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Full-Text Articles in Medicine and Health Sciences

The Cardio-Protective Effects Of Substance P In Both Ischemia/Reperfusion And And Short-Term Hypoxia Rat Models, Shaiban Jubair Dec 2014

The Cardio-Protective Effects Of Substance P In Both Ischemia/Reperfusion And And Short-Term Hypoxia Rat Models, Shaiban Jubair

Theses and Dissertations

Substance P, a member of the tachykinin family, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers surround coronary vessels, making them ideally positioned to sense changes in coronary pressure and/or flow. Recent studies have identified substance P as being protective acutely following ischemia-reperfusion due to its ability to induce coronary blood vessel vasodilation. In addition, studies conducted on non-cardiac tissue have reported substance P to be protective against cell death through a mechanism involving activation of anti-apoptotic AKT pathway. However, the possibility of substance P being similarly cardioprotective has not been reported. Accordingly, the purpose …


Early Screening And Identification Of Preschool Children Affected By Serious Emotional Disorders, Cathy Renee Robey-Williams Dec 2014

Early Screening And Identification Of Preschool Children Affected By Serious Emotional Disorders, Cathy Renee Robey-Williams

Theses and Dissertations

Mental illness has surpassed physical health problems as the leading cause for morbidity and mortality in American children. National prevalence of serious emotional disorders in the 0-5 age group has ranged from 9.5% to 14.2%. Of the 15 million children affected by mental illness, less than 20- 25% receive any treatment. Nationwide, early screening, identification, and treatment of preschoolers with emotional or behavioral disorders have become a critical priority in order to reduce the increasing burden of healthcare costs for mental illness and psychiatric care. The purpose of this study was to test the feasibility of a screening process for …


Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath Dec 2014

Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath

Theses and Dissertations

Inhibition of CDK2 activity in G1 and S phases of the cell cycle can promote selective apoptosis of cancer cells through the E2F1 pathway. Currently available CDK inhibitors target the ATP binding pocket and result in lack of specificity for the cell cycle vs. the transcriptional CDKs. It has been shown that a peptide HAKRRLIF derived from the tumor suppressor p21 binds to the cyclin binding groove (CBG) and selectively inhibits cell cycle CDKs (CDK2/Cyclin A, CDK2/Cyclin E and CDK4/Cyclin D). The CBG is unique to cell cycle CDKs hence targeting this site avoids the inhibition of transcriptional CDKs can …


The Effects Of Multiple Gratitude Interventions Among Informal Caregivers Of Persons With Dementia And Alzheimer's Disease, Cristy Degregory Dec 2014

The Effects Of Multiple Gratitude Interventions Among Informal Caregivers Of Persons With Dementia And Alzheimer's Disease, Cristy Degregory

Theses and Dissertations

The purpose of this group randomized intervention trial was to examine the impact of participation in three telephone-based gratitude interventions on the physical, psychological and social functioning of participants in caregiver support groups who are unpaid family caregivers of persons with dementia and Alzheimer’s disease. Fredrickson’s (2001) Broaden-and-Build Theory informed the investigation of the effect of three gratitude interventions on participants’ levels of gratitude, positive aspects of caregiving, subjective well-being, physical health and mental health. This was a randomized, wait-list controlled study involving informal caregivers involved in support groups. The research questions were: 1.) How does gratitude contribute to subjective …


Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad Dec 2014

Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad

Theses and Dissertations

Population connectivity, particularly in open systems, is an important metric for understanding population-level processes on both ecological and evolutionary timescales. In coastal marine systems, adults are typically sedentary and dispersal occurs primarily during a larval stage when individuals are transported in ocean currents. Because coastal marine populations exist as networks of interconnected subpopulations, variation in the magnitude and extent of population connectivity can have profound effects on population dynamics and species distribution limits. Connectivity is a complex process, affected by a multitude of factors, including adult inputs and physical dispersal, which operate at multiple scales and may interact. This dissertation …


Impacts Of Adolescents' Emotional And Behavioral Concerns And Social Skills On Parenting Stress, Marissa Miller Dec 2014

Impacts Of Adolescents' Emotional And Behavioral Concerns And Social Skills On Parenting Stress, Marissa Miller

Theses and Dissertations

Minimal literature has examined predictors of parenting stress for parents of adolescents and what may contribute to the impact of these predictors, particularly those regarding adolescent behavior. The current study sought to evaluate whether adolescents’ internalizing and externalizing behaviors significantly predicted parenting stress and whether adolescent social skills moderated the relationship. Covariates of gender, age, ethnicity, and socioeconomic status were entered first into a multiple regression moderation model and followed by internalizing and externalizing behaviors, social skills, and interaction terms, respectively. The overall model explained 19 percent of the variance in parenting stress. While internalizing behaviors significantly predicted parenting stress, …


Metformin Arrests Growth And Induces Apoptosis Of Neuroblastoma Cells, Nadia Al-Sammarraie Dec 2014

Metformin Arrests Growth And Induces Apoptosis Of Neuroblastoma Cells, Nadia Al-Sammarraie

Theses and Dissertations

Neuroblastoma is one of the most common solid neoplasms in children, which affects sympathetic neurons with a wide range of genetic abnormalities, especially MYCN amplification, a molecular marker of poor prognosis. Despite advance therapy, still the mortality rate for advance disease is high with frequent relapse and resistance to cytotoxic therapy with evidence of p53 mutation. Metformin, an oral hypoglycemic medication, is a relatively safe and cost effective drug with wide clinical applications, mainly for treatment of Type 2 diabetes. Recent studies have showed promising anticancer effect of metformin on various cancer types, especially on p53 mutant cells. In our …


Gestational Weight Gain, Pregnancy Outcomes, And Use Of Perinatal Health Services, Lujing Zhan Dec 2014

Gestational Weight Gain, Pregnancy Outcomes, And Use Of Perinatal Health Services, Lujing Zhan

Theses and Dissertations

This dissertation consists of three studies that were undertaken to better understand 1) the role of gestational weight gain (GWG) during early pregnancy on subsequent blood pressure changes and the risk of pregnancy-induced hypertension (PIH), 2) the causal effect of GWG in both early and mid-late pregnancy on the subtypes of preterm births, and 3) the impact of personal capital on the use of perinatal health services (i.e., prenatal care use and preconception care counseling). The first two studies were based on the data from the 1988 National Maternal and Infant Health Survey and the third study employed the data …


Weight-Gain And Energy Balance, Benjamin Thomas Gordon Dec 2014

Weight-Gain And Energy Balance, Benjamin Thomas Gordon

Theses and Dissertations

Energy balance is the result of a dynamic relationship between energy intake (EI), energy expenditure (EE) and energy storage (ES). These three components of energy balance have extremely complicated associations, and all three major components are consistently influenced by physiologic, psychological, and sociologic factors. Concerted changes between EE and EI result in alterations of the ES. Most often in clinical and research settings, bodyweight is used as marker of body composition (i.e., ES) changes. Traditional measurements of bodyweight do not give an accurate portrayal of ES change or the role it has in energy balance. This dissertation supplies new methods …


Simulation Based Evaluation Of Multiscale Small Area Health Models, Purbasha Dasgupta Dec 2014

Simulation Based Evaluation Of Multiscale Small Area Health Models, Purbasha Dasgupta

Theses and Dissertations

The effects of scale on the analysis of spatial data, often referred to as the modifiable areal unit problem in spatial studies, is one of the issues often encountered in small area health models. These spatial effects of scale are also seen in the areas of disease mapping where data are usually available in counts. Often there is a need to consider the different scales of aggregation that exist within count data, since inferences based on analyses can vary if we change the definition of the unit of analysis. This thesis provides a framework that describes the distribution of relative …


Impact Of Multi-Hospital System Organizational Structure On Financial Performance And Quality Of Care In Rural Hospitals, George Raul Audi Dec 2014

Impact Of Multi-Hospital System Organizational Structure On Financial Performance And Quality Of Care In Rural Hospitals, George Raul Audi

Theses and Dissertations

Considering the increasing challenge to providing access to affordable healthcare in the United States and its effect on the economy, it is critical for patients, healthcare organizations, financial institutions, and federal and state agencies to understand the impact of different organizational structures within affiliated hospitals. The objective of this study was to investigate the impact of different organizational structures within rural multi-hospital systems (MHS) on the hospitals’ financial performance and the quality of patient care. The data for this study were drawn by linking two national datasets: the 2011 American Hospital Association (AHA) Annual Survey and the 2012 American Hospital …


Effect Of Primary Care Physician Density On Late Stage Cervical Cancer Diagnosis, Emily Haanschoten Dec 2014

Effect Of Primary Care Physician Density On Late Stage Cervical Cancer Diagnosis, Emily Haanschoten

Theses and Dissertations

INTRODUCTION: Late-stage cervical cancer diagnosis is an important contributing factor to the cervical cancer mortality rate. Screening for cervical cancer is a vital tool in reducing the number of late-stage cases, preventing incident cases and reducing mortality. Access to care is often a significant barrier to receiving these services. Women who have no usual source of care report significantly lower percentages of Pap tests than women who have a usual source. South Carolina ranks 13th in the US in cervical cancer incidence and 7th in cervical cancer mortality. South Carolina also struggles with a primary care physician shortage, ranking 39th …


Examining The Influence Of Healthy Eating Identity On Shopping Behaviors, Jordan Brittingham Dec 2014

Examining The Influence Of Healthy Eating Identity On Shopping Behaviors, Jordan Brittingham

Theses and Dissertations

Eating identity is shown to be a promising measure capable of enhancing our understanding of nutrition behavior. Persons with healthy eating identities are less likely to consume the typical American diet and report healthier diets in general. While there are several studies linking healthy eating identity and diet, there is currently no research examining healthy eating identity in relation to food shopping behavior, an important aspect of nutritional intake. The purpose of this study was to examine the influence of healthy eating identity on shopping behaviors including supermarket utilization, supercenter utilization, likelihood of shopping at the nearest store, distance to …


Periodontal Microorganisms, Obesity, Chronic Inflammation, And Type 1 Diabetes, Georges Joseph Nahhas Dec 2014

Periodontal Microorganisms, Obesity, Chronic Inflammation, And Type 1 Diabetes, Georges Joseph Nahhas

Theses and Dissertations

Periodontal disease is a low-grade chronic inflammation in the tissues surrounding the teeth caused by multiple, mostly gram-negative pathogens. It is associated with diabetes, obesity, and chronic inflammation. The specific roles that periodontal microorganism play in these conditions are not well-studied. Hereby, we explored how periodontal bacteria from sub gingival plaque clustered in youth with and without type 1 diabetes, and how such patterns related to body-mass-index percentile (BMI percentile), C-reactive protein (CRP) and adiponectin. Cross-sectional data were collected from 105 youth with type 1 diabetes and 71 without diabetes. Participants were between 12 and 19 years of age receiving …


Quality Improvement Project: A Comparison Of Daily Routine Chest Radiography Versus Clinically-Indicated Chest Radiography In Preventing Ventilator-Associated Pneumonia In Adult Icu Patients On Ventilators: An Evidenced Based Practice Project, Kimberly Mckenney Dec 2014

Quality Improvement Project: A Comparison Of Daily Routine Chest Radiography Versus Clinically-Indicated Chest Radiography In Preventing Ventilator-Associated Pneumonia In Adult Icu Patients On Ventilators: An Evidenced Based Practice Project, Kimberly Mckenney

Theses and Dissertations

Ventilator-associated pneumonia is one of the critical complications identified by a chest x-ray (CXR). However, there is a controversy about the use of CXRs. Overuse of the CXR has also identified concern among the ICU patient population. The purpose of this evidenced-based practice project was to determine if there were differences in patient outcomes when receiving daily routine CXRs as compared to clinically-indicated CXRs. Patient outcomes measured were: ICU length of stay, complications while on the ventilator and ICU mortality, number of ventilator days, diagnostic efficacy, therapeutic efficacy, costs, and radiation exposure The author identified 30 articles in the search …


Single Nucleotide Polymorphisms In Dna Repair And Oxidative Stress Genes, And Their Interaction With Antioxidants On Prostate Cancer Aggressiveness, Samuel Antwi Dec 2014

Single Nucleotide Polymorphisms In Dna Repair And Oxidative Stress Genes, And Their Interaction With Antioxidants On Prostate Cancer Aggressiveness, Samuel Antwi

Theses and Dissertations

Prostate cancer is the leading invasive malignancy and the second most common cause of cancer death among American men. Despite compelling evidence that oxidative stress, ineffective DNA damage repair, and habitually low antioxidants intake may act in tandem to influence prostate carcinogenesis, few studies have examined gene-diet interactions involving these risk factors. Even fewer studies have examined such interactions in relation to prostate cancer aggressiveness. This study investigated whether single nucleotide polymorphisms (SNPs) in DNA repair- and oxidative stress-related genes modulated associations between antioxidant intake and prostate cancer aggressiveness. We utilized data from the North Carolina-Louisiana Prostate Cancer Project (PCaP) …


Exploring The Association Between Depression And Obesity Among Alzheimer's Patients, Stephanie Clugstone Dec 2014

Exploring The Association Between Depression And Obesity Among Alzheimer's Patients, Stephanie Clugstone

Theses and Dissertations

Alzheimer’s disease (AD) is a neurological disorder that affects elderly individuals, and is becoming an increasing concern among the aging population of the world. Due to the projected increase in incidence of AD, modifiable risk factors such as depression and obesity should be evaluated, as prevention is the only current option. This study aimed to determine the prevalence of obesity and depression among AD patients, and to evaluate the association between depression and obesity. Patients were chosen from a subset of the South Carolina Alzheimer’s disease registry, which included information about weight status and depression, as well as several other …


Assessing Risk Factors And Levels Of Functioning Across The Continuum Of Psychosis, James Castorina Dec 2014

Assessing Risk Factors And Levels Of Functioning Across The Continuum Of Psychosis, James Castorina

Theses and Dissertations

Schizophrenia and other related psychotic disorders are often associated with impairments in social and general functioning. It has been proposed that there may be underlying factors such as personality traits or cognitive abilities that contribute to one's psychosis proneness, or levels of schizotypy. In the current study, we expect to see a decline in overall functioning and verbal memory according to symptom severity. Particularly, we hypothesize a similar pattern with overall functioning and verbal memory in regards to negative symptomology with comparable results between an outpatient sample and those with high levels of schizotypy. Furthermore, based on prior research, we …


Development Of Speech Recognition Threshold And Word Recognition Materials For Native Vietnamese Speakers, Claire Hanson Dec 2014

Development Of Speech Recognition Threshold And Word Recognition Materials For Native Vietnamese Speakers, Claire Hanson

Theses and Dissertations

Despite the documented need for reliable speech audiometry materials for measures such as speech recognition threshold and word recognition score, such recorded materials are not available in the Vietnamese language. The purpose of this study was to develop, digitally record, evaluate, and psychometrically equate a set of Vietnamese bisyllabic and monosyllabic word lists for use in the measurement of speech recognition and word recognition ability, respectively. To create the speech recognition threshold materials, common Vietnamese bisyllabic words were digitally recorded by male and female talkers of Vietnamese and presented for evaluation to 20 native speakers of Vietnamese with normal hearing. …


The Effects Of Nebulized Saline Treatments On Diphthongal Vowel Production On Female Subjects With Sjögren's Syndrome, Keri Lynn Perry Dec 2014

The Effects Of Nebulized Saline Treatments On Diphthongal Vowel Production On Female Subjects With Sjögren's Syndrome, Keri Lynn Perry

Theses and Dissertations

The purpose of this study was to analyze and quantify the effects of a nebulized saline treatment on speech production in eight females with Primary Sjögren's Syndrome (SS). The duration, formant frequency onset and offset, and slope were measured to determine the quality of participants' production of diphthongal American English vowels. Acoustic data were examined before treatment began, immediately following treatment, and during a one-week follow-up to determine the effects of a laryngeal hydration program that used nebulized saline to increase hydration of structures in the vocal tract. The vowels produced during the initial baseline condition were acoustically relatively similar …


Cost Effectiveness Of Treating Generalized Anxiety Disorder In Adolescence: A Comparison By Provider Type And Therapy Modality, Kathryn Evelyn Reynolds Dec 2014

Cost Effectiveness Of Treating Generalized Anxiety Disorder In Adolescence: A Comparison By Provider Type And Therapy Modality, Kathryn Evelyn Reynolds

Theses and Dissertations

Generalized anxiety disorder (GAD) is frequently found in primary care settings and is highly prevalent among adolescents. The purpose of this study was to examine the cost effectiveness by provider type and therapy modality in treating adolescents (ages 13-17) with a GAD diagnosis (DSM-IV 300.02). A national insurance company in the United States provided outpatient and unidentifiable data for adolescent GAD cases (n = 2,932). These cases were used to analyze the cost effectiveness, total cost, treatment length, dropout, and readmission rates for the treatment of adolescents with GAD. Descriptive statistics signify that the mean cost of treatment for GAD …


Language Pathways Defined In A Patient With Left Temporal Lobe Damagesecondary To Traumatic Brain Injury: A Qeeg & Mri Study, Janelle Lee Bailey Dec 2014

Language Pathways Defined In A Patient With Left Temporal Lobe Damagesecondary To Traumatic Brain Injury: A Qeeg & Mri Study, Janelle Lee Bailey

Theses and Dissertations

Though the current understanding of language processing is incomplete, it has been established that the left hemisphere is dominant for language in the majority of the population. Damage to language centers of the brain and to white matter tracts connecting these language centers results in a language deficit known as aphasia. Neuroplasticity in the brain can often compensate for these language deficits by strengthening neuronal connections between the right and left hemisphere, or by enhancing the neuronal connectivity of undamaged areas in the left hemisphere. Thus the brain can compensate for damaged language centers by using alternative cortical areas. These …


Bilingual Language Assessment: Contemporary Practice Versus Recommended Practice, Graciela Arias Nov 2014

Bilingual Language Assessment: Contemporary Practice Versus Recommended Practice, Graciela Arias

Theses and Dissertations

Due to the increasing number of culturally and linguistically diverse students within American school systems, speech-language pathologists (SLPs) in school settings must be prepared to distinguish between typically developing bilingual students and those with language impairments. The purpose of this study was to identify current practices of school-based SLPs for bilingual language assessment and compare them to both American Speech-Language-Hearing Association (ASHA) best practice guidelines, and mandates of the Individuals with Disabilities Education Act (IDEA). The study was modeled to replicate Caesar and Kohler's (2007) study to include a nationally representative sample. While the survey was opened over 400 times, …


Voice Features Of Sjogren's Syndrome: Examination Of Relative Fundamental Frequency (Rff) During Connected Speech, Victoria Anne Lovett Nov 2014

Voice Features Of Sjogren's Syndrome: Examination Of Relative Fundamental Frequency (Rff) During Connected Speech, Victoria Anne Lovett

Theses and Dissertations

The purpose of this study was to examine the effectiveness of relative fundamental frequency (RFF) in quantifying voice disorder severity and possible change with treatment in individuals with Primary Sjögren's Syndrome (SS). Participants completed twice-daily audio recordings during an ABAB within-subjects experimental study investigating the effects of nebulized saline on voice production in this population. Voice samples of the Rainbow Passage from seven of the eight individuals with Primary SS involved in a larger investigation met inclusion criteria for analysis, for a total of 555 tokens. The results indicated that RFF values for this sample were similar to previously reported …


Moderators Of The Relationship Between Perceived Employability And Voluntary Turnover, Joseph Kenneth Morrison Oct 2014

Moderators Of The Relationship Between Perceived Employability And Voluntary Turnover, Joseph Kenneth Morrison

Theses and Dissertations

This thesis reports a quantitative research project examining the relation between perceived employability and voluntary turnover and the moderating roles played by job embeddedness and perceived organizational support. This examination uses archival data from 230 participants from a multinational organization using zero-order correlations and moderated binary logistic regression techniques. Significant correlational effects were found between perceived employability and voluntary turnover. Significant moderated logistic regression effects were found when adding job embeddedness and perceived organizational support to the perceived employability and voluntary turnover logistic regression model. Following the results is a discussion of the implications of this research, both theoretically and …


Coping Strategies, Psychopathological Symptoms, And Posttraumatic Growth Following Trauma And Stressful Life Events, Jessica Henninger Sep 2014

Coping Strategies, Psychopathological Symptoms, And Posttraumatic Growth Following Trauma And Stressful Life Events, Jessica Henninger

Theses and Dissertations

The current study examined the predictive value of stressful life experiences and coping strategies on posttraumatic growth and psychopathological symptoms. Using the Traumatic Life Events Questionnaire (TLEQ), the Brief COPE, the Brief Symptom Inventory (BSI), and the Posttraumatic Growth Inventory (PTGI), hierarchical linear regression models were used to explore the contribution of specific coping strategies to predict posttraumatic growth and psychopathological symptoms following exposure to a trauma/stressful life event. We hypothesized that coping styles such as planning, humor, and acceptance would predict more adaptive outcomes, whereas coping styles such as venting, substance use, and denial would predict more maladaptive outcomes. …


Quantifying Voice Change After Hydration Treatment In Primary Sjögren’S Syndrome Using The Cepstral Spectral Index Of Dysphonia (Csid), Alison Miner Sep 2014

Quantifying Voice Change After Hydration Treatment In Primary Sjögren’S Syndrome Using The Cepstral Spectral Index Of Dysphonia (Csid), Alison Miner

Theses and Dissertations

Primary Sjögren's Syndrome (SS) is an autoimmune disease that causes dehydration of the eyes, mouth, and throat. Individuals with Primary SS are at risk for voice problems associated with vocal fold dehydration. Topical hydration treatments show promise in reducing the negative effects of vocal fold dehydration on voice production. However, no studies have examined the preventive effects of topical hydration treatments on voice production in individuals at risk for vocal fold dehydration. The purpose of this study was to quantify the effects of a topical vocal fold hydration treatment on voice production in individuals with Primary SS using the Cepstral …


The Effect Of The Victim-Offender Relationship And Pre-Assault Intoxication On Ptsd Symptom Severity, Diandra Meloni Aug 2014

The Effect Of The Victim-Offender Relationship And Pre-Assault Intoxication On Ptsd Symptom Severity, Diandra Meloni

Theses and Dissertations

College-aged women are at an increased risk for experiencing non-consensual sexual contact (i.e. sexual assault) relative to the general population. Women who endure a sexual assault are at an increased risk for developing Post-traumatic Stress Disorder (PTSD). Intoxication by drugs and/or alcohol during an assault is linked to victims experiencing less severe PTSD symptoms; however, little is known about how the victim-offender relationship relates to PTSD symptom severity. The current study sampled 125 university women on measures that assessed degree of sexual victimization and resulting PTSD symptoms. It was hypothesized that both intoxication and the victim-offender relationship would affect PTSD …


Impulsivity Traits As Determinants For Smoking Behavior, Stacey Munyon Aug 2014

Impulsivity Traits As Determinants For Smoking Behavior, Stacey Munyon

Theses and Dissertations

The notion that smoking is in direct relation to the character trait of impulsivity is widely agreed upon. This study examines the individual character traits of the UPPS-P impulsivity scale that comprise the construct of impulsivity as they relate to cigarette smoking. This study seeks to illustrate whether or not there is determination of smoking behavior as a result of high levels of one or more of these impulsive traits. Analysis will be evaluated through means of several different analyses of variance to determine if any relationships are present.


The Victimization-Substance Relationship: An Examination Of Nonconsensual Sexual Experiences And Post-Assault Substance Use, Jessica Melillo Aug 2014

The Victimization-Substance Relationship: An Examination Of Nonconsensual Sexual Experiences And Post-Assault Substance Use, Jessica Melillo

Theses and Dissertations

Women with nonconsensual sexual experience (NSE) history are at elevated risk of experiencing revictimization and engaging in post-NSE substance use. Though the risk of college women experiencing NSEs has been well-established, high school women have been mostly overlooked in the literature, especially in relation to revictimization pathways. Substance use post-high school NSE, post-college NSE, and post-revictimization were examined, with revictimization being defined as an NSE in high school and an NSE in college. Female college students (N = 195) completed measures that assessed degree of sexual victimization, quantity and frequency of alcohol consumption and illicit drug use, and substance-related consequences. …