Medicine and Health Sciences Commons^™

Examining Crowdsourced Social Media Platforms And Their Association With College Students' Alcohol Consumption, Perceived Risk, And Behaviors, Danielle Gentile

Theses and Dissertations

Introduction: High-risk alcohol use by U.S. college students remains a significant threat to individual health and community well-being. Newly-emerging social media platforms and apps which relay information about alcohol-related law enforcement serve as an intriguing addition to college alcohol-use environments. The purpose of this study was to examine the information delivered to users by the local social media platform @Drinking Ticket (DT), determine which types of information were then relayed to others, and clarify how this information influences alcohol use, perceived risk, and alcohol-related risk behaviors among college students. Methods: One year of DT tweets (n=854 tweets) were qualitatively coded …

Sleep Disruption And Cancer Incidence In A Southeastern Veteran Population, Alexandria F. Delage

Theses and Dissertations

Sleep disruption influences biological processes that can facilitate carcinogenesis. However, studies examining the relationship between sleep disruption and cancer risk have been inconclusive. This retrospective cohort study used de-identified data from the Veterans Administration (VA) electronic medical record to test the hypothesis that sleep disorder diagnoses among Veterans seeking care in the Southeast United States Service Network are associated with increased risk for cancer of the prostate, breast, colorectum, or total cancer (1999-2010, N=663,869). Sleep disorders were defined as patients with an in- or out-patient diagnosis as specified by the International Classification of Sleep Disorders. Cancer cases were defined as …

Smoking-Related Stigma: A Public Health Tool Or A Damaging Force ?, Paula A. Lozano

Theses and Dissertations

Cigarette smoking is the leading cause of preventable death in the world. In an effort to address the tobacco epidemic, the World Health Organization’s Framework Convention on Tobacco Control (FCTC) has formulated a number of policies that are thought to reduce cigarette consumption by making smoking socially unacceptable. It is possible that tobacco control policies that aim to make smoking socially unacceptable may also result in the stigmatization of smokers. Social factors such as social norms and socioeconomic status may also influence the development of smoking-related stigma. While some researchers suggest that smoking-related stigma may be an important public health …

Re-Contacting Cancer Genetic Counseling Patients: Expectations Of Patients And Physicians, Zoe Elizabeth Siegel

Theses and Dissertations

The landscape of cancer genetic counseling and testing is rapidly evolving. Genetic testing technology is improving, management guidelines are evolving, and genetic testing options are expanding. These frequent updates to the components of cancer genetics have increased the complexity of managing patient care over time. In particular, this raises questions on the duty to re-contact patients as new information becomes available. This study explored healthcare providers’ duty to re-contact through the interests and expectations of patients, including which circumstances warrant re-contacting, which healthcare provider is responsible for re-contacting the patient, and the preferred method of re-contacting. Physicians’ opinions on whether …

Bayesian Semiparametric Quantile Regression For Clustered Data, Xin Tong

Theses and Dissertations

Traditional frequentist quantile regression makes few assumptions on the form of the error distribution and thus is able to accommodate non-normal errors. However, inference on the quantile regression models could be challenging for the unknown error distribution, though asymptotic or resampling methods were developed. Bayesian literature on quantile regression with random effects is relatively limited. The quantile regression approach proposed in this dissertation is founded on Bayesian probabilistic modeling for the underlying unknown distributions. By adopting the error density with a nonparametric scale mixture models, we developed Bayesian semiparametric models to make an inference on any quantile of interest and …

Hiv-1 Transgenic Rat: Selective Alterations In Motivation And Histological Examination Of Medium Spiny Neurons Of The Nucleus Accumbens, Michael N. Cranston

Theses and Dissertations

Motivational alterations in HIV-1+ individuals are associated with decreased performance on tasks involving frontal-subcortical circuitry and the nucleus accumbens. In the present study, the HIV-1 transgenic (Tg) rat was used to assess long-term HIV-1 viral protein exposure on motivated behavior using activity chambers (40x40cm) and voluntary wheel running. Adult ovariectomized female HIV-1 Tg animals (n=21) to F344 controls (n=26) were pair-housed under a 12:12 light/dark cycle. Voluntary running was measured with 34 cm-diameter running wheels for ~60 minutes/day for 3 ½ months. There were no significant differences between HIV-1 Tg and F344 control rats in voluntary wheel running during the …

Job Satisfaction And Intent To Quit Outcomes Among Home Health Aides In Home Health Care Industry Of The United States: A Multilevel Study, Seokwon Yoon

Theses and Dissertations

Backgrounds: Home health aides’ job satisfaction and intent to quit have been attributed to organizational and community level factors. The objective is to determine the effects of individual-, organizational-, and community-level factors on job satisfaction or intent to quit among home health aides.

Methods: This research used data from two subsets of the 2007 National Home and Hospice Care Survey and the 2007 National Home Health Aides Survey, sampling six eligible workers across the agencies in the Unites States. As another data source, the present study uses Area Health Resource File. The author used hierarchical linear modeling technique for handling …

Non-Steroidal Anti-Inflammatory Drug Effects On Core Temperature, Hydration, Gastrointestinal Distress, And Performance In Exercising Humans, Dawn Marie Emerson

Theses and Dissertations

Naproxen is a commonly used non-steroidal anti-inflammatory drug designed to relieve pain and inflammation. Due to potentially adverse effects on the gastrointestinal (GI) tract, cardiovascular and immune system, and renal function, naproxen may negatively affect thermoregulation, fluid and electrolyte balance, and performance during exercise, particularly in the heat. Therefore, the purpose of this study was to determine the effects of naproxen on core temperature (Tc), inflammation, hydration, GI distress, and performance during cycling in a hot environment. We utilized a double-blind, randomized and counterbalanced, cross-over design to determine the effects of naproxen (dose = 3 220 mg naproxen sodium pills) …

Molecular Cues Of Pattern-Recognition-Receptor Pathways In Redox-Toxicity-Driven Environmental Nafld, Suvarthi Das

Theses and Dissertations

With the pandemic proportions of obesity and a correlative increase in fatty liver disease, there was a dire need to explore the missing link between the changed environment and progression of NAFLD in obesity. My research implies that environmental toxin bromodichloromethane induces early liver lesions in obesity, and is mediated by the synchronous insult of oxidative stress and increased levels of the adipokine leptin. In a two-pronged approach to investigate the molecular cues, I looked at the role of Purinergic receptor X7 and Toll 4 receptor. Both rodent models and cell-based systems were used. Also, in order to validate my …

Phonological And Orthographic Repetition Effects Across Words In Adult Skilled Sentence Reading: An Eye Movement Analysis, Ti Yan

Theses and Dissertations

Visual word recognition is central to skilled silent reading. This project investigated the situation in which two words within a sentence share phonological information. Previous eye movement reading studies have made attempts to understand how prior exposure to a word could influence the speed of recognizing another phonologically and/or orthographically similar word. Results have been accounted for by different visual word recognition models which agree on the competition among similar words in the lexicon. However, a closer inspection revealed several concerns. First, there is little direct evidence demonstrating the across-word effect in normal reading. Second, the existing work in English …

Effectiveness Of Community-Based Eibi Treatment: A Longitudinal Analysis Of Adaptive Behavior And Language Outcomes, John Kuntz

Theses and Dissertations

Autism spectrum disorders (ASDs) are a group of lifelong, neurodevelopmental disorders characterized by deficits in social interaction, communication, relationship development and by the presence of repetitive or stereotypical behaviors including restricted interests. Continued advances in understanding treatment outcomes and broadening access to effective treatment is critical to improving the quality of life of children with autism and their families and minimizing the cost associated with care. The overall aim of this study is to assess the effectiveness of a community-based implementation of an Early Intensive Behavioral Intervention (EIBI) treatment program through a large-sample, longitudinal secondary analysis of administrative data. Additionally, …

Prospective Assessment Of Health Disparities And Injury Risk Factors At Basic Combat Training At Ft. Jackson, Kristin Lescalleet

Theses and Dissertations

Numerous recruits for Basic Combat Training (BCT) for the Army fail to complete the course due to injury and time lost. This study was designed to provide a more thorough list of risk factors involved in injury and attrition through real-time data analysis throughout a cycle of BCT. Throughout BCT, a researcher was placed in the Battalion Aid Station (BAS) and recorded the reason for the visit, whether it was a new or existing condition, injury location, medical history, and how long this injury has been an issue. Several risk factors were tested: sex, age, and ethnicity/race. It was found …

Transcriptional And Post-Transcriptional Regulation Of Nrf2 In The Heart By The Deubiquitinase Cyld, Bryan J. Mathis

Theses and Dissertations

The cylindromatosis (CYLD) is a K63-linked deubiquitinase (DUB) that has been linked to the regulation of multiple physiological or pathological processes, such as neural development, inflammation and fibrosis. However, a novel paradigm for CYLD has been recently postulated; namely that of CYLD as a mediator of cardiac disease. Nuclear factor, erythroid-2 related factor 2 (Nrf2), a master antioxidant transcription factor, has been shown to suppress cardiac pathological remodeling and dysfunction via downregulation of reactive oxygen species formation (ROS). It is normally regulated by Kelch-like ECH associated protein 1 (Keap1). However, the regulatory link between CYLD and Nrf2 in the diseased …

Low-Intensity Physical Activity And Cardiometabolic Risk Factors Among Older Adults With Multiple Chronic Conditions, Yueyao Li

Theses and Dissertations

Introduction:

Cardiovascular disease (CVD) is the leading cause of death among older adults in the Unites States and is driven largely by cardiometabolic risk factors including elevated blood pressure and blood glucose. Studies have found the protective effect of moderate intensity physical activity (MIPA) and vigorous intensity physical activity (VIPA) on cardiometabolic risk factor; however, the association between light physical activity (LIPA) and cardiometabolic risk factor among older adults is not clear.

Objectives:

1. Examine the association between LIPA and cardiometabolic risk factors.
2. Examine whether the association between LIPA and cardiometabolic risk factor is moderated by multiple chronic conditions. …

Vitamin D And Stress Fractures In Collegiate And Professional Athletes, Christian Michael Askew

Theses and Dissertations

An important aspect of orthopedics and sports medicine is to provide quality care and oversight for the overall health and wellbeing of athletes. Research in these fields aims to understand the underlying mechanisms of sport-induced injuries in order to improve treatment plans and prevent future complications. Overuse bone stress injuries are prominent among elite athletes and can cause detrimental setbacks to training and performance. Thus, prevention of these injuries is of primary concern. Vitamin D has been known to play an integral role in skeletal metabolism. Current research suggests vitamin D status may be indicative of bone density, structural integrity, …

Examining Infant Health Outcomes Impacted By South Carolina's Regionalized System Of Perinatal Care, Michael Grady Smith

Theses and Dissertations

Perinatal regionalization systems have been shown to reduce the risk of neonatal mortality when very low birth weight infants are delivered in Level III hospitals with neonatal intensive care units, sub-specialist staffing, and adequate experience caring for high-risk pregnancies and neonates. However, studies to date examining the association between delivery in Level III hospitals and neonatal mortality have not accounted for censoring due to fetal deaths. Furthermore, studies of perinatal regionalization to date have not adequately assessed the association between delivery hospital level of care and the infant’s hospital length of stay. This dissertation examined 8,594 very low birth weight …

Conversations About Sexuality On A Public University Campus: Exploring Perspectives From Campus Ministry Leaders And Students, Charis Rebecca Davidson

Theses and Dissertations

Since the 1800s, religious organizations have been a presence on public universities. However, there is limited research on the influence these organizations may have on student health communication and behaviors. Prior research on campus ministries has focused primarily on the culture of individual organizations. In this study, researchers explored the goals and experiences of USC leaders related to communication around sexuality with their students, as well as student perceptions of these messages, and how students incorporate religious messages about sexuality into their lives. The present study had four aims:

1. Assess whether students participating in campus ministries at USC differ …

Multi-Symptom Management In Hospice Patients During End-Of-Life Transition, Ashley N. B. Sirianni

Theses and Dissertations

The purpose of this quality improvement project is to compare the provider’s perception following an educational model of using single symptom management versus multi-symptom management during the end-of-life transition in adult patients for improved quality of life outcomes. The appraised evidence indicates that it is critical to have anticipatory medications at the patient’s residence to manage multiple symptoms rather than focusing exclusively on a single symptom management such as pain management. In February 2016, the author conducted an educational model among hospice providers for increasing knowledge and awareness of multi-symptom management. Thirty (n = 30) Clinical Nursing Directors, Licensed Practical …

Practice Characteristics That Matter In The Provision Of Health Education Services By Primary Care Physicians, George Paul Newby Jr.

Theses and Dissertations

The onset of chronic disease is occurring earlier and more often in the lives of adult citizens of the United States. The literature has effectively demonstrated the efficacy that physician provision of health education services offers their patients and the positive effects it has for lowering risk factors for chronic disease. The literature has described the complexities physicians encounter in providing these services. The literature is not as plentiful in defining and describing the characteristics of physician practice that are associated with increased health education provision.

This study is an analysis of the factors that are associated with provision of …

Understanding Conceptualizations And Structural Environment For Improving Pre-Pregnancy Planning For Adolescent Girls And Young Women In Harare, Zimbabwe, Chiwoneso Beverley Tinago

Theses and Dissertations

Zimbabwe has a high maternal mortality with adolescent girls and young women facing disproportionately high risk of maternal morbidity and mortality. Current approaches to reducing maternal mortality in Zimbabwe focus on the pregnancy period with antenatal care, obstetric care, and micronutrient supplementation during pregnancy. Although important, these approaches are not reaching a large number of women and may benefit from integration with pre-pregnancy approaches. The importance of pre-pregnancy interventions to promote young women’s health has been emphasized, yet many young women in developing countries like Zimbabwe do not have access to pre-pregnancy care because little is understood about the concept …

Fostering Humanism In Medicine: A Mixed Methods Study On The Influence Of Humanism In Medicine Workshops On Medical Student Empathy, Marion J. Lombardi

Theses and Dissertations

Medicine has evolved to encompass an alliance between the doctor and patient, in which the doctor must understand the patient holistically (Kaba & Sooriakumaran, 2007). Research suggests that doctor-patient relationship focused training has a meaningful effect on measured health outcomes in patients with conditions such as obesity, diabetes, asthma or osteoarthritis (Reiss & Reinero, 2014). Therefore, the humanistic qualities of medicine, encompassing honesty, integrity, caring, compassion, altruism, empathy, and respect for self, patients, and others are more important than ever in cultivating a strong doctor-patient relationship (Weissmann et al., 2006).

Existing research suggests an underlying capacity for emotional intelligence (EI) …

Breast Cancer Risk Assessment: Evaluation Of Screening Tools For Genetics Referral, Maren Lothyan Zaro

Theses and Dissertations

Purpose: This study assessed effectiveness of five tools recommended by the US Preventive Services Task Force (USPSTF), designed to help primary care clinicians determine which unaffected patients to refer to genetics specialists for breast cancer risk assessment based on concerning family history. Design: This descriptive secondary analysis included 85 women aged 40-74. All participants had a first-degree female relative previously diagnosed with breast cancer who also had uninformative negative BRCA1/2 tests. Methods: Each pedigree was evaluated using the five tools including the Family History Screen-7 (FHS-7), Pedigree Assessment Tool (PAT), Manchester Scoring System, Referral Screening Tool (RST), and Ontario-Family History …

The Effects Of A Social Communication Intervention On The Production Of Emotion Words For Children With Language Impairment, Emilee Anne Longmore

Theses and Dissertations

Many school-age children with a diagnosis of Language Impairment (LI) also have social communication difficulties. Some of these difficulties are related to deficits in emotion understanding. This thesis evaluates the effects of a social communication intervention designed to increase the production of emotion-based words as an indicator of emotional competence. For five elementary school-aged children with LI, the production of emotion-based words was analyzed by first determining the frequency of words produced in preintervention sessions for the following categories: happiness, sadness, anger, fear, surprise, and disgust. Following these measures, the participants received 20 intervention sessions over the course of treatment. …

Bidirectional Interference Between Simulated Driving And Speaking, Kelsey Lynn Simmons

Theses and Dissertations

The purpose of this study was to examine interference between concurrently performed speaking and driving tasks. Participants included 60 adults, 30 males and 30 females, with no history of communication disorders. They were divided into three different age groups of 20 participants each: younger (20s), middle-aged (40s), and older (60s). The participants were given a list of topics to consider and were instructed to select eight topics that they could talk about; they completed five practice trials of the driving simulator prior to the experimental recording to eliminate practice effects. Each participant completed the speaking task and driving task both …

Critical Care Nurses' Perceptions Of End-Of-Life Care: Comparative 17-Year Data, Nicole Lamoreaux

Theses and Dissertations

BACKGROUND: Nurses working in intensive care units (ICUs) frequently care for patients and their families at the end-of-life (EOL). Providing high quality EOL care is important for both patients and families, yet ICU nurses face many obstacles that hinder EOL care. Researchers have identified various ICU nurse-perceived obstacles, but no studies have been found addressing the progress that has been made over the last 17 years.
OBJECTIVE: To determine the most common and current obstacles in EOL care as perceived by ICU nurses and then to evaluate whether or not meaningful changes have occurred since data were first gathered in …

Psychometrically Equivalent Bisyllabic Word Lists For Spanish Pediatric Word Recognition Testing, Brenda Karina Peterson

Theses and Dissertations

While recorded speech audiometry materials have been developed in Spanish for adults, currently there are no speech audiometry materials available in Spanish that are suitable for a pediatric population. Thus, the purposes of this study were (a) to analyze Spanish bisyllabic words previously developed for adults to determine the words' appropriateness when testing word recognition scores in native Spanish-speaking children and (b) to compare the logistic regressions results from the Spanish adult data obtained in a previous study with the logistic regressions from Spanish pediatric data obtained in the present study. Using common-use children's dictionaries in the Spanish language, a …

The Efficacy Of A Literature-Based Social Communication Intervention On Teacher Report Of Sociability For Children With Language Impairment, Mnisa Lyn Harlow

Theses and Dissertations

Recent research indicates that children with language impairment (LI) often experience difficulties with social communication. Although the empirical basis for general social communication intervention is growing, information documenting the efficacy of these interventions for children with LI remains limited. The purpose of this study was to examine the effectiveness of a social communication intervention on teacher perceptions of sociability in five elementary-aged children with LI. The intervention focused on the presentation and use of children's stories to target aspects of emotion understanding. The two sociability subscales of the Teacher Behavior Rating Scale (TBRS), impulse control/likeability and prosocial behavior, were used …

Mean Length Of Utterance And Developmental Sentence Scoring In The Analysis Of Children's Language Samples, Laurie Lynne Chamberlain

Theses and Dissertations

Developmental Sentence Scoring (DSS) is a standardized language sample analysis procedure that uses complete sentences to evaluate and score a child’s use of standard American-English grammatical rules. Automated DSS software can potentially increase efficiency and decrease the time needed for DSS analysis. This study examines the accuracy of one automated DSS software program, DSSA Version 2.0, compared to manual DSS scoring on previously collected language samples from 30 children between the ages of 2;5 and 7;11 (years;months). The overall accuracy of DSSA 2.0 was 86%. Additionally, the present study sought to determine the relationship between DSS, DSSA Version 2.0, the …

The Association Between Articulator Movement And Formant Trajectories In Diphthongs, Katherine Morris Mckell

Theses and Dissertations

The current study examined the association between formant trajectories and tongue and lip movements in the American English diphthongs /aɪ/, /aʊ/, and /ɔɪ/. Seventeen native speakers of American English had electromagnetic sensors placed on their tongues and lips to record movement data along with corresponding acoustic data during productions of the diphthongs in isolation. F1 and F2 trajectories were extracted from the middle 50% of the diphthongs and compared with time-aligned kinematic data from tongue and lip movements. The movement and formant tracks were converted to z-scores and plotted together on a common time scale. Absolute difference scores between kinematic …

Range Of Motion And Plantar Foot Pressures In Those With And Without A Lateral Hip Shift During An Overhead Squat, Erin M. Lally

Theses and Dissertations

Context: Asymmetrical loading between lower limbs can theoretically be explained as an inequality of strength, neuromuscular control, or subconscious reliance on one leg more than the other. Asymmetries are often identified utilizing costly equipment such as force plates and 3D motion analysis cameras. It is important to establish less costly ways of identifying movement and loading asymmetries for clinicians to utilize. One qualitative assessment that may identify asymmetries is a ‘lateral hip shift’ during an overhead squat. Objective: To identify differences in lower extremity range of motion (ROM) and plantar foot pressures in individuals with and without a lateral hip …