the TALH. The …

Professional Product Review Vol. 10 No. 1, American Dental Association, Council On Scientific Affairs

Professional Product Review

A user-friendly newsletter from the ADA Council on Scientific Affairs offering scientifically sound, unbiased, and clinically relevant information to member dentists about professional dental products tested by the ADA. This collection is historical and may not reflect current standards. For up-to-date information contact the ADA.