Medicine and Health Sciences Commons^™

Humor's Effect On Short-Term Memory In Older Adults: An Innovative Wellness Paradigm, Gurinder Singh Bains

Loma Linda University Electronic Theses, Dissertations & Projects

Context: With ageing, the detrimental effects of stress can impair the ability to learn and sustain memory. Humor and the associated mirthful laughter can reduce stress by decreasing the hormone cortisol. Chronic release of cortisol can damage hippocampal neurons leading to impairment of learning and memory. Objectives: To examine the effect of watching a humor video on short term memory in older adults. Design: A randomized, controlled trial. Setting: Loma Linda University, Loma Linda, CA. Participants: 30 subjects: 20 normal healthy, older adults, 11 males and 9 females; 10 Type 2 Diabetic older adults, 6 males and 4 females. Intervention: …

Screening For Torticollis And Plagiocephaly: The Role Of The Pediatrician, Lisa Ann Change-Yee Hwang

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to examine the effects of providing a standardized screening examination to a group of attending and resident physicians on the rate of torticollis and plagiocephaly diagnoses, the age at time of diagnosis, and the attitudes and practice patterns of the physicians. All subjects were given a standardized screening procedure by verbal instruction and handout, and also completed a pre-­‐ and post-­‐intervention questionnaire, which assessed the 􀂕􀂗􀂄􀂌􀂇􀂅􀂖􀂕􀇯􀀃 practice regarding the diagnosis and management of torticollis and plagiocephaly. A retrospective chart review was conducted to ascertain the changes in frequency and mean age of patients diagnosed …

Co-Constructing Cultural Attunement With Latino Clients In Couple Therapy, Marco Antonio Elias-Juarez

Loma Linda University Electronic Theses, Dissertations & Projects

There is a need for culturally attuned approaches for couple’s therapy with Mexican/ Mexican-American people (Falicov, 2009). However, there have been few theoretical frameworks to conceptualize cultural attunement, and attunement has been primarily understood as a skill or as an attitude rather than as a relationship or as a series of clinical concepts with steps to follow (Hoskins, 1999; Oakes, 2011). From the social constructionist perspective, cultural attunement is related to the cultural context and cultural interactions that shape beliefs and attitudes about what is meaningful in establishing deep relationships for Latino and non-Latino therapists and their Mexican and Mexican-American …

The Association Of Health Literacy With Self-Care Agency In Older Adults In Jamaica, Heather F. Fletcher

Loma Linda University Electronic Theses, Dissertations & Projects

Older adults are the fastest growing segment of the population in Jamaica. With an increase from 10% (252,225) of the total Jamaican population in 1995 to 11% (279,051) in 2005, the rate is expected to rise to 25% by 2025. Thus, it will be critically important to understand factors that may contribute to health maintenance, disease prevention, and wellness promotion. Two such factors – not studied extensively in this country - are health literacy and self-care. The purposes of this study were to (a) generate health literacy profile data with the newly-developed Health Literacy Questionnaire for community-dwelling older adults in …

Exosomal Survivin-T34a: A Novel, Potential Cancer Therapeutic, Jonathan Richard Aspe

Loma Linda University Electronic Theses, Dissertations & Projects

Pancreatic cancer is the fourth most common cause of cancer fatality in American men and women with a less than 5% survival rate. Currently, if diagnosed early, surgical resection remains the only viable cure. However, only 20% of pancreatic cancer patients meet these criteria. It is therefore necessary to discover new therapies or therapeutic combinations in order to impact significantly this deadly disease. The anti-metabolite agent Gemcitabine is currently being employed to treat pancreatic cancer. While Gem-citabine has shown significant benefit in clinical applications, its ability to more than modestly impact pancreatic cancer is limited. It has been speculated that …

Benefits And Barriers To Hiv Testing In A Population Of Federal Detention Inmates, Nicole A. Knight

Loma Linda University Electronic Theses, Dissertations & Projects

Voluntary HIV testing in combination with early medical intervention has been shown to be effective in reducing the rate of new infections and improving the health and life expectancy of those living with HIV. There are however several high-risk populations in the US that remain largely unreached by HIV testing efforts, some of which could be reached while they spend time in prison or jail. Per current Bureau of Prisons (BOP) policy, HIV testing is routinely offered only to “high risk” pretrial and sentenced inmates. We conducted a cross-sectional study with 721 pretrial and sentenced inmates who entered a large …

Towards A Better Treatment Of Parkinson's Disease, Bradley Darryl Karain

Loma Linda University Electronic Theses, Dissertations & Projects

Current therapies for Parkinson's Disease, the second most common neurodegenerative disorder, do not prevent disease progression, and induce extremely detrimental side-effects. Improving the best current pharmacological therapy, L-DOPA, carries important clinical benefits, partly by reducing the dose-related side-effects which occur after five to ten years of use. Thus the central aim of this proposal is to determine whether low doses of a D2 antagonist may, by selectively blocking the dopamine autoreceptor-mediated feedback inhibition of dopamine neurons, potentiate L-DOPA's effect on individual basal ganglia neurons and its antiparkinsonian effects in Parkinsonian animals. Electrophysiology (extracellular single-cell recording in the globus pallidus) and …

Survivin: Regulation By Yy1 And Role In Pancreatic Cancer Combination Therapy, Nicholas R. Galloway

Loma Linda University Electronic Theses, Dissertations & Projects

Despite significant clinical and basic science advancements, cancer remains a devastating disease that affects people of all ages, races, and background. Survivin, the fourth most common transcript found in cancer cells, is a protein that is thought to be involved in the enhanced proliferation, survival, and metastasis of cancer cells. Therefore understanding how this gene is regulated is potentially of vital importance to improving cancer management and therapy. Our work has identified a novel transcriptional regulator of survivin called Yin Yang 1 (YY1). YY1 is a transcription factor that has been observed to activate some gene promoters and repress others, …

Comparison Of Occlusal Plane Orientation Obtained Using Five Facebow Systems, Thomas C. Maveli

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: An in vitro investigation analyzing the sagittal and coronal orientation of the occlusal plane using five different facebow transfer systems. MATERIALS AND METHODS: A phantom head containing a maxillary typodont (the control) was oriented so that Frankfort Horizontal Plane (FHP) corresponds with the horizon. The angle between the occlusal plane of the maxillary arch of the phantom head and the FHP was measured along the sagittal and coronal planes using a digital protractor. Fifteen Facebow records using each of 5 facebow transfer systems (the test groups) were made on the phantom head containing the maxillary typodont. Diagnostic casts of …

Retinoic Acid Regulation Of Thyroid Hormone Action In Bone Cells, Anjali Babbar

Loma Linda University Electronic Theses, Dissertations & Projects

Retinoic acid and thyroid hormone are known to play key roles in the regulation of endochondral ossification. However, the issue of whether these two hormones interact with each other to regulate bone functions remains to be established. We investigated how thyroid hormone and retinoic acid interact to regulate cells involved in endochondral bone formation. We demonstrate that thyroid hormone treatment stimulates differentiation of ATDC5 chondrocytes and promotes formation of mineralized nodules while retinoic acid treatment at high dose inhibits chondrocyte differentiation and formation of mineralized nodules. Furthermore, thyroid hormone induced mineralized nodule formation is inhibited by co-treatment with retinoic acid …

Acculturation And Cardiovascular Behaviors Among Adult Asian-Americans, Monideepa Bhattacharya Becerra

Loma Linda University Electronic Theses, Dissertations & Projects

Background: The World Health Organization recommends the promotion of positive cardiovascular behaviors (healthy diet and physical activity), while reducing negative ones (tobacco and alcohol abuse) as critical steps in reducing the burden of cardiovascular diseases. Researchers have highlighted the role of acculturation in predicting such behaviors among immigrants, though similar studies among Asian-American subgroups are lacking. This study examines the putative relationship between acculturation and aforementioned cardiovascular behaviors among six Asian-American subgroups.

Methods: A secondary analysis of the California Health Interview Survey 2007, 2009, and 2011 public access data was conducted. Acculturation was assessed utilizing proxy measures of language spoken …

Inter-Rater Reliability Of Lumbar Segmental Instability Tests And The Subclassification, Faisal Mohammad Alyazedi

Loma Linda University Electronic Theses, Dissertations & Projects

Objectives: This study investigated the inter-rater reliability of three structural end-range lumbar segmental instability tests with the highest positive Likelihood Ratio against flexion-extension radiographs, and three functional mid-range clinical tests that predict the success of lumbar stabilization exercises in patients with recurrent or chronic low back pain (R/CLBP). It also investigated the reliability of lumbar segmental instability subclassification as: Functional, Structural and Combined Instability. Method: 40 adult with R/CLBP patients (30 men and 10 women), 18 to 80 years of age, underwent repeated measurements of specific clinical tests for structural or functional lumbar segmental instability. Results: Other than the Lack …

Sympathetic Nerve Modulation Of Joint Pathology In Adjuvant-Induced Arthritis, Carlo Anthony Wood

Loma Linda University Electronic Theses, Dissertations & Projects

Background: There is increasing data suggesting a net increase in sympathetic tone plays an important role in rheumatoid arthritis. Several studies have reported altered distribution and density of autonomic nerves in patients with rheumatoid arthritis and animal models for the disease. This provides anatomical evidence that supports a neurally-mediated drive in inflammation and joint destruction. Methods: Adult rats were injected with complete Freund’s adjuvant. At 12 days post immunization, animals were randomly placed into a drug treatment group (SH1293, which interacts with - and ß2-ARs), an adjuvant arthritic group, or a control group. These animals were sacrificed at 14, 21, …

Expression And Function Of Ca2+-Activated K+ Channels In Uterine Arteries, Ronghui Zhu

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic hypoxia during pregnancy is one of the most common insults to the maternal cardiovascular system and fetal development, and is associated with increased uterine vascular tone and heightened risk of preeclampsia and fetal intrauterine growth restriction (IUGR). The present study tested the hypothesis that calcium-activated potassium (KCa) channels play an essential role in uterine vascular adaptation to pregnancy, which is inhibited by chronic hypoxia during gestation. Uterine arteries (UAs) were isolated from nonpregnant ewes (NPUAs) and near-term pregnant ewes (PUAs) that had been maintained at sea level (~300 m) or exposed to high altitude (3,801 m) for 110 days. …

Student Healthcare Providers' Illness Narratives: Impact On Family-Focused Care, Lindsey Ann Lawson

Loma Linda University Electronic Theses, Dissertations & Projects

In this study, we interviewed 30 students training for three areas of healthcare: medicine, nursing, and medical family therapy (MedFT). Through grounded theory analysis of these interviews, we looked to understand how these providers connected their own experiences with illness to their clinical work, particularly in including patients’ family members in care. The majority of participants, and especially those in medicine and nursing disciplines, described a tension between their desire to connect with patients and families and their developing definition of professionalism. For others, the impact of students’ personal experiences with illness seemed to provide a different definition of professionalism, …

Radiosensitization Of Head & Neck Carcinoma Cells By Linifanib, A Receptor Tyrosine Kinase Inhibitor, Heng-Wei Hsu

Loma Linda University Electronic Theses, Dissertations & Projects

Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop combination therapy to improve clinical outcome. The mechanisms between antiangiogenic agents and ionizing radiation are complicated and involve many interactions between the vasculature, tumor stroma and tumor cells. The proliferation and metastasis of tumor cells rely on angiogenesis/blood vessel formation. …

Caveolins And Njks Influence Brain Endothelial Permeability After Juvenile Tbi, David Olufemi Ajao

Loma Linda University Electronic Theses, Dissertations & Projects

Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and …

Association Of Dietary Intake Patterns With Emotion Regulation, Megan Holt

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Western dietary patterns, characterized by high intakes of trans fatty acids (TFA’s), are associated with numerous preventable chronic diseases. Conversely, a Mediterranean dietary pattern is known to be favorably associated with health. Recent findings suggest a correlation between Mediterranean dietary patterns and positive affect, and an inverse correlation with negative affect. Trans fatty acid intake is also associated with negative affect. Further, affect disturbances are associated with emotion dysregulation. We have yet to understand the association of diet with emotion regulation after taking affect disturbances into consideration. The purpose of this study was to examine effects of Mediterranean diet …

Effects Of Parental Trauma Experience On Second Generation Cambodian Americans, Sophorn Theam Choau

Loma Linda University Electronic Theses, Dissertations & Projects

This study explores the parent-child relationship between second generation Cambodian Americans (SGCA) and their first generation parents, as reported by SGCA. Specifically this study examined the effects of parental trauma from the Khmer Rouge (Cambodian genocide), on SGCA in relation to SGCA's mental health status, parent-child communication, cohesion, flexibility, and academic achievements. This study was conceptualized through the effects of intergenerational trauma. A quantitative approach was used to analyze the data. Instruments used to measure the variables in the research included Harvard Trauma Questionnaire Revised Cambodian Version (HTQ), Brief Symptom Inventory-18 (BSI-18), Family Adaptability and Cohesion Evaluation Scales (FACES-IV), and …

Correlating Vomer With Ceph Vectors In High And Low Mandibular Plane Angle Cases, Christopher James Wood

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Growth of the maxilla and mandible follow identifiable vectors of facial growth such as the Rickett’s Facial Axis (FA) and the Down’s Y-axis (YA). The purpose of this study was to evaluate the correlation between the anterior inferior vomer axis (AIVA) and posterior inferior vomer axis (PIVA) with the FA and YA in cases with high (32 degrees and above) and low (20 degrees and below) mandibular plane angles.

Methods: Pretreatment cone beam computed tomography (CBCT) scans of 94 patients treated at the Loma Linda University Graduate Orthodontic Clinic meeting the inclusion criteria were used in this …

Never Smokers -- Are They More Sensitive To The Respiratory Health Effects Of Ambient Air Pollution?, Zuhair Saleh Natto

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Several studies show an association between ambient particulate matter (PM) and all-cause mortality. The Adventist Health and Smog 1 (AHSMOG-1) study (N=6,338) has previously found associations between ambient air pollution and incident chronic obstructive pulmonary disease (COPD) using the spatial interpolation method from the three nearest fixed monitoring stations to residence and workplace. However, few studies have assessed the risk of death among disease specific subgroups such as those with COPD.

Objectives: The aims of this study were 1) to assess the effect of chronic exposure to ambient air pollutants on risk of all-cause mortality among persons with COPD …

Perceived Attitudes And Staff Roles Of Community Based Outpatient Clinics In Disaster Management, Pauline Antoinette Hodge-Hilton

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: Natural and manmade disasters have claimed the lives of thousands of individuals in the US and caused billions of dollars in property damage. First responders carry the responsibility of disaster management, leaving other health care professionals such as medical clinic staff underutilized to support the clinic staff. We explored how medical and support staff in Community-based Outpatient VHA Clinics (CBOC) perceive their roles in disaster response, their attitudes about clinic readiness and continuity of care during disasters, and their ability to function in a post disaster environment.

Methods: A mixed method study was conducted to answer questions related to …

Effect Of Attending Doctor Changes On Orthodontic Treatment Times And Results, Emily Caskey Peppers

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The objective of this study was to determine if there was any significant difference in treatment time or results due to varying levels of attending doctor coverage in the Loma Linda University (LLU) graduate orthodontics clinic. Methods and Materials: The main study group of 191 subjects was split into high, medium and low coverage groups by primary attending doctor coverage and then by original attending doctor coverage. Treatment times, treatment results, and other variables were evaluated for each of the groups. Treatment results were evaluated using UK Peer Assessment Rating (PAR) scores. A second study group (289 subjects) included …

Role Of Vimf In Gingipain Maturation In Porphyromonas Gingivalis, Arun S. Muthiah

Loma Linda University Electronic Theses, Dissertations & Projects

Gingipain activity in Porphyromonas gingivalis, the major etiological agent in adult periodontitis, is post-translationally regulated by unique Vim proteins including VimF, a putative glycosyltransferase. To ascertain the VimF mediated phenotype we first inactivated the vimF gene in P. gingivalis ATCC 33277 (FLL476), a less virulent fimbriated strain. We observed that the vimF-defective mutant (FLL476) showed a phenotype similar to that of the vimF-defective mutant (FLL95) in the P. gingivalis W83 background. While hemagglutination was not detected and autoaggregationn was reduced, biofilm formation was increased in FLL476. Also, invasive capacity decreased for this mutant. Furthermore, fimbrial structures were missing in FLL476, …

Study Of Brief Single Session Medical Family Therapy With Low-Income Patients, Mayuri Pandit

Loma Linda University Electronic Theses, Dissertations & Projects

Medical Family Therapy (MedFT) has been promoted as beneficial for vulnerable patient populations. However, there is a need for MedFT effectiveness studies with longitudinal randomized control trials. Thus, this pilot study investigated the results of a brief single session of MedFT over a one-week period with low-income primary care patients. Effectiveness in this study was defined as increasing a sense agency and communion and decreasing psychological distress. Results suggested that over time, MedFT may increase some sense of agency for lower-income patients, increase patient satisfaction with care, increase family support for patients with higher education, and decrease depression symptoms for …

Comparison Between Ceph Analysis On Lateral Cephs, Cbct Scans, And Mri Scans, Jeffrey W. Lam

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Most current methods of obtaining images for orthodontic diagnosis and treatment planning involve the use of ionizing radiation. Given that patients often need records taken several times during treatment, an alternative should be found that does not involve ionizing radiation. Magnetic resonance imaging (MRI) exists as a possible alternative. Purpose: The purpose of this study is to compare cephalometric measurements obtained from lateral cephs, cone beam computed tomography (CBCT) scans, and MR scans. Methods: Lateral cephs, CBCTs, and MRIs were taken on 22 patients. 3 separate readers traced the images and the data was analyzed using Bland-Altman plots. Results: …

Comparison Of Digital And Cbct Synthesized Lateral Cephalograms, Da Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The purpose of this study was to compare the precision of lateral cephalometric Ricketts analysis measurements from NewTom 5G CBCT (NewTom) synthesized lateral cephalograms with Sirona Orthophos XG Plus (Sirona) digital lateral cephalograms. Materials & Methods: A Sirona digital lateral cephalogram and a NewTom synthesized lateral cephalogram of a phantom in the orthogonal and perspective projections were created. Metal washers in each plane of the phantom were measured in the vertical and horizontal dimensions and compared across the different imaging modalities. In Group 1, forty patients were randomly selected from the Loma Linda University Graduate Orthodontic Clinic who had …

Periodontal Health Of Anterior Teeth With Two Types Of Fixed Retainers, Andrew I. Corbett

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Fixed retainers for anterior teeth have become a popular method for maintaining the position and function of teeth after orthodontic treatment. Various retainer designs, wire sizes and types have been used over the years. One problem with fixed retainers is that they complicate oral hygiene and therefore might negatively affect the periodontal tissues if left in place for long periods of time. Purpose: The purpose of this study is to compare the periodontal health of maxillary and mandibular anterior teeth retained with two different types of fixed retainers. Methods: Male and female subjects who had been in continuous orthodontic …

Photos And Silhouettes In Evaluating The Need For Bsso Surgery In Adult Females, Jessicah L. Moretz

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The objective of this study was to determine the anterior/posterior position of the mandible at which an orthodontist and oral surgeon would advise bilateral sagittal split osteotomy advancement or set back when evaluating adult female photos and silhouettes. Material & Methods: Fifty-one adult female profile photos and lateral cephalograms were collected. Subjects were selected who met three criteria: 1) ANB of 0-2, 2) balanced profile image, and 3) age greater than 18. The image and cephalometric tracing were morphed together to allow software simulation of mandibular prognathia and retrognathia in 2 mm increments. Orthodontists and oral surgeons evaluated morphed …

Successful Aging And Creativity : An Investigation On Functional Status And Psychological Wellbeing In Older Adults, Mirie E. Levy

Loma Linda University Electronic Theses, Dissertations & Projects

Objectives: While the literature supports the maintenance of functional status as integral to successful aging, the relationship of creativity on functional status has received little attention. Creativity has been associated with health and aging in the research but only a small number of studies have examined creativity interventions to enhance functional status and boost psychological wellbeing.

Methods: A pretest-posttest quasi-experimental design was used to investigate an 8-week creativity intervention on functional status and psychological wellbeing in older adults. Sample subjects were 92 men and women all over age 60. A series of two-way mixed ANOVAs measured differences between treatment and …