Medicine and Health Sciences Commons^™

The Effects Of Socioeconomic, Built Environment, And Food Environment Factors On Childhood Obesity In Montclair, California, Krystal Redman

Loma Linda University Electronic Theses, Dissertations & Projects

This observational study examines the relationship between socioeconomic status (SES), built environment, and food environment factors and childhood obesity. In this study, the participants were selected from three elementary schools located in the innercity of Montclair, California. Information about each student’s health and family income and was gathered. In addition, the number of parks, fast food restaurants, and grocery stores within the school district border lines were tallied. I also observed the quality of the parks and food sold in the markets, built environment I hypothesized that childhood obesity is associated with SES (i.e., income level and education level), the …

Fetal Programming And Later Obesity In A Predominantly Latino Wic Population, Eric George Walsh

Loma Linda University Electronic Theses, Dissertations & Projects

Background: In utero stressors may work to program the metabolism of the developing fetus in such a way that predisposes him/her to obesity later on. Studies have shown that breastfeeding is protective against childhood obesity and suggest that after six months the weight gain in breastfed babies slows opposed to formula fed babies who continue with rapid weight gain. This slowing of weight gain has been shown to be protective against adiposity and later life weight gain.

Purpose: This study looks to further explore these findings in a low income Latino population adding mother’s feelings about the pregnancy and the …

Vegf And Sympathetic Perivascular Nerves Contribute To Hypoxic Remodeling Of Ovine Cranial Arteries, Olayemi Olufikayo Adeoye

Loma Linda University Electronic Theses, Dissertations & Projects

Chronic hypoxia complicates many pregnancies and can result in postnatal pathologies that include compromised fetal cardiovascular structure and function. Mechanisms involved remain unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis explored the hypothesis that VEGF contributes to hypoxic fetal vascular remodeling through direct effects on SM cells and indirectly through perivascular nerves. Using a chronic hypoxia sheep model, this work demonstrated that: 1) hypoxia potently upregulates VEGF receptor expression but not endogenous VEGF level in fetal ovine carotid arteries; 2) both chronic hypoxia and VEGF exert similar effects on smooth muscle contractile …

Sleep-Wake Cycle Assessment In Type 2 Diabetes And Salivary Melatonin Correlates, Paula Regina Aguiar Cavalcanti

Loma Linda University Electronic Theses, Dissertations & Projects

p=.047). Additionally, there were significant inverse relationships between melatonin collected at two hours before bed time and latency (ρ=-.87; p=.001), wake after sleep onset (ρ =-.69; p=.02) and nocturnal activity (ρ =-.67; p=.03). Latency was inversely correlated with melatonin collected at bed time (ρ =-.69; p=.02). These findings suggest that T2DM presents disturbances in the homeostatic and circadian drives, mainly characterized by less consistency across days of the daily circadian signal, higher rhythm fragmentation and lower rhythm amplitude. In addition to the lower melatonin levels, the decrease in the amplitude of the activity rhythm may also be involved in circadian …

Buffering Effect Of Relational Support In African American Marriages, Aimee Galick

Loma Linda University Electronic Theses, Dissertations & Projects

Racial discrimination is a common experience for African Americans in this country. Racial discrimination can have a negative effect on the physical and mental health of marital partners, as well the quality and stability of the relationship. Few studies investigate relational support as an important coping strategy. Bodenmann's (1995) divorce-stress model asserts that positive dyadic coping strategies such as relational support can buffer partners and marriages from the negative consequences of stress. Socio-emotional relational therapy (SERT) provides marital and family therapists with a model of relational support in couple relationships. SERT's definition formed the basis for the conceptualization of relational …

Effect Of Procedural Pain On Purines, Mda And Allantoin In Premature Infants, Megan Sue Holden

Loma Linda University Electronic Theses, Dissertations & Projects

Identifying and measuring the biochemical effects of procedural pain in infants is a continuing challenge for clinicians. To address this issue we evaluated the relationship between procedural pain, ATP utilization (hypoxanthine and uric acid), and oxidative stress (MDA and allantoin) in premature infants. Through these studies we found that 1) a single heel-lance significantly increases plasma uric acid in rabbit kits, 2) tape removal increases MDA and prevents a decrease in uric acid in the plasma of premature infants, and 3) a single dose of oral sucrose before a heel-lance is sufficient to significantly increase plasma markers of ATP utilization …

Family Acculturation And Asthma Outcomes In Latino Children, Tania M. Barreno

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Asthma is the primary chronic disease diagnosed in children. California has had some of the highest asthma prevalence rates within the nation. The literature indicates that there is a poor understanding of asthma outcome and management. However, studies exploring the role of acculturation on such outcomes are limited. Thus, the goal of this research was to conduct a secondary analysis of the Child Questionnaire from the California Health Interview Survey (CHIS) 2007 and 2009 cross-sectional data to explore the determinants of asthma outcomes as it relates to family acculturation.

Methodology: The quantitative data were analyzed using Stata. Descriptive statistics, …

Small Molecule Inhibitors Of Hpv16 E6, Chung-Hsiang Yuan

Loma Linda University Electronic Theses, Dissertations & Projects

High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the interactions between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened libraries of small molecules for candidates that could block E6/caspase 8 binding, and identified several candidates from different chemical classes. Testing hits for dose-dependency and specificity in vitro and for toxicity …

The Public Health Impact Of Maternal Smoking Cessation During Pregnancy : The San Bernardino County Experience, Michael Batech

Loma Linda University Electronic Theses, Dissertations & Projects

Most studies of maternal tobacco cessation during pregnancy have estimated measures of effect that can be useful in identifying the exposure as an etiologic risk factor in maternal and child health. However, in the case of maternal tobacco use there is overwhelming evidence for a causal role in adverse infant outcomes, and public health needs to focus on measures of potential impact in order to better prioritize and allocate resources toward interventions. The aims of this dissertation were: 1) to investigate the public health impact of smoking cessation during pregnancy among mothers giving birth in San Bernardino County, California; and …

Role Of Igf-Ii, Prl, And Fabps In The Breast Cancer Disparity Among Aa Women, Teleka Cassandra Patrick

Loma Linda University Electronic Theses, Dissertations & Projects

It is well documented that African-American (AA) patients present with more advanced states of breast cancer and have lower survival rates than Caucasian-Americans (CA). Epidemiological data have shown that pregnancy and lactation at an early age in humans reduce the risk of breast cancer. Studies in mice and rats have shown that lactation stimulates the expression of intracellular fatty-acid binding protein 3 (FABP3). FABP3 is detected in human breast tissue and is known as mammary-derived growth inhibitor (MDGI) because it has a strong inhibitory effect on cell proliferation. FABP5 is also expressed in the breast, and has been associated with …

Stress, Depression, Quality Of Life, And Language Recovery In Constraint Induced Aphasia Therapy (Ciat), Brian Sharp

Loma Linda University Electronic Theses, Dissertations & Projects

Traditional aphasia treatment approaches focus initially on restoration of language, but quickly move to use of alternative modes of communication when progress is slow. Constraint Induced Aphasia Therapy (CIAT), a more intensive form of treatment, is based on the concept of frequent, long sessions and forced use of the impaired language system. Prior to the present study, the relationship between CIAT and stress had not been explored; therefore, this study compared cortisol stress levels and improvement of language skills in two groups of subjects, all of whom presented with expressive aphasia. Ten subjects participated in CIAT, and received 10 days …

Microglia And Complement In Alzheimer's Disease With Cerebral Amyloid Angiopathy, Matthew K. Zabel

Loma Linda University Electronic Theses, Dissertations & Projects

Alzheimer’s disease (AD) is the most common form of dementia and completely lacks any viable, long-term therapeutic intervention. This is partly due to an incomplete understanding of AD etiology and the possible confounding factors associated with its genotypic and phenotypic heterogeneity. Cerebral amyloid angiopathy (CAA) is a common, yet frequently overlooked, pathology associated with AD. A pathological hallmark of AD consists of extracellular amyloid-beta (Aβ) deposits, while CAA

manifests with deposition Aβ within the smooth muscle layer of cerebral arteries and arterioles. The role of Aβ in AD and CAA pathophysiology has long been controversial. Although it may have toxic …

Physician Couples: A Qualitative Inquiry Focused On Gendered Power And Marital Equality, Sarah C. Stuchell

Loma Linda University Electronic Theses, Dissertations & Projects

How couples “do” gender and power in their marriages is a relevant topic for today’s couples. Despite social changes toward equality in many realms, gender continues to organize relationships in ways that give husbands more power than wives. However, some contemporary couples make conscious decisions to resist forces toward organizing according to stereotypical gender ideals and to “do” gender differently in their relationships. For couples in which one or both is a physician, power is also deeply embedded in the physician status, with families tending to organize around the physician’s demands. While these effects reinforce male dominance when the husband …

Ontogeny Of Venom Use And Venom Composition In The Western Widow Spider Latrodectus Hesperus, David Roger Nelsen

Loma Linda University Electronic Theses, Dissertations & Projects

I investigated the behavioral ecology of venom and venom use by the western widow spider (Latrodectus hesperus), emphasizing the role of ontogeny. In an introductory paper, I reviewed existing definitions of venom and poison, and refined these by adding a third category of toxic biological secretions: toxungen. These three can be distinguished by mode of toxin delivery and presence of a wound. In the first of four empirical studies, I investigated venom use by adult females in the context of threat assessment. A single brief poke at the lowest threat level elicited primarily avoidance responses ("move" and "retract"), repeated prodding …

Maternal Smoking, Weight Status And Preecalmpsia And Eclampsia Risk Among Women Living In San Bernardino County, Fiona Bedelia Lewis

Loma Linda University Electronic Theses, Dissertations & Projects

Preeclampsia is defined as pregnancy-induced hypertension affecting between 2% and 8% of pregnancies and accounting for about 10-15% of maternal deaths worldwide. Eclampsia is defined as the occurrence of one or more episodes of seizures in a pregnant woman related only to a preeclampsia diagnosis. Preeclampsia, if poorly managed, can progress to eclampsia resulting in injury and death to both mother and infant. The etiology of preeclampsia is not completely understood. Oxidative stress leading to abnormal placenta development and endothelial dysfunction are thought to be key components in the biological mechanism of preeclampsia.

Modifiable risk factors include maternal body weight …

Perinatal Nicotine Exposure And Programming Of Hie Sensitive Phenotype In Neonatal Rat Brains, Yong Li

Loma Linda University Electronic Theses, Dissertations & Projects

Large epidemiological and animal studies have revealed a clear association of adverse intrauterine environment with the increased risk of metabolic, cardiovascular and neurological diseases. Maternal smoking is the single most widespread perinatal insult in the world and has been associated with adverse pregnancy outcomes for mother, fetus and the newborn. Our study aims to test the hypothesis that perinatal nicotine exposure induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model …

Anterior Cruciate Ligament Elasticity And Force For Knee Flexion During The Menstrual Cycle In Women, Haneul Lee

Loma Linda University Electronic Theses, Dissertations & Projects

Numerous studies have been conducted on changes of knee ligament laxity during the menstrual cycle (MC) since there are more injuries in certain phases. Some researchers believe that since estrogen receptor β exists in ligaments and tendons in the knee, estrogen may modulate towards a state of laxity. However, increased tissue temperature also observed during the MC can predispose ligament and tendon laxness. The number of women using oral contraceptive pills (OCP) has constantly increased in the United States. This exogenous source of synthetic forms of steroid hormones prevents ovulation by maintaining more consistent daily hormone levels than occurs. Since …

Negotiating Marital Care: Co-Creating The Connected Egalitarian Relationship, Lena Lopez Bradley

Loma Linda University Electronic Theses, Dissertations & Projects

Research suggests that couples seek connection and equality within the marital relationship, yet they continue to struggle due to the continued impact of traditional gender ideologies (Coontz, 2006; Knudson-Martin & Mahoney 2009). The current body of literature reveals little about how specific relational negotiation practices contribute to attaining an equal and connected relationship over time. This study utilizes grounded theory methodology and a feminist social constructionist framework to explore how traditional gender constructs impact couples’ ability to negotiate connected egalitarianism within relationship over time.

The analysis of 68 interviews with two sets of couples—parents of children 5 years old and …

The Association Of Diet And Physical Activity With Stroke Mortality Results From The Adventist Health Study-1, Tahereh Zamansani

Loma Linda University Electronic Theses, Dissertations & Projects

Stroke is one of the leading causes of death and disability, with major global public health implications. Stroke ranks No. 4 among all causes of death, behind heart disease, cancer, and chronic lower respiratory disease (CLRD). Stroke accounts for almost 1 of every 18 deaths in the United States. Women accounted for 60.6% of stroke deaths. Death certificate data show that the mean age at stroke death was 79.6 years; males had a younger mean age (76.3) than females.

There is still a great scientific uncertainty among researchers and epidemiologists about the magnitude of any preventive effect, mechanisms of action …

Beliefs About Complementary And Alternative Medicine In Hiv-Infected Black Women Using The Theory Of Planned Behavior, Stephanie G. Lino

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Black women make up 12% of the female population in the U.S, yet they account for 66% of new HIV infections. In 2002, AIDS was the most cited reason for death among Black women age 25-34. While prevention remains, a major effort targeting treatment efficacy and modalities for this sub-group need to be better understood.

Purpose. The purpose of this study is to assess whether HIV-positive Black women’s attitudes, subjective norms and perceived behavioral control are related to intention of dietary supplements and spiritual practices use in their HIV treatment.

Method. In phase one, Grounded Theory methods (N= …

Regulation Of Igfbp-5 And Osteoblast Functions By Nuclear Factor I, Laura A. Perez-Casellas

Loma Linda University Electronic Theses, Dissertations & Projects

The Insulin-like Growth Factor (IGF) system is a major target of GC inhibition in bone. We found that GCs inhibit expression of IGF binding protein-5 (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter activity was mediated by a composite response element that has binding sites for transcription factor activator protein 2 (AP-2) and nuclear factor I (NFI). The work in this dissertation identifies the NFI gene family as an important regulator of IGFBP-5 transcription primarily in human, as well as murine osteoblasts. The mechanism of IGFBP5 gene regulation involves …

Effect Of Passive Vibration On Skin Blood Flow In Good Glycemic Control And Poor Glycemic Control Type 2 Diabetics, Kanikkai Steni Balan Sackiriyas

Loma Linda University Electronic Theses, Dissertations & Projects

Microcirculation regulated by the sympathetic system and vascular endothelium plays a significant role in the homeostasis of temperature and wound healing. Damage to the autonomic nervous system and endothelial system resulting from aging and diabetes decreases the potential of wound healing. Insulin resistance and impaired wound healing associated with type 2 diabetes can lead to diabetic foot ulceration (DFU). Factors such as the increased insulin resistance, impaired wound healing and DFU can increase the risk of amputation in type 2 diabetics (T2D). In research, passive vibration (PV) was effective in increasing skin blood flow (SBF) in healthy individuals as well …

Evaluation Of Accuracy Of Impression Materials With Different Mixing Techniques, James Ywom

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: To investigate gypsum compatibility and dimensional stability of irreversible hydrocolloid impression materials with three mixing techniques. A comparison between vacuum-mixed, mechanically-mixed and manually-mixed techniques was evaluated for each impression material. Materials and Methods: Three irreversible hydrocolloid impression materials Kromopan 100® (Lascod™), Identic® (Dux dental™), and Jeltrate Plus® (Dentsply™) were tested gypsum compatibility in accordance with ANSI/ADA Specification No. 18 for alginate impression materials. The test for linear dimensional stability was tested in accordance with ANSI/ADA Specification No. 19 for elastomeric impression materials. A One-way ANOVA test was used to analyze dimensional stability at a significance level of (p < 0.05). Conclusion: The vacuum mixing technique facilitates the mixing of irreversible hydrocolloid impression materials and improves the compatibility with gypsum material and reproduces a more dimensionally accurate cast than the other mixing techniques.

Evaluation Of The Survival Effect For Various Treatment Modalities Among Stage Ii And Iii Rectal Cancer Patients In California, 1994-2009, Myung Mi Cho

Loma Linda University Electronic Theses, Dissertations & Projects

Background: European trials evaluating the effect of preoperative (PreOP) versus postoperative chemoradiotherapy (PostOP CRT) found no survival benefit. However, the effect of a change from PostOP to PreOP CRT has not been evaluated in a population-based setting. We sought to evaluate multimodal treatment changes and overall survival for perioperative (PeriOP) CRT versus surgery alone and for PreOP versus PostOP CRT from 1994 through 2009 among patients receiving radical surgery for stage II and III rectal cancer (RC).

Patients and Methods: We conducted a nonconcurrent cohort study evaluating demographic predictors of multimodal therapy for stage II and III RC using …

The Morbidity & Mortality Of Prevalent Heart Failure, Jennifer Kwon

Loma Linda University Electronic Theses, Dissertations & Projects

The first study population included 292 unselected consecutive patients from the LLUMC heart failure clinic who were enrolled in the study from January to July 2006 and were followed up through the end of December 2010. The treatment policy at the clinic was to uptitrate dosages of beta-adrenergic blockade (β-blockers), angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) to the most tolerable levels in order to reach target dosages, as recommended by the Heart Failure Society of America (HFSA). Patients were classified into systolic heart failure (ejection fraction (EF) < 40%) or diastolic heart failure (EF≥40%). All dosages of β-blockers, ACEi and ARB were extracted through chart reviews and were used as the main predictors of the patients' survival. Results from analyses showed that reaching target dosages of β-blockers and ACEi/ARB may increase survival when compared to not reaching target among the systolic HF population (HR_{β_biockers}= 0.64, 95% CI 0.26-1.56 and HR_ACEi/ARB=0.50, …

Exploring Healthcare Simulation As A Platform For Interprofessional Education, Janice Christine Palaganas

Loma Linda University Electronic Theses, Dissertations & Projects

Interprofessional education (IPE) is gradually recognized as essential to patient safety and implemented as a standard for healthcare education through professional organization recommendations and accrediting bodies. Given the increasing adoption of experiential and team-based learning, healthcare simulation (HCS) has become a preferred vehicle for IPE. As healthcare professional educators explore simulation as a platform for IPE, a need to better understand the state of the science has become apparent. This descriptive comparative study examines how the most commonly used simulation modalities and IPE teaching methods (low-technology versus high-technology; multiprofessional versus collaborative team-based activities; observational versus active methods; standardized patients versus …

In‐Vitro Comparison Of Tensile Bond Strength Of Denture Adhesives On Denture Bases, Doris Rachel Kore

Loma Linda University Electronic Theses, Dissertations & Projects

PURPOSE: To evaluate the tensile bond strength (TBS) of three cream denture adhesives and one wafer denture adhesive on three denture base materials at five time intervals up to 24 hours. METHODS: Fixodent (Proctor & Gamble™), Super Poligrip (GlaxoSmithKline™), Effergrip (Prestige Brands, Inc.™), and SeaBond (Combe™) were tested with the Instron testing machine on three denture base resin cylinder models fabricated from two heat‐polymerized (Lucitone 199 and SR Ivocap) and one visible lightcured, shade stable (Eclipse) acrylic resins. Laboratory prepared artificial saliva with mucin was used for the control study. In accordance with ADA specifications, the TBS was tested at …

Effectiveness Of Resin Infiltration And Mi Paste Cpp-Acp In Masking White Spot Lesions, Melissa Wu Bailey

Loma Linda University Electronic Theses, Dissertations & Projects

The development of decalcification around orthodontic brackets and bands, commonly called white spot lesions (WSLs), is often observed in patients with poor oral hygiene during treatment (Behnan et al., 2010, Rodgers et al., 2010). In many instances, these WSLs continue to be visible after the removal of fixed appliances and after natural remineralization. The purpose of this in vitro study was to compare the effectiveness of two treatment modalities, resin infiltration (RI) and Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), at improving the light reflectivity and thus the appearance of WSLs using spectrophotometric analysis. Sixty extracted human third molars were partially …

Accuracy Of Ortho Insight 3d Digital Scanner In Mesial-Distal Tooth Measurements, Andrew A. Ferris

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Digital scanners and software may be used to measure mesial-distal (MD) tooth width for orthodontic diagnosis and treatment planning. Although there have been many studies performed on different digital scanners, accuracy of mesial-distal tooth measurements using the Ortho Insight 3D scanner and its software (Motionview Software LLC) has not been reported. Purpose: The objective of this study was to determine if the MD tooth measurements from the digital models scanned by Ortho Insight 3D are accurate compared to the measurements taken directly from the teeth and models with a digital caliper. Material and Methods: Individual MD tooth measurements were …

Dental And Buccal Bone Stability After Rapid Maxillary Expansion And Fixed Orthodontic Treatment, Allison Milliner

Loma Linda University Electronic Theses, Dissertations & Projects

The objective of this study was to quantitatively evaluate, via CBCT, the dental and osseous effects of patients who had completed comprehensive orthodontic treatment with rapid maxillary expansion (RME) in conjunction with Ricketts prescription brackets. Thirty consecutive patients (16 males, 14 females; mean age = 13.9  1.9 years) who required RME as part of their orthodontic treatment and had pre-RME (T1), post-RME (T2) and final orthodontic (T3) CBCT images were included in the study. Thirteen patients had 2-banded, while 17 had 4-banded appliances. Measurements of interdental distance (ID), interdental angle (IA), buccal bone thickness (BBT) and buccal marginal bone …