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Research outputs 2022 to 2026

Articles 61 - 90 of 2205

Full-Text Articles in Medicine and Health Sciences

Maximal Motor Unit Firing Rates Decline With Amyotrophic Lateral Sclerosis Progression, Gabriel L. Fernandes, Lucas B.R. Orssatto, Matheus D. Pinto, Joao S. Henkin, Ehsan Shandiz, Pamela A. Mccombe, Robert D. Henderson, Gabriel S. Trajano May 2026

Maximal Motor Unit Firing Rates Decline With Amyotrophic Lateral Sclerosis Progression, Gabriel L. Fernandes, Lucas B.R. Orssatto, Matheus D. Pinto, Joao S. Henkin, Ehsan Shandiz, Pamela A. Mccombe, Robert D. Henderson, Gabriel S. Trajano

Research outputs 2022 to 2026

Objective: Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper and lower motor neurons and their motor units (MUs). MU loss is compensated by collateral sprouting and reinnervation of muscle fibres. There is limited information about the properties of these surviving MUs as these processes take place. High-density surface electromyography (HD-sEMG) decomposition enables non-invasive analysis of individual MU firing behaviour during maximal voluntary contractions and assess their changes with ALS progression. Methods: Thirty-nine individuals with ALS (24 men; mean age 63 ± 16 years) completed up to five visits (interval 20.0 ± 7.9 weeks). Tibialis anterior HD-sEMG recordings …

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Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo May 2026

Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo

Research outputs 2022 to 2026

Introduction We aimed to explore the potential incremental cost-effectiveness of the PRODEMOS coach-supported mobile health intervention for primary prevention of dementia versus standard of care provided to people aged 55–75 years with low socio-economic status (SES) in the United Kingdom (UK), and any SES in China. Methods 12–18-month PRODEMOS trial (ISRCTN15986016) efficacy outcomes on hypertension, obesity, hypercholesterolemia, physical inactivity and smoking were extrapolated to lifetime impact on dementia onset, myocardial infarction, stroke and death using a health-economic open-source simulation model. Results Simulated outcomes showed dementia cases were avoided (UK = -206 (-658 to 281), China = -140 (-456 to 205) …

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Key Insights From The International Icu Diary Conference 2025, Peter Nydahl, Bev Ewens, Anne Sophie Debue, Xavier Fiorilla, Kristin Gabriel, Alessandro Galazzi, Louise Gallie, Nikolas Groth, Carly Hickey, Mark Hudson, Fiona Lynch, Nicola Maxwell, Margo Van Mol, Caroline Renner, Louise Rose, Kate Tantam, Lioudmila Karnatovskaia, Christina Jones May 2026

Key Insights From The International Icu Diary Conference 2025, Peter Nydahl, Bev Ewens, Anne Sophie Debue, Xavier Fiorilla, Kristin Gabriel, Alessandro Galazzi, Louise Gallie, Nikolas Groth, Carly Hickey, Mark Hudson, Fiona Lynch, Nicola Maxwell, Margo Van Mol, Caroline Renner, Louise Rose, Kate Tantam, Lioudmila Karnatovskaia, Christina Jones

Research outputs 2022 to 2026

We report on the 2025 International ICU Diary Conference that provided a comprehensive update on current knowledge, innovations and global practices related to ICU diaries. Held in a 6-week online format, the event featured 23 speakers and was attended by mean 69.7 (SD 20.5) participants per session. Topics included development of ICU diaries, use in special settings, digital diaries, survivors' and families' experiences, Post-Intensive-Care Syndrome and follow-up and implementation projects. Highlights were innovative solutions for digital diaries and the report of persons with lived and living experiences with diaries, changing the focus on humanising critical care. Relevance for Practice: ICU …

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Transitioning To Adolescent And Young Adult Or Adult Cancer Survivorship Care: A Systematic Review Of Contemporary Guidelines And Trials, Darren Haywood, Hammersley, Ursula Sansom-Daly, Jordana Mcloone, Evan Dauer, Helen Wilding, Nicolas H. Hart, Thomas Walwyn May 2026

Transitioning To Adolescent And Young Adult Or Adult Cancer Survivorship Care: A Systematic Review Of Contemporary Guidelines And Trials, Darren Haywood, Hammersley, Ursula Sansom-Daly, Jordana Mcloone, Evan Dauer, Helen Wilding, Nicolas H. Hart, Thomas Walwyn

Research outputs 2022 to 2026

Background: Health service transitions of child, adolescent, and young adult cancer survivors between paediatric and adult cancer care services are pervasively fragmented, resulting in poor coordination, reduced satisfaction, and adverse outcomes for cancer survivors and significant others (e.g., caregivers and family members). Numerous trials and clinical guidelines have been developed to support care transitions, but their convergence, divergence, and methodological quality remain unclear. To advance clinical practice and quality research about care transitions, a synthesis of trials and guidelines on child, adolescent, and young adult care transition across age-appropriate cancer services is required to inform future research, practice, guideline, and …

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Between-Session Reliability And Sensitivity Of Force Production Characteristics Across Various Force-Time Points During The Isometric Single-Leg Long-Lever Bridge, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort May 2026

Between-Session Reliability And Sensitivity Of Force Production Characteristics Across Various Force-Time Points During The Isometric Single-Leg Long-Lever Bridge, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort

Research outputs 2022 to 2026

The purpose of this study was to assess the between-session reliability of peak force and early force-time variables in a unilateral isometric hamstring assessment (isometric long-lever bridge). The sample consisted of 30 collegiate male athletes (age: 19.4±1.3 years; height: 1.79±0.1 m; body mass: 80.4±10.3 kg) with no history of recent hamstring injury (<6 months) who volunteered to participate in the study. All participants performed 3 unilateral maximal voluntary isometric contractions (MVIC) with their heels on force plates and shoulders elevated 15.24 cm, while their hips were secured with a loaded barbell. Data was analyzed to assess the reliability of force values at 50, 100, 150, 200, 250 ms, and peak force (N) across three repeated sessions. Moderate-good relative and absolute reliabilities were observed across all early force-time variables with lower bound ICC values≥0.51 (0.51–0.71) and point estimate CV%≤12.65% (7.63–12.65), with moderate relative (ICC≥0.74; range 0.74–0.92) and absolute (CV%≤6.50%; range 6.48–6.50) reliability for peak force. Trivial to small effect sizes (g≤0.4) were observed between sessions. These findings suggest that the isometric single-leg long-lever bridge (SL-LLB) can be used to reliably monitor peak and rapid force generating capacities to track performance changes over time due to training adaptations as well as acute or chronic fatigue.

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Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call May 2026

Beyond The First Bout: Adaptations To Repeated Injuries Across Physiological And Pathological Conditions, Cory W. Baumann, Christopher P. Ingalls, Kazunori Nosaka, Jarrod A. Call

Research outputs 2022 to 2026

Skeletal muscle exhibits remarkable plasticity following injury, yet most research has focused on responses to a single bout of eccentric contractions. This review addresses adaptations to repeated eccentric contraction–induced injuries across physiological and pathological conditions, with emphasis on insights from preclinical rodent models. In healthy muscle, the repeated bout effect (RBE) reduces strength loss and accelerates recovery after subsequent bouts. However, these adaptations are highly condition dependent. Aging can attenuate the RBE, while dystrophic muscle remains vulnerable to repeated injury despite compensatory remodeling. Other factors, including but not limited to, chronic alcohol intake and malignant hyperthermia can influence these responses, …

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Diacylglycerol Kinase Eta As A Novel Target In Nras Mutant Melanoma, Haley P. Wilson, Casey D. Stefanski, Signe Caksa, Glenn L. Mersky, Scott D. Varney, Jelan I. Haj, Dan A. Erkes, Timothy J. Purwin, Vivian Chua, Andrew E. Aplin May 2026

Diacylglycerol Kinase Eta As A Novel Target In Nras Mutant Melanoma, Haley P. Wilson, Casey D. Stefanski, Signe Caksa, Glenn L. Mersky, Scott D. Varney, Jelan I. Haj, Dan A. Erkes, Timothy J. Purwin, Vivian Chua, Andrew E. Aplin

Research outputs 2022 to 2026

NRAS mutations occur in 10%–30% of cutaneous melanomas and are associated with high tumor mutational burden. Mutant NRAS signaling drives aberrant cell growth and proliferation, in part, through activation of the RAF–MEK-ERK1/2 kinase pathway; however, targeted therapies to this pathway have limited effectiveness in patients with NRAS mutant melanoma. The role of other targetable signaling pathways in NRAS mutant melanoma is poorly characterized. Here, we demonstrated that one isoform of diacylglycerol kinase, diacylglycerol kinase eta (DGKη), a lipid signaling regulator, was highly expressed in NRAS mutant melanoma patient samples. Knockdown of DGKH in NRAS mutant melanoma cell lines resulted in …

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Neuromuscular Performance Changes In Response To The Australian Special Forces Selection Course, Angela Uphill, Kristina L. Kendall, Stuart Guppy, Michael Vacher, Simon Parker, Hannah Brown, Brendan Ashmore, Travis Zomer, G. Gregory Haff May 2026

Neuromuscular Performance Changes In Response To The Australian Special Forces Selection Course, Angela Uphill, Kristina L. Kendall, Stuart Guppy, Michael Vacher, Simon Parker, Hannah Brown, Brendan Ashmore, Travis Zomer, G. Gregory Haff

Research outputs 2022 to 2026

Introduction: Strenuous military activities, such as Special Forces (SF) selection courses, are known to involve high physical loads in the presence of food and sleep deprivation, which can have detrimental impacts on physical performance. Understanding the magnitude of performance deficit and the time required for recovery associated with these events, is important for injury prevention and maintaining operational readiness. The purpose of this study was to investigate the changes in physical performance in response to the Australian SF Selection Course (SF-SC) and to monitor recovery throughout 8 weeks following the course. Materials and Methods: Ninety-three healthy male participants (age: 28 …

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Role Of Allied Health Professions In Falls Prevention For Community-Dwelling Older Adults: A Scoping Review, Amy Lawton, Nicholas Tripodi, Rebecca Wospil, Breanna M. Wright, Hylton B. Menz, Suzanne Martin, Daniel R. Bonanno, Corey Linton, Andisheh Bastani, Andrew Ross, Rees Thomas, Daniel Corcoran, Timothy Mcnamara, Danielle Baxter, Brett Vaughan, Rebecca Lane, Jack Feehan May 2026

Role Of Allied Health Professions In Falls Prevention For Community-Dwelling Older Adults: A Scoping Review, Amy Lawton, Nicholas Tripodi, Rebecca Wospil, Breanna M. Wright, Hylton B. Menz, Suzanne Martin, Daniel R. Bonanno, Corey Linton, Andisheh Bastani, Andrew Ross, Rees Thomas, Daniel Corcoran, Timothy Mcnamara, Danielle Baxter, Brett Vaughan, Rebecca Lane, Jack Feehan

Research outputs 2022 to 2026

Objective: Falls among community-dwelling older adults are prevalent and have serious individual, societal and economic consequences. Allied health professionals provide key falls prevention interventions yet their representation in current clinical practice guidelines is inconsistent. Increased recognition of allied health roles and delivering context-specific guidelines for falls care could help to address workforce gaps and optimise care approaches. This scoping review explored the roles of the allied health professions in falls prevention screening, assessment and intervention for community-dwelling older adults. Design: Scoping review, using the Joanna Briggs Institute methodology for scoping reviews. Data sources: PubMed, CINAHL, Scopus, Cochrane, Web of Science …

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Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer Apr 2026

Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer

Research outputs 2022 to 2026

This mouse study investigates the efficacy of ellagic acid (EA), a potent antioxidant in fruits and nuts, and inulin, a prebiotic known for gut microbiota benefits, in nonalcoholic steatohepatitis (NASH). A Western-style diet (WD) was used to induce NASH in C57BL/6J male mice for 16 weeks. Mice then received EA (100 mg/kg/day, oral gavage, 5 days/week) and/or 5% inulin (w/w in diet) for 12 weeks while continuing WD. Inulin increased energy intake and trended toward higher body weight and fasting glucose. EA reduced liver weights and restored the liver-to-body weight ratio. EA and inulin combined significantly reduced steatosis and hepatocyte …

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A Supervised, Online, Home-Based Eccentric Resistance Exercise Program For Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease, Kedar S. Deshpande, Nosaka, Aus Molan, Isaac S. Raj, John K. Olynyk, Oyekoya T. Ayonrinded Apr 2026

A Supervised, Online, Home-Based Eccentric Resistance Exercise Program For Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease, Kedar S. Deshpande, Nosaka, Aus Molan, Isaac S. Raj, John K. Olynyk, Oyekoya T. Ayonrinded

Research outputs 2022 to 2026

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common non-communicable chronic liver disease worldwide, increasing long-term risk of cirrhosis, type 2 diabetes mellitus, and cardiovascular diseases. Although reducing liver steatosis by increasing physical activity can lower these risks, patients with MASLD often struggle to exercise regularly. We examined the effects of a supervised, home-based, online bodyweight eccentric exercise program on liver and metabolic markers, and physical fitness in patients with MASLD. Methods: Sixteen adults with MASLD (24–91 years) were assigned to an exercise group (n = 9) or a control group receiving lifestyle counselling (n = 7). The …

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Rapid Isometric Hamstring Strength Scores From Professional Soccer Players At Pre-Season: Positional Differences And Relationship To Peak Force, Nicholas Joel Ripley, Ross, Jack Fahey, Christopher Bramah, Paul Jones, Paul Comfort Apr 2026

Rapid Isometric Hamstring Strength Scores From Professional Soccer Players At Pre-Season: Positional Differences And Relationship To Peak Force, Nicholas Joel Ripley, Ross, Jack Fahey, Christopher Bramah, Paul Jones, Paul Comfort

Research outputs 2022 to 2026

The assessment of rapid force within a single joint assessment is becoming common practice within elite sport environments. Recent observations have highlighted that rapid force maybe more sensitive to fatigue than peak force within the hamstrings. Yet limited information exists on rapid force production in elite male soccer players. Eighty-nine senior professional men’s soccer players (age; 24.2±5.1 years, height; 1.83±0.05 m, mass; 78.95±7.53 kg) participated within the present study they performed two isometric assessments at joint angles of 30° and 90° of hip flexion and knee. They performed three trials with mean and standard deviation determined differences between soccer positions …

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The Association Of Apolipoprotein E Ε4 With Symptomatic Intracerebral Hemorrhage, Mri Markers And Cognition In Dutch-Type Hereditary Cerebral Amyloid Angiopathy, Maaike C. Van Der Plas, Rosemarie Van Dort, Ingeborg Rasing, Yongxi Long, Erik W. Van Zwet, Matthias J.P. Van Osch, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Gisela M. Terwindt, Marianne A.A. Van Walderveen, Marieke J.H. Wermer Apr 2026

The Association Of Apolipoprotein E Ε4 With Symptomatic Intracerebral Hemorrhage, Mri Markers And Cognition In Dutch-Type Hereditary Cerebral Amyloid Angiopathy, Maaike C. Van Der Plas, Rosemarie Van Dort, Ingeborg Rasing, Yongxi Long, Erik W. Van Zwet, Matthias J.P. Van Osch, Hamid R. Sohrabi, Kevin Taddei, Samantha L. Gardener, Ralph N. Martins, Steven M. Greenberg, Gisela M. Terwindt, Marianne A.A. Van Walderveen, Marieke J.H. Wermer

Research outputs 2022 to 2026

Background: Apolipoprotein E (APOE) genotype influences the presence, course and severity of sporadic cerebral amyloid angiopathy (sCAA). We investigated the effect of the APOE ε4-allele on clinical and neuroradiological outcomes in mutation-carriers with Dutch-type hereditary (D-)CAA. Methods: Participants with D-CAA from a prospective cohort study, with data collected on history of symptomatic intracerebral hemorrhages (sICH) and vascular risk factors, underwent 3 Tesla magnetic resonance imaging (MRI) scans to assess macrobleeds, cerebral microbleeds (CMBs), cortical superficial siderosis (cSS), enlarged perivascular spaces (EPVS), white matter hyperintensity (WMH) volume and WMH multispot lesions. Global cognition was measured using Montreal Cognitive Assessment (MoCA) and …

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Effects Of Photobiomodulation On Oral Mucositis, Oral Pain, Xerostomia, Salivary Flow Rate, And Quality Of Life In Patients With Head And Neck Cancer: A Systematic Review And Meta-Analysis, Mônica N.M. Pedroso, Anderson Rech, Natalia Casagrande, Júlia F. Pissaia, Julia S. Zardo, Vitória L. Borges, Stephanie R. Bombana, Cindranne Torres Muller, Priscila Casara, Janaína Brollo, Claudio P. Júnior, Carin W. Gallon, Pedro Lopez Apr 2026

Effects Of Photobiomodulation On Oral Mucositis, Oral Pain, Xerostomia, Salivary Flow Rate, And Quality Of Life In Patients With Head And Neck Cancer: A Systematic Review And Meta-Analysis, Mônica N.M. Pedroso, Anderson Rech, Natalia Casagrande, Júlia F. Pissaia, Julia S. Zardo, Vitória L. Borges, Stephanie R. Bombana, Cindranne Torres Muller, Priscila Casara, Janaína Brollo, Claudio P. Júnior, Carin W. Gallon, Pedro Lopez

Research outputs 2022 to 2026

Purpose: To systematically review and analyze the effects of photobiomodulation on oral mucositis, xerostomia, salivary flow rates, oral pain, and quality of life in patients with head and neck cancer. Methods: A systematic search of six databases was conducted up to April 2025. Eligible randomized controlled trials (RCTs) examined the effects of photobiomodulation on the specified outcomes in patients with head and neck cancer. Pooled estimates (risk ratio [RR] and standardized mean difference [SMD]) were calculated using a three-level mixed-effects meta-analysis. Results: Thirty-three articles describing 30 RCTs (n = 1748) were included. Photobiomodulation significantly reduced the risk of severe oral …

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Self-Management Challenges And Psychosocial Support Needs In Clean Intermittent Catheterization: A Qualitative Study Of Individuals With Neurogenic Bladder And Caregivers, Lianyu Zou, Xiaomei Wu, Shun Chen, Shuluan Feng, Xiaohua Huang, Weiting Liu Apr 2026

Self-Management Challenges And Psychosocial Support Needs In Clean Intermittent Catheterization: A Qualitative Study Of Individuals With Neurogenic Bladder And Caregivers, Lianyu Zou, Xiaomei Wu, Shun Chen, Shuluan Feng, Xiaohua Huang, Weiting Liu

Research outputs 2022 to 2026

Background – Clean intermittent catheterization (CIC) is widely regarded as the preferred approach to bladder management for individuals with neurogenic bladder (NB). Nevertheless, a considerable gap persists between evidence and clinical practice: patients and caregivers frequently encounter self-management barriers that compromise clinical outcomes during CIC. This qualitative study explores these barriers to provide an empirical foundation for developing tailored strategies that improve quality of care. Design – A descriptive qualitative study. Methods – From August to October 2025, a convenience sampling method was employed to recruit 16 participants individuals with NB or their long-term caregivers from the Department of Rehabilitation …

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Disuse-Induced Muscle Atrophy And Muscle Weakness From Hospitalization To Spaceflight: Exercise Succeeds In Prevention And Treatment—A Meta-Analysis, Camila S. Padilha, Figueiredo, Rafael Deminice, S. Ribeiro, Robert U. Newton, Nicolas H. Hart, José Cesar Rosa-Neto, Marília Seelaender, Fábio Santos Lira Apr 2026

Disuse-Induced Muscle Atrophy And Muscle Weakness From Hospitalization To Spaceflight: Exercise Succeeds In Prevention And Treatment—A Meta-Analysis, Camila S. Padilha, Figueiredo, Rafael Deminice, S. Ribeiro, Robert U. Newton, Nicolas H. Hart, José Cesar Rosa-Neto, Marília Seelaender, Fábio Santos Lira

Research outputs 2022 to 2026

Background: Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain. Methods: This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus, CINAHL and SciELO from inception to May 2021, with an update in March 2025. Randomized and nonrandomized controlled trials examining exercise interventions during or after muscle disuse were included according to the PICOS framework. Random-effects meta-analysis evaluated effects on muscle strength, power and mass across hospitalization, bed rest and spaceflight conditions. Effect sizes (ES) are reported as …

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Length And Framing Of Anti-Junk Food Ads Impact Inclinations To Consume Junk Food Among Normal Weight, Overweight, And Adults With Obesity, Ross C. Hollett, Brennen Mills, Stephanie L. Godrich, Julia Butt, Gina S.A. Trapp Apr 2026

Length And Framing Of Anti-Junk Food Ads Impact Inclinations To Consume Junk Food Among Normal Weight, Overweight, And Adults With Obesity, Ross C. Hollett, Brennen Mills, Stephanie L. Godrich, Julia Butt, Gina S.A. Trapp

Research outputs 2022 to 2026

Background: Unrestricted junk food advertising increases the risk of short-term junk food consumption among viewers. We aimed to estimate the impact of junk food and anti-junk food advertisements differing in length and framing on junk food consumption inclinations. Methods: Adult participants (N = 505) were exposed to a randomly selected junk food advertisement or anti-junk food advertisement and reported their immediate craving and consumption intentions. These responses were separately analysed for two groups based on Body Mass Index (BMI): participants classified as within the normal range (18.5–25), and a combined group with BMI values indicating either overweight (25+) or obesity …

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3-Deoxyanthocyanidins Inhibit Β-Amyloid Aggregation, Toxicity, And Mitochondrial Dysfunction: Evidence From Mc-65 Cells And Molecular Dynamics Simulations, Rasheed A. Abdulraheem, Ammar U. Danazumi, Philipp Nitschke, Luke Gray Whiley, Abdulrahman Ibrahim Tudu, Ranil Coorey, Zhoyu Li, Prashant Bharadwaj, Vijay Jayasena, Stuart K. Johnson, Ralph N. Martins, W. M.A.D.Binosha Fernando Apr 2026

3-Deoxyanthocyanidins Inhibit Β-Amyloid Aggregation, Toxicity, And Mitochondrial Dysfunction: Evidence From Mc-65 Cells And Molecular Dynamics Simulations, Rasheed A. Abdulraheem, Ammar U. Danazumi, Philipp Nitschke, Luke Gray Whiley, Abdulrahman Ibrahim Tudu, Ranil Coorey, Zhoyu Li, Prashant Bharadwaj, Vijay Jayasena, Stuart K. Johnson, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Accumulation of amyloid-beta (Aβ42) senile plaques in the brain is a hallmark of Alzheimer's disease (AD). Although some drug have been approvaled recently, none has demonstrated robust disease-modifying outcome. The 3-deoxyanthocyanidins (3-DXA) and their derivatives represent a more stable class of polyphenols, present at uniquely high concentrations in sorghum grains. Although 3-DXA exhibit strong potential to modulate protein aggregation processes, their effects on AD pathology remain unexplored. In this study, we investigated the inhibitory effects of three 3-DXA derivatives, apigeninidin chloride (AC), luteolinidin chloride (LC), and 7-methoxy apigeninidin (7-MAC), on Aβ42 aggregation and associated neurotoxicity. Thioflavin T fluorescence assay was …

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Using Social Network Analysis To Visualise Place-Based Partnerships For Systems Change In Regional Australia, Stephanie L. Godrich, Isabelle Chiera, Melissa Stoneham, Jess Doe, Amanda Devine, Emily Humphreys Apr 2026

Using Social Network Analysis To Visualise Place-Based Partnerships For Systems Change In Regional Australia, Stephanie L. Godrich, Isabelle Chiera, Melissa Stoneham, Jess Doe, Amanda Devine, Emily Humphreys

Research outputs 2022 to 2026

Issue Addressed: Social network analysis (SNA) is a novel approach to investigating food security systems change in regional and remote communities. With short-term, siloed food security solutions often proving ineffective, this study used SNA to visualise how organisations across a vast area in Western Australia (WA) were working in partnership to support systems change and identify where these partnerships could be strengthened. Methods: One hundred and one food security initiative leaders, representing 148 initiatives, participated in semi-structured interviews. The number and type of regional partnerships were measured, and region-based partnership network typologies determined. Results: Most regions’ partnership networks were ‘Scattered …

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Combined Effect Of Sarcopenia And Impaired Respiratory Function On All-Cause Death: A Nationwide Cohort Study, Chutao Wu, Dan Wu, Mu Li, Senrong Lu, Yukai Wang, Yulong Lan Apr 2026

Combined Effect Of Sarcopenia And Impaired Respiratory Function On All-Cause Death: A Nationwide Cohort Study, Chutao Wu, Dan Wu, Mu Li, Senrong Lu, Yukai Wang, Yulong Lan

Research outputs 2022 to 2026

Background: Respiratory fitness and sarcopenia status have been reported to be cross-sectionally linked with each other and increase mortality risk. However, little is currently known regarding the connection between impaired respiratory function and sarcopenia and their joint effect on future death risk. Methods: This study included 12 027 participants (50.8% were women; mean [SD] age, 58.9 [9.3] years) from a nationwide, prospective cohort in China (China Health and Retirement Longitudinal Study). Respiratory function was assessed by peak expiratory flow (PEF). Sarcopenia status was assessed according to the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria. Time-to-event survival analyses and …

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Preoperative Health During A Pandemic: An Observational Study Assessing Lifestyle Changes In Patients Associated With Covid-19 In Western Australia, Nadine Radin, Dana Hince, Jim Codde, Paola Chivers, Dale W. Edgar Apr 2026

Preoperative Health During A Pandemic: An Observational Study Assessing Lifestyle Changes In Patients Associated With Covid-19 In Western Australia, Nadine Radin, Dana Hince, Jim Codde, Paola Chivers, Dale W. Edgar

Research outputs 2022 to 2026

Background and Aim: Healthcare service disruptions resulting from the COVID-19 pandemic led to substantial changes in surgical pathways across public hospitals in Western Australia (WA). These disruptions, compounded by restrictions and containment measures, influenced the health and lifestyle behaviours of the WA community, including patients awaiting surgery. This study aimed to assess changes in self-reported modifiable lifestyle risk factors among patients during COVID-19. Methods: This observational study analysed hospital patient data across three seasonally matched calendar periods: Period 1 (January–March 2019 vs 2020), Period 2 (March–July 2019 vs 2020), and Period 3 (July–December 2019 vs 2020). Multivariable regression models were …

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Utilizing And Optimizing Forecasting Models For Nursing Demand: A Narrative Review, Kalpana Singh, Liyan Ajit D. Souza, Ananth Nazarene, Amane Mounia, Mahmoud Abdelwahab Khedr, Ahmad Mousa, Rebecca Rejo George, Abdulqadir J. Nahwan Apr 2026

Utilizing And Optimizing Forecasting Models For Nursing Demand: A Narrative Review, Kalpana Singh, Liyan Ajit D. Souza, Ananth Nazarene, Amane Mounia, Mahmoud Abdelwahab Khedr, Ahmad Mousa, Rebecca Rejo George, Abdulqadir J. Nahwan

Research outputs 2022 to 2026

Background: Accurately forecasting nursing demand is essential for effective workforce planning in the context of increasing patient volumes and the growing complexity of healthcare systems. Reliable forecasting supports optimal staffing, enhances patient care quality, and reduces operational risks. However, traditional forecasting approaches are increasingly challenged by evolving clinical demands, rising chronic disease burden, and rapid technological advancements. Aim: This narrative review aimed to (1) map existing models used for predicting nursing demand, (2) identify key predictive methodologies, data inputs, and evaluation metrics, and (3) highlight existing gaps and implications for healthcare policy and workforce management. Methods: A comprehensive narrative literature …

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A Flexible Wearable Glucose Sensor For Noninvasive Diabetes Screening: Functional Equivalence And Model Interpretability, Wenhan Xie, Wang, Hao Liu, Shuo Chen, Peng Wang, Yumei Han, Xianxiang Chen, Zhen Fang, Zhan Zhao, Guohong Zhang, Xiuhua Guo Apr 2026

A Flexible Wearable Glucose Sensor For Noninvasive Diabetes Screening: Functional Equivalence And Model Interpretability, Wenhan Xie, Wang, Hao Liu, Shuo Chen, Peng Wang, Yumei Han, Xianxiang Chen, Zhen Fang, Zhan Zhao, Guohong Zhang, Xiuhua Guo

Research outputs 2022 to 2026

Real-world evidence for wearable noninvasive glucose monitoring (NIGM) remains limited. To evaluate the functional equivalence of a wearable NIGM device and explore its utility for T2DM and prediabetes screening. In this multicenter study, 12-h daytime glucose profiles obtained by a flexible reverse iontophoresis-based electrochemical sensor were compared with capillary glucose using functional equivalence. Subgroup analyses were conducted. Screening models of T2DM and prediabetes were developed using elastic net and Logistic regression. A total of 135 participants (mean age 35.3 years; 60.0% female) were included, and no serious device-related adverse events were reported. Compared to the capillary measurements, functional equivalence was …

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Abca4 Versus Prph2-Associated Retinopathy: Clinical And Electrophysiological Findings, Rachael C. Heath Jeffery, A. Thompson, Johnny Lo, Andrea L. Vincent, Minal Patil, Lorenzo Bianco, Maurizio Battaglia Parodi, Lucia Ziccardi, Carmen Dell’Aquila, Lucilla Barbano, Wei Chao Tang, Choi Mun Chan, Camiel J.F. Boon, Jonathan Hensman, Ta Ching Chen, Chien Yu Lin, Pei Lung Chen, Ajoy Vincent, Anupreet Tumber, Elise Heon, John R. Grigg, Robyn V. Jamieson, Elisa E. Cornish, Benjamin N. Nash, Jeremy Chou, Tina M. Lamey Apr 2026

Abca4 Versus Prph2-Associated Retinopathy: Clinical And Electrophysiological Findings, Rachael C. Heath Jeffery, A. Thompson, Johnny Lo, Andrea L. Vincent, Minal Patil, Lorenzo Bianco, Maurizio Battaglia Parodi, Lucia Ziccardi, Carmen Dell’Aquila, Lucilla Barbano, Wei Chao Tang, Choi Mun Chan, Camiel J.F. Boon, Jonathan Hensman, Ta Ching Chen, Chien Yu Lin, Pei Lung Chen, Ajoy Vincent, Anupreet Tumber, Elise Heon, John R. Grigg, Robyn V. Jamieson, Elisa E. Cornish, Benjamin N. Nash, Jeremy Chou, Tina M. Lamey

Research outputs 2022 to 2026

Purpose. The purpose of this study was to characterize the clinical features, electrophysiology, and variant spectrum in ABCA4- and PRPH2-retinopathies and to identify novel electrodiagnostic biomarkers to differentiate between these two genotypes. Methods. We conducted an international multicenter case-control study of patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-retinopathy. Age at symptom onset, best-corrected visual acuity (BCVA), electroretinography (ERG) components, and fundus autofluorescence (FAF) imaging were compared. Subgroup exploratory analysis was performed on those patients with a phenotype similar to central areolar choroidal dystrophy (“CACD-like”), those with flecks distributed throughout the posterior pole (“fleck-like”) and a healthy …

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Collaboration Between People Admitted To Acute Mental Health Units, Their Family Members And Nurses In The Detection Of Mental State Changes And Recovery: A Qualitative Systematic Review, Karen Foster, Coventry, Yvonne Middlewick, Lindsay Smith, Beverley Ewens Apr 2026

Collaboration Between People Admitted To Acute Mental Health Units, Their Family Members And Nurses In The Detection Of Mental State Changes And Recovery: A Qualitative Systematic Review, Karen Foster, Coventry, Yvonne Middlewick, Lindsay Smith, Beverley Ewens

Research outputs 2022 to 2026

Mental health nurses can engage with people with mental health challenges and their families due to their presence on acute mental health units. This presence helps to facilitate recovery-focused care within a physically and emotionally safe environment. Mental health care should be person-centred, individualised, and include wherever possible family and other people in the person's support network. The objective of this systematic review was to explore the existing qualitative literature that describes experiences of collaboration between people with lived experience of mental health challenges, their family members, and nurses in relation to changes in mental state during an admission to …

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Impact Of Cannabis And Cannabis Legalization On Us Atrial Septal Defect Rates, Albert Stuart Reece, Hulse Apr 2026

Impact Of Cannabis And Cannabis Legalization On Us Atrial Septal Defect Rates, Albert Stuart Reece, Hulse

Research outputs 2022 to 2026

Atrial septal defect (ASD) affects 1:11.3 children in some US states; however, the antecedents of these trends are yet to be identified. A total of 1882 ASD rates (ASDRs) for 2003–2020 were sourced from the National Birth Defects Prevention Network reports. A total of 406,893 ASDs are reported. Substance (cigarettes, binge alcohol, cannabis, cannabinoids, analgesics, cocaine) exposure data were taken from the National Survey of Drug Use and Health. Income and ethnicity data were derived from the US Census. Adjustment was performed by mixed effects, survey and generalized additive regression. Causal analysis was by inverse probability weighting and E-values. Data …

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Influence Of Simulator Physical Fidelity And Immersion On Decision-Making Skill, Presence, And Cognitive Load, Zachariah G. Hoyne, Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker Apr 2026

Influence Of Simulator Physical Fidelity And Immersion On Decision-Making Skill, Presence, And Cognitive Load, Zachariah G. Hoyne, Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

In a variety of domains such as law enforcement and sport, virtual reality is being explored to simulate field-based decision-making contexts. 360-degree video virtual reality (360VR) is innovative as it can immerse the user in a simulated environment, present egocentric, stereoscopic vision and allows for head movements to perceive visual information. However, it is unknown whether physical, rather than psychological fidelity, is crucial for performance, and its impact upon cognitive load, relative to immersion. This study investigated simulator fidelity, presence, and cognitive load across immersion (two-dimensional video and 360VR) in an exemplar sport-specific decision-making task. Thirty skilled Australian Rules Football …

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Longitudinal Assessment Of Health-Related Quality Of Life In Adults With Ckd, Owen Ng, Teixeira-Pinto, Anh Kieu, Anita Van Zwieten, Anoushka Krishnan, Kirsten Howard, Wai H. Lim, Jeremy R. Chapman, Simon D. Roger, Michael J. Bourke, Shaundeep Sen, Steven J. Chadban, Carol A. Pollock, Allison Jaure, Jonathan C. Craig, Jean Yang, Germaine Wong Apr 2026

Longitudinal Assessment Of Health-Related Quality Of Life In Adults With Ckd, Owen Ng, Teixeira-Pinto, Anh Kieu, Anita Van Zwieten, Anoushka Krishnan, Kirsten Howard, Wai H. Lim, Jeremy R. Chapman, Simon D. Roger, Michael J. Bourke, Shaundeep Sen, Steven J. Chadban, Carol A. Pollock, Allison Jaure, Jonathan C. Craig, Jean Yang, Germaine Wong

Research outputs 2022 to 2026

Key Points: Dialysis linked with poorer quality of life compared with transplant patients and patients with CKD. Quality of life trends were similar in both domain-specific and overall quality-of-life measures. Background: There are sparse data about the change in health-related quality of life (HRQoL) with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific quality of life and determined the factors that were associated with this change. Methods: Data were sourced from a multicenter study that included 1290 adult patients aged 18 years and older across six centers in …

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Space-Time Analysis Of Burgeoning Us Atrial Septal Defect Rates Driven By Cannabis, Albert Stuart Reece, Kenneth Hulse Apr 2026

Space-Time Analysis Of Burgeoning Us Atrial Septal Defect Rates Driven By Cannabis, Albert Stuart Reece, Kenneth Hulse

Research outputs 2022 to 2026

Atrial septal defect (ASD) has become increasingly common in the USA and now affects 1 in 11.3 children in some places, but space–time analysis has not been applied to this emerging trend. ASD rate (ASDR) data were obtained from the National Birth Defects Prevention Network 2003–2020. Substance (cigarettes, alcohol, cannabis, analgesics, cocaine) use data were obtained from the National Survey of Drug Use and Health. Income data were obtained from the US Census. Analysis was limited to the Non-Hispanic White population by technical factors. Time-sequential univariate and bivariate maps were prepared for both covariates and outcomes and their combinations. Spatial …

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The Effect Of Midwife-Led Continuous Labor Support Care On Delivery Mode And Timely Initiation Of Breastfeeding In Primigravida Women In Northwest Ethiopia: A Hybrid Type I Implementation Study, Mengstu Melkamu Asaye, Aragaw, Eden Bishaw Taye, Kihinetu Gelaye Wudineh, Sara Bayes Apr 2026

The Effect Of Midwife-Led Continuous Labor Support Care On Delivery Mode And Timely Initiation Of Breastfeeding In Primigravida Women In Northwest Ethiopia: A Hybrid Type I Implementation Study, Mengstu Melkamu Asaye, Aragaw, Eden Bishaw Taye, Kihinetu Gelaye Wudineh, Sara Bayes

Research outputs 2022 to 2026

Midwife-led continuous labor and childbirth support reduces the episiotomy rate and increases the rates of vaginal delivery and early initiation of breastfeeding. However, no studies have yet been conducted in Ethiopia. This study aimed to evaluate the effect of midwife-led continuous labor and childbirth support. A quasi-experimental study involving 419 primigravida women compared an intervention given by trained midwives at two hospitals to routine at two others. Data were collected from July to December 2024 through interviews and record reviews. The McNemar test was used to compare changes, with a p-value of less than 0.05. Midwife-led continuous labor support increased …

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