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Research outputs 2022 to 2026

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Full-Text Articles in Medicine and Health Sciences

Nursing Students' Evaluation Of Primary Health Care Clinical Placements - A Cross-Sectional Study, Debbie Procter, Megan Lee, Debbie Massey, Kylie Mccullough, Karen Strickland Jul 2026

Nursing Students' Evaluation Of Primary Health Care Clinical Placements - A Cross-Sectional Study, Debbie Procter, Megan Lee, Debbie Massey, Kylie Mccullough, Karen Strickland

Research outputs 2022 to 2026

Aim: Evaluate quality and satisfaction of nursing students' Primary Health Care clinical placements. Background: There is growing recognition of the need to expand the Primary Health Care nursing workforce, with positive clinical placement experiences considered essential for preparing and inspiring future careers in these settings; however, few graduate nurses choose this career path. Design: A cross-sectional study design using purposive sampling. Participants: Data were sourced from National Placement Evaluation Centre's 2023/2024 dataset using the validated PET–Nursing survey. The tool includes 20 items across two subscales - Clinical Environment and Learning Support, with the final item assessing overall placement satisfaction. Surveys …

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Sagittal Abdominal Diameter And Abdominal Aortic Calcification Are Associated With Incident Major Adverse Cardiovascular Events: The Manitoba Bone Density Registry, Haftom N. Abraha, Abadi K. Gebre, Marc Sim, Cassandra Smith, Syed Zulqarnain Gilani, Zaid Ilyas, Fatima Zarzour, John T. Schousboe, Lisa M. Lix, Neil Binkley, Siobhan Reid, Barret A. Monchka, Douglas Kimelman, Joshua R. Lewis, William D. Leslie Jul 2026

Sagittal Abdominal Diameter And Abdominal Aortic Calcification Are Associated With Incident Major Adverse Cardiovascular Events: The Manitoba Bone Density Registry, Haftom N. Abraha, Abadi K. Gebre, Marc Sim, Cassandra Smith, Syed Zulqarnain Gilani, Zaid Ilyas, Fatima Zarzour, John T. Schousboe, Lisa M. Lix, Neil Binkley, Siobhan Reid, Barret A. Monchka, Douglas Kimelman, Joshua R. Lewis, William D. Leslie

Research outputs 2022 to 2026

BackgroundSagittal abdominal diameter (SAD), a measure of visceral adiposity, has been linked to major adverse cardiovascular events (MACE). However, the relationship between SAD and abdominal aortic calcification (AAC), a marker of subclinical vascular disease, and whether they independently and jointly predict MACE remains unclear.ObjectiveTo investigate whether weight-normalized SAD and AAC scored using a validated machine learning algorithm (ML-AAC24) are independently and jointly associated with incident MACE.MethodsSAD and ML-AAC24 were measured from dual-energy X-ray absorptiometry (DXA) posteroanterior and lateral spine images, respectively, from the Manitoba Bone Density registry.ResultsAmong 8806 individuals (mean age 75.1 ± 6.6 years, 93.9% women), 11.3% experienced MACE …

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The Effects Of Anti-Parkinsonian Medications On Bone Mineral Density: A Systematic Review, Mícheál Ó Breasail, Motaz B. El-Leissy, Karan P. Singh, Matthew Smith, Jakub Mesinovic, Marc Sim, Andrew Evans, David Blacker, Saman Heshmat, Neil Mahant, Christian Girgis, Peter R. Ebeling, Ayse Zengin Jul 2026

The Effects Of Anti-Parkinsonian Medications On Bone Mineral Density: A Systematic Review, Mícheál Ó Breasail, Motaz B. El-Leissy, Karan P. Singh, Matthew Smith, Jakub Mesinovic, Marc Sim, Andrew Evans, David Blacker, Saman Heshmat, Neil Mahant, Christian Girgis, Peter R. Ebeling, Ayse Zengin

Research outputs 2022 to 2026

IntroductionParkinson's disease (PD) is associated with elevated fracture risk, particularly at the hip. Antiparkinsonian medications have also been associated with increased fracture risk; although their direct effects on bone mineral density (BMD) remains unclear.ObjectiveInvestigate whether antiparkinsonian medications influence BMD.MethodsA systematic search of four databases (Embase, MEDLINE, APA PsycINFO, Web of Science) was conducted up to 24/11/2025 using terms related to PD, antiparkinsonian medications and bone.ResultsA total of 748 records were identified, with 543 screened following deduplication. Fourteen studies underwent full-text review, of which seven met inclusion criteria. Three studies assessed bone mineral content or surrogate measures at non-standard sites (hand …

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The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati Jul 2026

The Impact Of Hypertensive Disorders Of Pregnancy On Cognitive Outcomes In Offspring: Systematic Review And Meta-Analysis, Berihun Dachew, Tusa, Getinet Ayano, Kim Betts, Amanuel Gebremedhin, Daniel Rudaizky, Gizachew A. Tessema, Rosa Alati

Research outputs 2022 to 2026

Purpose To synthesis the available research on the association between hypertensive disorders during pregnancy (HDP) and adverse cognitive outcomes in children. Methods PubMed, MEDLINE, Embase, Scopus, CINAHL, and PsycInfo were searched from inception to February 2026 to identify relevant studies. Effect estimates and 95% confidence intervals (CIs) were extracted and pooled using inverse variance–weighted random-effects meta-analysis. Results Thirty-nine observational studies published between 1982 and 2026, covering over 12.5 million mother-offspring pairs, were included in the final analysis. The findings indicate that HDP were associated with a 39% increased risk of Intellectual Disability (ID) (OR = 1.39, 95% CI = 1.30–1.47) …

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Norm Dust Intake: Comparison Of Personal Air Sampling And Bioassays, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani Jun 2026

Norm Dust Intake: Comparison Of Personal Air Sampling And Bioassays, Gregory S. Hewson, Martin I. Ralph, Marcus Cattani

Research outputs 2022 to 2026

Intake of naturally occurring radioactive materials (NORM), particularly the inhalation of thorium-bearing dust in mineral sand operations, has traditionally been assessed via personal air sampling (PAS). However, data from bioassay studies suggest that the actual intake determined via PAS may be underestimated. This review integrates thorium intake estimates derived from historical bioassay datasets, such as urine, faeces, lung counting, and thoron-in-breath tests, with historical PAS data. The findings indicated that bioassay-based predictions of intake were consistently greater, with mean bioassay-to-PAS intake ratios ranging from 2.6 to 4.2. The contributing factors to this discrepancy include biokinetic model uncertainties, potential dust sampler …

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Patterns Of Language And Visuospatial Lateralisation In Three-Year-Old Children, Josephine E. Quin-Conroy, Donna M. Bayliss, Stephanie J. Bovell, Debra Eamer, Georgina H.M. Earl, Simon E. Fisher, Clyde Francks, Murray T. Maybery, Sarah Pillar, Desiree Silva, Andrew J.O. Whitehouse, Nicholas A. Badcock Jun 2026

Patterns Of Language And Visuospatial Lateralisation In Three-Year-Old Children, Josephine E. Quin-Conroy, Donna M. Bayliss, Stephanie J. Bovell, Debra Eamer, Georgina H.M. Earl, Simon E. Fisher, Clyde Francks, Murray T. Maybery, Sarah Pillar, Desiree Silva, Andrew J.O. Whitehouse, Nicholas A. Badcock

Research outputs 2022 to 2026

Little is known about how or when language and visuospatial processing lateralise in the brain, and if individual differences in lateralisation are related to early language or visuospatial abilities. We explored if patterns of language and visuospatial lateralisation are related to cognitive skills in young children. A large sample of 3-year-olds (n = 136) attempted two functional transcranial Doppler ultrasound (fTCD) tasks to estimate language and visuospatial lateralisation. At the group level, language was lateralised to the left hemisphere, but visuospatial processing was weakly lateralised to the right hemisphere. The relationship between patterns of lateralisation and cognitive skills was investigated …

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Maternal Prenatal Anxiety And Risk Of Preterm Birth And Low Birthweight: Evidence From A Cumulative Meta-Analysis With Stability Thresholds, Bereket Duko, Desta, Biniyam Sahiledengle, Yohannes Tekalegn Efa, Tenaw Tiruye, Lisa Whitehead, Gavin Pereira, Amanuel Tesfay Gebremedhin Jun 2026

Maternal Prenatal Anxiety And Risk Of Preterm Birth And Low Birthweight: Evidence From A Cumulative Meta-Analysis With Stability Thresholds, Bereket Duko, Desta, Biniyam Sahiledengle, Yohannes Tekalegn Efa, Tenaw Tiruye, Lisa Whitehead, Gavin Pereira, Amanuel Tesfay Gebremedhin

Research outputs 2022 to 2026

Background: We conducted cumulative meta-analyses to quantify the degree to which maternal prenatal anxiety impacts preterm birth (PTB) and low birthweight (LBW), and to identify when findings reached stability, enabling confident recommendations for early interventions. Methods: Following PRISMA guidelines, we systematically searched PubMed/MEDLINE, PsycINFO, Scopus, EMBASE, CINAHL (EBSCO), ProQuest, and the Cochrane Library from database inception to May 7, 2025. The methodological quality of included studies was assessed using the Newcastle–Ottawa Scale. Inverse variance weighted random-effects cumulative meta-analysis was performed to pool adjusted odds ratios (AORs) with sequential inclusion of newly published studies. Stability thresholds were computed to assess sufficiency …

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Shape-Based Profiling Of Cortical Bone Mineral Density In Growing Children: A Proof-Of-Concept Pqct Study, Anna Maria Markarian, R. Taaffe, Daniel Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Daniel J. Schiferl, Robert U. Newton Jun 2026

Shape-Based Profiling Of Cortical Bone Mineral Density In Growing Children: A Proof-Of-Concept Pqct Study, Anna Maria Markarian, R. Taaffe, Daniel Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Daniel J. Schiferl, Robert U. Newton

Research outputs 2022 to 2026

Background: Understanding how bones adapt during growth is essential for promoting lifelong skeletal health. Peripheral quantitative computed tomography (pQCT) is a widely used imaging technique for assessing volumetric bone mineral density (vBMD) in pediatric populations; however, conventional methods may obscure subtle cortical adaptations. The primary aim of this study was to evaluate the feasibility of shape-based cortical vBMD profiling, with an exploratory objective of assessing its sensitivity to inter-individual variation in lean mass index (LMI). Methods: Eighteen children (6–12 years) underwent pQCT scanning at the 38% and 66% tibial sites (distal and proximal diaphysis). Cortical vBMD was quantified across three …

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Higher Sodium Intake Is Associated With Episodic Memory Decline In Cognitively Unimpaired Older Males: A 6-Year Longitudinal Study, Francisca Chuwa, Stephanie R. Rainey-Smith, Hilal Salim Said Al Shamsi, Hamid Sohrabi, Kevin Taddei, Colin L. Masters, Ralph N. Martins, Samantha L. Gardener Jun 2026

Higher Sodium Intake Is Associated With Episodic Memory Decline In Cognitively Unimpaired Older Males: A 6-Year Longitudinal Study, Francisca Chuwa, Stephanie R. Rainey-Smith, Hilal Salim Said Al Shamsi, Hamid Sohrabi, Kevin Taddei, Colin L. Masters, Ralph N. Martins, Samantha L. Gardener

Research outputs 2022 to 2026

Recent evidence has suggested an association between high sodium intake and development of cognitive impairment. However, while animal studies demonstrate consistent relationships between sodium intake and cognitive impairment, this relationship remains less clear in humans. Our aim was to investigate the relationship between self-reported baseline sodium intake and cognitive decline over 72 months. Cognitively unimpaired participants (n = 1208) from the Australian Imaging, Biomarkers and Lifestyle study were included (70.87 years of age; 41 % male). Participants completed a food frequency questionnaire to quantify sodium intake and underwent comprehensive neuropsychological assessment at baseline and four additional timepoints, 18 months apart. …

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Aviation Accident Investigation Analysis Methodologies Used By 12 Government Safety Investigation Authorities, Kym Bills, Leesa Costello, Marcus Cattani Jun 2026

Aviation Accident Investigation Analysis Methodologies Used By 12 Government Safety Investigation Authorities, Kym Bills, Leesa Costello, Marcus Cattani

Research outputs 2022 to 2026

Introduction: Leading government Safety Investigation Authorities (SIAs) that investigate major aviation accidents are members of the International Transportation Safety Association (ITSA). Investigation analysis methodology details are rarely included on SIA websites, in final accident reports, shared with peers, or specified by the International Civil Aviation Organization (ICAO). Some ‘New View’ safety researchers assume SIAs don't use systemic methodologies and that accident investigation has little value. Because of the sensitivity of SIA work and need to prioritize safety value from available investigation funding, there has been little academic research on choice and use of investigation analysis methodologies to address these issues …

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Impacts Of The Early Collaborative Intervention On Mother-Preterm Infant Interaction At One Month Of Age: Secondary Analysis Of A Randomized Controlled Trial, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Thomas Abrahamsson, Evalotte Mörelius Jun 2026

Impacts Of The Early Collaborative Intervention On Mother-Preterm Infant Interaction At One Month Of Age: Secondary Analysis Of A Randomized Controlled Trial, Charlotte Sahlén Helmer, Ulrika Birberg Thornberg, Thomas Abrahamsson, Evalotte Mörelius

Research outputs 2022 to 2026

Background A sensitive, well-functioning maternal interaction is vital for healthy infant development. For moderate to late preterm infants, this is even more important as this group of infants are at increased risk of facing neurodevelopmental disorders. The Early Collaborative Intervention supports parent-preterm infant interaction and includes three sessions, two in the hospital and one after discharge. Objective To investigate the impact of the Early Collaborative Intervention, compared with standard care, on mother-preterm infant interaction at one month corrected age. Design A longitudinal randomized controlled trial, reporting secondary outcomes from the first follow-up. Setting The intervention was conducted at a pediatric …

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Defining Varus Thrust Assessment And Measurement: A Scoping Review, Haonan Shen, Nicole D'Souza, Claire E. Hiller, Marnee J. Mckay, Kun Hu, Zhiyong Wang, Milena Simic Jun 2026

Defining Varus Thrust Assessment And Measurement: A Scoping Review, Haonan Shen, Nicole D'Souza, Claire E. Hiller, Marnee J. Mckay, Kun Hu, Zhiyong Wang, Milena Simic

Research outputs 2022 to 2026

Objective: The primary aim of this scoping review was to identify and evaluate the methodologies used for classifying and quantifying varus thrust of the knee during walking. The secondary aim was to report outcomes of reliability, validity, prevalence, and quantitative cutoffs of varus thrust in existing studies. Methods: A systematic literature search was conducted across five electronic databases from inception to April 2024. Studies that reported varus thrust during gait in adults were included. Two independent reviewers extracted data, and data were synthesized based on thrust classification methods, prevalence, reliability, and validity results. Results: A total of 59 studies were …

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Protective Potential Of Minimally Processed, Plant-Derived Foods Against Steatotic Liver Disease In Early Adulthood, Yasmina Tashkent, Jocelyn M. Choo, Steven L. Taylor, Therese A. O'Sullivan, Dujinthan Jayabalan, Sophie J. Miller, Richard Woodman, Luis Calzadilla-Bertot, Oyekoya T. Ayonrinde, Lawrence J. Beilin, Trevor A. Mori, John K. Olynyk, Alan J. Wigg, Kate R. Muller, Leon A. Adams, Geraint B. Rogers Jun 2026

Protective Potential Of Minimally Processed, Plant-Derived Foods Against Steatotic Liver Disease In Early Adulthood, Yasmina Tashkent, Jocelyn M. Choo, Steven L. Taylor, Therese A. O'Sullivan, Dujinthan Jayabalan, Sophie J. Miller, Richard Woodman, Luis Calzadilla-Bertot, Oyekoya T. Ayonrinde, Lawrence J. Beilin, Trevor A. Mori, John K. Olynyk, Alan J. Wigg, Kate R. Muller, Leon A. Adams, Geraint B. Rogers

Research outputs 2022 to 2026

Background & aims: The incidence of steatotic liver disease (SLD) among younger adults is increasing globally. While poor diet is a recognised risk factor, the impact of specific dietary components is unclear. We investigated associations between dietary patterns and SLD markers in younger adults. Methods: Analysis involved 887 members of the Raine Study Generation 2 cohort, assessed at age 27. SLD was defined using a validated MRI volumetric liver fat fraction equation. Dietary intake, assessed by food frequency questionnaires, was summarised using a modified Overall Diet Score (ODS) that classified foods as “healthy” or “unhealthy.” Associations between diet and SLD …

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Body Mass-Normalized Handgrip Strength As A Better Indicator Of General Health Than Absolute Values In Middle-Aged Women, Ricardo M. Lima, Trezise, Sally Poppitt, Amanda Devine, Anthony J. Blazevich Jun 2026

Body Mass-Normalized Handgrip Strength As A Better Indicator Of General Health Than Absolute Values In Middle-Aged Women, Ricardo M. Lima, Trezise, Sally Poppitt, Amanda Devine, Anthony J. Blazevich

Research outputs 2022 to 2026

Objectives: To examine the association between HGS and physical function, quality of life (QoL), and cardiometabolic risk markers in midlife women, and verify potential discrepancies between absolute and relative HGS on these relationships. Study design: This cross-sectional study enrolled 83 participants (50.7±5.3y) who completed handgrip (hydraulic dynamometer), knee extensor and plantar flexor (isokinetic dynamometry) strength tests, and body composition evaluations (DXA). A variety of physical function tests, QoL (SF-36) and cardiometabolic blood markers were also measured. Results: Participants below the cutoff for HGS/body mass (0.34) did not differ in height but were significantly (P<0.01) heavier (80.8±12.8 vs. 68.6±11.4 kg), had higher BMI (30.0±4.2 vs. 25.4±4.0 kg/m2) and body fat (39.9±4.4 …

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Precision Nutrition In Breast Cancer: Towards Patient- And Tumour-Informed Dietary Strategies, Cristina Crespo-García, R. Taaffe, Carolyn Peddle-Mcintyre, Emily Jeffery, John P. Campbell, Robert Thomas, Daniel A. Galvao, Robert U. Newton Jun 2026

Precision Nutrition In Breast Cancer: Towards Patient- And Tumour-Informed Dietary Strategies, Cristina Crespo-García, R. Taaffe, Carolyn Peddle-Mcintyre, Emily Jeffery, John P. Campbell, Robert Thomas, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Dietary strategies are increasingly recognized as important modulators of breast cancer outcomes, acting through effects on metabolic regulation, weight management, hormone signalling, immune function, and the gut microbiome. However, breast cancer heterogeneity and inter-individual variability mean that generic dietary guidelines may not fully capture patient needs. Precision nutrition offers the opportunity to align dietary interventions with tumour subtype, treatment context, and host biology, potentially enhancing therapeutic response and survivorship in patients diagnosed with breast cancer. In this narrative review, we summarize evidence on dietary patterns and prognosis, and explore how targeted interventions, including fasting regimens, ketogenic diets, and caloric restriction, …

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The Effect Of Vigorous Physical Activity On The Incidence Of Kidney Cancer, Lawrence H. Kim, Bang, Daniel Galvao, David P. Smith, Manish I. Patel Jun 2026

The Effect Of Vigorous Physical Activity On The Incidence Of Kidney Cancer, Lawrence H. Kim, Bang, Daniel Galvao, David P. Smith, Manish I. Patel

Research outputs 2022 to 2026

Background: Kidney cancer incidence is increasing. While physical activity can reduce the risk of several cancers, the role of vigorous physical activity (VPA) in kidney cancer prevention remains unclear. We examined associations between physical activity intensity and kidney cancer incidence in a large Australian cohort. Methods: Data were obtained from 267,357 adults aged ≥ 45 years in the New South Wales 45 and Up Study. Physical activity, including walking, moderate physical activity (MPA), and VPA, was self-reported at baseline using the validated Active Australia Survey and categorised according to WHO guidelines. Multivariable Cox proportional hazards models estimated hazard ratios and …

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A Qualitative Exploration Of Unanticipated Effects Experienced By People With Chronic Obstructive Pulmonary Disease Who Participated In Interventions Designed To Reduce Sedentary Behaviour, Fiona Coll, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill Jun 2026

A Qualitative Exploration Of Unanticipated Effects Experienced By People With Chronic Obstructive Pulmonary Disease Who Participated In Interventions Designed To Reduce Sedentary Behaviour, Fiona Coll, Vinicius Cavalheri, Daniel F. Gucciardi, Kylie Hill

Research outputs 2022 to 2026

Introduction: This study explored the lived experiences of people with chronic obstructive pulmonary disease (COPD) who participated in interventions designed to reduce the accumulation of sedentary behaviour in prolonged uninterrupted bouts. Methods: Ten participants with stable COPD participated in a multi-component intervention that spanned over 9 months and was designed to address the intervention message ‘If you have been sitting or resting continuously for 30 min, stand up and move’. Interventions comprised participation in an 8-week programme of supervised exercise training coupled with behaviour change techniques. Throughout the intervention period the person delivering the intervention kept detailed notes of their …

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Dietary Vitamin K Intakes, Chronic Obstructive Pulmonary Disease, Adult Asthma, And Lung Function: A Prospective Cohort Study In The Uk Biobank, Chengfeng Li, Pratik Pokharel, Marc Sim, Kevin Murray, Catherine P. Bondonno, Benjamin H. Parmenter, Liezhou Zhong, Montana Dupuy, Howraman Meteran, Jette Jakobsen, Allan Linneberg, Tilman Kühn, Aedín Cassidy, Nicola P. Bondonno Jun 2026

Dietary Vitamin K Intakes, Chronic Obstructive Pulmonary Disease, Adult Asthma, And Lung Function: A Prospective Cohort Study In The Uk Biobank, Chengfeng Li, Pratik Pokharel, Marc Sim, Kevin Murray, Catherine P. Bondonno, Benjamin H. Parmenter, Liezhou Zhong, Montana Dupuy, Howraman Meteran, Jette Jakobsen, Allan Linneberg, Tilman Kühn, Aedín Cassidy, Nicola P. Bondonno

Research outputs 2022 to 2026

Background: Vitamin K–dependent proteins are important for maintaining lung structure and function, yet few studies have examined dietary vitamin K intake in relation to chronic respiratory disease. Objectives: This study aimed to investigate the associations between dietary intakes of vitamin K1 and vitamin K2 and the incidence of chronic obstructive pulmonary disease (COPD), asthma, and lung function. Methods: We analyzed data from 179,062 UK Biobank participants without COPD or asthma. Associations between dietary vitamin K1 and K2 intakes, estimated using the Oxford WebQ 24-h recall, and incident COPD and asthma, identified through hospital, death, and primary care records, were examined …

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Factors Impacting Western Australian Midwives' Intention To Stay: A Mixed Methods Study, Christine Atkinson, Dianne Bloxsome, Zoe Bradfield, Kate Buchanan, Sarah Dawson, Frances Finch, Sadie Geraghty, Sara Bayes Jun 2026

Factors Impacting Western Australian Midwives' Intention To Stay: A Mixed Methods Study, Christine Atkinson, Dianne Bloxsome, Zoe Bradfield, Kate Buchanan, Sarah Dawson, Frances Finch, Sadie Geraghty, Sara Bayes

Research outputs 2022 to 2026

Problem Midwifery workforce sustainability remains a critical concern for maternity services. Existing literature predominantly focuses on burnout and attrition, offering limited insight into what influences midwives’ decisions to remain within specific workplaces. Background Midwives consistently report strong professional commitment alongside growing workforce instability. National data indicate that uncertainty about current roles does not necessarily reflect disengagement from the profession. Understanding workplace-level influences on retention is therefore essential for targeted workforce strategy. Aim To examine how workplace stress and satisfaction with the practice environment are associated with Western Australian midwives’ intention to stay in their current job and in the profession. …

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Multi-Sensory Information And Simulator Immersion: Impact On Decision-Making Performance, Presence, And Cognitive Load, Zachariah G. Hoyne, Khaya Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker Jun 2026

Multi-Sensory Information And Simulator Immersion: Impact On Decision-Making Performance, Presence, And Cognitive Load, Zachariah G. Hoyne, Khaya Morris-Binelli, Sean Müller, Benjamin Piggott, Paola Chivers, Evan Dekker

Research outputs 2022 to 2026

Immersive technologies such as 360-degree video virtual reality (360VR) provide unique opportunities to simulate representative environments to investigate decision-making in a safe and cost-effective manner. Inclusion of multi-sensory visual, contextual, and auditory information is important to enhance simulator psychological fidelity. Yet, the influence of increased sensory information on decision-making, presence, and cognitive load in 360VR compared to less immersive two-dimensional video simulators is unknown. This study investigated multi-sensory information, presence, and cognitive load across immersion conditions (360VR and two-dimensional video) in an exemplar sport-specific decision-making task. Fifteen higher-skilled and 15 lesser-skilled Australian Rules Football players completed a decision-making task which …

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Occupational Therapy Intervention For Children With Developmental Coordination Disorder: A Survey Of Occupational Therapists In Australia, Jacqui Hunt, Jill G. Zwicker, Annette Raynor, Erin Godecke Jun 2026

Occupational Therapy Intervention For Children With Developmental Coordination Disorder: A Survey Of Occupational Therapists In Australia, Jacqui Hunt, Jill G. Zwicker, Annette Raynor, Erin Godecke

Research outputs 2022 to 2026

Introduction: Developmental coordination disorder (DCD), a common neurodevelopmental condition, is associated with persistent motor and psychosocial difficulties impacting participation and quality of life. International guidelines recommend activity-/participation-focused, task-specific interventions; however, little is known about how Australian occupational therapists translate these recommendations into clinical practice. This study aimed to describe current Australian occupational therapy intervention for children with (or suspected to have) DCD and identify factors that shape occupational therapists' intervention choices. Methods: A cross-sectional online survey was distributed to Australian occupational therapists via professional organisations/social media September–October 2020. Eligible participants were registered occupational therapists with ≥15% children in their caseload. …

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The Interplay Between Osteosarcopenia And Intrinsic Capacity: Insights And Associations With All-Cause Mortality In The Toledo Study For Healthy Aging, Ivan Baltasar-Fernandez, Pedro L. Valenzuela, Irene Rodríguez-Gómez, Fabio Quiñonez-Bareiro, Luis M. Alegre, Konstantinos Prokopidis, Leocadio Rodriguez-Mañas, Ignacio Ara, Oscar Rosas-Carrasco, Lana J. Williams, Robinson Ramirez-Vélez, Julie A. Pasco, Guy Hajj-Boutros, Raman Agnihotram, Marc Sim, Wayne Lok Ok Choo, Mahdi Imani, Ana M. Ayala-Copete, Julia Chabot, Miguel G. Borda, Nailton J. Neto, Claire Godard-Sebillotte, Howard Bergman, Anna Andrianova, Hidenori Arai, Pierrette Gaudreau Jun 2026

The Interplay Between Osteosarcopenia And Intrinsic Capacity: Insights And Associations With All-Cause Mortality In The Toledo Study For Healthy Aging, Ivan Baltasar-Fernandez, Pedro L. Valenzuela, Irene Rodríguez-Gómez, Fabio Quiñonez-Bareiro, Luis M. Alegre, Konstantinos Prokopidis, Leocadio Rodriguez-Mañas, Ignacio Ara, Oscar Rosas-Carrasco, Lana J. Williams, Robinson Ramirez-Vélez, Julie A. Pasco, Guy Hajj-Boutros, Raman Agnihotram, Marc Sim, Wayne Lok Ok Choo, Mahdi Imani, Ana M. Ayala-Copete, Julia Chabot, Miguel G. Borda, Nailton J. Neto, Claire Godard-Sebillotte, Howard Bergman, Anna Andrianova, Hidenori Arai, Pierrette Gaudreau

Research outputs 2022 to 2026

Background: Osteosarcopenia—the coexistence of osteopenia/osteoporosis and sarcopenia—is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults. Methods: We conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1 ± 6.0 years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains. …

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Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond May 2026

Impact Of Travel Time To Health Facilities On Perinatal Outcomes: A Systematic Review With Narrative Synthesis And Meta-Analysis, Sanam Roder-Dewan, Marwa Ramadan, Paul Ouma, Alexander Manu, Emelda A. Okiro, Natalie Strobel, Bibian N. Robert, Emily Odipo, Peter M. Macharia, Anthony Danso-Appiah, David C. Goodman, Queen Dube, Gagan Gupta, Hema Magge, Karen Edmond

Research outputs 2022 to 2026

Background: Evidence-based global guidance on safe travel time for small or sick newborns who require transfer to health facilities after birth is lacking. A two-hour threshold is frequently cited in low- and middle-income countries (LMICs), while 30 minutes is commonly used in high-income countries (HICs). Although these thresholds are widely referenced, their empirical basis and consistency across levels of newborn care and journey types have not been systematically examined. This study synthesises the evidence linking travel time and perinatal outcomes. Methods: We conducted a systematic review with narrative synthesis and meta-analysis to assess the impact of travel time or distance …

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A High-Throughput Assay For Monitoring And Quantifying Amyloid-Β Accumulation And Clearance In Alzheimer's Disease Cell Models, Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M.A.D.Binosha Fernando, Ralph Martins, Prashant Bharadwaj May 2026

A High-Throughput Assay For Monitoring And Quantifying Amyloid-Β Accumulation And Clearance In Alzheimer's Disease Cell Models, Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M.A.D.Binosha Fernando, Ralph Martins, Prashant Bharadwaj

Research outputs 2022 to 2026

Amyloidogenic proteins, such as amyloid-β (Aβ), self-assemble into cross-β fibrils whose accumulation is central to Alzheimer's disease (AD). Measuring Aβ aggregation and clearance in living cells remains challenging using current cell-based assays, which are often low-throughput or not suited for real-time monitoring. This study aimed to (1) develop a robust, quantitative, and scalable fluorescence-based assay using Amytracker to monitor Aβ accumulation and clearance in an Aβ-producing neuronal cell model, and (2) validate its utility for mechanistic studies and therapeutic screening. We established a plate-based fluorescence assay using Amytracker in MC65 neuronal AD model expressing the Amyloid precursor protein C-terminal fragment …

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Circulating Sphingomyelins Correlate With Plasma T-Tau In Cognitively Unimpaired Older Adults At Risk Of Developing Alzheimer's Disease, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Steve Pedrini, Hamid R. Sohrabi, Nicholas J. Ashton, Henrik Zetterberg, Manohar L. Garg, Kaj Blennow, Ralph N. Martins May 2026

Circulating Sphingomyelins Correlate With Plasma T-Tau In Cognitively Unimpaired Older Adults At Risk Of Developing Alzheimer's Disease, Tahmida Sharmin, James D. Doecke, Pratishtha Chatterjee, Steve Pedrini, Hamid R. Sohrabi, Nicholas J. Ashton, Henrik Zetterberg, Manohar L. Garg, Kaj Blennow, Ralph N. Martins

Research outputs 2022 to 2026

Alterations in plasma sphingomyelin (SM) levels have been reported in Alzheimer's disease (AD), pointing to disturbances in lipid metabolism that may contribute to disease pathogenesis. Neuronal damage in early AD triggers tau release into central and peripheral systems. Despite influence from peripheral contributions, alterations in plasma total-tau (T-tau) remain valuable in indicating AD-related neurodegeneration. Investigating relationships between SM metabolism and tau release during preclinical AD may uncover important biochemical processes and support advancing early non-invasive detection and treatment approaches. This cross-sectional study investigated cognitively unimpaired (CU) older adults from the KARVIAH cohort, grouped by cortical amyloid-β (Aβ) status through positron …

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A Systematic Review And Meta-Analysis On The Levels Of Supportive Care Needs In Adults With Cancer, Caroline B. Silveira, Rech, Maria Petropoulou, Pietro S. Rössler, Francine F. De Souza, Helena B. Böhmer, Amanda L. Giacomet, Richard Alejandro B. De Barros, Lucélia De C. De Barros, Vagner R.Z.B. Pereira, Nanci Da S.T. Junqueira, Pedro Lopez May 2026

A Systematic Review And Meta-Analysis On The Levels Of Supportive Care Needs In Adults With Cancer, Caroline B. Silveira, Rech, Maria Petropoulou, Pietro S. Rössler, Francine F. De Souza, Helena B. Böhmer, Amanda L. Giacomet, Richard Alejandro B. De Barros, Lucélia De C. De Barros, Vagner R.Z.B. Pereira, Nanci Da S.T. Junqueira, Pedro Lopez

Research outputs 2022 to 2026

Objective: To estimate the levels of supportive care needs among adults with cancer using the Supportive Care Needs Survey–Short Form 34 (SCNS-SF34) and to examine demographic, clinical, and treatment-related determinants. Methods: A systematic review and meta-analysis was conducted (CRD42024604977). Studies reporting SCNS-SF34 scores in adults with cancer were included. Searches were performed across six different databases (November 2024; updated August 2025). Random-effects meta-analyses were undertaken to estimate the pooled mean scores across the five SCNS-SF34 domains and total score. Subgroup and meta-regression analyses explored potential determinants. Results: Ninety-five studies (n = 32,493) were analysed. The unmet needs observed tended to …

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A Clinical Study Examining The Effects Of Dietary Nitrate On Urinary N-Nitrosamines, Catherine P. Bondonno, Michaela L. Sundqvist, Sujata Shinde, Kevin Croft, Jonathan M. Hodgson, Mattias Carlström, Eddie Weitzberg, Jon O. Lundberg May 2026

A Clinical Study Examining The Effects Of Dietary Nitrate On Urinary N-Nitrosamines, Catherine P. Bondonno, Michaela L. Sundqvist, Sujata Shinde, Kevin Croft, Jonathan M. Hodgson, Mattias Carlström, Eddie Weitzberg, Jon O. Lundberg

Research outputs 2022 to 2026

BackgroundInorganic nitrate from dietary sources has raised health concerns due to its possible conversion into carcinogenic N-nitrosamines, leading to strict regulations on nitrate concentrations in food and drinking water.ObjectivesIn this study, which was a part of a larger randomized controlled trial, we evaluated urinary excretion of N-nitrosamines in response to daily dietary nitrate intake over a 5-wk period using 2 different forms of nitrate administration.MethodsA total of 231 participants with mild hypertension were randomly assigned into 3 groups. Group 1 (n = 78) consumed vegetables low in nitrate along with a placebo capsule (300 mg potassium chloride). Group 2 (n …

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Associations Between Source-Specific Nitrate And Nitrite Intakes And Metabolic Dysfunction-Associated Steatotic Liver Disease In Two Prospective Cohorts, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Liezhou Zhong, Dorit W. Erichsen, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Alysha S. Thompson, Tilman Kühn, Aedín Cassidy, Anja Olsen, Catherine P. Bondonno May 2026

Associations Between Source-Specific Nitrate And Nitrite Intakes And Metabolic Dysfunction-Associated Steatotic Liver Disease In Two Prospective Cohorts, Nicola P. Bondonno, Pratik Pokharel, Benjamin H. Parmenter, Liezhou Zhong, Dorit W. Erichsen, Jörg Schullehner, Kirsten Frederiksen, Cecilie Kyrø, Peter Fjeldstad Hendriksen, Jonathan M. Hodgson, Torben Sigsgaard, Christina C. Dahm, Anne Tjønneland, Alysha S. Thompson, Tilman Kühn, Aedín Cassidy, Anja Olsen, Catherine P. Bondonno

Research outputs 2022 to 2026

SummaryBackground and AimsDietary nitrate and nitrite may have source-dependent effects on liver health: plant-sourced nitrate may confer hepatoprotective benefits via its conversion to nitric oxide, whereas nitrate and nitrite from animal foods, processed meats, or contaminated drinking water may promote liver injury via their conversion to N-nitrosamines. We aimed to examine associations between source-specific nitrate and nitrite intakes and incident metabolic dysfunction-associated steatotic liver disease (MASLD) in two large cohorts. Secondary aims were to assess associations with liver MRI biomarkers and to evaluate whether nitric oxide-pathway gene variants modify associations with plant-sourced nitrate/nitrite.MethodsWe analysed 53,854 participants from the Danish Diet, …

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How Employment-Based Clinical Experience During Undergraduate Education Influences Transition To Practice: A Qualitative Systematic Review, Seung A. Park, Marion Eckert, Rebecca Sharp, Belinda Clark, Micah D.J. Peters May 2026

How Employment-Based Clinical Experience During Undergraduate Education Influences Transition To Practice: A Qualitative Systematic Review, Seung A. Park, Marion Eckert, Rebecca Sharp, Belinda Clark, Micah D.J. Peters

Research outputs 2022 to 2026

Aim: To synthesize qualitative evidence on the experiences of undergraduate nursing students and new graduate nurses engaged in formal paid employment models or health-related work during their undergraduate studies, to examine how these employment-based clinical experiences influence their transition to nursing practice, and to identify elements that facilitate or hinder this transition. Design: Qualitative systematic review. Methods: Searches were conducted in MEDLINE, Embase, Emcare (Ovid), CINAHL Complete (EBSCOhost), ERIC (ProQuest), and gray literature sources, including ProQuest Dissertations and Theses and Google Scholar. No date or country limits were applied, although only English-language studies were included. The review followed JBI methodology …

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A Comparison Of Treadmill Preferred Walking Speed Assessments: Reliability Of Common Protocols And The Novel Treadpws Test, Kirsty A. Mcdonald, Ella Li, John Kerr, Jessica C. Selinger, Kimberley S. Van Schooten May 2026

A Comparison Of Treadmill Preferred Walking Speed Assessments: Reliability Of Common Protocols And The Novel Treadpws Test, Kirsty A. Mcdonald, Ella Li, John Kerr, Jessica C. Selinger, Kimberley S. Van Schooten

Research outputs 2022 to 2026

Background: Human locomotion studies often require participants to self-select a preferred walking speed (PWS), yet there is no consensus or standard protocol for determining this speed. We developed a new protocol to determine PWS (TreadPWS Test). Research question: We compared the TreadPWS Test to three other common protocols in the literature (Dingwell PWS Test, Jordan PWS Test, Dal PWS Test) across a range of reliability and implementation metrics. Methods: Healthy participants (N = 20) attended two sessions within a seven-day period, during which a PWS was determined using each protocol. One test (Dal PWS Test) was conducted overground, and the …

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