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Articles 181 - 196 of 196
Full-Text Articles in Medicine and Health Sciences
Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie
Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie
Turkish Journal of Medical Sciences
Background/aim: Multitarget therapy for lupus nephritis (LN) remains in its exploratory phrase and the recent evidence is insufficient. This study aimed to evaluate the efficacy and safety of mycophenolate mofetil (MMF), tacrolimus (TAC), and steroids (multitarget therapy) versus intravenous cyclophosphamide (IVC) and steroids in induction treatment of LN. Materials and methods: We searched for randomized controlled trials of MMF plus TAC versus IVC in LN using PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the China Biology Medicine Database, and the China National Knowledge Infrastructure Database. We assessed the retrieved citations and selected studies according to predefined inclusion and …
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord …
Effects Of Tourniquet Usage In Lower Extremity Surgery On Optic Nerve Sheath Diameter, Ahmet Beşi̇r, Ersagun Tuğcugi̇l
Effects Of Tourniquet Usage In Lower Extremity Surgery On Optic Nerve Sheath Diameter, Ahmet Beşi̇r, Ersagun Tuğcugi̇l
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate changes in intracranial pressure following tourniquet deflation using noninvasive ultrasonographic optic nerve sheath diameter (ONSD) measurements. Materials and methods: Our study included 59 adult patients between the ages of 18 and 65 years from the American Society of Anesthesiologists (ASA) I/II risk groups who were scheduled to undergo elective orthopedic surgery of the lower extremities using a tourniquet under general anesthesia. ONSD and end-tidal CO2 (ETCO2) were measured 5 times: 15 min prior to the anesthesia induction; just prior to the deflation of the tourniquet; and at 5, 10, and 15 …
Dynamic Thiol-Disulfide Homeostasis Is Disturbed In Hepatitis B Virus-Related Chronichepatitis And Liver Cirrhosis, Ramazan Dertli̇, Muharrem Keski̇n, Murat Biyik, Hüseyi̇n Ataseven, Hakki Polat, Ali̇ Demi̇r, Pembe Oltulu, Sali̇m Neşeli̇oğlu, Özcan Erel, Mehmet Asil
Dynamic Thiol-Disulfide Homeostasis Is Disturbed In Hepatitis B Virus-Related Chronichepatitis And Liver Cirrhosis, Ramazan Dertli̇, Muharrem Keski̇n, Murat Biyik, Hüseyi̇n Ataseven, Hakki Polat, Ali̇ Demi̇r, Pembe Oltulu, Sali̇m Neşeli̇oğlu, Özcan Erel, Mehmet Asil
Turkish Journal of Medical Sciences
Background/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigate dynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis. Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentrations were measured using an automated method. Results: Mean serum total thiol concentrations in the control, CHB, and cirrhosis groups were 481.64 ± 37.87 µmol/L, 438.50 ± 71.35 µmol/L, and 358.07 ± 80.47 µmol/L, …
Value Of Shear Wave Elastography By Virtual Touch Tissue Imaging Quantification Inpatients With Diffuse Thyroid Gland Pathology, Feri̇de Kural Rahatli, Hale Turnaoğlu, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Kemal Murat Haberal, Aresh Soudmand, Ni̇hal Uslu
Value Of Shear Wave Elastography By Virtual Touch Tissue Imaging Quantification Inpatients With Diffuse Thyroid Gland Pathology, Feri̇de Kural Rahatli, Hale Turnaoğlu, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Kemal Murat Haberal, Aresh Soudmand, Ni̇hal Uslu
Turkish Journal of Medical Sciences
Background/aim: This study was performed to assess the diagnostic accuracy of shear wave elastography by virtual touch tissue imaging quantification in patients with diffuse thyroid gland pathology and to differentiate Graves' disease from Hashimoto's thyroiditis. Materials and methods: Thirty patients with Hashimoto's thyroiditis and 22 patients with Graves' disease were evaluated with conventional ultrasonography and shear wave elastography by virtual touch tissue imaging quantification. Thirty healthy participants formed the control group. Ten elastographic measurements of each thyroid lobe were performed in all three study groups. The mean shear wave velocity was calculated and compared between the patients and controls. Results: …
Effects Of Computer-Assisted Cognitive Rehabilitation In Benign Multiple Sclerosis, Erdi̇l Arsoy, Erdem Tüzün, Recai̇ Türkoğlu
Effects Of Computer-Assisted Cognitive Rehabilitation In Benign Multiple Sclerosis, Erdi̇l Arsoy, Erdem Tüzün, Recai̇ Türkoğlu
Turkish Journal of Medical Sciences
Background/aim: Benign multiple sclerosis (BMS) patients display preserved somatic neurological functions but nevertheless may develop cognitive dysfunction. Our aim was to explore the impact of computer-assisted cognitive rehabilitation (CCR) on cognitive functions of BMS patients. Materials and methods: Age- and sex-matched BMS patients (n = 21), non-BMS patients (n = 22), and healthy individuals (n = 38) were recruited for evaluation of cognitive functions. CCR was administered to 10 BMS patients and a panel of neuropsychological tests were employed at baseline and 6 months. CCR was based on mental exercise software containing attention, memory, reasoning, visual, and verbal task modules. …
Determining The Effect Of Long-Term Dexamethasone And Prednisolone Treatment Onsugammadex, Ebru Bi̇ri̇ci̇k, Ersel Güleç, Işil Öcal, Mehmet Bertan Yilmaz, Feri̇de Karacaer, Di̇lek Özcengi̇z
Determining The Effect Of Long-Term Dexamethasone And Prednisolone Treatment Onsugammadex, Ebru Bi̇ri̇ci̇k, Ersel Güleç, Işil Öcal, Mehmet Bertan Yilmaz, Feri̇de Karacaer, Di̇lek Özcengi̇z
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the effect of long-term use of dexamethasone and prednisolone on the reversal effect of sugammadex. Materials and methods: TTwenty-four male Wistar albino rats were divided into three groups. Dexamethasone (600 µg/kg) was given to group D, prednisolone (10 mg/kg) was given to group P, and an equivalent volume of saline per day was administered intraperitoneally to group S for 14 days, respectively. The left hemidiaphragm with attached phrenic nerve was maintained in Krebs solution. Sugammadex (30 µmol/L) was applied while rocuronium (10 µmol/L) was present in an organ bath and a single twitch was obtained. …
Invasive Nontyphoidal Salmonella Disease In Southern India: A 5-Year Experience From Atertiary Care Hospital, Sudipta Patra, Yasha Mukim, Muralidhar Varma, Chiranjay Mukhopadhyay
Invasive Nontyphoidal Salmonella Disease In Southern India: A 5-Year Experience From Atertiary Care Hospital, Sudipta Patra, Yasha Mukim, Muralidhar Varma, Chiranjay Mukhopadhyay
Turkish Journal of Medical Sciences
Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, and outcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center. Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medical records of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immune status, treatment, and clinical outcome. Results: A total of 40 blood culture-confirmed cases of iNTS were diagnosed during the study period. Among these 40 isolates, 9 (22.5%) were identified as Salmonella Typhimurium. Fever (67.5%) with gastrointestinal disturbance (40%) was …
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Serum Adma, Endothelial Dysfunction, And Atherosclerosis In Hypervolemichemodialysis Patients, İbrahi̇m Doğan, Bariş Eser, Sultan Özkurt, Özlem Yayar, Bülent Özgür, Hüseyi̇n Kayadi̇bi̇, Tolga Doğan, Ahmet Musmul, Mehmet Soydan
Turkish Journal of Medical Sciences
Background/aim: Asymmetric dimethyl arginine (ADMA) is a strong predictor of cardiovascular disease and mortality in patients under hemodialysis treatment. We aimed to investigate the relationship among volume status, endothelial dysfunction, and ADMA in hemodialysis patients. Materials and methods: A total of 120 patients with a history of hemodialysis treatment were included. ADMA and CRP were measured. Echocardiographic evaluation and carotid artery intima-media thickness (CIMT) measurements were performed. Patients were divided into two groups according to clinical evaluation, ultrafiltration rate, vena cava inferior diameter (VCI), and cardiothoracic index (CTI); the two groups were hypervolemic and normovolemic. Results: The hypervolemic group included …
Evaluation Of Postural Stability In Overweight And Obese Middle-Aged Men, Mohammadreza Rezaeipour
Evaluation Of Postural Stability In Overweight And Obese Middle-Aged Men, Mohammadreza Rezaeipour
Turkish Journal of Medical Sciences
Background/aim: Weight gain is associated with balance disorders. This study intends to evaluate the postural stability in a natural stance in overweight and obese men by measuring the center of pressure (CoP) velocity in the medial-lateral (ML) and anteriorposterior (AP) directions. Materials and methods: A total number of 111 men categorized according to body mass index (BMI) into normal weight, overweight, and obese categories underwent a measurement of quiet standing with eyes open (EO) and with eyes closed (EC). Postural stability was assessed using a force platform. The average of CoP velocity was assessed in the two directions. Results: In …
The Role Of Melatonin In Preventing Ovarian Tissue Damage In Rats Exposed To Magnetic Fields, Zahi̇de Küçük, Uğurkan Erkayiran, Muzaffer Çaydere, Damla Kayalp, Deni̇z Karçaaltincaba
The Role Of Melatonin In Preventing Ovarian Tissue Damage In Rats Exposed To Magnetic Fields, Zahi̇de Küçük, Uğurkan Erkayiran, Muzaffer Çaydere, Damla Kayalp, Deni̇z Karçaaltincaba
Turkish Journal of Medical Sciences
Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields. Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatonin administration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatonin administration (n = 10). The magnetic field was applied at a dose of 20 μT for 30 min/day for 10 days. Melatonin was orally administered at a dose of 10 mg/kg. We evaluated follicle count, degree of fibrosis, amount of …
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Turkish Journal of Medical Sciences
Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
Turkish Journal of Medical Sciences
Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor ß (HGFß) protein expression were estimated. Liver sections were stained for histological …
Comparison Of The E Ects Of Diclofenac Potassium And Tenoxicam On Postoperative Pain, Swelling, And Trismus Following Third Molar Surgery, Ahmet Taylan Çebi̇, Meti̇n Berk Kasapoğlu, Seli̇n Eren, Çeti̇n Kasapoğlu
Comparison Of The E Ects Of Diclofenac Potassium And Tenoxicam On Postoperative Pain, Swelling, And Trismus Following Third Molar Surgery, Ahmet Taylan Çebi̇, Meti̇n Berk Kasapoğlu, Seli̇n Eren, Çeti̇n Kasapoğlu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare two nonsteroidal antiin ammatory agents in relation to pain, swelling, and trismus following impacted third molar surgery. Materials and methods: The study was a randomized and a double-blinded study and included 50 healthy individuals. A er the operation, patients were randomly assigned to 2 groups in which diclofenac potassium and tenoxicam were used. Impacted third molars were surgically extracted with local anesthesia. Pain was assessed postoperatively by visual analog scale at the 2nd, 6th, 8th, 12th, 24th, and 48th hours and on the 3rd, 5th, and 7th days. Swelling was evaluated using the method …
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber
Turkish Journal of Medical Sciences
Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs as a biomarker in the diagnosis of MODY3. Materials and methods: MIN6 cells were transfected with the HNF1A cDNA expression vector for overexpression or with siRNA specific to HNF1A to silence its expression. The HNF1A-regulated miRNAs were determined by RNA-Seq of the total RNA extract. Expressions of the candidate miRNAs in blood samples of MODY3, type 1 diabetes, and type 2 diabetes patients and in …
Evaluation Of The Histopathological Effects Of Salbutamol Inhaler Treatment In An Experimentally Induced Rat Model Of Pulmonary Contusion, Berat Di̇lek Demi̇rel, Tuğba Ayçi̇çek, Seda Gün, Sertaç Hancioğlu, Ünal Biçakci, Mehmet Ender Aritürk, Riza Feri̇t Bernay
Evaluation Of The Histopathological Effects Of Salbutamol Inhaler Treatment In An Experimentally Induced Rat Model Of Pulmonary Contusion, Berat Di̇lek Demi̇rel, Tuğba Ayçi̇çek, Seda Gün, Sertaç Hancioğlu, Ünal Biçakci, Mehmet Ender Aritürk, Riza Feri̇t Bernay
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of salbutamol inhaler treatment in an experimentally induced model of pulmonary contusion. Materials and methods: Thirty-two male Wistar albino rats were randomly divided into four groups: the control group (CG), sham group (SG), treatment group 1 (TG1), and treatment group 2 (TG2). Experimental contusion was established by targeting the right lung tissue. After 72 h, histopathological evaluation for the severity of edema, hemorrhage, and leukocyte infiltration was performed in both sides of the lungs. Results: Examination of right lung tissues revealed a significant difference in edema, hemorrhage, leukocyte infiltration, and total lung …