Medicine and Health Sciences Commons^™

Laboratory Management Models In Core Facilities, Karmen Michael Owen

Theses and Dissertations

Core biotechnology facilities are often defined as laboratories that house shared resources for research. These laboratories are of great importance to research communities because a large portion of scientific research data is generated at these facilities. Different investigators can use core facilities to help further their research. In a university setting, there are several management strategies from small cores that house a specific type of instrument, to large cores that house many different technologies. Funding strategies also differ significantly, from those that are funded by a small group of well-funded investigators, to cores managed by a specific department or school, …

Phoneme Stability In Speech Production Of Cognate And Non-Cognate Nouns In A Bilingual With Aphasia, Katherine Vlach

Theses and Dissertations

With the growing bilingual population in the world comes a greater incidence of bilingual aphasia, a communication disorder characterized by expressive or receptive language impairment in one or both of a bilingual speaker’s languages. The cognate facilitation effect, which has greatly been explored in healthy bilingual studies, has shown that cognates are named faster and more accurately than non-cognates; as the cognate facilitation effect is also retained in bilingual speakers with aphasia, it is thought that cognates could potentially be used as a treatment tool to facilitate lexical access, particularly when a bilingual speaker with aphasia presents with one of …

Cardiac Imaging In Mice With Micro-Computed Tomography: An Assessment, Kyle Porter Stegmann

Theses and Dissertations

While echocardiography continues to be a renowned imaging approach to study LV function and geometry in mice, contrast enhanced micro-CT has recently gained popularity because of the high-resolution three-dimensional images produced. However, comparative analyses between echocardiography and micro-CT are limited and conflicting. Therefore, to demonstrate the validity of micro-CT against echocardiography, this study aimed to compare identical measurements of LV function and geometry in wildtype and genetically modified mice in which confounding parameters such as time and anesthetic conditions were taken into consideration. Globally deleted FAP knockout mice (n=12) and age-matched wild type mice (n=14) were included in this study. …

The Correlation Between Bilingual Children’S Self-Reported Language Proficiency And Their Scores On Dual-Language Standardized Assessments, Andrea Elise Vargas

Theses and Dissertations

This study aimed to evaluate the relation between bilingual Spanish-English speaking children’s self-reported language proficiencies and bilingual experiences and their scores on norm-referenced standardized dual-language assessments. Additionally, the relation between bilingual children’s self-reported language proficiencies and bilingual experiences and parent reports of children’s Spanish and English input and output was examined. The Houston Questionnaire, a novel tool designed to provide insight into bilingual children’s self-perceptions of language proficiencies and experiences, was administered to gather such information for this study. A sample of bilingual children local to Columbia, South Carolina completed a battery of dual-language standardized assessments in kindergarten, and then …

Academic Impacts Of Intergenerational Trauma: Assessing The Relationship Between Ace Scores Of Parents And The Language And Literacy Development Of Their Elementary-Aged Children, Paige Lee Banaszak

Theses and Dissertations

This paper contributes to the current literature by investigating factors that may contribute to language and literacy difficulty among children, to support the future development of effective intervention techniques. The data analyzed in this paper was collected from children and families participating in Reach Every Reader, a research study currently being conducted to improve literacy outcomes in the U.S. by developing a computer-adaptive screening assessment tool to identify children at risk for language and literacy difficulties early in their educational development. Children enrolled in kindergarten through third grade completed tasks that target language and literacy skills, and their parent(s) completed …

The Effect Of Visual Feedback On Vocal Compensation Abilities In Individuals With Post-Stroke Aphasia, Marissa Rylee Olson

Theses and Dissertations

Speech production is a complex and highly organized process comprised of various sensory and perceptual components. Post-stroke aphasia can impair speech production abilities by interrupting individuals’ ability to detect and correct speech errors and produce their targeted behavior. Contemporary models of speech production aim to understand the relationship between sensory systems and the human ability to produce perceptually accurate speech. This study seeks to understand the relationship between visual feedback and vocal compensation abilities in individuals with post-stroke aphasia to determine the effectiveness of incorporating visual feedback into therapeutic expressive language intervention. It was hypothesized that that the multi-sensory experimental …

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …

Substance Use Disorder Treatment Among African American Men Living In The Rural South Of The United States, Serge Raoul Wandji

Theses and Dissertations

Substance use disorders (SUD) affect more than 40 million Americans. African American (AA) men are disproportionally affected by the negative health and social consequences of SUD, and men in rural areas may be particularly at risk due to disadvantaged socioeconomic conditions and persistent race-related stressors such as perceived discrimination. The overall purpose of this study is to advance the understanding of factors associated with SUD treatment acceptance and relapse potential among Southern rural AA men.

This purpose was achieved by determining differences in treatment acceptance and relapse potential by race and gender among rural residents admitted in a SUD treatment …

Exploration Into The Relationship Between Colitis And Depression: A Potential Role For The Aryl Hydrocarbon Receptor, Kasie Lynn Roark

Theses and Dissertations

Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders with unclear etiology comprised of two defined disorders – Crohn’s Disease (CD) and Ulcerative Colitis (UC). IBD leads to chronic pain, socially isolating symptoms, and an overall reduction in patient quality of life. There is currently no cure for IBD. Due to decreased mucous production and weakening of the colonic epithelial lining, gut-microbiota and their metabolites can invade the intestinal lamina propria and circulate systemically, a term known as “leaky gut”. Recent studies show a relationship exists between peripheral inflammation, such as IBD, and depression. The gut-brain axis (GBA) …

Nurse Perceptions Of Caring And Professional Governance, Lan Angela Nguyen

Theses and Dissertations

Background: Caring, a characteristic of an effective work environment, and clinical nurse control over the professional governance of nursing practice results in higher nursing retention and better patient outcomes. Although the concepts of caring and professional governance of nursing practice, and their discrete associations with patient outcomes, are widely studied, little to no research is published on the nature of the relationship between caring and professional governance of nursing practice. Without understanding this relationship, it is challenging to explore the impact of this relationship on nursing practice and patient outcomes.

Aims: The purpose of this study was to describe nurse …

Volume Change Measurements Of Cancer Cells In A Microfluidics Platform, Yukuan Yu

Theses and Dissertations

Understanding the function of aquaporins in transcellular transport is vital for homeostasis, pathophysiology, and translational potential in AQP-based diagnostics and therapeutics. Microfluidics device has the potential to evaluate the function of aquaporins with precise control and manipulate micro-scale fluid due to good optical quality and short processing distance. This work has two parts: cell culture in a microfluidic chip to characterize aquaporins’ function and visualization of single cell volume change under osmotic pressure shock in a homemade imaging dish. For the first part, we established a microfluidics platform for future modification and measurement of the dynamic volume change of biological …

Food Insecurity In Youth And Young Adults With Diabetes: Prevalence And Association With Health Behaviors, Lauren Helene Martini

Theses and Dissertations

Given the life-long impact of diabetes(1-5), it is important to engage in behaviors that promote health and wellness to delay or prevent negative health outcomes(3, 6-10). Despite this, youth and young adults with diabetes generally do not adhere to nutritional(11-17) or physical activity(18, 19) recommendations. In households experiencing financial difficulties, especially those who are having difficulty providing sufficient food to all of its members, adhering to recommendations may be even more difficult.

The purpose of this dissertation is to better understand and contextualize food insecurity among youth and young adults (YYA) with youth-onset T1DM and T2DM. The first aim addresses …

Meta-Analysis Of Factors Impacting Reading Impairment Rates In Studies Of Children With Developmental Language Disorder (Dld), Kayla Dewey

Theses and Dissertations

Purpose - Developmental language disorder (DLD) is a common yet underdiagnosed disorder centered on difficulties with oral language, and often associated with word reading and reading comprehension difficulties. Numerous studies have documented high rates of reading impairment in children with DLD, but the specific rates vary widely across studies. The purpose of this meta-analysis was to help provide accurate prognostic information about this disorder by determining the average proportion of participants with DLD who also had reading impairment, and to determine whether variability in the rate of reading impairment was significantly influenced by studies’ methodological features, including recruitment method, type …

Orthographic Knowledge And Phonological Awareness In Children With Speech Sound Disorder, Anna Marie Ehrhorn

Theses and Dissertations

Speech sound disorder (SSD) puts children at risk for word reading difficulties but does not guarantee them. Research on early literacy skills in children with SSD has primarily focused on phonological awareness due to speech sound deficits associated with SSD. Researchers have begun to examine multiple factors beyond phonological awareness that may impact word reading and spelling development. Orthographic knowledge is another essential factor understudied in children with SSD. Previous research has shown that orthographic properties of words influence phonological awareness performance in skilled readers and children with reading difficulties. No known previous studies have examined whether orthography influences phonological …

Greenspace Across The United States: Exploring Equity And Associations With Physical Activity, Obesity, And Health-Related Quality Of Life, Ellen W. Stowe

Theses and Dissertations

Neighborhood greenspace is important for health and well-being but may not be equitably present in neighborhoods across the United States. Also, many adults are physically inactive, have obesity, and report poor health-related quality of life. Greenspace has been tied to these health conditions, but with mixed findings. The purpose of this study was to 1) use an environmental justice perspective to examine variations in 11 measures of greenspace by neighborhood race/ethnicity, income, and rurality in block groups across the contiguous United States and 2) examine 11 greenspace measures in connection to physical activity, obesity, and health-related quality of life in …

Behavioral And Neurophysiological Measures Of Speech Auditory Feedback Processing Impairment In Left Hemisphere Stroke, Stacey Sangtian

Theses and Dissertations

The purpose of this study was to identify behavioral and neural correlates of impaired speech auditory feedback processing in people with a history of left-hemisphere stroke (LHS). To do this, we used the altered auditory feedback (AAF) paradigm to externally induce speech errors by randomly shifting the pitch frequency of the online auditory feedback up or down at ±100 cents in 38 LHS and 27 neurologically intact control participants under two experimental conditions: 1) active vocalizations of a steady speech vowel sound “ah,” and 2) passive listening to the playback of the same self-produced vocalizations. Randomized control trials were included …

Nutrition Facts Label Use Among U.S. Adolescents, Jennifer Beth Mandelbaum

Theses and Dissertations

Despite the promise of Nutrition Facts label (NFL) use as a population-level intervention with broad reach, few studies have examined determinants of adolescents’ NFL use, and how this label use may be associated with nutrition behaviors. This study used data from the International Food Policy Study, an online cross-sectional survey of trends in dietary patterns and policy-relevant behaviors in the U.S. and five other countries. First, this study examined 1) whether NFL use was associated with healthy eating efforts and 2) whether there were sociodemographic differences in NFL use among U.S. adolescents. Results demonstrated that NFL use was positively associated …

Peromyscus Maniculatus Bairdii And Peromyscus Maniculatus Sonoriensis Polymorphisms, Matthew Dixon Lucius

Theses and Dissertations

Sequencing technology has advanced greatly over the past couple of decades. This has led to many studies developing hypotheses based on genomic data. This requires many genomic studies to have up-to-date information on the species’ or subject’s genome being investigated. If a study does not have accurate or up-to-date background information, then they cannot fully develop their theories that are being established. In this study, I utilize outbred Peromyscus maniculatus, deer mice that are genetically diverse, to record the polymorphisms that are found throughout the Peromyscus maniculatus genome. I first explore the differences between the polymorphisms found in Peromyscus …

Genomic Analysis Workflows To Identify Mutational Signatures And Structural Variations In Ovcar8 Cells And Rad51d-Deficient Mouse Embryonic Fibroblasts, Manli Yang

Theses and Dissertations

Specific genomic profiles associated with exposure to DNA damaging agents have been identified in cancer related genes, revealing that mutational patterns can be carcinogen- specific. However, there have been limited efforts to demonstrate similar clear relationships for endogenous mutational processes. One endogenous source of mutations is contamination of the deoxynucleotide pool with damaged bases that, if incorporated into DNA, cause mutations.

The Catalog of Somatic Mutations In Cancer (COSMIC) represents an international effort to characterize mutations in cancer. A mutational signature is the pattern of mutations generated by a mutational process. Each mutational process contains two parts: DNA damage and …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia Therapy: A Proof-Of-Concept Study, Lynsey Mcgrath Keator

Theses and Dissertations

Identifying effective and efficient rehabilitation tools is crucial to improve language outcomes for persons living with chronic aphasia. Speech entrainment has proved to be particularly successful in improving speech output in nonfluent aphasia. It is hypothesized that, for patients with aberrant oscillatory synchronization between anterior and posterior language regions of the left hemisphere, speech entrainment may act as an external gaiting mechanism to bolster an impaired efference copy and improve synchrony between these regions. Theoretical and empirical evidence supports this idea that speech production relies on anterior-posterior connectivity in the left hemisphere.

Transcranial alternating current stimulation (tACS) delivers low, periodically-alternating …

Unearthing An Emerging Neglected Bacterial Disease: Evidence Of Spotted Fever Group Rickettsioses In El Salvador, Kyndall Christian Braumuller

Theses and Dissertations

The main objectives of this dissertation were to investigate the seroprevalence of Spotted Fever Group Rickettsioses (SFGR) antibodies in a specific vulnerable population at high risk for vector-borne disease in El Salvador, understand the relevant risk factors for SFGR past and acute infection in this same population through logistic regression modeling, and clarify the presence of SFGR bacteria in locally collected ticks.

SFGR are a group of bacterial diseases caused by species in the Rickettsia genus of the phylogenetic spotted fever group. These are tick-borne diseases (TBD) that have been described in almost every region of the world. SFGR are …

Feasibility And Preliminary Outcomes Of A 6-Week Mindful Walking Program To Maintain And Improve Cognition In Adults At Risk For Alzheimer’S Disease Or Other Related Dementias, Caroline Mannion Wood

Theses and Dissertations

The present study examined the impact of a 6-week Mindful Walking intervention. Participants completed 30 minute walking sessions twice a week for 6 weeks. Ten older adults attended 100% of the supervised walking sessions. Pre-post comparison of the Montreal Cognitive Assessment and examination of subtests of the Montreal Cognitive Assessment did not reveal a significant change in mean scores (p.05, one-tailed). The number of steps accumulated as a result of Mindful Walking and other activities measured with the ActivPAL and change in MoCA total scores did not reach significance. Generally, the Mindful Walking program was well-liked (4 on a scale …

Rural-Urban Differences In Survival Among People With Early Onset Colorectal Cancer, Radhika Ranganathan

Theses and Dissertations

Colorectal cancer (CRC) is the third most common cancer and the second most among cancer deaths both in the US and globally. Early Onset Colorectal Cancer (EOCRC), occurring between the ages of 20 and 49, has continued to rise over the past decades. Several studies have reported a persistent increase in EOCRC incidence and mortality, especially in rural areas as compared to urban areas, despite decreases in rates for people over the age of 50 years. Increase in EOCRC may have played a role in lowering the age of screening recommendation to 45-49 age group. The objective of this study …

Living With Ulcerative Colitis: Exploring Dietary Inflammatory Intake, Physical Activity, And Methods To Manage The Burden Of Illness, Kelli E. Dubois

Theses and Dissertations

Ulcerative Colitis (UC) is a chronic illness under the umbrella of Inflammatory Bowel Disease (IBD). IBD is becoming a global health issue as incidence rates are rising throughout the world. UC is characterized by chronic inflammation and ulcerations in the colon’s mucosal lining due to abnormal inflammatory and immune system responses. Patients with UC experience a range of gastrointestinal and extraintestinal symptoms as well as psychosocial challenges throughout the course of illness that generate a significant burden on daily life. Periods of active disease, or flares, present exacerbations of disease symptoms and the greatest burden on daily functioning, yet disease …

Measuring Orthographic Influences On Phonological Processing In Beginning Readers: An Eyetracking Study, Emily Grace Fisher

Theses and Dissertations

Purpose – Both orthographic and phonemic awareness are essential to reading. However, the role of orthographic knowledge in phonemic awareness has not been thoroughly investigated in beginning readers until recently. The purpose of this study was to examine if orthographic knowledge influenced phonological processing in beginning readers and to establish a proof of concept for the use of eyetracking measures to examine these skills in young children.

Method – 22 participants, aged 6-7 years, completed norm-referenced assessments of language and reading ability as well as experimental measures of orthographic and phonological awareness while their eye movements were monitored.

Results – …

Association Between Postpartum Weight Retention And The Dietary Inflammatory Index, Nyrobi Tyson

Theses and Dissertations

Objective: The objective of this thesis is to examine the relationship between the Dietary Inflammatory Index (DII), measured during the postpartum period, and postpartum weight retention.

Setting and Participants: We used the Infant Feeding Practices Study (IFPS) II (n=5000), a longitudinal study of women from late pregnancy through their infant’s first year of life conducted between 2005 and 2007. Survey topics included feeding practices, infant health, food allergies, sleeping arrangements, mother’s employment, childcare, and mother’s dietary intake.

Main Outcomes: Postpartum weight retention (PPWR) was calculated in kilograms by subtracting self-reported body weight at 3, 6, 9, and 12 months postpartum …

Hiv-Related Stigma, Sexual And Gender Minority-Related Stigma, And Health Outcomes Among Msm Living With Hiv: Measurement, Impact, And Intersectionality, Tianyue Mi

Theses and Dissertations

Background: Many men who have sex with men (MSM) living with human immunodeficiency virus (HIV) experience suboptimal health outcomes compared to nonMSM males living with HIV, including a faster decline in CD4 count before initiating antiretroviral therapy (ART), slower immune recovery after initiating ART, more mental health problems, suboptimal ART adherence, and lower retention in care. MSM living with HIV are often exposed to multiple layered stigmas, including, but not limited to, stigma related to being infected with HIV and stigma related to sexual and gender minority (SGM) status. Although various scales of HIV-related stigma have been frequently used for …

Investigating The Impact Of Nonlinguistic Cognitive Reserve On Naming Pre- And Post-Treatment, Lillian Jarold

Theses and Dissertations

Background: The relationship between linguistic and nonlinguistic cognition in persons with aphasia is complex and often debated in the literature. Furthermore, the impact of nonlinguistic cognition on aphasia treatment outcomes is unclear. The present study sought 1) to examine the relationship between WAIS scores and performance on a test of naming and 2) to examine the relationship between WAIS scores and change scores on a test of naming between baseline and post-treatment in persons with chronic aphasia.

Method: This retrospective study utilized data from participants (N=102) who were recruited for a multi-center cross-over trial (POLAR: Predicting Outcomes of Language Rehabilitation). …

Food Insecurity Resilience Of Refugee Families In The United States: A Qualitative Study, Maryam Suliman Alhabas

Theses and Dissertations

Refugee families living in the United States often encounter a number of challenges while trying to build a new home and maintain their household food security. Refugee families at high risk of experiencing food insecurity in the resettlement country. Food insecurity among US refugee families is a major public health concern as it adversely impacts their health and wellbeing, since it affects dietary intake and mental health and associated with illness, poor nutrition, and obesity. Little is known about what happens when refugee families face food insecurity experience, and the role of their social contexts in that experience. The objective …

Exploration Of The Role Of Neighborhood Residential Segregation By Race And Ethnicity In Obesity Risk Among School-Aged, Melissa L. Fair

Theses and Dissertations

Youth obesity prevalence remains high, despite decades of intervention. Grounded in the social ecological model, neighborhoods and schools are important settings in addressing the complex systems that influence obesity. Contributing to disparities, by race/ethnicity, Black and Hispanic youth are more likely to live in segregated neighborhoods and attend segregated schools, which are also more likely to have high rates of poverty and are less likely to have high quality nutrition and built environments. Leveraging data from local school district (district and state department of education) and national datasets (ACS, Childhood Opportunity Index 2.0), this study examined the associations between school …