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Full-Text Articles in Medicine and Health Sciences

A Delphi Study Assessing Long-Term Access To Electronic Medical Records (Emr), Byron D. Nicholson Mar 2008

A Delphi Study Assessing Long-Term Access To Electronic Medical Records (Emr), Byron D. Nicholson

Theses and Dissertations

This research effort addressed the issue of long-term access to electronic medical records as technological generations become obsolete, thereby preventing the access to patient health information. Using the Delphi methodology, experts with experience in electronic medical records and applicable systems provided insight based on their years of hands-on experience managing and/or using records and these systems. The end result of this research was a collection of ideas that medical institutions and medical informaticians must consider to ensure that patients and hospitals do not lose long-term access to electronic medical records as electronic medical records and technology continually evolves. Results of …

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Micro-Etched Platforms For Thermal Inactivation Of Bacillus Anthracis And Bacillus Thuringiensis Spores, Leslie S. Hawkins Mar 2008

Micro-Etched Platforms For Thermal Inactivation Of Bacillus Anthracis And Bacillus Thuringiensis Spores, Leslie S. Hawkins

Theses and Dissertations

This research developed and applied microlithography techniques to etch microscope slide platforms in order to measure thermal inactivation of Bacillus thuringiensis and Bacillus anthracis spores, two closely related Bacillus species. B.t. is widely used as a surrogate for B.a. in response studies and in some field studies. This work addressed the previously identified problem of measuring both spore growth and spore thermal kill threshold using the traditional method of spreading a diluted spore solution on a plate. The micro-etched platforms forced spore separation thereby preventing neighbor growth from obscuring germination and initial vegetative growth measurements using a microscope. The technique …

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Three Models Of Anthrax Toxin Effects On The Map-Kinase Pathway And Macrophage Survival, Daniel J. Schneider Mar 2008

Three Models Of Anthrax Toxin Effects On The Map-Kinase Pathway And Macrophage Survival, Daniel J. Schneider

Theses and Dissertations

Lethal factor (LF), a component of anthrax toxin, is the primary virulence factor that allows Bacillus anthracis to evade the immune response by blocking the activation of mitogen-activated protein kinase (MAPK) enzymes. This research modifies three published MAPK models to reflect this signal inhibition and to estimate a first-order reaction rate by fitting the models to published viability data for two macrophage cell lines cultured with the LF-producing Bacillus anthracis-Vollum1B strain. One model appears to be ill-suited for this purpose because not all relevant MAPK components could be integrated into the inhibition equations. Despite different underlying parameters and values, the …

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Nucleoplasmic And Cytoplasmic Degradation Of Telomerase: Implications Toward Telomerase-Based Cancer Therapy, Binh Nguyen Mar 2008

Nucleoplasmic And Cytoplasmic Degradation Of Telomerase: Implications Toward Telomerase-Based Cancer Therapy, Binh Nguyen

Theses and Dissertations

Telomerase is a ribonucleoprotein that is reactivated in cancer cells to allow for continuous cellular division and indefinite growth. With telomerase being expressed in more than 85% of all cancer, it is imperative that we understand how to selectively inactivate and degrade this unique DNA polymerase. In doing so, we can specifically target tumor cells to erode their telomeres so that they will undergo apoptosis or senescence. Through this research, we have learned that telomerase can be degraded in the nucleoplasm by Hsp90 chaperone inhibition and in the cytoplasm by the dominant negative mutant, D712A V713I. These findings should guide …

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Accuracy Of Automated Analysis Of Language Samples From Persons With Deafness Or Hearing Impairment, Anne M. Hasting Mar 2008

Accuracy Of Automated Analysis Of Language Samples From Persons With Deafness Or Hearing Impairment, Anne M. Hasting

Theses and Dissertations

Developmental Sentence Scoring (DSS) and the Language Assessment, Remediation, and Screening Procedure (LARSP) are among the more common analyses for syntax and morphology, and automated versions of these analyses have been shown to be effective. This study measured the accuracy of automated DSS and LARSP on the written English output of six prelingually deaf young adults, ranging in age from 18 to 32 years. The samples were analyzed using the DSS and LARSP programs on Computerized Profiling; manual analysis was then performed on the samples. Point-by-point accuracy for DSS and for each level of LARSP was reported. Characteristics of the …

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The Effects Of Deep Brain Stimulation On The Speech Of Patients With Parkinson's Disease, Erin Suzanne Bjarnason Mar 2008

The Effects Of Deep Brain Stimulation On The Speech Of Patients With Parkinson's Disease, Erin Suzanne Bjarnason

Theses and Dissertations

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has received more attention in recent years as a treatment option for regulating the symptoms of Parkinson's disease. Previous studies of DBS documented consistent improvements in motor function but more variability in speech outcomes. In the present study, six participants diagnosed with idiopathic Parkinson's disease who reported worsened speech with stimulation were recorded performing speech acoustic tasks with the stimulators on, and again with the stimulators off. Improvements were noted for most participants in measurements of formant slopes, long term average spectrum (LTAS) of a sustained vowel, and spirantization with stimulation …

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Event Related Potentials Of Syntactic Language Processing In Two Children With Specific Language Impairment: A Case Study, Melissa Ann Willes Mar 2008

Event Related Potentials Of Syntactic Language Processing In Two Children With Specific Language Impairment: A Case Study, Melissa Ann Willes

Theses and Dissertations

This study examined the electrophysiological activity of two children with Specific Language Impairment (SLI) and two aged-matched peers while listening to syntactically correct sentences versus syntactically incorrect sentences. The study specifically analyzed the N400 and P600 components. The N400 component is a negative wave occurring approximately 400 ms post-stimulus and is elicited by semantically incorrect stimuli. The P600 component is a positivity that occurs approximately 600 ms post-stimulus and reflects processing of syntactically incorrect stimuli. The participants in the study included a 7-year-old child and a 9-year-old child with SLI and two age-matched peers with typically developing language. Each participant …

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The Effect Of Regional Dialect On The Validity And Reliability Of Word Recognition Scores, Jamie Ann Garlick Mar 2008

The Effect Of Regional Dialect On The Validity And Reliability Of Word Recognition Scores, Jamie Ann Garlick

Theses and Dissertations

The purpose of this study was to examine the effect of talker and listener dialect on the validity and reliability of word recognition scores from two sets of Mandarin speech audiometry materials. Four lists of bisyllabic words in Mainland Mandarin and Taiwan Mandarin dialects were administered to 16 participants of each dialect with normal hearing across two test sessions. The performance on materials presented in the native dialect was compared to performance on non-native dialect assessment to determine validity and reliability of test materials. Statistical analysis indicated significant differences between word recognition scores across test sessions, talker and listener dialect, …

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The Effect Of Non-Native Dialect On Speech Recognition Threshold For Native Mandarin Speakers, Nathan Edward Richardson Mar 2008

The Effect Of Non-Native Dialect On Speech Recognition Threshold For Native Mandarin Speakers, Nathan Edward Richardson

Theses and Dissertations

Speech recognition thresholds are used for several clinical purposes, so it is important that they be accurate reflections of hearing ability. Variations in the acoustic signal may artificially decrease threshold scores, and such variations can result from being tested in a second dialect. Thirty-two native Mandarin-speaking subjects (sixteen from mainland China and sixteen from Taiwan) participated in speech recognition threshold testing in both dialects to see whether using non-native dialect test materials resulted in a significantly lower score. In addition, tests were scored by two interpreters, one from each dialect, to see whether the scorer's dialect resulted in a significantly …

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In Vitro Toxicity Of Aluminum Nanoparticles In Human Keratinocytes, Stephanie Mccormack-Brown Mar 2008

In Vitro Toxicity Of Aluminum Nanoparticles In Human Keratinocytes, Stephanie Mccormack-Brown

Theses and Dissertations

Nanotechnology promises to be the defining technology of the 21st century. At an annual investment of $1B, it provides significant contributions to manufacturing, medicine, energy conservation, and the environment. Nanoparticles are structures with at least one dimension in the 1 to 100 nanometer (nm) range. DoD and US Air Force interest in aluminum nanoparticles (AL NPs) stems from its ability to enhance combustion jet fuel, thus increasing fuel efficiency. The addition of AL NPs to JP-8 may pose a unique dermal hazard to aircraft maintenance workers. There is no published data on AL NP toxicity effects on human skin. This …

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Gliotoxin Production In Aspergillus Fumigatus, Susan Musyimi Jan 2008

Gliotoxin Production In Aspergillus Fumigatus, Susan Musyimi

Theses and Dissertations

Aspergillus fumigalus is a ubiquitous fungus that causes an infection called aspergillosis in immune-compromised surgery patients (Latge, 2001, 384; Bok et al. 2006). Aspergillosis cases have increased in the past decade due to the increasing number of patients undergoing immunosuppressive therapy and receiving organ transplants (Bok et al. 2006). Although there is still disagreement as to the causative agent of the symptoms accompanying aspergillosis, many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin …

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Density Of Gutta Percha By Weight In Straight Root Canals And Curved Root Canals After Single Cone, Cold Lateral, And Warm Vertical Condensation, Gerald Clay Sparrow Jan 2008

Density Of Gutta Percha By Weight In Straight Root Canals And Curved Root Canals After Single Cone, Cold Lateral, And Warm Vertical Condensation, Gerald Clay Sparrow

Theses and Dissertations

The purpose of this study was to compare the density of gutta percha following three different obturation techniques using two split-tooth models. One split-tooth model was constructed with a straight rooted maxillary incisor and the other with the curved palatal root of a maxillary molar. Each tooth was obturated using single cone, cold lateral, and warm vertical obturation techniques without sealer. Each obturation technique was performed 20 times for each of the root systems. The weights of the gutta percha were recorded for each root type and obturation technique by subtracting the post-fill weight from the pre-fill weight of the …

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A Comparison Of Five Radiographic Systems To D-Speed Film In The Detection Of Artificial Bone Lesions, David Lloyd Hadley Jan 2008

A Comparison Of Five Radiographic Systems To D-Speed Film In The Detection Of Artificial Bone Lesions, David Lloyd Hadley

Theses and Dissertations

The purpose of this study was to compare three direct digital sensors (Kodak 6100, Schick CDR, and Dexis PerfectSize), a phosphor plate system (OpTime), and F-speed film to standard D-speed film in the detection of artificial bone lesions prepared in mandible bone sections. Multiple artificial bone lesions were prepared at varying depths in the cortical bone. Specimens were imaged with six different radiographic systems. Radiographs were randomly presented to nine different observers. A logistic regression analysis indicated that the ability of the different radiographic systems to detect the bone lesions was significantly different at the mean percentage of cortical bone …

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Orthodontic Bracket Bond Strength Using Self-Etching Primer With Or Without Pumice Or Acid Etch Pretreatment, Ana Paula Decastro Jan 2008

Orthodontic Bracket Bond Strength Using Self-Etching Primer With Or Without Pumice Or Acid Etch Pretreatment, Ana Paula Decastro

Theses and Dissertations

The purpose of this study was to compare the shear bond strength of orthodontic brackets to enamel in four bonding protocols: SEP without prior pumicing (None), Pre-etch and SEP without prior pumicing (Pre-etch), control: SEP with prior pumicing (Pumice), and Pre-etch and SEP with prior pumicing (Both). 80 extracted bovine incisors were randomly divided into 4 groups of 20, and brackets were bonded under the different experimental conditions. Debonding force was measured with an Instron universal testing machine. A two-way ANOVA comparing the four groups indicated that there was a significant difference in debonding force (P = 0.001). The SEP …

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Quantifiying The Depth Of Oral Sedation Using Bispectral Index Monitoring, John Flowers Jan 2008

Quantifiying The Depth Of Oral Sedation Using Bispectral Index Monitoring, John Flowers

Theses and Dissertations

Purpose: To determine whether Bispectral Index Monitoring is an effective tool for quantifying sedation depth after the administration of oral drug regimens in children.Methods: This retrospective study reviewed the charts of 75 children who received oral conscious sedation for dental treatment. Data collected from the chart included; 1) BIS values at 5 minute intervals and at five critical events: pre-operative, local anesthesia delivery, rubber dam placement (if utilized), during operative treatment, and postoperatively, 2) behavior ratings at the five critical events and an overall behavior assessment, 3) treatment data, and 4) demographic data. Results: The mean BIS value for orally …

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Assessment Of Seminary Education On End Of Life Issues, Stefan Hakon Pomrenke Jan 2008

Assessment Of Seminary Education On End Of Life Issues, Stefan Hakon Pomrenke

Theses and Dissertations

Background: The US health care system faces increased costs from end of life (EOL) care. The intensive approach to EOL treatment with greater use of procedures in ICUs has led to decedent spending six times greater than that of survivors in the hospital. Experts in ICU and Palliative care fields have called for greater utilization of end of life planning and education. To date, EOL education has been dominated by the technologically driven medical field and the church has been under-utilized. The US population relies on clergy support for many mental health and EOL issues. Clergy report feeling uncomfortable in …

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Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar Jan 2008

Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar

Theses and Dissertations

The purpose of this investigation was to evaluate the effects of smoking and gender on 1) tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) in a population of healthy subjects and 2) TIQs in an alcohol-dependent population undergoing in-patient detoxification. Comparison in plasma TIQs between the populations was additionally conducted. To support the clinical investigations, a HPLC-FD method was developed and validated to assess plasma concentrations of BCs, harman and norharman, while a HPLC-ESI-MS/MS method was validated to quantify the TIQs, R/S-salsolinol along with dopamine. Forty-one young volunteers were recruited including 19 nonsmokers (NS), 11 light smokers (LS) and 11 heavy smokers (HS), …

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Esthetic Posterior Stainless Steel Crowns And Their Relative Shear Strengths, Lonny Dale Carmichael Jan 2008

Esthetic Posterior Stainless Steel Crowns And Their Relative Shear Strengths, Lonny Dale Carmichael

Theses and Dissertations

Purpose: The purpose of this study was to evaluate esthetic posterior stainless steel crowns (EP-SSC) and compare their relative shear strengths.Methods: Sixty EP-SSC were compared. 15 crowns from NuSmile® Primary Crowns, Kinder Krowns, and Dental Innovators 1UP and EC Crowns were studied. The crowns were cemented to a typodont tooth then thermally cycled in water baths to simulate oral conditions. Shear strengths were evaluated by subjecting these crowns to simulated forces of occlusion.Results: The force required to cause shearing of the esthetic facings was statistically significant. With the 1UP crown being significantly weaker than the other crowns tested. Conclusion: The …

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How Well Does Spirituality Predict Health Status In People Living With Hiv-Disease?, Rachel Kidd Cobb Jan 2008

How Well Does Spirituality Predict Health Status In People Living With Hiv-Disease?, Rachel Kidd Cobb

Theses and Dissertations

Problem: The United States of America has one of the highest number of HIV infections in the world; approximately 1.3 million people in North America were living with HIV in 2007. Factors influencing HIV survival are essential to disease management and care. Research findings suggest religion and spirituality may be essential components to health and well-being in individuals with HIV-Disease. Purpose: This study was designed to determine how well spirituality predicted health status in a convenience sample of 39 adults diagnosed with HIV-Disease. Procedure: A model building approach was used to explore relationships among the five variables of the Neuman …

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Effect Of Thyroid Hormones On At1r Mrna Levels In Hek 293 Cells: Implications For Early-Onset Hypertension In Children Born Of Preeclamptic Women, Amanda Eddins Jan 2008

Effect Of Thyroid Hormones On At1r Mrna Levels In Hek 293 Cells: Implications For Early-Onset Hypertension In Children Born Of Preeclamptic Women, Amanda Eddins

Theses and Dissertations

This experiment tested the effect of thyroid hormones, T3 or T4, on angiotensin II type 1 receptor mRNA levels in human embryonic kidney cells (HEK). Maternal preeclampsia is a prediction of higher ambulatory blood pressure (ABP) in the exposed offspring. The mother's blood pressure affects the blood pressure of the fetus since the placenta mediates blood flow. Thyroid hormone can increase production of angiotensinogen, which is a part of the renin-angiotensin system (RAS). RAS regulates blood pressure. Hypothesis: HEK 293 cells treated with T3 and T4 will have more angiotensin II type I receptors than those not treated with T3 …

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Investigation Of Inosine And Hypoxanthine As Biomarkers Of Cardiac Ischemia In Plasma Of Non-Traumatic Chest Pain Patients And A Rapid Analytical System For Assessment, Don E. Farthing Jan 2008

Investigation Of Inosine And Hypoxanthine As Biomarkers Of Cardiac Ischemia In Plasma Of Non-Traumatic Chest Pain Patients And A Rapid Analytical System For Assessment, Don E. Farthing

Theses and Dissertations

Each year in the U.S., approximately 7-8 million patients with non-traumatic chest pain visit hospital emergency departments (ED) for medical evaluation. It is estimated that approximately 2-5% of these patients are experiencing acute cardiac ischemia, but due to the shortcomings of current test methods, they are incorrectly diagnosed and discharged without appropriate treatment provided, thus leading to poor patient outcome and potential medical malpractice litigation.The goals of this research were to evaluate plasma samples for potential biomarker(s) of acute cardiac ischemia prior to heart tissue necrosis, and to ultimately develop a rapid method for detection of the potential biomarker(s) in …

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Delineation Of Malignant Areas In Histological Images Of Head -Neck Cancer, Mutlu Mete Jan 2008

Delineation Of Malignant Areas In Histological Images Of Head -Neck Cancer, Mutlu Mete

Theses and Dissertations

Histopathology remains one of the most critical steps in diagnosis and treatment of any kind of cancer. Recently, the improvements in imaging techniques led to the discovery of virtual histological slides, which in fact are high resolution images with a resolution of 0.25 μm/pixel. These images enabled researchers to investigate cancer cell morphologies at the finest level. Traditionally, assessment of tumor margins is done manually by a histopathologist. The procedure requires histological processing of the tumor and examining multiple tissue sections. The number of sections varies based on the size, location, and type of tumor. The recognition of cancer areas …

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Physical And Computational Models Of Human Lung For Optimizing Respiratory Drug Delivery, Mohammed Ali Jan 2008

Physical And Computational Models Of Human Lung For Optimizing Respiratory Drug Delivery, Mohammed Ali

Theses and Dissertations

Respiratory drug particles aerosolized from the commercially available drug delivery devices may charge electrostatically. Investigations of the relevance of this charge on deposition in the human lung are just quite a few and they started early eighties though the aerosol science study is a decade old discipline. Additionally, the localized deposition of drug particles at desired sites such as inflamed tissue and appropriate receptors has been recognized by clinical investigators as being critical factors for the effective administration of respiratory drugs. To accomplish these tasks, it is imperative to undertake in vitro and in silico studies of medicinal drug aerosol …

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Physicians' Communication With Older Patients, Particularly Older African American Women, About Sexual Health And Sexual Risk Behaviors For Human Immunodeficiency Virus (Hiv) And Acquired Immune Deficiency Syndrome (Aids)*, Regina Vaughn Gibson Jan 2008

Physicians' Communication With Older Patients, Particularly Older African American Women, About Sexual Health And Sexual Risk Behaviors For Human Immunodeficiency Virus (Hiv) And Acquired Immune Deficiency Syndrome (Aids)*, Regina Vaughn Gibson

Theses and Dissertations

HIV/AIDS is rising among people age 50 and older in the U.S. but primary care physicians may not be talking to their older patients about sexual health and high-risk sexual behaviors nor routinely testing them for HIV/AIDS. Do primary care physicians in Arkansas obtain sexual histories on their older patients? Are primary care physicians in Arkansas knowledgeable enough about HIV to impart risk-reduction information to their older patients? These are but two of the questions this research seeks to answer. Contrary to what the medical or general population believes, many older persons remain sexually active throughout their lifetime. The problem …

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The Integrated Implementation Of Surgical Simulations Through Modeling By Means Of Imaging, Comprehension, Visualization, Deformation, And Collision Detection In Virtual Environments, Sinan Kockara Jan 2008

The Integrated Implementation Of Surgical Simulations Through Modeling By Means Of Imaging, Comprehension, Visualization, Deformation, And Collision Detection In Virtual Environments, Sinan Kockara

Theses and Dissertations

Advances in information technology based applications in medicine and biology help to improve the conventional methods of delivering health services by enhancing and complementing traditional approaches of medical education, diagnostic techniques, intra-operative assistance, and pre/post operative services etc. Individualized medical training by virtual simulations and the use of advanced visualization techniques in cell biology will impact the way medicine is practiced and biological processes are understood. Although enhancing visualization and presenting the unreality in a form of blended virtuality is exceedingly accepted in medicine and biology, it brings many challenging but intriguing and intertwined multi disciplinary problems that are required …

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Virtual Environments And Their Applications In Surgical Training, Tansel Halic Jan 2008

Virtual Environments And Their Applications In Surgical Training, Tansel Halic

Theses and Dissertations

The advances in the application of Virtual Environments (VE) in medicine help to improve the conventional methods of delivering health services by enhancing and complementing traditional approaches of medical education, diagnostic techniques, intraoperative assistance, pre-post operative services etc. Virtual Reality (VR) and Augmented Reality (AR) are two forms of VEs that revolutionize medical training and fill the deficiencies in the traditional teaching/learning methods in medicine. Although presenting the unreality in a form of blended virtuality is exceedingly accepted in medicine, it brings many challenging but intriguing and intertwined multi disciplinary problems that are required to be addressed. This thesis proposal …

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The Influence Of Environmental Factors And Organizational Characteristics On Innovations In Family Medicine Practices In Virginia, Debora Goetz Goldberg Jan 2008

The Influence Of Environmental Factors And Organizational Characteristics On Innovations In Family Medicine Practices In Virginia, Debora Goetz Goldberg

Theses and Dissertations

Family medicine practices are currently threatened by factors such as poor reimbursement, physician stress, shortage of providers, and difficulties in providing prompt access and reliable continuity of care. The external environment faced by family medicine practices is extremely complex and characterized by high pressure from regulatory sources, decreasing reimbursement levels, an increasing rate of change in technologies and care delivery processes, and increasing patient and community expectations. Over the last several years there have been many efforts in family medicine to respond to the challenges presented by the external environment. The majority of these efforts focus on redesigning the delivery …

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Virginia Emergency Department Physician Knowledge Of The Emergent Treatment Of Avulsed Teeth, Joy Leatrice Barnes Phelps Jan 2008

Virginia Emergency Department Physician Knowledge Of The Emergent Treatment Of Avulsed Teeth, Joy Leatrice Barnes Phelps

Theses and Dissertations

Purpose: The purpose of this study was to determine the knowledge and treatment protocols for physicians in Virginia emergency departments in regards to the emergent treatment of avulsed teeth.Methods: Using a cross sectional survey design, an 8-item questionnaire regarding the treatment of avulsed teeth was emailed to 75 emergency department chairpersons in Virginia. After 30 days, a reminder paper copy of the questionnaire was mailed and an email reminder with the on-line link was sent. After 60 days the study was closed. Comparisons were made using chi-square analysis based on percentages to test for significance. Results: The response rate was …

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Alternative Orthodontic Bonding Protocol Using Self Etching Primer, Rush-Baker Gaines Caldwell Jan 2008

Alternative Orthodontic Bonding Protocol Using Self Etching Primer, Rush-Baker Gaines Caldwell

Theses and Dissertations

The purpose of the current study was to develop a bonding method that can achieve clinically acceptable bond strength values while leaving a minimum amount of adhesive on the tooth surface during the debonding process. One hundred teeth were randomly assigned into groups. Five different enamel surface preparation protocols were tested (N = 20, each): Conventional acid etch, standard SEP, SEP applied with a light brush stroke (altered SEP 1), SEP applied directly to the composite of pre-coated bracket (altered SEP 2), and Primer Only groups. Brackets were debonded using an Instron universal testing machine (Instron, Canton, MA) in shear …

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Endocannabinoid Modulation Of Spatial Memory In Aversively And Appetitively Motivated Barnes Maze Tasks, John Pinckney Harloe Jan 2008

Endocannabinoid Modulation Of Spatial Memory In Aversively And Appetitively Motivated Barnes Maze Tasks, John Pinckney Harloe

Theses and Dissertations

Genetic deletion or pharmacological blockade of the CB1 receptor has been reported to impair extinction learning in aversive conditioning (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether the differential effects caused by CB1 receptor disruption on extinction result from the hedonics (i.e., aversive vs. appetitive) or is related to the required responses associated with these disparate tasks. In order to evaluate whether the hedonics is the determining factor, we used either aversive (i.e., escape from bright lights and air turbulence) or appetitive (i.e., …

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