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Research outputs 2022 to 2026

Articles 121 - 150 of 2205

Full-Text Articles in Medicine and Health Sciences

Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy Mar 2026

Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy

Research outputs 2022 to 2026

Background and aim: Higher dietary flavonoid intake has been associated with lower risks of mortality and major chronic disease, yet its relationship with psychological well-being (PWB), a key contributor to health and quality of life, remains unclear. This study aimed to investigate bidirectional associations between dietary flavonoid intake and two PWB facets: happiness (positive emotional state) and optimism (generalized expectation of positive outcomes). Specifically, we examined whether (1) overall flavonoid-rich dietary patterns (flavodiet score), (2) intake of specific flavonoid-rich foods, and (3) total flavonoid and subclass intakes were each associated with happiness and optimism over time. Methods: Data were drawn …

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Psychosocial Determinants Of Hand Hygiene Practices Among Children And Adolescents Living With Hiv In The Northern City Of Malawi, Balwani Chingatichifwe Mbakaya, Maggie Zgambo, Richard Moyo, Paul Uchizi Kaseka, Obed Nkhata, Fatch Kalembo Feb 2026

Psychosocial Determinants Of Hand Hygiene Practices Among Children And Adolescents Living With Hiv In The Northern City Of Malawi, Balwani Chingatichifwe Mbakaya, Maggie Zgambo, Richard Moyo, Paul Uchizi Kaseka, Obed Nkhata, Fatch Kalembo

Research outputs 2022 to 2026

Background: The common cause of death in HIV and AIDS patients are opportunistic infections such as diarrhoea, acute respiratory infections, and skin conditions. Many of these infections are spread through contaminated hands. Therefore, this study aimed at exploring hand hygiene practices among HIV positive children and adolescents in Mzuzu City, Malawi. Methodology: A cross-sectional study was used to collect data from children and adolescents living with HIV (aged between 9 and 18 years) WHO were attending teen clubs in Mzuzu City. Data were analysed using Stata 17. Chi-Square and logistic regression analysis were used to examine the association among multiple …

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Remnant Cholesterol And Atherosclerotic Cardiovascular Disease Risk In Populations With Different Low-Density Lipoprotein Cholesterol Elevations: A Prospective Cohort Study, Hong Zheng, Guanlin Chen, Zhenyu Huo, Yulong Lan, Yuxian Wang, Peng Fu, Weiqiang Wu, Haixiang Zheng, Kuangyi Wu, Zegui Huang, Dan Wu, Shouling Wu, Youren Chen Feb 2026

Remnant Cholesterol And Atherosclerotic Cardiovascular Disease Risk In Populations With Different Low-Density Lipoprotein Cholesterol Elevations: A Prospective Cohort Study, Hong Zheng, Guanlin Chen, Zhenyu Huo, Yulong Lan, Yuxian Wang, Peng Fu, Weiqiang Wu, Haixiang Zheng, Kuangyi Wu, Zegui Huang, Dan Wu, Shouling Wu, Youren Chen

Research outputs 2022 to 2026

Background: Low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) are risk factors for atherosclerotic cardiovascular disease (ASCVD). However, the extent to which differences in RC levels affect ASCVD risk in populations with varying degrees of LDL-C elevation remains unclear. This study aimed to investigate whether RC can provide additional risk stratification value across different sexes, ages, and elevated LDL-C statuses. Methods: This study included 12 743 elevated LDL-C participants (LDL-C ≥3.4 mmol/L) and 50 073 age- and sex-matched non-elevated LDL-C controls from the Kailuan Study. Elevated LDL-C participants were categorized by RC levels into <0.5, 0.5 to <1.0, and ≥1.0 mmol/L subgroups. Kaplan-Meier curves and Cox proportional hazards models were used to assess the relationship between RC levels and ASCVD risk across different sexes, ages, and high LDL-C statuses. Results: During a median follow-up of 12.8 years, 1686 elevated LDL-C participants (13.2%) and 5252 non-elevated LDL-C participants (10.5%) developed ASCVD. In the borderline-high LDL-C group (3.4 ≤ LDL-C < 4.1 mmol/L), those with the lowest RC levels showed no significant risk difference compared with controls (hazard ratio [HR], 1.03 [95% CI, 0.93-1.13]), and this pattern remained consistent across different sexes and ages. In contrast, in the high LDL-C group (LDL-C ≥4.1 mmol/L), even when RC was at the lowest level, ASCVD risk remained significantly higher than that of controls (HR, 1.20 [95% CI, 1.02-1.41]). CONCLUSIONS: In the borderline-high LDL-C population, those with the lowest RC levels showed no significant risk difference compared with controls, and this pattern remained consistent across different sexes and age subgroups. In the high LDL-C population, even when RC was at the lowest level, ASCVD risk remained significantly higher than that of controls.

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Perceptions Of Ischaemic Heart Disease Risk Among Indian Migrants In Australia: A Qualitative Study, Kunwar Kaur, Ma'en Zaid Abu-Qamar, Amineh Rashidi, Nilufeur Mckay, Rosemary Saunders Feb 2026

Perceptions Of Ischaemic Heart Disease Risk Among Indian Migrants In Australia: A Qualitative Study, Kunwar Kaur, Ma'en Zaid Abu-Qamar, Amineh Rashidi, Nilufeur Mckay, Rosemary Saunders

Research outputs 2022 to 2026

Background: Ischaemic heart disease (IHD) is a global health issue, with people of Indian origin facing earlier onset and more severe cases, leading to higher mortality at younger ages compared to Western countries. Indian migrants maintain similar risks post-migration. Managing modifiable risk factors and improving risk knowledge and health-seeking behaviours are essential, but research on IHD risk perceptions among Indian migrants is limited. Aim: This study explores how first-generation Indian migrants perceive their IHD risk and the factors influencing these perceptions. Methods: As a component of a mixed- method study, a qualitative descriptive study design was employed to examine study …

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Immediate Skin-To-Skin Contact At Very Preterm Birth And Effect On Infant Socio-Emotional Stress Response And Mother–Infant Cortisol Co-Regulation: Secondary Outcomes From The Randomised Clinical Immediate Parent-Infant Skin-To-Skin Study (Ipistoss), Karoline Lode-Kolz, Siri Lillieskold, Hanne Brit Hetland, Eleonora Mascheroni, Stina Klemming, Hanne Pike, Agnes Linner, Nils J. Bergman, Bjorn Westrup, Ulrika Ådén, Evalotte Morelius, Rosario Montirosso, Wibke Jonas, Siren Rettedal Feb 2026

Immediate Skin-To-Skin Contact At Very Preterm Birth And Effect On Infant Socio-Emotional Stress Response And Mother–Infant Cortisol Co-Regulation: Secondary Outcomes From The Randomised Clinical Immediate Parent-Infant Skin-To-Skin Study (Ipistoss), Karoline Lode-Kolz, Siri Lillieskold, Hanne Brit Hetland, Eleonora Mascheroni, Stina Klemming, Hanne Pike, Agnes Linner, Nils J. Bergman, Bjorn Westrup, Ulrika Ådén, Evalotte Morelius, Rosario Montirosso, Wibke Jonas, Siren Rettedal

Research outputs 2022 to 2026

Objective To explore the effects of immediate parent–infant skin-to-skin contact (iSSC) at very preterm birth on maternal–infant behavioural responses and hypothalamic–pituitary–adrenal (HPA) axis reactivity to age-appropriate socio-emotional stress at 4months corrected age. Design Two secondary outcomes from a multicentre randomised controlled trial with two non-blinded parallel groups. Setting Three Scandinavian neonatal intensive care units, level 2 and level 3. Participants 91 infants born at gestational age 28+0to 32+6 from April 2018 to June 2021. Singletons and twins with a second caregiver present were included, regardless of mode of birth. Higher-order births, infants with congenital infections and major malformations were excluded. …

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Pathological Response Calculation Assessment Remains Accurate With Reduced Tumor Bed Examination After Neoadjuvant Immunotherapy In Clinically Detectable Stage Iii Melanoma, R. V. Rawson, N. G. Maher, A. M. Menzies, S. N. Lo, N. Mesbah Ardakani, L. A. Jackett, I. A. Vergara, T. E. Pennington, K. F. Shannon, S. Ch’Ng, M. Gonzalez, E. M. Burton, M. W. Lucas, I. L.M. Reijers, E. A. Rozeman, D. E. Gyorki, S. Sandhu, M. S. Carlino, J. Howle, M. Khattak, A. Van Der Westhuizen, M. C. Andrews, V. Atkinson, A. C.J. Van Akkooi, A. J. Spillane, R. P.M. Saw Feb 2026

Pathological Response Calculation Assessment Remains Accurate With Reduced Tumor Bed Examination After Neoadjuvant Immunotherapy In Clinically Detectable Stage Iii Melanoma, R. V. Rawson, N. G. Maher, A. M. Menzies, S. N. Lo, N. Mesbah Ardakani, L. A. Jackett, I. A. Vergara, T. E. Pennington, K. F. Shannon, S. Ch’Ng, M. Gonzalez, E. M. Burton, M. W. Lucas, I. L.M. Reijers, E. A. Rozeman, D. E. Gyorki, S. Sandhu, M. S. Carlino, J. Howle, M. Khattak, A. Van Der Westhuizen, M. C. Andrews, V. Atkinson, A. C.J. Van Akkooi, A. J. Spillane, R. P.M. Saw

Research outputs 2022 to 2026

Background: Neoadjuvant immunotherapy produces event-free survival advantage over adjuvant therapy for patients with surgically resectable macroscopic stage IIIB/C/D melanoma. Pathological response, determined as percentage residual viable tumor (% RVT), provides critical prognostic information and informs management decisions. Here, we assessed accuracy of %RVT calculation when reduced tumor bed (TB) was examined and leverage these results proposing streamlined protocols for pathological examination. Patients and methods: Comprehensive histopathological examination was carried out on 134 patient specimens after neoadjuvant immunotherapy with ipilimumab and nivolumab. Impact on %RVT when evaluating less TB than recommended by the initial International Neoadjuvant Melanoma Consortium (INMC) protocol was …

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Children's Experiences Of Functional Constipation: A Qualitative Reflexive Thematic Analysis, Gunilla Flankegård, Patrik Rytterström, Berit M. Gustafsson, Evalotte Mörelius Feb 2026

Children's Experiences Of Functional Constipation: A Qualitative Reflexive Thematic Analysis, Gunilla Flankegård, Patrik Rytterström, Berit M. Gustafsson, Evalotte Mörelius

Research outputs 2022 to 2026

Background: Childhood functional constipation, a common concern within child healthcare, necessitates oral and rectal medical treatments, that are mostly administered by parents in the home environment. It is important to gather children's perspectives in child- and family-centred care. The private nature of toileting, bowel movements, and faecal incontinence are areas of taboo and stigmatisation. Research is scarce on how children perceive this common but private situation of oral and rectal constipation treatment. Objective: To explore children's experiences of functional constipation and its treatments. Design: A qualitative interview study with a constructionist epistemology and a predominantly experiential orientation. Setting: Individual interviews …

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Contemporary Structures, Processes, And Outcomes Of Critical Care Nursing Education: An Integrative Review, Farida Saghafi, Carol Grech, Belinda Causby, Angelique Clarke, Jacqueline Jauncey-Cooke, Deb Massey, Kaye Rolls, Kylie Thompson, Melanie Greenwood Feb 2026

Contemporary Structures, Processes, And Outcomes Of Critical Care Nursing Education: An Integrative Review, Farida Saghafi, Carol Grech, Belinda Causby, Angelique Clarke, Jacqueline Jauncey-Cooke, Deb Massey, Kaye Rolls, Kylie Thompson, Melanie Greenwood

Research outputs 2022 to 2026

Objective: The critical care workforce requires nurses who are specialised, educated, and adaptable to manage complex situations, with the capability to make informed decisions for optimal patient care. The Australian College of Critical Care Nurses supports evidence-based practice through an education position statement, which is periodically updated to reflect evolving needs. In this review, our aim was to inform revisions to the position statement on critical care nurse education by examining the structure, processes, and outcomes of contemporary education programs designed to enhance the capability of registered nurses working in critical care environments internationally. Review method used: An integrative review …

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Intrapartum Experiences Of Gestational Surrogates And Intended Parents In Australia: A Qualitative Study, Jutharat Attawet, Leo Ng, Evie Kendal, Yunjing Qiu, Myles Ojabo, Sarah Jefford, Micah D.J. Peters Feb 2026

Intrapartum Experiences Of Gestational Surrogates And Intended Parents In Australia: A Qualitative Study, Jutharat Attawet, Leo Ng, Evie Kendal, Yunjing Qiu, Myles Ojabo, Sarah Jefford, Micah D.J. Peters

Research outputs 2022 to 2026

Background Gestational surrogacy is an increasingly visible, though tightly regulated, pathway to parenthood in Australia, yet intrapartum care remains under-examined. Existing maternity models are grounded in woman-centred care and offer limited guidance for births involving surrogates and intended parents within a triadic care relationship. Objectives To describe the intrapartum experiences of gestational surrogates and intended parents in Australia and to identify care processes that support or hinder respectful, inclusive practice. Methods A descriptive qualitative study was conducted with purposive sampling. Seventeen participants took part between December 2024 and May 2025, comprising nine gestational surrogates and eight intended parents who had …

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Pediatric Pqct-Derived Tibial Bone Mineral Density Estimates: A Systematic Review And Meta-Regression, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Mark Markarian, Daniel J. Schiferl, Robert U. Newton Feb 2026

Pediatric Pqct-Derived Tibial Bone Mineral Density Estimates: A Systematic Review And Meta-Regression, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Jodie Cochrane Wilkie, Carolyn J. Peddle-Mcintyre, Mark Markarian, Daniel J. Schiferl, Robert U. Newton

Research outputs 2022 to 2026

Background: Assessing bone mineral density (BMD) in children and adolescents is essential for detecting skeletal deficits and fracture risk. Peripheral quantitative computed tomography (pQCT) has gained increasing attention as a valuable imaging tool due to its ability to assess bone quality. Unlike dual-energy x-ray absorptiometry, pQCT provides volumetric BMD measurements and distinguishes between cortical and trabecular compartments. Despite these advantages, its clinical adoption remains limited due to the lack of reference data and standardized protocols. Methods: A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science from inception to November 2024. Studies reporting pQCT-derived tibial BMD …

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Evaluation Of Host-Immune Biomarker Signatures As Multiplex Qpcr Diagnostic Assays: A Pilot Study Toward Meeting Who Target Product Profiles For Tb Diagnosis In India, Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, Saka Vinod Kumar, Sanjeev Kumar, Seshadri S. Vasan, Karen Elizabeth Kempsell Feb 2026

Evaluation Of Host-Immune Biomarker Signatures As Multiplex Qpcr Diagnostic Assays: A Pilot Study Toward Meeting Who Target Product Profiles For Tb Diagnosis In India, Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, Saka Vinod Kumar, Sanjeev Kumar, Seshadri S. Vasan, Karen Elizabeth Kempsell

Research outputs 2022 to 2026

Background: Tuberculosis (TB) remains the leading cause of death from a single infectious agent. Current diagnostic tools are limited, especially in low-resource settings. The World Health Organization's (WHO) Target Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-human primate (NHP) TB infection study dataset (GSE76703) and two previously published human datasets (GSE144127, GSE42834), which include other disease group comparators, including sarcoidosis. These were also evaluated in a small-scale, exploratory qPCR pilot study to assess the feasibility …

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Feasibility And Implementation Of Interval-Gap4: A Global Randomised Controlled Trial Of Intense Hybrid-Supervised/Self-Managed Versus Self-Directed Exercise For Metastatic Prostate Cancer, Stacey A. Kenfield, Nicolas H. Hart, Kerry S. Courneya, Rosemary Greenwood, June M. Chan, Jennette Sison, Li Zhang, Sarah Rudman, Leah Ung, Moritz Schumann, Erin L. Van Blarigan, Sam Mckeown, Charles J. Ryan, James Catto, Daniel A. Galvão, Robert U. Newton, Fred Saad Feb 2026

Feasibility And Implementation Of Interval-Gap4: A Global Randomised Controlled Trial Of Intense Hybrid-Supervised/Self-Managed Versus Self-Directed Exercise For Metastatic Prostate Cancer, Stacey A. Kenfield, Nicolas H. Hart, Kerry S. Courneya, Rosemary Greenwood, June M. Chan, Jennette Sison, Li Zhang, Sarah Rudman, Leah Ung, Moritz Schumann, Erin L. Van Blarigan, Sam Mckeown, Charles J. Ryan, James Catto, Daniel A. Galvão, Robert U. Newton, Fred Saad

Research outputs 2022 to 2026

Background and objective: Physical activity is associated with a lower risk of mortality in men with prostate cancer (PC); yet, randomised controlled trials with survival endpoints are nonexistent. INTense ExeRcise for surviVAL-Global Action Plan 4 (INTERVAL-GAP4) was a global phase 3 trial designed to test whether structured, hybrid-supervised/self-managed exercise improves survival in men with metastatic PC. The trial was stopped early due to poor accrual. This paper reports feasibility and implementation outcomes. Methods: Men with metastatic PC were randomised (1:1) to a supervised/self-managed moderate- to high-intensity resistance and aerobic programme (three sessions per week for 2 yr) or to self-directed …

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Making It Up As We Go: Midwives’ Perceptions Of Preparedness And Role Clarity In Surrogacy Birth Care, Jutharat Attawet, Leo Ng, Yunjing Qiu, Evie Kendal, Myles Ojabo, Sarah Jefford, Micah D.J. Peters Feb 2026

Making It Up As We Go: Midwives’ Perceptions Of Preparedness And Role Clarity In Surrogacy Birth Care, Jutharat Attawet, Leo Ng, Yunjing Qiu, Evie Kendal, Myles Ojabo, Sarah Jefford, Micah D.J. Peters

Research outputs 2022 to 2026

Background Surrogacy poses unique clinical, psychosocial, and organisational challenges. Midwives, often with limited experience, education, and guidance, may feel uncertain about providing appropriate care, potentially affecting the quality of care and experiences of surrogates, intended parents, and newborns. Objective This study explored how midwives navigate surrogacy birth care, with a focus on role clarity, involvement of intended parents, and preparedness across the intrapartum and postnatal continuum. Method An interpretative phenomenological design was adopted. Five midwives with experience in surrogacy births were recruited through professional networks and the Australian College of Midwives newsletter. In-depth interviews were conducted and analysed using reflexive …

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Missed Care Prevalence And Associated Factors In Acute Care Settings: A Systematic Review And Meta-Analysis, Afia Achiaa Sarpong, Lucy Gent, Amanda Towell-Barnard, Diana Arabiat Feb 2026

Missed Care Prevalence And Associated Factors In Acute Care Settings: A Systematic Review And Meta-Analysis, Afia Achiaa Sarpong, Lucy Gent, Amanda Towell-Barnard, Diana Arabiat

Research outputs 2022 to 2026

Aim: The aim of the study was to comprehensively analyse the prevalence and factors associated with missed nursing care in acute care settings. Methods: A systematic review was conducted to estimate the prevalence of missed nursing care, types of activities missed and associated factors in acute care hospital settings. Five electronic databases (CINAHL, Embase, Medline, PubMed and Scopus) were searched from inception to 14th December 2022. Type of missed care and associated factors were classified based on missed care concepts, definition and measurement. Random effects meta-analysis was performed to estimate proportions and levels of types of nursing activities missed. Results: …

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Peak Lower Limb Joint Angles Are Weak Predictors Of Hamstring Length Change During Sprinting, Shayne Vial, Jodie Cochrane Wilkie, Anthony J. Blazevich, Daniel Kadlec Feb 2026

Peak Lower Limb Joint Angles Are Weak Predictors Of Hamstring Length Change During Sprinting, Shayne Vial, Jodie Cochrane Wilkie, Anthony J. Blazevich, Daniel Kadlec

Research outputs 2022 to 2026

Non-contact hamstring injuries (HSIs) commonly occur during the late swing phase of sprinting, when muscle–tendon units (MTUs) approach maximum length. Although sagittal-plane pelvis, hip and knee angles are often used as surrogate measures of overall hamstring lengthening, their predictive validity remains uncertain. This study investigated whether peak three-dimensional lower limb joint angles predict length change in the biarticular hamstring MTUs from peak hip flexion through to toe off (0–100 %) in fourteen intermediate-level male soccer players sprinting at maximal speed (8.56 ± 0.47 m·s−1). Participant-specific musculoskeletal models were used to compute MTU lengths for the biceps femoris long head (BFlh), …

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Carbohydrate Restriction Drives Greater Perturbations In Circulating Metabolites Than Low Energy Availability In Elite Male Athletes, Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K.A. Mckay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke Feb 2026

Carbohydrate Restriction Drives Greater Perturbations In Circulating Metabolites Than Low Energy Availability In Elite Male Athletes, Kyle A. Dunlop, Nathan G. Lawler, Jamie Whitfield, Alannah K.A. Mckay, Nicolin Tee, Megan L. Ross, Stacey N. Reinke, John A. Hawley, David Broadhurst, Louise M. Burke

Research outputs 2022 to 2026

Periods of low energy availability (LEA) are common in elite athletes and typically arise from reduced energy intake, often involving some degree of carbohydrate (CHO) restriction. Whether the metabolic profile created by energy restriction per se is distinct compared to that driven by CHO restriction is unknown. Using untargeted metabolomics, we examined metabolic perturbations linked to CHO restriction and energy restriction in plasma from elite male endurance athletes. In a semi-randomized controlled trial, athletes (n = 20) completed one of three 5-day dietary interventions: high energy-high CHO (HCHO); LEA (energy-restricted, CHO-reduced); or low-CHO, high-fat (LCHF; energy-matched, CHO-restricted). Plasma samples were …

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Back-On-Track: Protocol For Randomised Controlled Feasibility Trial Of Behavioural Activation In Farmers With Mood Problems, Alison Kennedy, Richard Gray, Martin Jones, Anna Greene, Lauren Mitchell, Meera Senthuren, Suzy Malseed, Feby Savira, Kelly Barnes, Kate Gunn, Susan Brumby Feb 2026

Back-On-Track: Protocol For Randomised Controlled Feasibility Trial Of Behavioural Activation In Farmers With Mood Problems, Alison Kennedy, Richard Gray, Martin Jones, Anna Greene, Lauren Mitchell, Meera Senthuren, Suzy Malseed, Feby Savira, Kelly Barnes, Kate Gunn, Susan Brumby

Research outputs 2022 to 2026

The mental health of people living in farming communities has been identified as an important public health issue. Cumulative exposure to a range of situational factors contributes to heightened risk of poor mental health and suicide. Access to evidence-based psychological treatments is limited by the availability of skilled mental health professionals. The aim of this trial—co-designed by members of the farming community—is to establish the feasibility of conducting randomised controlled, trial-testing, peer-worker-delivered Behavioural Activation in the farming community. We will undertake a single-blind, parallel group, randomised controlled feasibility trial in rural Australia. People living in farming communities aged over 15 …

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Comment On ‘Muscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study’ By Chien Et Al., Ricardo M. Lima, Anthony J. Blazevich Feb 2026

Comment On ‘Muscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study’ By Chien Et Al., Ricardo M. Lima, Anthony J. Blazevich

Research outputs 2022 to 2026

No abstract provided.

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Harmonizing Neuropsychological Test Data Across Prospective Studies, Rosita Shishegar, James D. Doecke, Yen Ying Lim, Pierrick Bourgeat, Vincent Dore, Bhargav Tallapragada, Simon M. Laws, Tenielle Porter, Samantha Burnham, Azadeh Feizpour, Ashley Gillman, Michael Weiner, Jason Hassenstab, Christopher C. Rowe, Victor L. Villemagne, Colin L. Masters, Jurgen Fripp, Hamid Sohrabi, Paul Maruff Feb 2026

Harmonizing Neuropsychological Test Data Across Prospective Studies, Rosita Shishegar, James D. Doecke, Yen Ying Lim, Pierrick Bourgeat, Vincent Dore, Bhargav Tallapragada, Simon M. Laws, Tenielle Porter, Samantha Burnham, Azadeh Feizpour, Ashley Gillman, Michael Weiner, Jason Hassenstab, Christopher C. Rowe, Victor L. Villemagne, Colin L. Masters, Jurgen Fripp, Hamid Sohrabi, Paul Maruff

Research outputs 2022 to 2026

Introduction: Alzheimer's disease (AD) research relies on large datasets and advanced statistical models. However, individual population studies often lack sufficient sample size for conclusive results. Harmonizing cognitive test data across studies can address this gap, despite differences in testing protocols. This study harmonizes cognitive data from three major AD cohorts to support robust clinical–pathological modelling. Methods: Information from the Alzheimer's Disease Neuroimaging Initiative (N = 1446); Australian Imaging, Biomarkers and Lifestyle (N = 1764); and Open Access Series of Imaging Studies-3 (N = 440) were integrated, including cognitive scores, demographics, genetics, and clinical and neuroimaging data. Neuropsychological tests relevant to …

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Increasing Phytochemical-Rich Foods And Lactobacillus Probiotics In Men With Low-Risk Prostate Cancer – A Randomised, Double-Blind, Placebo-Controlled Trial, Robert J. Thomas, Stacey A. Kenfield, Madeleine Williams, Robert U. Newton, Jeffrey Aldous, Anita Mitra, Zahoor Fazili Feb 2026

Increasing Phytochemical-Rich Foods And Lactobacillus Probiotics In Men With Low-Risk Prostate Cancer – A Randomised, Double-Blind, Placebo-Controlled Trial, Robert J. Thomas, Stacey A. Kenfield, Madeleine Williams, Robert U. Newton, Jeffrey Aldous, Anita Mitra, Zahoor Fazili

Research outputs 2022 to 2026

Men on active surveillance (AS), with prostate cancer, are very interested in dietary strategies that could improve their symptoms and help prevent progression of their disease. In this real-world trial involving 208 men, intake of phytochemical-rich food capsules helped slow prostate-specific antigen (PSA) progression significantly, and improved urinary symptoms and erectile function. What was novel about this study was that men randomised to take an additional blend of five Lactobacillus probiotics had a further three-fold slowing of PSA progression as well as reduction of inflammation. Currently, nearly 50% of men opt out of AS within 5 yr. If confirmed with …

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Novel Small-Molecule Analogues Of Iu1 Ameliorate Amyloid-Β Mediated Toxicity In Alzheimer’S Disease Cell And Worm Models, Ajish Ariyath, Fraulein Denise Arigo, Izhar Wallach, W. M.A.D.Binosha Fernando, Ralph N. Martins, Prashant Bharadwaj Feb 2026

Novel Small-Molecule Analogues Of Iu1 Ameliorate Amyloid-Β Mediated Toxicity In Alzheimer’S Disease Cell And Worm Models, Ajish Ariyath, Fraulein Denise Arigo, Izhar Wallach, W. M.A.D.Binosha Fernando, Ralph N. Martins, Prashant Bharadwaj

Research outputs 2022 to 2026

Dysregulation of the deubiquitinating enzyme Ubiquitin-specific peptidase 14 (USP14) is implicated in several neurodegenerative diseases, and IU1, an allosteric inhibitor, has shown neuroprotective effects by reducing protein aggregate toxicity. This study aimed to develop new IU1 analogues and evaluate their ability to mitigate amyloid-β (Aβ) accumulation and toxicity in Alzheimer’s disease (AD) cell and Caenorhabditis elegans worm models. IU1 and 71 newly designed analogues identified using the AtomNet® virtual screening platform were assessed in an amyloid precursor protein-C terminal fragment/amyloid-β (APP-C99/Aβ)-producing AD cell model using a high-throughput toxicity assay. Lead compounds were further evaluated for their effects on neurodegeneration, …

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Plasma Biomarker Progression Across The Alzheimer's Disease Amyloid Beta And Tau Positron Emission Tomography Trajectories, Rodrigo Cánovas, Christopher J. Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S. Saad, Gallen Triana-Baltzer, Hartmuth C. Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W. Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C. Rowe, Colin L. Masters, James D. Doecke Feb 2026

Plasma Biomarker Progression Across The Alzheimer's Disease Amyloid Beta And Tau Positron Emission Tomography Trajectories, Rodrigo Cánovas, Christopher J. Fowler, Azadeh Feizpour, Vincent Dóre, Pierrick Bourgeat, Ziad S. Saad, Gallen Triana-Baltzer, Hartmuth C. Kolb, Manu Vandijck, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Jurgen Fripp, Simon Laws, Anthony W. Bannon, Kaj Blennow, Henrik Zetterberg, Stephanie Rainey-Smith, Sulantha Mathotaarachchi, Christopher C. Rowe, Colin L. Masters, James D. Doecke

Research outputs 2022 to 2026

Introduction: With increased uptake in disease-modifying treatments for amyloid beta (Aβ) removal, it is important to measure performance of highly sensitive plasma biomarkers to detect the presence of Aβ and tau in cognitively impaired populations. Methods: In this study, we investigated a large set of plasma biomarkers for their capability to predict Aβ and tau positron emission tomography (PET) and their association with increasing Aβ and tau burden. RESULTS: From the biomarkers assessed, tau phosphorylated at threonine 217 (pTau217) showed the largest increases across the full range of Aβ and tau levels. Furthermore, pTau217/Aβ42 had the smallest proportion of participants …

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Regulation Of Autophagy-Mediated Pathways By Diet, Physical Activity, And Sleep In Alzheimer's Disease, Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M.A.D.Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey-Smith, Ralph Martins, Prashant Bharadwaj Feb 2026

Regulation Of Autophagy-Mediated Pathways By Diet, Physical Activity, And Sleep In Alzheimer's Disease, Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M.A.D.Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey-Smith, Ralph Martins, Prashant Bharadwaj

Research outputs 2022 to 2026

Alzheimer's disease (AD) is a progressive, age-related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction. Autophagy, a cellular degradation and recycling process, plays a vital role in maintaining neuronal health and is increasingly recognized as a therapeutic target in AD. Lifestyle factors such as diet, physical activity, and sleep can positively influence autophagy and support cognitive function. Intermittent fasting (IF) and calorie restriction (CR) activate autophagy and promote longevity; physical activity enhances cerebral blood flow and …

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Taurine Supplementation And Human Heat Tolerance: Mechanisms, Evidence, And Integration With Heat Acclimation, Cooling, And Hydration, Siavash Naddafha, Jeffrey R. Stout, Cassandra Evans Feb 2026

Taurine Supplementation And Human Heat Tolerance: Mechanisms, Evidence, And Integration With Heat Acclimation, Cooling, And Hydration, Siavash Naddafha, Jeffrey R. Stout, Cassandra Evans

Research outputs 2022 to 2026

Heat exposure during strenuous exercise increases core temperature and cardiovascular strain, impairing performance and elevating the risk of heat illness. Standard countermeasures include heat acclimation, cooling, and hydration/electrolyte planning. Taurine is a sulfur-containing amino acid present in excitable tissues and widely used as an oral supplement; emerging human trials suggest it can augment thermoregulation, primarily by enhancing eccrine sweating and evaporative heat loss. This narrative review synthesizes mechanistic and applied evidence on taurine during exercise in hot environments and evaluates potential interactions with acclimation, cooling strategies (pre- and per-cooling), and hydration practices. Across a small number of randomized, mostly double-blind …

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Identification Of Slc3a2 As A Potential Therapeutic Target Of Ferroptosis In Bladder Cancer, Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S. Gray Jan 2026

Identification Of Slc3a2 As A Potential Therapeutic Target Of Ferroptosis In Bladder Cancer, Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S. Gray

Research outputs 2022 to 2026

Bladder cancer (BC) represents the most prevalent malignancy within the urinary system. Mounting evidence underscores the critical involvement of ferroptosis in cancer pathogenesis; Consequently, this study delves into its molecular underpinnings and therapeutic potential specifically in BC. Methods: We analyzed gene expression profiles from The Cancer Genome Atlas (TCGA) and the Gene Expression Om-nibus (GEO) repositories. Ferroptosis-related genes (FRGs) were selected from the FerrDb database. Utilizing systematic bioinformatics analyses, we identify differentially expressed and prognostic FRGs and construct an FRGs prognostic model. Combined with protein-protein interaction (PPI) analysis, solute carrier family 3 member 2 (SLC3A2) was selected for further study. …

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Evaluating The Efficacy Of Aerobic Exercise As Therapy For Depression And Anxiety In Women With Pcos: A Systematic Review, Lorna Evelyn Mansell, Caitlin Fox-Harding, Robert U. Newton, Pedro Lopez Da Cruz, Sara Bayes, Favil Singh Jan 2026

Evaluating The Efficacy Of Aerobic Exercise As Therapy For Depression And Anxiety In Women With Pcos: A Systematic Review, Lorna Evelyn Mansell, Caitlin Fox-Harding, Robert U. Newton, Pedro Lopez Da Cruz, Sara Bayes, Favil Singh

Research outputs 2022 to 2026

Objective This systematic review aims to evaluate the effectiveness of exercise interventions in alleviating depression and anxiety symptoms in women with polycystic ovary syndrome (PCOS). Data sources PubMed, CINAHL, Cochrane Library, SportDiscus, EMBASE and Web of Science databases were searched from their inception to July 2025. Eligibility criteria for selecting studies Randomised controlled trials were eligible if they examined the effects of exercise lasting ≥4 weeks on validated measures of depression and/or anxiety in women aged 18–45 with PCOS diagnosed using the Rotterdam criteria. Publications not written in English were excluded. Data extraction and synthesis Two reviewers independently extracted data …

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High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim Jan 2026

High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …

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Delirium In The Acute Care Setting From The Families Perspective: A Scoping Review, Amber Mclean, Beverley Ewens, Amanda Towell-Barnard Jan 2026

Delirium In The Acute Care Setting From The Families Perspective: A Scoping Review, Amber Mclean, Beverley Ewens, Amanda Towell-Barnard

Research outputs 2022 to 2026

Aim: To explore the existing literature on delirium within the acute care setting from the family members' perspective and summarise key findings. Design: A scoping review guided by Arksey and O'Malley's methodological framework and refined by the Joanna Briggs Institute. Review Methods: The Population, Concept, and Context framework recommended by the Joanna Briggs Institute's scoping review protocol identified the main concepts in the primary review question. The inclusion criteria focused on primary research studies from any chronological date that explored the family members' experience of delirium within the acute care setting. Following screening by two independent reviewers, data extraction was …

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Reflections From A Community Capacity Building Forum To Support People Bereaved By Suicide, Colleen Carlon, Jacquie Tarrant, Marie Eckersley, Priscilla Vindin Jan 2026

Reflections From A Community Capacity Building Forum To Support People Bereaved By Suicide, Colleen Carlon, Jacquie Tarrant, Marie Eckersley, Priscilla Vindin

Research outputs 2022 to 2026

An estimated half the population may be impacted by suicide loss. The combination of grief and trauma makes the experience particularly complex. Recognised as the most stigmatised of all sudden losses people bereaved by suicide are in sociocultural contexts that disrupt constructive grief processes and create barriers for help seeking and supportive responses. Effecting change in this context poses a significant health promotion challenge. Social workers in the South West Region of Western Australia sought to develop and deliver a unique postvention approach aimed at strengthening the self-support capacity of people bereaved by suicide while building broader community capacity for …

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Ensuring That Marginalized Young People Feel Welcome, Understood, And Empowered In Health Services: A Qualitative Examination Of The Service Needs Of Aboriginal Lgbtqa+ Young People, Shakara Liddelow-Hunt, Ashleigh Lin, Yael Perry, Braden Hill, Bep Uink Jan 2026

Ensuring That Marginalized Young People Feel Welcome, Understood, And Empowered In Health Services: A Qualitative Examination Of The Service Needs Of Aboriginal Lgbtqa+ Young People, Shakara Liddelow-Hunt, Ashleigh Lin, Yael Perry, Braden Hill, Bep Uink

Research outputs 2022 to 2026

A lack of appropriate care and discrimination in healthcare settings likely compounds the existing risks to mental health and well-being for Aboriginal and Torres Strait Islander lesbian, gay, bisexual, trans, queer/questioning, and asexual (LGBTQA+) young people. The current study contributes findings from Aboriginal LGBTQA+ young people’s perspectives on their health service needs and preferences. Data consists of qualitative interviews and focus groups with N = 14 Aboriginal LGBTQA+ young people aged 14–25 years in Boorloo (Perth), Western Australia. The data was analyzed using reflexive thematic analysis. Analysis identified three major themes: (1) Unmet need for “whole self” care, (2) Communicating …

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