Medicine and Health Sciences Commons^™

Source Localization In Cross Modality Matching Of Brightness And Loudness Of Young Adults, Tawnya Nadine Coates

Theses and Dissertations

Cross modality matching is a magnitude matching procedure, developed to study the relationships between sensory modalities. Auditory and visual sensory integration can be examined through cross modality matching of brightness and loudness. Brightness and loudness are natural correlates of one another as they both represent the parameter of intensity for their respective sensory modalities. Past studies have demonstrated that typical individuals tend to match brighter lights with louder sounds and dimmer lights with softer sounds. The current study utilized a modified cross modality matching procedure, combined with electroencephalography (EEG) data, to examine the cortical response to sensory integration. It was …

The Effect Of Quality Of Life And Health Behaviors In Schizotypy, Victoria Giordano

Theses and Dissertations

Individuals diagnosed with schizophrenia are typically found to engage in higher rates of poorer health behaviors, such as higher rates of smoking and poorer nutrition. Along with poorer health behaviors, individuals with schizophrenia tend to report a lower quality of life than an individual without a schizophrenia diagnosis. Our study chose to look at schizotypy, or sub-clinical schizophrenia, and its relation to quality of life and health behaviors. We found that individuals that measure high on the subclinical schizotypy scale tend to mirror the health and quality of life ratings of an individual diagnosed with schizophrenia - they are more …

Evidence For The Inhibition Of Dengue Virus Binding In The Presence Of Silver Nanoparticles, Kelley J. Williams

Theses and Dissertations

Dengue is an emerging hemorrhagic fever virus and widely considered the most important arbovirus in the world. Dengue virus (DENV) is a positive-sense RNA virus that exists in 4, potentially 5, antigenic serotypes. Currently, no vaccines or treatments are approved for DENV infections. Unsuccessful vaccine trials open the door for non-traditional treatments such as silver nanoparticles. Silver nanoparticles (AgNP) are known to inhibit viral replication of numerous viruses but have never before been tested for inhibition of dengue virus type 2 (DENV2, ATCC® VR-1584^TM). For the first time, this research presents up to a 96% reduction in DENV2 …

Enhanced Light Trapping By Metallic Nanorod Arrays For Organic Photovoltaic Cells, Rosure Borhanalden Abdulrahman

Theses and Dissertations

Metallic nanostructures can exhibit different optical properties compared to bulk materials mainly depending on their shape, size, and separation. Vertically aligned arrays of aluminum (Al) nanorods of different lengths and morphologies were fabricated by DC sputtering using the glancing angle deposition (GLAD) method. Detailed structural and optical properties of GLAD Al nanorod were investigated and compared to those of conventional flat Al thin film coatings. Optical characterization results show that total reflectance is inversely proportional to nanorod length in the wavelength range 200-1800 nm, due to the enhanced surface plasmon resonance and light trapping among the nanorods. In addition, we …

Associations Between Physical Activity And Weight Status With Grade-School Performance, Taylor Panfil

Theses and Dissertations

Physical activity and weight control are predictive of childhood health, but more recent research suggests they may also be associated with academic success.

PURPOSE: To explore the relationships between physical activity, weight status, and academic performance in children.

METHODS: 614 third-to-fifth grade children (53.9% female, age 9.6 ± 0.9 years) from two Midwestern communities participated. Physical activity was assessed using a Digiwalker 200-SW pedometer worn for seven consecutive days. Teachers provided an estimate of general academic performance, and children were categorized into three performance groups (high, moderate, low). School behavior (attentiveness, staying on task, interruptive behavior) was assessed by the …

A Prescription For Better Health: The Role Of On-Line Research In Doctor-Nurse-Patient Communication, Julie Anne Maio

Theses and Dissertations

As more technological media are made available to health consumers, patients take to the Internet to research ailments, side effects, and pressing health matters. Patients widely use this information to feel empowered and in control of their health. Yet, many sources perpetuate false information, or are deemed untrustworthy by healthcare professionals (HCPs). This dissonance can create a lack of collaborative communication between patients and the healthcare team. As such, the present study examined perceived credibility of online sources (.org websites, .com websites, forums, social media, etc.), patient intent to disclose online information, patient empowerment, HCPs communication styles, HCP-patient partnerships and …

The Relationship Among Male Pornography Use, Attachment, And Aggression In Romantic Relationships, Andrew P. Brown

Theses and Dissertations

Clinicians and researchers question how pornography might be impacting the people who view it and their partners. In particular, does pornography link to couples attachment and levels of aggression? Using data collected by the RELATE institute a sophisticated structural equation model was set up to answer this question. In particular, an actor partner interdependence model was used to analyze the relationship among male pornography use, insecure attachment behaviors, relational aggression, and physical aggression in 1630 heterosexual couples. Results indicate higher reports of male pornography use are associated with higher reports of insecure attachment behaviors, relational aggression, and physical aggression. Differences …

A Longitudinal Study Of Therapist Emotion Focused Therapy Interventions Predicting In-Session Positive Couple Behavior, Josh Novak

Theses and Dissertations

This is a longitudinal multilevel analysis using third party coded data of 15 couples therapy sessions to identify which therapist Emotion Focused Therapy interventions (Management of Couple's Interaction, Working with Primary Emotion, Managing Defensive Responses, Reframing the Problem in Terms of the Cycle, and Placing Emerging Emotions into the Cycle) influenced husband-to-wife and wife-to-husband exchanges of Positive Behaviors (warmth, prosocial behaviors, communication, assertiveness, and listening). A mixed effects model was used to examine within- and between-individual variability. Men and women were modeled separately. A series of two-level multilevel models of change were examined, where Time is Level 1 and Individual …

Facilitative Implicit Rules And Adolescent Emotional Regulation, Lexie Y. Pfeifer

Theses and Dissertations

Research has linked emotional regulation to the adaptive functioning of adolescents. Further research suggests that family processes, which include implicit rules, impact children's emotional regulation. The current study examined the impact of implicit rules that are facilitative of family connectedness on development of adolescents' emotional regulation. Data came from the Flourishing Families Project (FFP), a seven-year longitudinal study measuring family processes that impact adolescent development. The sample was collected in the northwestern United States and consisted of 500 families with a target child between the ages of 10 and 14 years. Participants filled out self-report measures on implicit family rules …

Avoidant Parental And Self Conflict-Resolution Styles And Marital Relationship Self-Regulation: Do Perceived Partner Attachment Behaviorsplay A Moderating Role?, Erin L. Rackham

Theses and Dissertations

Relationship self-regulation (RSR) refers to the “work”, or effort and strategies, that partners put into keeping their relationships healthy. Past RSR research has not taken into account distal and proximal variables that may affect RSR, such as parental and current relationship avoidant conflict-resolution style (CRS). In this study, we examine the relationships between parental avoidant CRS and current relationship avoidant CRS, as well as self-report of RSR in the relationship. Additionally, the perception of one's partner's attachment behaviors consisting of responsiveness, engagement, and accessibility is included in the model to test for moderation of the relationship between current relationship avoidant …

Brain Mapping Of The Latency Epochs In A Mcgurk Effect Paradigm In Music Performance And Visual Arts Majors, Lauren Donelle Nordstrom

Theses and Dissertations

The McGurk effect is an illusion that occurs when an auditory /ba/ is combined with a visual /ga/. The two stimuli fuse together which leads to the perception of /da/, a sound in between /ba/ and /ga/. The purpose of this study was to determine whether music performance and visual arts majors process mismatched auditory and visual stimuli, like the McGurk effect, differently. Nine syllable pairs were presented to 10 native English speakers (5 music performance majors and 5 visual arts majors between the ages of 18 and 28 years) in a four-forced-choice response paradigm. Data from event-related potentials were …

External Validity Of Grammatical Word Category Classification Using An Adaptation And Selection Model, Michelle Chatterton

Theses and Dissertations

The process of acquiring language requires children to learn grammatical categories and apply these categories to new words. Researchers have proposed various explanations of this process in the form of algorithms and computational modeling. Recently, adaptation and selection models have been tested and applied as a possible explanation to the process of acquiring grammatical categories. These studies have proven promising, however, the external validity of this approach has not been examined by grammatically coding samples outside the training corpus. The current thesis applies an adaptation and selection model, which pauses the evolution of dictionaries after every thousand cycles to allow …

Modeling Children's Acquisition Of Grammatical Word Categories From Adult Input Using An Adaptation And Selection Algorithm, Nicole Adele Stenquist

Theses and Dissertations

It is understood that children learn the use of grammatical categories in their native language, and previous models have only been partially successful in describing this acquisition. The present study uses an adaptation selection algorithm to continue the work in addressing this question. The input for the computer model is child-directed speech towards three children, ages ranging from 1;1 to 5;1 during the course of sampling. The output of the model consists of the input words labeled with a grammatical category. This output data was evaluated at regular intervals through its ability to correctly identify the grammatical categories of language …

Monophthongal Vowel Production In Females With Primary Sjögren's Syndrome Following A Hydration Treatment Of Nebulized Saline, Kara Rytting

Theses and Dissertations

Sjögren's Syndrome (SS) is an autoimmune disease that causes extreme dryness, or sicca,of the eyes and mouth, as well as other potential drying of the throat and intestines. Speech, voice, and swallowing problems are common in individuals with SS. Therefore, this study examined the possible changes in acoustic characteristics of monophthongs (/i, æ, α, u, ʌ/) in eight females with SS following laryngeal hydration treatments. An ABAB experimental design was implemented. Treatment consisted of nebulized isotonic saline immediately following completion of audio-recordings. Using acoustic analysis software the duration, formant frequencies, and vowel space area (VSA) was calculated for the participant's …

Interactions Between Race, Gender, And Income In Relationship Education Outcomes, Andrew K. Thompson

Theses and Dissertations

Researchers and policymakers have become interested in the use of relationship education programs as a means to remedy the effects of family instability. Research suggests that relationship education produces positive outcomes with some groups. However, whether populations who are socially and economically more at-risk of relationship problems and relationship dissolution are gaining from relationship education remains an open question. Ecocultural Theory is used to conceptualize the research question and to illustrate the importance of studying diverse populations. The purpose of this study is to assess relationship education outcomes for select at-risk groups. The sample for this study (n=1,907) comes from …

Attachment Behaviors As A Moderator Of The Relationship Between Disapproval And Relationship Satisfaction, Lauren Drean

Theses and Dissertations

Both approval and disapproval of one's social network have been shown to predict relationship outcomes. Additional research has shown that attachment can buffer the negative effects of various factors (e.g., depression) on relationships. This thesis researches the effects of disapproval of friends and family and attachment on relationship outcomes. More specifically this study looks at the potential moderating effects of couple-specific attachment behaviors on the relationship between social network disapproval and relationship quality. The RELATE data set was used to study couples and their relationship quality. The study looked at 858 married couples and found that one's own attachment behaviors …

The Effect Of Muscle Energy Technique On Forward Shoulder Posture, Pectoralis Minor Length, And Upper Extremity Blood Flow In Collegiate Female Swimmers, Elizabeth Gross

Theses and Dissertations

Context: Overhead sports are at an increased risk of shoulder injury, particularly when scapular posture is restricted. Pectoralis minor length has been linked to scapular malpositioning and forward shoulder posture. Upper extremity blood flow has also been linked to shortened pectoralis minor length, which could lead to thoracic neurovascular occlusion. Swimmers specifically may be at an increased risk for shoulder injury if the pectoralis minor is shortened. Stretching of the pectoralis minor has been suggested as a treatment to correct shortening of the muscle, however research examining muscle energy technique (MET) applied to the pectoralis minor is limited. Objective: To …

An Examination Of The Relationships Between Rumination, Social Problem-Solving, Mindfulness And Depressive Symptomology, Taylor Wiltsee

Theses and Dissertations

The present study will examine the relationships between rumination, social problem-solving, mindfulness, and depressive symptomology. These relationships will be evaluated by means of Pearson correlations, and the testing of the proposed path model using AMOS. In order to test our hypotheses, undergraduate students were asked to complete a battery of self-report measures to quantify ruminative tendencies, problem-solving ability, mindfulness skills, and depressive symptom severity and were given course credit for participation. Results indicate that hypotheses were partially supported. Bivariate correlations yielded statistically significant relationships between each of the constructs, with rumination positively associated with depressive symptoms, and negatively associated with …

Stakeholder Perspectives Of The Effectiveness Of Augmentative And Alternative Communication Techniques In Children With Autism, Daria Constantinescu

Theses and Dissertations

The purpose of this study was to utilize focus groups and individual interviews to investigate the effectiveness and efficiency of augmentative and alternative (AAC) techniques in facilitating language in children with Autism Spectrum Disorder (ASD) as expressed by the opinions and attitudes of stakeholders involved in the process. ASD is a disorder that affects an individual's social and communication skills that usually surfaces within a child's first three years of life. There have been numerous studies conducted comparing different types of AAC intervention systems, but there is little information on stakeholders' opinions. The current study utilized one focus group interview …

Rural Emergency Nurses' End-Of-Life Care Obstacles Experiences: Stories From The Last Frontier, Jonathan Rohwer

Theses and Dissertations

Introduction: Rural emergency nurses face unique obstacles to providing quality end-of-life (EOL) care. Stories provided by emergency nurses embody their most difficult EOL care obstacles. Methods: A questionnaire was sent to 53 rural hospitals. Respondents were asked to share stories that epitomized the obstacles faced while providing EOL care in the rural emergency setting. Results: The lack of an ideal death (nurse personally knows the patient, issues with family members, and unknown patient wishes) was the top obstacle. Other reported obstacles were insufficient ED staff and power struggles between nurses and physicians. Discussion: Rural emergency nurses often provide EOL care …

Age Related Decline In Memory: Examining The Mediation Effect Of Processing, Executive Functioning And Intelligence In Normal Adults, Jada J. Stewart

Theses and Dissertations

Multiple mediation analyses that collectively examine the prominent theories of cognitive aging (i.e., Common Cause, Processing, and Executive Decline Hypotheses) along with other cognitive domains that are sensitive to aging are rare. Moreover, having identified that cognition begins to decline as early as 30 years old, few studies have examined the mechanisms that underlie memory change among younger aging individuals. As a result, it is unclear whether relevant mediating variables have been excluded from early research on age-related memory decline, or to what extent rehabilitative strategies are applicable as early interventions for maintaining cognitive functioning into late life.

The present …

Proof-Of-Concept Of Environmental Dna Tools For Atlantic Sturgeon Management, Jameson Hinkle

Theses and Dissertations

Abstract

The Atlantic Sturgeon (Acipenser oxyrinchus oxyrinchus, Mitchell) is an anadromous species that spawns in tidal freshwater rivers from Canada to Florida. Overfishing, river sedimentation and alteration of the river bottom have decreased Atlantic Sturgeon populations, and NOAA lists the species as endangered. Ecologists sometimes find it difficult to locate individuals of a species that is rare, endangered or invasive. The need for methods less invasive that can create more resolution of cryptic species presence is necessary. Environmental DNA (eDNA) is a non-invasive means of detecting rare, endangered, or invasive species by isolating nuclear or mitochondrial DNA (mtDNA) from the …

The Effects Of Curcumin On The Expression Of P53 And Bcl-2 Oncoproteins On The Human Breast Carcinoma Cell Line Mda-Mb 468, Angelin S. Shajan

Theses and Dissertations

We studied the effects of curcumin on the proliferation and viability of MDA-MB-468 breast cancer cells and its effects on the expression ofBcl-2 and p53 proteins in these cells. Based on previous studies, we predicted a dose-dependent increase in p53 (tumor suppressor) expression, and a decrease in Bcl-2 (anti-apoptotic oncoprotein) expression. Briefly, MDA-MB468 cells were seeded into 12-well plates at 2.0 * 104 cells/well and allowed to grow for 72 hrs. Cells were treated with curcumin at 0, 25, 50 and 100 pM in triplicate at time zero and cultured for another 24 hours. All data were obtained using a …

Deconstructing Anesthesia Handoffs During Simulated Intraoperative Anesthesia Care, Jason S. Lowe

Theses and Dissertations

Anesthesia patient handoffs are a vulnerable time for patient care and handoffs occur frequently during anesthesia care. Communication failures contribute to patient harm during anesthesia patient handoffs. The Joint Commission has recognized the potential for communication failure during patient handoffs and has recommended processes to improve handoff safety. Handoffs are made more difficult by latent conditions such as time constraints, pressure and distractions, which often result in incomplete or inaccurate handoff reports. This nonexperimental, correlation study identified the latent conditions that occur during the handoff process and their relationship to the quality of the handoff. This research shows an inverse …

Elucidation Of A Novel Pathway In Staphylococcus Aureus: The Essential Site-Specific Processing Of Ribosomal Protein L27, Erin A. Wall

Theses and Dissertations

Ribosomal protein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a critical role in substrate stabilization during protein synthesis. This function is mediated by the L27 N-terminus, which protrudes into the peptidyl transferase center where it interacts with both A-site and P-site tRNAs as well as with 23S rRNA. We observed that L27 in S. aureus and other Firmicutes is encoded with a short N-terminal extension that is not present in most Gram-negative organisms, and is absent from mature ribosomes. The extension contains a conserved cleavage motif; nine N-terminal amino acids are …

High School Teacher And Administrator Perceptions Of Student Health Promotion: An Exploratory Study, Sarah B. Conklin

Theses and Dissertations

The current study explored the high school health promotion environment with regards to physical activity, nutrition, and sedentary behaviors from the perspective of high school health and physical education teachers and administrators. Specifically, potential strategies for a prevention program to promote student physical activity participation and healthy eating, and decrease student sedentary time were explored.

Individual semi-structured interviews were conducted with physical education teachers to explore potential strategies to promote student health behaviors. Next, interviews were conducted with high school administrators to determine the feasibility of recommended strategies. Teachers and administrators in the current study expressed a need for strategies …

The Slc22 Transporter Family: Novel Insights To Roles In Drug Efficacy, Drug-Drug Interactions And Mood Disorders, Xiaolei Pan

Theses and Dissertations

Numerous studies have demonstrated the impact of organic cation (OCTs; SLC22 family) and anion transporters (OATs; SLC22 family) on the efficacy and safety of clinically important therapeutics. To be specific, OCTs and OATs have been identified as determinants for uptake into and secretion from enterocytes, hepatocytes and renal proximal tubular cells, and are frequent sites of drug-drug interaction (DDI). In addition, OCTs expressed in brain are components of the low-affinity, high capacity clearance pathway (uptake-2) for biogenic monoamine neurotransmitters. As a result, OCTs may represent novel targets for mood disorders.

The inhibitory effects of several therapeutic agents, designed drugs and …

The Effect Of Optogenetic Manipulation Of Ss Interneurons Within Malformed, Epileptogenic Cortex, Nicole Ekanem

Theses and Dissertations

A large percentage of individuals with intractable epilepsies have an accompanying cortical malformation, the underlying cellular mechanisms of which are poorly understood. It is known however that in an animal model for one such malformation, polymicrogyria, epileptogenesis occurs most easily from an adjacent area termed the paramicrogyral region (PMR). Previous studies implicate SS interneurons as a potential contributor to this pathology, which lead to our hypothesis: in PMR, SS interneurons exert a higher modulatory influence on excitatory pyramidal cells, as compared to the same by SS interneurons within homologous control cortex.

Using a freeze-lesion model for polymicrogyria in transgenic mice …

Reproductive Health And Behavior: The Role Of Abuse And Couple Pregnancy Intent, Susan Cha

Theses and Dissertations

Background: Rapid repeat pregnancy (RRP), a pregnancy occurring less than 24 months from a prior birth, and unintended pregnancy-related induced abortions can be prevented with family planning. However, few studies have adequately addressed the role of male partners in reproductive decision-making. Objectives: The goal of this research is to understand the interrelationships between couple pregnancy intention, intimate partner violence (IPV), reproductive health and behaviors. Specifically, this project aims to: (1) examine the extent to which couple pregnancy intentions are associated with RRP and (2) induced abortions among women in the U.S., and (3) examine the extent to which …

Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah

Theses and Dissertations

G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. The serotonin 5HT2A receptor (or 2AR) is one of the GPCRs coupled to Gq proteins, activating PLC and hydrolyzing PIP2. This hydrolysis causes a diffusion of bound PIP2 away from the channel binding site resulting in G protein-gated inwardly rectifying K⁺ channel (GIRK) inhibition and a downstream stimulation of Ca²⁺ release from endoplasmic reticulum stores. Previous experiments have demonstrated that the serotonin 5HTA receptor is a target of serotonergic psychedelic drugs, such as LSD, and partially mediates the action of many …