Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Serum Vasohibin-1 And Suppression Of Tumorigenicity-2 Levels In Children Withpredialysis Chronic Kidney Disease, Nuran Çeti̇n, Nadi̇de Meli̇ke Sav
Turkish Journal of Medical Sciences
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study. Glomerular filtration rate (GFR) and urinary excretion of protein were measured in 24-h urine samples. Serum vasohibin-1 levels and sST2 were measured. …
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
In Vivo Attenuation Of Angiogenesis In Hepatocellular Carcinoma By Nigella Sativa, Moustafa Fathy, Toshio Nikaido
Turkish Journal of Medical Sciences
Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor ß (HGFß) protein expression were estimated. Liver sections were stained for histological …