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Articles 31 - 60 of 19995

Full-Text Articles in Medicine and Health Sciences

Conjunctival Papilloma Across Eras: Comparison Of Historical And Modern Cohorts, Lily C. Farrell, Robert J. Medina, Justin C. Muste, Hemal P. Patel, Sara E. Lally, Ralph C. Eagle C. Eagle, Carol L. Shields, Tatyana Milman Oct 2026

Conjunctival Papilloma Across Eras: Comparison Of Historical And Modern Cohorts, Lily C. Farrell, Robert J. Medina, Justin C. Muste, Hemal P. Patel, Sara E. Lally, Ralph C. Eagle C. Eagle, Carol L. Shields, Tatyana Milman

Wills Eye Hospital Papers

Objective: To evaluate and compare epidemiology, clinical and histopathologic features, and outcomes of conjunctival papilloma in historical and modern cohorts. Design: Retrospective comparative cohort study. Participants: Patients with conjunctival papilloma at a tertiary referral center between 2015 and 2024. Methods: A retrospective review of Oncology and Pathology records was conducted to identify all patients with conjunctival papilloma over a 10-year period (2015–2024). Data collected included demographics, HPV vaccination status, clinical tumor characteristics, treatment modalities, outcomes, and histopathologic findings of excised lesions. Patients were stratified by age (≤20 vs.> 20 years). Findings were compared with a historical cohort managed at the …


There's No Vision Like Low Vision: Living With And Serving Those With Macular Degeneration And Stargardt Macular Dystrophy, Paul B. Freeman Od Oct 2026

There's No Vision Like Low Vision: Living With And Serving Those With Macular Degeneration And Stargardt Macular Dystrophy, Paul B. Freeman Od

Optometric Clinical Practice

Book Review: Perski T, There's No Vision Like Low Vision: Living with and Serving Those with Macular Degeneration and Stargardt Macular Dystrophy, Inicio Press, 2025. 306 pages, Paperback, $14.99, ISBN 978-1-998315-48-2, Kindle $9.99 ISBN 978–1– 998315– 49–9


Pentosan Polysulfate Sodium (Pps, Elmiron) Maculopathy Demonstrates The Importance Of Coordinated Care From A Low Vision Perspective, Charlotte I. Spada Od, Stephanie Schmiedecke Barbieri Od, Patricia Sanchez Diaz Dvm, Phd, Jeffrey Rabin Od, Phd Oct 2026

Pentosan Polysulfate Sodium (Pps, Elmiron) Maculopathy Demonstrates The Importance Of Coordinated Care From A Low Vision Perspective, Charlotte I. Spada Od, Stephanie Schmiedecke Barbieri Od, Patricia Sanchez Diaz Dvm, Phd, Jeffrey Rabin Od, Phd

Optometric Clinical Practice

Background: Pentosan polysulfate sodium (PPS, Elmiron®) is a widely used medication to reduce pain caused by interstitial cystitis, a bladder disorder most often affecting females. PPS maculopathy is a novel form of toxic retinal disease often not recognized or mistaken for other retinal conditions such as macular degeneration due to the initial similarities on fundus exam. However, when visualized using fundus autofluorescence, affected eyes show characteristic hyper/hypo-autofluorescent patterns.

Case report: A patient taking PPS for 10 years presented with macular changes and complaints of blurry vision and nyctalopia. Clinical, electrodiagnostic, and genetic testing were performed including fundus autofluorescence and …


The Other Visual Acuity, Paul B. Freeman Od Oct 2026

The Other Visual Acuity, Paul B. Freeman Od

Optometric Clinical Practice

Editorial


Kidney Allograft Outcomes In Borderline And T Cell-Mediated Rejection With Microvascular Inflammation, Wai H. Lim, Jiayue Wang, Armando Teixeira-Pinto, Julie Ho, Ryan Gately, Dharshana Sabanayagam, Esther Ooi, Farzaneh Boroumand, K. Shuvo Bakar, Lin Zhu, Helen Pilmore, William Mulley, Jennifer Li, Brian Nankivell, John Kanellis, Peter Nickerson, Chris Wiebe, Germaine Wong Oct 2026

Kidney Allograft Outcomes In Borderline And T Cell-Mediated Rejection With Microvascular Inflammation, Wai H. Lim, Jiayue Wang, Armando Teixeira-Pinto, Julie Ho, Ryan Gately, Dharshana Sabanayagam, Esther Ooi, Farzaneh Boroumand, K. Shuvo Bakar, Lin Zhu, Helen Pilmore, William Mulley, Jennifer Li, Brian Nankivell, John Kanellis, Peter Nickerson, Chris Wiebe, Germaine Wong

Research outputs 2022 to 2026

Introduction: Microvascular inflammation (MVI) is a hallmark feature of antibody-mediated rejection (ABMR), but its prognostic significance when it occurs with T-cell-mediated rejection (TCMR) in the absence of other ABMR features remains unclear.

Methods: We examined the association between pure TCMR phenotypes, defined by the presence or absence of MVI, and graft survival using restricted mean survival time (RMST), and assessed interactions with rejection involving a “v” lesion.

Results: Among 1614 recipients with first biopsy-proven pure TCMR (2010–2023), 85% had no MVI, 8% subthreshold MVI (Banff glomerulitis [g] + peritubular capillaritis [ptc] = 1), and 7% with MVI (g + ptc …


Lowering A1c In Haitian Creole Adults With Type 2 Diabetes, Tammy W. Russell Oct 2026

Lowering A1c In Haitian Creole Adults With Type 2 Diabetes, Tammy W. Russell

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Haitian Creole–speaking adults with type 2 diabetes receiving care in a federally funded primary care clinic experienced gaps in glycemic control, follow-up attendance, preventive kidney screening, and access to linguistically appropriate diabetes care. The organizational baseline urine albumin-to-creatinine ratio (UACR) screening rate was 41.8%, demonstrating an opportunity to improve preventive diabetes management.

Aim of the Project: The aim was to implement a Chronic Care Model (CCM)-based interdisciplinary intervention over 12 weeks to improve diabetes outcomes, follow-up care, and UACR screening among Haitian Creole–speaking adults with type 2 diabetes.

Review of the Evidence: Current evidence supports structured chronic disease management, …


Correlation Of Esophageal Dysfunction On High-Resolution Manometry And Chest Ct In Scleroderma, Thao G. Huynh, Zsuzsanna H Mcmahan Oct 2026

Correlation Of Esophageal Dysfunction On High-Resolution Manometry And Chest Ct In Scleroderma, Thao G. Huynh, Zsuzsanna H Mcmahan

Summer Research Program Abstracts

No abstract provided.


The 1993 E. Coli Outbreak: The Epidemic That Spurred Changes For Food Regulations, Piper G N Ruebling Sep 2026

The 1993 E. Coli Outbreak: The Epidemic That Spurred Changes For Food Regulations, Piper G N Ruebling

Undergraduate Research Symposium

An overview of the 1993 E. coli outbreak that occurred in the Northwest region of the United States. The outbreak came from not enough regulation to detect disease before being sent from production to restaurants, most notably Jack-in-The-Box. The outbreak was a terrifying experience for several families, as children were the most affected. This single outbreak spurred changes for food safety in several ways, including bringing change to other countries that trade resources with the United States.


Modelling Acute Haemorrhagic Conjunctivitis In East Africa: An Integrated Approach To Transmission Dynamics And Outbreak Response Strategies, Geofrey Wingi Sikazwe Sep 2026

Modelling Acute Haemorrhagic Conjunctivitis In East Africa: An Integrated Approach To Transmission Dynamics And Outbreak Response Strategies, Geofrey Wingi Sikazwe

Tanzania Journal of Science

Acute hemorrhagic conjunctivitis (AHC) poses a significant global health risk, with the potential for rapid spread during outbreaks. For instance, a localized outbreak in Yunnan Province, China, recorded infection rates of up to 48%, illustrating how transmission can intensify under favourable epidemiological and environmental conditions. Existing mathematical models of AHC transmission overlook seasonal variations, a critical factor in epidemic spread. This study combines species distribution models (SDMs) and epidemiological modelling to analyse key drivers of AHC in East Africa. We use the SEIR type (Susceptible-Exposed-Infected-Recovered - incorporating waning immunity) framework with temperature-dependent infectivity rate as the key driver of an …


Hubungan Skor Rale Gambaran Foto Toraks Dengan Kadar D-Dimer Pada Pasien Covid-19, Marsa Zaidan, Arifin Arifin, Sulistyani Kusumaningrum, Ratih Tri Kusuma Dewi Sep 2026

Hubungan Skor Rale Gambaran Foto Toraks Dengan Kadar D-Dimer Pada Pasien Covid-19, Marsa Zaidan, Arifin Arifin, Sulistyani Kusumaningrum, Ratih Tri Kusuma Dewi

Jurnal Penyakit Dalam Indonesia

Introduction. COVID-19 pneumonia caused by SARS-CoV-2 leads to extensive pulmonary infiltrates. The Radiographic Assessment of Lung Edema (RALE) score is a quantitative radiological tool to evaluate the severity of lung lesions. Meanwhile, elevated D-dimer levels reflect coagulation and fibrinolysis activation. This study aimed to analyze the correlation between the initial RALE score on chest radiography and D-dimer levels upon hospital admission.

Methods. An analytical observational study with a cross-sectional design was conducted on hospitalized COVID-19 patients at Dr. Moewardi Hospital, Surakarta, from March to July 2021. A total of 98 patients were selected via simple random sampling based …


Hubungan Kadar Fibroblast Growth Factor-23 Dalam Serum Dengan Hipertrofi Ventrikel Kiri Dan Fraksi Ejeksi Ventrikel Kiri Pada Pasien Hemodialisis Di Rumah Sakit Cipto Mangunkusumo, Ester Morina Silalahi Ester, Maruhum Bonar Marbun, Eka Ginanjar, Hamzah Shatri Sep 2026

Hubungan Kadar Fibroblast Growth Factor-23 Dalam Serum Dengan Hipertrofi Ventrikel Kiri Dan Fraksi Ejeksi Ventrikel Kiri Pada Pasien Hemodialisis Di Rumah Sakit Cipto Mangunkusumo, Ester Morina Silalahi Ester, Maruhum Bonar Marbun, Eka Ginanjar, Hamzah Shatri

Jurnal Penyakit Dalam Indonesia

Introduction. Fibroblast growth factor-23 (FGF-23) is a marker that indicates the process of bone mineral disorders in chronic kidney disease dialysis. An elevated FGF-23 causes a remodeling process that contributes to the development of left ventricle hypertrophy (LVH) and the still controversial direct decline of left ventricle ejection fraction (LVEF) among hemodialysis patients. This study aimed to seek out the connection between FGF-23 levels in serum with left ventricle hypertrophy and left ventricle ejection fraction among regular hemodialysis patients.

Methods. A cross-sectional study was conducted to 111 regular hemodialysis patients for twice a week in Cipto Mangunkusumo Hospital …


Bambara Groundnut (Vigna Subterranea L.) Supplementation Ameliorates The Histological Structure Of Skeletal Muscle In Protein-Deficient Mice, Raquellynda Fadilla Syafanisa, Rimonta Febby Gunanegara, Sunarti Sunarti, Siti Aeniah, Ardaning Nuriliani Sep 2026

Bambara Groundnut (Vigna Subterranea L.) Supplementation Ameliorates The Histological Structure Of Skeletal Muscle In Protein-Deficient Mice, Raquellynda Fadilla Syafanisa, Rimonta Febby Gunanegara, Sunarti Sunarti, Siti Aeniah, Ardaning Nuriliani

Makara Journal of Science

Protein deficiency may cause histological alterations and pathological effects in skeletal muscle, leading to reduced mus-cle size and functional degeneration. Bambara groundnuts contain essential amino acids that have the potential to meet the body’s protein requirements. Therefore, this study aimed to investigate the effect of bambara groundnut supplemen-tation on skeletal muscle in protein-deficient mice. Twenty-five female mice were divided into five groups (control, pro-tein deficiency, and protein deficiency with 100, 200, and 300 g of bambara groundnut supplementation/kg of feed). The treatment was administered for 2 months. At the end of the experiment, the left gastrocnemius muscles of the mice …


Glp-1 Receptor Agonists And Wound Healing In Diabetic Foot Ulcers: A Scoping Review, Merlin Sajeev, Amanda L. Killeen Sep 2026

Glp-1 Receptor Agonists And Wound Healing In Diabetic Foot Ulcers: A Scoping Review, Merlin Sajeev, Amanda L. Killeen

School of Podiatric Medicine - Student Research

Level of Evidence: Level 5

Poster Category: Non-sponsored

Introduction: Diabetic foot ulcers (DFUs) are a major complication of diabetes and are associated with delayed wound healing, infection, amputation, and substantial morbidity. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and may influence inflammation, vascular function, and tissue repair. However, clinical evidence evaluating their relationship with DFU healing remains limited.

Aim: To characterize available clinical evidence examining the association between GLP-1 RA use and wound-healing outcomes in patients with diabetic foot ulcers.

Methods: PubMed and Google Scholar were searched for English-language studies published from 2021–2026 using terms combining “GLP-1 receptor …


From Advisory To Action: The Case For Preserving Paccarb In The Fight Against Antimicrobial Resistance, Leila S. Hojat, Muhammad Dhanani, Amy Y. Kang, Salome O. Chitavi, Robert A. Weinstein, Edward Stenehjem Sep 2026

From Advisory To Action: The Case For Preserving Paccarb In The Fight Against Antimicrobial Resistance, Leila S. Hojat, Muhammad Dhanani, Amy Y. Kang, Salome O. Chitavi, Robert A. Weinstein, Edward Stenehjem

Pharmacy Faculty Articles and Research

The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was established to advise the government on strategies to mitigate antimicrobial resistance (AMR) and its increasing threat to public health and national security. Its members included experts from diverse disciplines such as healthcare, veterinary medicine, industry, public health, and agriculture who were positioned to interface with key stakeholders and the public in an aspirational multidisciplinary approach to combating AMR. The council was successful in elevating AMR as a national priority and played a crucial role in watershed events for antimicrobial stewardship (AS) such as the development of the second National Action …


Management Of Non-Survivable Head Trauma: Opportunities For Improvement, Sanjana R. Salwi, Mackenzie D. Castellanos, Therese Murphy, Pious D. Patel, Sonia Ajmera, Alex P. Vaz, Connor A. Wathen, Niels D. Martin, Monisha A. Kumar, James M. Schuster, Dmitriy Petrov Sep 2026

Management Of Non-Survivable Head Trauma: Opportunities For Improvement, Sanjana R. Salwi, Mackenzie D. Castellanos, Therese Murphy, Pious D. Patel, Sonia Ajmera, Alex P. Vaz, Connor A. Wathen, Niels D. Martin, Monisha A. Kumar, James M. Schuster, Dmitriy Petrov

Department of Neurosurgery Faculty Papers

BACKGROUND: Managing patients with non-survivable head trauma who do not meet brain death criteria presents significant ethical and clinical challenges. Decisions frequently fall to surrogates with limited guidance, particularly when organ donation status is unknown. This study assessed physician perspectives on communication, interventions, and institutional factors.

METHODS: We conducted a national survey of academic neurosurgery, trauma surgery, and neurocritical care programs. Items examined communication barriers, interventions by donor status, institutional support, and a dissonance measure for interventions viewed as inappropriate.

RESULTS: A total of 133 physicians responded. Top communication barriers were medical literacy, unclear patient values, and intrafamily conflict. Physicians …


Prenatal Cannabis Exposure Is Associated With Occipitotemporal Brain Surface Area In Neonates, Alexander J. Dufford, Sun Hyung Kim, Martin Styner, Xinyi Shen, Erika Iisa, Marilyn A. Huestis, Peter Fried, Christine Conageski, Jocelyn E. Phipers, Cristina Sempio, Jost Klawitter, Pilyoung Kim, Tessa L. Crume Sep 2026

Prenatal Cannabis Exposure Is Associated With Occipitotemporal Brain Surface Area In Neonates, Alexander J. Dufford, Sun Hyung Kim, Martin Styner, Xinyi Shen, Erika Iisa, Marilyn A. Huestis, Peter Fried, Christine Conageski, Jocelyn E. Phipers, Cristina Sempio, Jost Klawitter, Pilyoung Kim, Tessa L. Crume

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Prenatal cannabis use has been associated with neurodevelopmental consequences for the offspring beginning in childhood; however, it is unclear if neonatal brain structural morphometry is impacted shortly after birth.

OBJECTIVE: We examined differences in regional surface morphometry among neonates exposed to chronic in utero cannabis compared to unexposed neonates.

DESIGN: The Moms Helping Moms study is a prospective pre-birth cohort selected based on chronic prenatal cannabis use and an unexposed control group. Exclusion criteria included alcohol, tobacco, or other substance use. Participants included in this analysis included 18 mother-neonate pairs with prenatal cannabis exposure and 21 unexposed pairs. Chronic …


Brittle Bone Disorders Consortium Of The Rare Disease Clinical Research Network, Bettina Willie Sep 2026

Brittle Bone Disorders Consortium Of The Rare Disease Clinical Research Network, Bettina Willie

Funded Research Records

No abstract provided.


Successful Treatment Of Recurrent Epithelioid Trophoblastic Tumor (Ett) With Pembrolizumab After Pembrolizumab: A Case Report And Review Of Literature In Treatment Of Ett, Sarah Mokma, Sarah Alnaif, Nicholas Cardillo Sep 2026

Successful Treatment Of Recurrent Epithelioid Trophoblastic Tumor (Ett) With Pembrolizumab After Pembrolizumab: A Case Report And Review Of Literature In Treatment Of Ett, Sarah Mokma, Sarah Alnaif, Nicholas Cardillo

Abington Jefferson Health Papers

BACKGROUND: Epithelioid Trophoblastic Tumors (ETT) are rare, which makes an optimal treatment regimen difficult to determine. Since PD-L1 is expressed in placental tissue and in gestational trophoblastic neoplasia (GTN), immunotherapies such as pembrolizumab have been proposed as possible treatments.

CASE PRESENTATION: The case presented is a 50-year-old postmenopausal female who presented with postmenopausal bleeding and a large, fungating cervical mass. Cervical biopsies confirmed ETT. The patient underwent primary debulking surgery with radical abdominal hysterectomy, bilateral salpingo-oophorectomy, and sigmoid colon resection. The patient was diagnosed with a FIGO Stage IV ETT due to tumor extension to sigmoid colon with a high-risk …


Validation Of Next‑Generation Sequencing‑Derived Circulating Mrna Variants As Potential Diagnostic Tools In Hepatocellular Carcinoma And Cholangiocarcinoma, Daniel Zezulinski, Maarouf A. Hoteit, David E. Kaplan, Tingting Zhan, Cataldo Doria, Timothy M. Block, Aejaz Sayeed Sep 2026

Validation Of Next‑Generation Sequencing‑Derived Circulating Mrna Variants As Potential Diagnostic Tools In Hepatocellular Carcinoma And Cholangiocarcinoma, Daniel Zezulinski, Maarouf A. Hoteit, David E. Kaplan, Tingting Zhan, Cataldo Doria, Timothy M. Block, Aejaz Sayeed

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Liquid biopsy can transform oncology practice through early detection and real‑time monitoring of cancer progression and response to treatment. Circulating cell‑free tumor RNA offers promise as a novel and emerging alternative to circulating cell‑free tumor DNA for detecting the presence and understanding the biology of liver tumors. Both circulating DNA and RNA, which predominantly reside in extracellular vesicles, carry evidence of vital germline and somatic mutations. High impact single nucleotide changes, insertions and deletions in circulating RNA (ctRNA) serve a key role in cancer development and progression. Tumor cells exploit the RNA splicing machinery to induce structural and functional changes …


Exploring Which Ehr Interventions Improve Heart Failure Hospitalization Outcomes Across 10 Hospitals, Sheraz Qamar, Andres Alvarado, Thomas Buckwalter, Patricia C. Henwood, Dana Jordan, Cara Martino, Jeffrey Riggio, Charlotte Sacksteder, Jared Vanderzell, Alan Kubey Sep 2026

Exploring Which Ehr Interventions Improve Heart Failure Hospitalization Outcomes Across 10 Hospitals, Sheraz Qamar, Andres Alvarado, Thomas Buckwalter, Patricia C. Henwood, Dana Jordan, Cara Martino, Jeffrey Riggio, Charlotte Sacksteder, Jared Vanderzell, Alan Kubey

Department of Medicine Faculty Papers

BACKGROUND: Heart failure (HF) remains a major cause of mortality and hospitalization despite advances in guideline-directed medical therapy (GDMT). Electronic health record (EHR)-based clinical decision support tools may improve care delivery, but their impact on outcomes remains ill-defined.

PROJECT RATIONALE: As part of a system-wide HF quality improvement initiative, we evaluated 2 EHR interventions: an evidence-based HF admission order set promoting early diuresis and GDMT optimization, and a templated HF documentation tool (HFNOTE) designed to capture clinical complexity.

PROJECT SUMMARY: We analyzed 4,865 HF hospitalizations across 10 hospitals between December 2024 and June 2025. Overall risk-adjusted mortality index was 0.83 …


A Mixed Methods Study Of Inpatients’ Experiences, Priorities, And Health-Related Quality Of Life During High- Flow Nasal Cannula Therapy, Cintamani H. Ellsworth, Rebecca S. Bartlett Sep 2026

A Mixed Methods Study Of Inpatients’ Experiences, Priorities, And Health-Related Quality Of Life During High- Flow Nasal Cannula Therapy, Cintamani H. Ellsworth, Rebecca S. Bartlett

Journal of Patient-Centered Research and Reviews

Purpose: High-flow nasal cannula (HFNC) is an oxygen delivery method with numerous benefits for severely ill patients. There is a paucity of research focused on the perspectives of patients receiving HFNC oxygen therapy. This study aimed to engage with patients to gain a clearer understanding of their experiences, priorities, and health-related quality of life.

Methods: A cross-sectional, mixed methods study was completed with 10 adult inpatients who had received HFNC oxygen therapy during their hospital admission. Semi-structured interviews and the Patient Reported Outcomes Measurement Information System (PROMIS) Global Health Scale were used to identify participant perceptions of their physical and …


"Yellow Fever Epidemic", William Lindsey Mcdonald Sep 2026

"Yellow Fever Epidemic", William Lindsey Mcdonald

Research Articles

Draft of text for the historical marker in Tuscumbia, Alabama honoring those who died of the yellow fever epidemic in the fall of 1878.

The current historical marker for the yellow fever epidemic in Tuscumbia can be viewed on the Historical Marker Database.


Gender Differences In Presentation And Outcomes Of Spontaneous Coronary Artery Dissection (Scad): A Single Center Case Series Study, Abdul Nadeem Akhtar, Fnu Aisha, Aimen Binte Moazzam, Mohammad Omer Rehman Rana, Abida Perveen, Jahanzeb Malik Sep 2026

Gender Differences In Presentation And Outcomes Of Spontaneous Coronary Artery Dissection (Scad): A Single Center Case Series Study, Abdul Nadeem Akhtar, Fnu Aisha, Aimen Binte Moazzam, Mohammad Omer Rehman Rana, Abida Perveen, Jahanzeb Malik

Journal of Community Hospital Internal Medicine Perspectives

Background: Spontaneous Coronary Artery Dissection (SCAD) is an important non-atherosclerotic cause of acute coronary syndrome (ACS), predominantly affecting younger females. Despite increasing recognition, data on gender-based differences in SCAD presentation and outcomes remain limited, particularly in South Asian populations.

Methods: This retrospective case series included 24 patients diagnosed with SCAD at Abbas Institute of Medical Sciences (AIMS) between January 2022 and March 2025. Patient demographics, clinical presentation, angiographic findings, management strategies, and outcomes were analyzed with a focus on gender-based differences.

Results: Of the 24 patients, 17 were female (70.8%) and 7 were male (29.2%). Females were younger and had …


Intrawound Vancomycin For Prevention Of Surgical Site Infection: Meta-Analysis Of Randomized Clinical Trials, Shaan Patel, Shiva Nischal, Kush Kale, Angelette Mendonca, Nelson Sofoluke, Srinivas Prasad, James Harrop, Daniel Refai Sep 2026

Intrawound Vancomycin For Prevention Of Surgical Site Infection: Meta-Analysis Of Randomized Clinical Trials, Shaan Patel, Shiva Nischal, Kush Kale, Angelette Mendonca, Nelson Sofoluke, Srinivas Prasad, James Harrop, Daniel Refai

Department of Neurosurgery Faculty Papers

BACKGROUND: Surgical site infection remains a major cause of postoperative morbidity. Intrawound vancomycin has been proposed as an adjunct to standard prophylaxis, but its effectiveness across surgical settings remains uncertain. This systematic review and meta-analysis of randomized clinical trials aimed to evaluate the association between intraoperative intrawound vancomycin and surgical site infection in adults undergoing surgery.

METHODS: MEDLINE, Embase, and CENTRAL were searched from database inception to March 2026 for randomized clinical trials comparing intrawound vancomycin with standard care in adults undergoing operative procedures. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment using the Cochrane Risk of Bias …


Discovering Repurposable Drugs For Alzheimer's Disease And Related Dementias: Target Trial Emulation Using Decentralised Real-World Data, Qiong Wu, Lu Li, Yuqing Lei, Ting Zhou, Huilin Tang, Bingyu Zhang, Yiwen Lu, Maxwell Salvatore, Dazheng Zhang, Jiayi Tong, Tingyin Wang, Siqi Chen, Haoyang Li, Zhenxing Xu, Yu Huang, Yu Hu, Na Hong, Yujia Zhou, Fongci Lin, Kyra O'Brien, Yong Chen, Ruowang Li, Hua Xu, Fei Wang, Jiang Bian, David Wolk, Yong Chen Sep 2026

Discovering Repurposable Drugs For Alzheimer's Disease And Related Dementias: Target Trial Emulation Using Decentralised Real-World Data, Qiong Wu, Lu Li, Yuqing Lei, Ting Zhou, Huilin Tang, Bingyu Zhang, Yiwen Lu, Maxwell Salvatore, Dazheng Zhang, Jiayi Tong, Tingyin Wang, Siqi Chen, Haoyang Li, Zhenxing Xu, Yu Huang, Yu Hu, Na Hong, Yujia Zhou, Fongci Lin, Kyra O'Brien, Yong Chen, Ruowang Li, Hua Xu, Fei Wang, Jiang Bian, David Wolk, Yong Chen

College of Population Health Faculty Papers

BACKGROUND: Alzheimer's disease and related dementias (ADRD) affect nearly 6.9 million Americans, with the number expected to triple by 2050, while disease-modifying therapies remain unavailable. Drug repurposing, which identifies new indications for already approved medications, offers a more efficient and cost-effective pathway to accelerate development of effective therapies for ADRD. The aim of this study is to identify potential drug repurposing signals by systematically screening routinely prescribed drugs for associations with progression from mild cognitive impairment (MCI) to ADRD.

METHODS: We conducted a multi-site target trial emulation using electronic health record (EHR) data from four decentralised databases: INSIGHT Clinical Research …


Preparation Of Physician Assistant Students To Manage Patients Living With Hiv/Aids In A Primary Care Setting, Austin Parrish Sep 2026

Preparation Of Physician Assistant Students To Manage Patients Living With Hiv/Aids In A Primary Care Setting, Austin Parrish

SIU Journal of Medical Science Scholarly Works

This study examined Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS), Pre-Exposure Prophylaxis (PrEP), and Post-Exposure Prophylaxis (PEP) educational exposure among clinical-phase physician assistant (PA) students and evaluated how well current curricula prepare future providers for HIV prevention and care. A cross-sectional survey of 109 PA students assessed HIV-related knowledge, clinical exposure, and awareness of key public health concepts, while lecture materials from 30 PA programs were analyzed for curricular content. Students demonstrated moderate but incomplete baseline knowledge, and fewer than one-quarter reported observing PrEP prescribing during primary care rotations. Awareness of Undetectable = Untransmittable (U=U) was limited, with only …


Metabolomics In Renal Cystic Disease: Links To Mechanisms And Identification Of Pathways For Potential Prediagnosis, Liyan Chen, David Broadhurst, Armaghan Shafaei, Jacqueline K. Phillips, Shijie Tang, Hayley Abbiss Sep 2026

Metabolomics In Renal Cystic Disease: Links To Mechanisms And Identification Of Pathways For Potential Prediagnosis, Liyan Chen, David Broadhurst, Armaghan Shafaei, Jacqueline K. Phillips, Shijie Tang, Hayley Abbiss

Research outputs 2022 to 2026

Polycystic kidney disease (PKD) is a common hereditary kidney disorder with an insidious onset and complex mechanisms, making early diagnosis challenging. Current diagnostic methods, including imaging and genetic testing, have limitations. Imaging detects cysts only once formed, and genetic testing is costly, labor-intensive, and unable to guarantee complete diagnostic accuracy or predict onset and progression. Metabolomics may offer an approach to uncover PKD mechanisms by detecting metabolic alterations that precede clinical manifestations, enabling identification of disease-specific biomarkers, and providing earlier and more practical detection than imaging or genetic testing. This review synthesizes existing metabolomics studies of human PKD and renal …


Postoperative Complications In Patients With Sickle Cell Disease After Total Shoulder Arthroplasty, Katie Zehner, Gwyneth C. Maloy, John Slevin, Wesley Day, Mitchell K. Ng, Xuan Luo, Jonathan N. Grauer, Arya G. Varthi Sep 2026

Postoperative Complications In Patients With Sickle Cell Disease After Total Shoulder Arthroplasty, Katie Zehner, Gwyneth C. Maloy, John Slevin, Wesley Day, Mitchell K. Ng, Xuan Luo, Jonathan N. Grauer, Arya G. Varthi

Rothman Institute Papers

BACKGROUND: Sickle cell disease (SCD) encompasses a spectrum of genetic hematologic disorders characterized by erythrocyte sickling. Patients may experience musculoskeletal manifestations, such as osteonecrosis, which may warrant consideration for total shoulder arthroplasty (TSA). While prior literature suggests patients with SCD more frequently suffer complications after orthopaedic procedures, this is not well characterized for TSA.

METHODS: Adult TSA patients (older than 18 years) were identified in the 2010 to 2023 PearlDiver M170 database. Patients with SCD were matched 1:4 to patients without SCD based on age, sex, and Elixhauser Comorbidity Index (ECI). Ninety-day postoperative complications, emergency department (ED) visits, and readmissions …


Avoiding Unnecessary Surgery In Acute Longus Colli Calcific Tendinitis: A Clinical Image Of A Retropharyngeal Abscess Mimicker, Brandon M. Nielsen, Oluyemi O. Omotoso Aug 2026

Avoiding Unnecessary Surgery In Acute Longus Colli Calcific Tendinitis: A Clinical Image Of A Retropharyngeal Abscess Mimicker, Brandon M. Nielsen, Oluyemi O. Omotoso

HCA Healthcare Journal of Medicine

Acute calcific tendinitis of the longus colli (LCT) is a rare, benign condition that frequently mimics retropharyngeal abscesses (RPA), a true surgical emergency. We present a 34-year-old woman presenting with 4 days of severe posterior neck pain, stiffness, and odynophagia. Initial evaluation revealed significantly elevated inflammatory markers (erythrocyte sedimentation rate [ESR] 113 mm/hr, C-reactive protein [CRP] 128 mg/L) and leukocytosis, raising immediate concern for deep neck infection. Contrast-enhanced computed tomography (CT) demonstrated a retropharyngeal fluid collection; however, the absence of peripheral ring enhancement and the presence of a pathognomonic calcification anterior to the C1 arch pointed toward LCT. This distinction …


Gallbladder Ascariasis Presenting As Acalculous Biliary Colic, Carmen A. Urbina, Luigi G. Cubeddu, Luigi X. Cubeddu Aug 2026

Gallbladder Ascariasis Presenting As Acalculous Biliary Colic, Carmen A. Urbina, Luigi G. Cubeddu, Luigi X. Cubeddu

HCA Healthcare Journal of Medicine

We detail a case of gallbladder ascariasis, presenting as an acute episode of acalculous biliary colic, nausea, bloating, an unremarkable abdominal ultrasound, and negative helminth and protozoa stool smears. A follow-up ultrasound provided unexpected images consistent with gallbladder infection by Ascaris lumbricoides. Repeat ultrasonography performed 10 days after anthelmintic therapy showed no live worms and 2 newly appearing echogenic areas suggestive of gallbladder calculi that were confirmed following elective cholecystectomy. The case course highlights key clinical, diagnostic, and management considerations in gallbladder ascariasis and underscores the value of repeated ultrasonographic evaluation in affected patients.