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Full-Text Articles in Medicine and Health Sciences
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Structural Changes Of Placenta In Preeclamptic Patients: Light And Electron Microscopic Study, Reda Awadallah Saleh, Mohamed Abdel Monem Dkhil
Turkish Journal of Medical Sciences
Background: Preeclampsia is a disorder that occurs only during pregnancy and the postpartum period and affects both the mother and the unborn baby. It is a rapidly progressive condition characterized by high blood pressure and the presence of protein in the urine. The study was designed to investigate the histological and ultrastructural changes in placentas from pregnancies complicated by preeclampsia. Methods: Paraffin sections from placenta biopsies were prepared for light microscopic examination. For ultrastructural examination, biopsies were prepared and examined by digital scanning electron microscope. Results: Light microscopic examinations showed that the nuclei of syncytiotrophoblast layer were aggregated into clusters …
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress In Preeclampsia, Ekambaram Padmini, Bose Vijaya Geetha
Turkish Journal of Medical Sciences
Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnancies. Materials and Methods: Placental samples were collected after delivery from normotensive pregnancies and preeclamptic patients (n = 20, each). Lipid peroxidation product malondialdehyde (MDA) and nitrite and nitrate levels, along with antioxidants such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) …