Medicine and Health Sciences Commons^™

Glycosylation Of Igg Associates With Hypertension And Type 2 Diabetes Mellitus Comorbidity In The Chinese Muslim Ethnic Minorities And The Han Chinese, Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

Objectives: Hypertension and type 2 diabetes mellitus comorbidity (HDC) is common, which confers a higher risk of cardiovascular disease than the presence of either condition alone. Describing the underlying glycomic changes of immunoglobulin G (IgG) that predispose individuals to HDC may help develop novel protective immune-targeted and anti-inflammatory therapies. Therefore, we investigated glycosylation changes of IgG associated with HDC. Methods: The IgG N-glycan profiles of 883 plasma samples from the three northwestern Chinese Muslim ethnic minorities and the Han Chinese were analyzed by ultra-performance liquid chromatography instrument. Results: We found that 12 and six IgG N-glycan traits showed significant associations …

Patterns Of Immunotherapy-Induced Pneumonitis In Patients With Non-Small-Cell Lung Cancer: A Case Series, Sarah Picard, Desiree Goh, Ashley Tan, Nisha Sikotra, Eli Gabbay, Tim Clay

Research outputs 2014 to 2021

Background: Immunotherapy has become an efficacious option in the management of solid organ malignancies. Immune-related adverse events including pneumonitis are well described and may be particularly of concern in patients receiving immunotherapy for non-small-cell lung cancer. Case presentations: In this paper, we describe three cases of immunotherapy-induced pneumonitis occurring in the management of lung malignancy. Our cases include a 54-year-old Caucasian woman with squamous cell lung cancer who was successfully rechallenged with immunotherapy after prior significant pneumonitis, a 65-year-old Caucasian man with metastatic squamous cell lung cancer who developed pneumonitis after multiple cycles of uneventful immunotherapy, and a 73-year-old Caucasian …

Causal Inference Multiple Imputation Investigation Of The Impact Of Cannabinoids And Other Substances On Ethnic Differentials In Us Testicular Cancer Incidence, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2014 to 2021

Background: Ethnic differences in testicular cancer rates (TCRs) are recognized internationally. Cannabis is a known risk factor for testicular cancer (TC) in multiple studies with dose-response effects demonstrated, however the interaction between ancestral and environmental mutagenic effects has not been characterized. We examined the effects of this presumed gene-environment interaction across US states. Methods: State based TCR was downloaded from the Surveillance Epidemiology and End Results (SEER) website via SEERStat. Drug use data for cigarettes, alcohol use disorder, analgesics, cannabis and cocaine was taken from the National Survey of Drug Use and Health a nationally representative study conducted annually by …

Vitamin K Intake And Atherosclerotic Cardiovascular Disease In The Danish Diet Cancer And Health Study, Jamie W. Bellenge, Frederik Dalgaard, Kevin Murray, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Marc Sim, Kevin D. Croft, Gunnar Gislason, Christian Torp-Pedersen, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2014 to 2021

Background Dietary vitamin K (K1 and K2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food‐frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K1 and vitamin K2 were estimated from the food‐frequency questionnaire, …

Effects Of Exercise During Radiotherapy On Physical Function And Treatment-Related Side Effects In Men With Prostate Cancer: A Systematic Review And Meta-Analysis, Oliver Schumacher, Hao Luo, Dennis Taaffe, Daniel A. Galvao, Colin Tang, Raphael Chee, Nigel Spry, Robert Newton

Research outputs 2014 to 2021

Purpose

Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to mitigate radiation therapy–related fatigue in men with prostate cancer during radiation therapy, other adverse effects of treatment such as physical deconditioning, urinary symptoms, or sexual dysfunction have not been systematically reviewed in this patient population. Thus, the purpose of this review was to investigate the effect of exercise on physical function and treatment-related side effects in men with prostate cancer undergoing radiation therapy.

Methods

A …

The Tumor Suppressor Mir-642a-5p Targets Wilms Tumor 1 Gene And Cell-Cycle Progression In Prostate Cancer, Dianne J. Beveridge, Kirsty L. Richardson, Michael R. Epis, Rikki A. M. Brown, Lisa M. Stuart, Andrew J. Woo, Peter J. Leedman

Research outputs 2014 to 2021

RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously implicated microRNA-642a-5p (miR-642a-5p) as a tumor suppressor in prostate cancer (PCa), and here we characterize its mode of action, using 22Rv1 PCa cells. In an in vivo xenograft tumor model, miR-642a-5p induced a significant decrease in tumor growth, compared to negative control. Using RNA-Sequencing, we identified gene targets of miR-642a-5p which were enriched for gene sets controlling cell cycle; downregulated genes included Wilms Tumor 1 gene (WT1), NUAK1, RASSF3 and SKP2; and upregulated genes included IGFBP3 and GPS2. Analysis of …

Oat Intake And Risk Of Type 2 Diabetes, Cardiovascular Disease And All-Cause Mortality: A Systematic Review And Meta-Analysis, Faina Wehrli, Petek E. Taneri, Arjola Bano, Lia Bally, Lauren C. Blekkenhorst, Weston Bussler, Brandon Metzger, Beatrice Minder, Marija Glisic, Taulant Muka, Hua Kern

Research outputs 2014 to 2021

Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain the top disease and mortality burdens worldwide. Oats have been shown to benefit cardiovascular health and improve insulin resistance. However, the evidence linking oat consumption with CVD, T2D and all-cause mortality remains inconclusive. We conducted a comprehensive systematic review and meta-analysis of prospective cohort studies to evaluate the associations between oat consumption and risks of T2D, CVD and all-cause mortality in the general population. Five electronic databases were searched until September, 2020. Study specific relative risks (RR) were meta-analyzed using random effect models. Of 4686 relevant references, we included 9 articles, …

Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk

Research outputs 2014 to 2021

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic impacts. Previous treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by patients. The introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive developments. Decreasing the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence, the number of new infections. Antiviral treatments have decreased the rates of liver decompensation and as a result, lowered hospitalisation …

An Integrated Multicomponent Care Model For Men Affected By Prostate Cancer: A Feasibility Study Of Truenth Australia, Patsy Yates, Rob Carter, Robyn Cockerell, Donna Cowan, Cyril Dixon, Anne Magnus, Robert U. Newton, Nicolas H. Hart, Daniel A. Galvão, Brenton Baguley, Nicholas Denniston, Tina Skinner, Jeremy Couper, Jon Emery, Mark Frydenberg, Wei-Hong Liu

Research outputs 2014 to 2021

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer. Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-months program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Data were collected from multiple sources to evaluate: (1) recruitment capability and participant characteristics; (2) appropriateness and feasibility of delivering the specific intervention …

A Novel Boot Camp Program To Help Guide Personalized Exercise In People With Parkinson Disease, Josefa Domingos, John Dean, Travis M. Cruickshank, Katarzyna Śmiłowska, Júlio Belo Fernandes, Catarina Godinho

Research outputs 2014 to 2021

Given the variety of exercise programs available for people with Parkinson’s disease (PD), such individuals may struggle to make decisions about what exercise to perform. The objective of this study was to assess the usefulness, satisfaction, and preferences regarding participation in a PD-personalized educational and exercise boot camp program. Attendees participated in a four-day program consisting of exercise sessions, workshops, and social activities. We collected demographic and clinical information. We assessed satisfaction and preferences immediately after. At one-month follow-up, participants assessed usefulness and changes in exercise habits. Eight individuals diagnosed with PD, with a mean age of 59.5 ± 6.8 …

A Species-Wide Genetic Atlas Of Antimicrobial Resistance In Clostridioides Difficile, Korakrit Imwattana, César Rodríguez, Thomas V. Riley, Daniel R. Knight

Research outputs 2014 to 2021

Antimicrobial resistance (AMR) plays an important role in the pathogenesis and spread of Clostridioides difficile infection (CDI), the leading healthcare-related gastrointestinal infection in the world. An association between AMR and CDI outbreaks is well documented, however, data is limited to a few ‘epidemic’ strains in specific geographical regions. Here, through detailed analysis of 10330 publicly-available C. difficile genomes from strains isolated worldwide (spanning 270 multilocus sequence types (STs) across all known evolu-tionary clades), this study provides the first species-wide snapshot of AMR genomic epidemiology in C. difficile. Of the 10330 C. difficile genomes, 4532 (43.9%) in 89 STs across clades …

Association Of Genetic Variants With Prostate Cancer In Africa: A Concise Review, Emmanuel Acheampong, Evans A. Adu, Christian Obirikorang, George Amoah, Osei O. Afriyie, Joseph Yorke, Enoch O. Anto, Michael A. Gyamfi, Emmanuella N. Acheampong, Christian K. Gyasi-Sarpong, Francis A. Yeboah

Research outputs 2014 to 2021

Background: Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Main body: In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of …

Flavonoid Intake And Incident Dementia In The Danish Diet, Cancer, And Health Cohort, Catherine P. Bondonno, Nicola P. Bondonno, Frederik Dalgaard, Kevin Murray, Samantha L. Gardener, Ralph N. Martins, Stephanie R. Rainey-Smith, Aedín Cassidy, Joshua R. Lewis, Kevin D. Croft, Cecilie Kyrø, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson

Research outputs 2014 to 2021

No abstract provided.

Prevalence Of Distress, Its Associated Factors And Referral To Support Services In People With Cancer, Deborah Kirk, Istvan (Ishti) Kabdebo, Lisa Whitehead

Research outputs 2014 to 2021

Aims and objectives:

To (i) characterise prevalence of distress amongst people diagnosed with cancer, (ii) determine factors associated with increasing distress, (iii) describe reported problems for those with clinically significant distress and (iv) investigate the factors associated with referral to support services.

Background:

International studies report a high prevalence of clinically significant distress in people with cancer. Australian studies are notably lacking. Additionally, clinicians still do not fully understand the factors associated with cancer-related distress.

Design:

Period prevalence study.

Methods:

Distress screening data were analysed for 1,071 people accessing the Cancer Council Western Australia information and support line between 01/01/2016–31/12/2018. …

A Novel Augmented Deep Transfer Learning For Classification Of Covid-19 And Other Thoracic Diseases From X-Rays, Fouzia Atlaf, Syed M. S. Islam, Naeem K. Janjua

Research outputs 2014 to 2021

Deep learning has provided numerous breakthroughs in natural imaging tasks. However, its successful application to medical images is severely handicapped with the limited amount of annotated training data. Transfer learning is commonly adopted for the medical imaging tasks. However, a large covariant shift between the source domain of natural images and target domain of medical images results in poor transfer learning. Moreover, scarcity of annotated data for the medical imaging tasks causes further problems for effective transfer learning. To address these problems, we develop an augmented ensemble transfer learning technique that leads to significant performance gain over the conventional transfer …

Co-Design Of A Digital Dietary Intervention For Adults At Risk Of Type 2 Diabetes, Brenda S. J. Tay, Sarah M. Edney, Grant D. Brinkworth, David N. Cox, Bonnie Wiggins, Aaron Davis, Ian Gwilt, Annemien Haveman-Nies, Jillian C. Ryan

Research outputs 2014 to 2021

Background Co-design has the potential to create interventions that lead to sustainable health behaviour change. Evidence suggests application of co-design in various health domains has been growing; however, few public-facing digital interventions have been co-designed to specifically address the needs of adults at risk of Type 2 diabetes (T2D). This study aims to: (1) co-design, with key stakeholders, a digital dietary intervention to promote health behaviour change among adults at risk of T2D, and (2) evaluate the co-design process involved in developing the intervention prototype. Methods The co-design study was based on a partnership between nutrition researchers and designers experienced …

Identifying Critical Features Of Type Two Diabetes Prevention Interventions: A Delphi Study With Key Stakeholders, Jillian C. Ryan, Bonnie Wiggins, Sarah Edney, Grant D. Brinkworth, Natalie D. Luscombe-March, Kristin V. Carson-Chahhoud, Pennie J. Taylor, Annemien A. Haveman-Nies, David N. Cox

Research outputs 2014 to 2021

Aims This study aims to identify critically important features of digital type two diabetes mellitus (T2DM) prevention interventions. Methods A stakeholder mapping exercise was undertaken to identify key end-user and professional stakeholders, followed by a three-round Delphi procedure to generate and evaluate evidence statements related to the critical elements of digital T2DM prevention interventions in terms of product (intervention), price (funding models/financial cost), place (distribution/delivery channels), and promotion (target audiences). Results End-user (n = 38) and professional (n = 38) stakeholders including patients, dietitians, credentialed diabetes educators, nurses, medical doctors, research scientists, and exercise physiologists participated in the Delphi study. …

Potential Of Sorghum Polyphenols To Prevent And Treat Alzheimer's Disease: A Review Article, Nasim Rezaee, Warnakulasuriya Mary Ann Dipika Fernando, Eugene Hone, Hamid R. Sohrabi, Stuart K. Johnson, Stuart Gunzburg, Ralph Martins

Research outputs 2014 to 2021

Alzheimer’s disease (AD) is characterized by the excessive deposition of extracellular amyloid-beta peptide (Aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. This leads to neuronal damage, cell death and consequently results in memory and learning impairments leading to dementia. Although the exact cause of AD is not yet clear, numerous studies indicate that oxidative stress, inflammation, and mitochondrial dysfunction significantly contribute to its onset and progression. There is no effective therapeutic approach to stop the progression of AD and its associated symptoms. Thus, early intervention, preferably, pre-clinically when the brain is not significantly affected, is a …

Potential Role Of Exercise Induced Extracellular Vesicles In Prostate Cancer Suppression, Ying Zhang, Jin-Soo Kim, Tain-Zhen Wang, Robert U. Newton, Daniel A. Galvao, Robert A. Gardiner, Michelle M. Hill, Dennis Taaffe

Research outputs 2014 to 2021

Physical exercise is increasingly recognized as a valuable treatment strategy in managing prostate cancer, not only enhancing supportive care but potentially influencing disease outcomes. However, there are limited studies investigating mechanisms of the tumor-suppressive effect of exercise. Recently, extracellular vesicles (EVs) have been recognized as a therapeutic target for cancer as tumor-derived EVs have the potential to promote metastatic capacity by transferring oncogenic proteins, integrins, and microRNAs to other cells and EVs are also involved in developing drug resistance. Skeletal muscle has been identified as an endocrine organ, releasing EVs into the circulation, and levels of EV-containing factors have been …

Predictive Model And Feature Importance For Early Detection Of Type Ii Diabetes Mellitus, Eric Adua, Emmanuel A. Kolog, Ebenezer Afrifa-Yamoah, Bright Amankwah, Christian Obirikorang, Enoch O. Anto, Emmanuel Acheampong, Wei Wang, Antonia Y. Tetteh

Research outputs 2014 to 2021

Background: Accurate prediction and early recognition of type II diabetes (T2DM) will lead to timely and meaningful interventions, while preventing T2DM associated complications. In this context, machine learning (ML) is promising, as it can transform vast amount of T2DM data into clinically relevant information. This study compares multiple ML techniques for predictive modelling based on different T2DM associated variables in an African population, Ghana. Methods: The study involved 219 T2DM patients and 219 healthy individuals who were recruited from the hospital and the local community, respectively. Anthropometric and biochemical information including glycated haemoglobin (HbA1c), body mass index (BMI), blood pressure, …

Acceptability And Preliminary Efficacy Of A Web-And Telephone-Based Personalised Exercise Intervention For Individuals With Metastatic Prostate Cancer: The Exerciseguide Pilot Randomised Controlled Trial, Holly E. L. Evans, Daniel A. Galvão, Cynthia C. Forbes, Danielle Girard, Corneel Vandelanotte, Robert U. Newton, Andrew D. Vincent, Gary Wittert, Ganessan Kichenadasse, Suzanne Chambers, Nicholas Brook, Camille E. Short

Research outputs 2014 to 2021

Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote …

What Is The Minimal Dose For Resistance Exercise Effectiveness In Prostate Cancer Patients? Systematic Review And Meta-Analysis On Patient-Reported Outcomes, Pedro Lopez, Dennis R. Taaffe, Robert U. Newton, Laurien M. Buffart, Daniel A. Galvão

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Active treatments for prostate cancer are well known to result in several adverse effects such as fatigue, depression and anxiety symptoms, impacting the overall quality of life (QoL) and wellbeing of a considerable proportion of patients. Resistance-based exercise interventions have shown positive effects to reduce or mitigate these treatment-related side effects. However, the minimal dosage required to derive these benefits is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exercise components (mode, duration, volume and intensity) on fatigue, QoL, depression and anxiety. Methods: Using …

Asymmetric Thinning Of The Cerebral Cortex Across The Adult Lifespan Is Accelerated In Alzheimer’S Disease, James M. Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Andreas M. Brandmaier, Sandra Düzel, Hector A. Gonzalez, Rogier A. Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Athanasia M. Mowinckel, Lars Nyberg, Denise C. Park, Sara Pudas, Melissa M. Rundle, Kristine B. Walhovd, Anders M. Fjell, René Westerhausen, Colin L. Masters, Ashley I. Bush, Christopher Fowler, David Darby, Kelly Pertile, Carolina Restrepo, Blaine Roberts, Jo Robertson, Rebecca Rumble

Research outputs 2014 to 2021

© 2021, The Author(s). Aging and Alzheimer’s disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics …

Motor Developmental Outcomes In Children Exposed To Maternal Diabetes During Pregnancy: A Systematic Review And Meta-Analysis, Diana Arabiat, Mohammad A. L. Jabery, Vivien Kemp, Mark Jenkins, Lisa C. Whitehead, Gary Adams

Research outputs 2014 to 2021

© 2021 by the author. Licensee MDPI, Basel, Switzerland. Studies on the association of maternal diabetes with motor development in children provide inconsistent findings. We searched MEDLINE/PubMed, EMBASE, Emcare, PsycINFO, and Google Scholar databases for primary observational, case–control, or cohort studies that report on the motor development of children exposed to maternal diabetes during pregnancy. Quality appraisal and data extraction were performed independently and in duplicate. A meta-analysis of summary measures was performed using random-effect models. Eighteen studies were identified for inclusion, however, only 13 were included in the meta-analysis. Exposure to maternal diabetes during pregnancy was associated with a …

Major Histocompatibility Complex (Mhc) Associations With Diseases In Ethnic Groups Of The Arabian Peninsula, Halima Al Naqbi, Aurélie Mawart, Jawaher Alshamsi, Habiba Al Safar, Guan K. Tay

Research outputs 2014 to 2021

© 2021, The Author(s). Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are well documented. However, despite decades of research, the knowledge of MHC associations with human disease susceptibility have been predominantly studied in European origin, with limited understanding in different populations and ethnic groups. This is particularly evident in countries and ethnic populations of the Arabian Peninsula. Human MHC haplotypes, …

Association Between Fruit And Vegetable Intakes And Mental Health In The Australian Diabetes Obesity And Lifestyle Cohort, Joanna Rees, Simone Radavelli-Bagatini, Johnny Lo, Jonathan M. Hodgson, Claus T. Christophersen, Robin M. Daly, Dianna J. Magliano, Jonathan E. Shaw, Marc Sim, Catherine P. Bondonno, Lauren C. Blekkenhorst, Joanne M. Dickson, Joshua R. Lewis, Amanda Devine

Research outputs 2014 to 2021

Increasing prevalence of mental health disorders within the Australian population is a serious public health issue. Adequate intake of fruits and vegetables (FV), dietary fibre (DF) and resistant starch (RS) is associated with better mental and physical health. Few longitudinal studies exist exploring the temporal relationship. Using a validated food frequency questionnaire, we examined baseline FV intakes of 5845 Australian adults from the AusDiab study and estimated food group-derived DF and RS using data from the literature. Perceived mental health was assessed at baseline and 5 year follow up using SF-36 mental component summary scores (MCS). We conducted baseline cross-sectional …

Exercise Medicine In The Management Of Pancreatic Cancer: A Systematic Review, Hao Luo, Daniel A. Galvão, Robert U. Newton, Pedro Lopez Da Cruz, Colin Tang, Ciaran M. Fairman, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

The aim of this study was to examine the health-related effects of exercise in patients with pancreatic cancer (PanCa) through a systematic review of current evidence. Studies were obtained through searching PubMed, Web of Science, PsycINFO, Embase, CINAHL Plus, and Cochrane Library databases with additional hand searches. All intervention-based studies were included if it involved (1) adult patients with PanCa, (2) exercise training, and (3) findings in quality of life, cancer-related fatigue, psychological distress, and physical function. The review protocol was registered in PROSPERO: CRD42020154684. Seven trials described in 9 publications were included consisting of 201 patients with early-stage and …

Complete Genome Assemblies Of Three Highly Prevalent, Toxigenic Clostridioides Difficile Strains Causing Health Care-Associated Infections In Australia, Keeley O'Grady, Thomas V. Riley, Daniel R. Knight

Research outputs 2014 to 2021

Clostridioides difficile infection (CDI) is the leading cause of life-threatening health care-related gastrointestinal illness worldwide. Phylogenetically appropriate closed reference genomes are essential for studies of C. difficile transmission and evolution. Here, we provide high-quality complete hybrid genome assemblies for the three most prevalent C. difficile strains causing CDI in Australia.

Feasibility, Tolerance And Effects Of Adding Impact Loading Exercise To Pulmonary Rehabilitation In People With Chronic Obstructive Pulmonary Disease: Study Protocol For A Pilot Randomised Controlled Trial, Erin Cecins, Kylie Hill, Dennis R. Taaffe, David Manners, Anne-Marie Hill, Robert U. Newton, Daniel A. Galvão, Vinicius Cavalheri

Research outputs 2014 to 2021

Background:

Chronic obstructive pulmonary disease (COPD) is a disorder linked with a multitude of extra pulmonary manifestations (also known as treatable traits), including low bone mineral density (BMD). To date, no specific guidelines exist for the management of BMD in this population. Impact loading exercise has been identified as an intervention that improves or maintains BMD in other populations. However, the feasibility of and tolerance to impact loading exercise has not been tested in people with COPD. The aim of the proposed study will be to investigate the feasibility and tolerance of adding impact loading exercise to a standard pulmonary …

Usability, Acceptability, And Safety Analysis Of A Computer-Tailored Web-Based Exercise Intervention (Exerciseguide) For Individuals With Metastatic Prostate Cancer: Multi-Methods Laboratory-Based Study, Holly E. L. Evans, Cynthia C. Forbes, Daniel A. Galvão, Corneel Vandelanotte, Robert U. Newton, Gary Wittert, Suzanne Chambers, Andrew D. Vincent, Ganessan Kichenadasse, Danielle Girard, Nicholas Brook, Camille E. Short

Research outputs 2014 to 2021

Background:

Digital health interventions such as tailored websites are emerging as valuable tools to provide individualized exercise and behavioral change information for individuals diagnosed with cancer.

Objective:

The aim of this study is to investigate and iteratively refine the acceptability and usability of a web-based exercise intervention (ExerciseGuide) for men with metastatic prostate cancer and determine how well individuals can replicate the video-based exercise prescription.

Methods:

A laboratory-based multi-methods design was used, incorporating questionnaires, think-aloud tests, interviews, and movement screening among 11 men aged 63 to 82 years with metastatic prostate cancer. Overall, 9 participants were undergoing androgen deprivation therapy, …