Medicine and Health Sciences Commons^™

Skin Temperatures Of Back Or Neck Are Better Than Abdomen For Indication Of Average Proximal Skin Temperature During Sleep Of School-Aged Children, Veronique Bach, Chris R. Abbiss, Jean-Pierre Libert, Susan M. Mccabe

Research outputs 2014 to 2021

Purpose: The tight association between sleep, body temperature regulation, and patterns of skin temperature change highlights the necessity for accurate and valid assessment of skin temperatures during sleep. With increased interest in this functional relationship in infants and children, it is important to identify where to best measure proximal skin temperature and whether it is possible to reduce the number of sites of measures, in order to limit the experimental effects in natural settings. Thus, the aim of this study was to determine the most suitable single skin temperature sites for representation of average proximal skin temperature during sleep of …

Activate Or Inhibit? Implications Of Autophagy Modulation As A Therapeutic Strategy For Alzheimer’S Disease, Sharmeelavathi Krishnan, Yasaswi Shrestha, Dona P.W. Jayatunga, Sarah Rea, Ralph Martins, Prashant Bharadwaj

Research outputs 2014 to 2021

Neurodegenerative diseases result in a range of conditions depending on the type of proteinopathy, genes affected or the location of the degeneration in the brain. Proteinopathies such as senile plaques and neurofibrillary tangles in the brain are prominent features of Alzheimer’s disease (AD). Autophagy is a highly regulated mechanism of eliminating dysfunctional organelles and proteins, and plays an important role in removing these pathogenic intracellular protein aggregates, not only in AD, but also in other neurodegenerative diseases. Activating autophagy is gaining interest as a potential therapeutic strategy for chronic diseases featuring protein aggregation and misfolding, including AD. Although autophagy activation …

Confirmatory Factor Analysis And Reliability Of The Diabetes Treatment Satisfaction Questionnaire (Dtsq) For Arabic Speaking Patients With Type Ii Diabetes, Diana Arabiat, Lisa Whitehead, Buthina Abu Sheikh, Ebenezer Afrifa-Yamoah

Research outputs 2014 to 2021

Background: Treatment satisfaction is an important indicator for treatment compliance and glycemic control. Although psychometric properties of the Diabetes Treatment Satisfaction Questionnaire have been confirmed in several languages, it remains unclear the extent to which the factorial structure of this tool is valid for Arabic speaking populations.

Purpose: This study set out to confirm the construct validity of the Arabic version of the Diabetes Treatment Satisfaction Questionnaire (DTSQ) by investigating the fit of published factor structures and the reliability of responses in patients diagnosed with type 2 diabetes.

Methods: Data were from a large cross-sectional study of 1002 patients with …

Pilot Service Evaluation Of A Brief Psychological Therapy For Self-Harm In An Emergency Department: Hospital Outpatient Psychotherapy Engagement Service, Peter J. Taylor, Kirsten Fien, Helen Mulholland, Rui Duarte, Joanne M. Dickson, Cecil Kullu

Research outputs 2014 to 2021

© 2020 The Authors. Psychology and Psychotherapy: Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of British Psychological Society Background: Brief psychological therapies may be helpful for people who have recently self-harmed. The current paper reports on a service evaluation of a novel brief therapy service based within an Emergency Department, Hospital Outpatient Psychotherapy Engagement (HOPE) Service. This service combines elements of psychodynamic interpersonal and cognitive analytic therapy to help people who present with self-harm-related difficulties. The primary aim of this service evaluation was to ascertain the feasibility of HOPE in terms of attendance rates. …

Plasma High Density Lipoprotein Small Subclass Is Reduced In Alzheimer’S Disease Patients And Correlates With Cognitive Performance, Steve Pedrini, Eugene Hone, Veer B. Gupta, Ian James, Elham Teimouri, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Stephanie Rainey-Smith, Guiseppe Verdile, Hamid R. Sohrabi, Manfred R. Raida, Markus Wenk, Kevin Taddei, Pratishtha Chatterjee, Ian Martins, Simon Laws, Ralph Martins, Australian Imaging, Biomarkers And Lifestyle (Aibl) Research Group

Research outputs 2014 to 2021

Background:

The link between cholesterol and Alzheimer’s disease (AD) has received much attention, as evidence suggests high levels of cholesterol might be an AD risk factor. The carriage of cholesterol and lipids through the body is mediated via lipoproteins, some of which, particularly apolipoprotein E (ApoE), are intimately linked with AD. In humans, high density lipoprotein (HDL) is regarded as a “good” lipid complex due to its ability to enable clearance of excess cholesterol via ‘cholesterol reverse transport’, although its activities in the pathogenesis of AD are poorly understood. There are several subclasses of HDL; these range from the newly …

Sars-Cov-2 Updates In A West African Population And Precautionary Measures For Sustaining Quality Antenatal Care Delivery, Emmanuel Komla Senanu Morhe, Enoch Odame Anto, David Anthony Coall, Eric Adua, Alexander Yaw Debrah, Otchere Addai-Mensah, Michael Owusu, William K.B.A. Owiredu, Christian Obirikorang, Emmanuel Akomanin Asiamah, Emmanuel Acheampong, Evan Adu Asamoah, Lydia Abradu, Agartha Odame Anto, Youxin Wang, Haifeng Hou, Wei Wang

Research outputs 2014 to 2021

No abstract provided.

Lower-Body Power, Linear Speed, And Change-Of-Direction Speed In Division I Collegiate Women's Volleyball Players, Robert G. Lockie, J. Jay Dawes, Samuel J. Callaghan

Research outputs 2014 to 2021

© 2020 Institute of Sport. All rights reserved. Volleyball players need to sprint and change direction during a match. Lower-body power, often measured by jump tests, could contribute to faster movements. How different jumps relate to linear and change-of-direction (COD) speed has not been analyzed in Division I (DI) collegiate women's volleyball players. Fifteen female volleyball players completed the vertical jump (VJ), two-step approach jump (AppJ), and standing broad jump (SBJ). Peak power and power-to-body mass ratio (P:BM) were derived from VJ and AppJ height; relative SBJ was derived from SBJ distance. Linear speed was measured via a 20-m sprint …

South West Food Community: Understanding Systemic Change, And Its Associated Challenges And Successes, Among Food Security Projects, Johanna Rewa, Amanda Devine, Stephanie Godrich

Research outputs 2014 to 2021

Objective: The South West Food Community (SWFC) project (2018) aimed to identify initiatives working to support food security in the South West region of Western Australia, and to enhance how these initiatives functioned as a system. The SWFC project used a Systemic Innovation Lab approach that, prior to this study, had not been evaluated. This evaluation aimed to: i) measure system transitions (changes) to initiatives; and ii) understand the challenges and successes associated with system transitions.

Methods: SWFC initiative leaders (n=46) such as directors, managers or coordinators, volunteers or committee members were invited to participate in this evaluation. …

Resistance Mechanisms To Targeted Therapy In Braf-Mutant Melanoma - A Mini Review, Lokeswari P. Tangella, Michael E. Clark, Elin S. Gray

Research outputs 2014 to 2021

Background

The introduction of targeted therapies for the treatment of BRAF-mutant melanomas have improved survival rates in a significant proportion of patients. Nonetheless, the emergence of resistance to treatment remains inevitable in most patients.

Scope of review

Here, we review known and emerging molecular mechanisms that underlay the development of resistance to MAPK inhibition in melanoma cells and the potential strategies to overcome these mechanisms.

Major conclusions

Multiple genetic and non-genetic mechanisms contribute to treatment failure, commonly leading to the reactivation of the MAPK pathway. A variety of resistance mechanisms are enabled by the underlying heterogeneity and plasticity of melanoma …

A Randomized Control Trial Of Intensive Aphasia Therapy After Acute Stroke: The Very Early Rehabilitation For Speech (Verse) Study, Erin Godecke, Elizabeth Armstrong, Tapan Rai, Natalie Ciccone, Miranda L. Rose, Sandy Middleton, Anne Whitworth, Audrey Holland, Fiona Ellery, Graeme J. Hankey, Dominic A. Cadilhac, Julie Bernhardt, Verse Collaborative Group

Research outputs 2014 to 2021

Background

Effectiveness of early intensive aphasia rehabilitation after stroke is unknown. The Very Early Rehabilitation for SpEech trial (VERSE) aimed to determine whether intensive aphasia therapy, beginning within 14 days after stroke, improved communication recovery compared to usual care.

Methods

Prospective, randomized, single-blinded trial conducted at 17 acute-care hospitals across Australia/New Zealand from 2014 to 2018. Participants with aphasia following acute stroke were randomized to receive usual care (direct usual care aphasia therapy), or one of two higher intensity regimens (20 sessions of either non-prescribed (usual care-plus or prescribed (VERSE) direct aphasia therapy). The primary outcome was improvement of communication …

Improving Firefighter Tenability During Entrapment And Burnover: An Analysis Of Vehicle Protection Systems, Greg Penney, Daryoush Habibi, Marcus Cattani

Research outputs 2014 to 2021

When attempting to suppress severe wildfire the possibility for firefighting crews to be overrun by wildfire, known as entrapment and burnover, remains a catastrophic and all too common occurrence. While improvements have been made to vehicle protection systems to increase the safety of firefighters caught in burnover, the potential effectiveness of these systems remains limited. This study involved systematic analysis of 62 historical entrapment and burnover reports from the USA, Australian and New Zealand from 1978 to 2020 (Phase 1), and 135 simulated wildfires encompassing the 99th percentile of Australian fire weather conditions, fuel structures and terrain (Phase 2). Analysis …

Rural Dialysis Nurses’ Experiences With Challenging Patients: A Thematic Qualitative Analysis, Alycia Jacob, Caroline Vafeas, Laurita Stoneman, Elisabeth Jacob

Research outputs 2014 to 2021

Background: This study explored the experience of nurses encountering challenging patient behaviour while working at a rural hospital-based haemodialysis unit. Methods: Focus groups were conducted with haemodialysis nurses at a rural hospital. Five participants across two focus groups were asked questions regarding their experiences of challenging patients, including impacts that the experiences may have had on their ongoing professional practice. Transcripts of the focus groups were analysed thematically. Findings: Three themes arose from the focus group discussion – experiencing challenging behaviour, long-term relationships with patients, and nursing professionalism. Participants described challenges arising when caring for patients who were aggressive, did …

Reviewing The Current Methods Of Assessing Hydration In Athletes, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss

Research outputs 2014 to 2021

Background

Despite a substantial body of research, no clear best practice guidelines exist for the assessment of hydration in athletes. Body water is stored in and shifted between different sites throughout the body complicating hydration assessment. This review seeks to highlight the unique strengths and limitations of various hydration assessment methods described in the literature as well as providing best practice guidelines.

Main body

There is a plethora of methods that range in validity and reliability, including complicated and invasive methods (i.e. neutron activation analysis and stable isotope dilution), to moderately invasive blood, urine and salivary variables, progressing to non-invasive …

Validity And Reliability Of Methods To Determine Barbell Displacement In Heavy Back Squats: Implications For Velocity-Based Training, Brendyn B. Appleby, Harry Banyard, Prue Cormie, Stuart J. Cormack, Robert U. Newton

Research outputs 2014 to 2021

The purpose of this study was to investigate the validity and reliability of methods for determining barbell displacement during heavy back squats. Twelve well-trained rugby union players (mean ± SD 1 repetition maximum [1RM] 90° squat = 196.3 ± 29.2 kg) completed 2 sets of 2 repetitions at 70, 80, and 90% of 1RM squats. Barbell displacement was derived from 3 methods across 4 load categories (120–129, 140–149, 160–169, and 180–189 kg) including: a (a) linear position transducer (LPT) attached 65 cm left of barbell center, (b) 3D motion analysis tracking of markers attached to either end of a barbell, …

What Do We Know About The Nexus Between Culture, Age, Gender And Health Literacy? Implications For Improving The Health And Well-Being Of Young Indigenous Males, Anthony Merlino, James A. Smith, Mick Adams, Jason Bonson, Richard Osborne, Barry Judd, Murray Drummond, David Aanundsen, Jesse Fleay, Benjamin Christie

Research outputs 2014 to 2021

Health literacy, although diversely defined, refers to the abilities, relationships and external environments required for people to successfully promote health. Existing research suggests that health literacy is related to health inequities, including individual and community capacity to navigate health. A diverse range of factors shape health literacy abilities and environments, especially culture, gender and age. However, the nexus between these variables and their cumulative impact on health literacy development remains largely unexplored. Commentary that explores these dynamics among young Indigenous males is particularly scant. In turn, strategies to bridge health equity gaps have been obscured. This article brings together disparate …

Using Velocity To Predict The Maximum Dynamic Strength In The Power Clean, G. Gregory Haff, Amador Garcia-Ramos, Lachlan P. James

Research outputs 2014 to 2021

The primary aim of the present study was to examine the commonly performed training exercise for athlete preparation. Twenty-two recreationally trained males (age: 26.3 ± 4.1 y, height: 1.80 ± 0.07 m; body mass (BM): 87.01 ± 13.75 kg, 1-repetitoon maximum(1-RM)/BM: 0.90 ± 0.19 kg) participated in the present study. All subjects had their 1-RM power clean tested with standard procedures. On a separate testing day, subjects performed three repetitions at 30% and 45%, and two repetitions at 70% and 80% of their 1-RM power clean. During all trials during both sessions, peak velocity (PV) and mean velocity (MV) were …