Medicine and Health Sciences Commons^™

Erratum: Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis (Schizophrenia Bulletin (2015) 41 (1066-1075) Doi: 10.1093/Schbul/Sbv091), J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. K. Heinssen, L. J. Seidman, S. W. Woods, +4 Additional Authors

Journal Articles

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. An error in statistical syntax defining baseline disorder led to misidentification of baseline anxiety disorder in five cases in one of the two reported samples (PREDICT). NAPLS-1 data and previous publications of PREDICT data were not affected. The error affected rows in Table 1 labeled 'DSM-IV anxiety' and 'Any mood/anx disorder' and rows in Table 3 labeled 'Baseline Anxiety Excluded' and 'Any Baseline Mood/ Anxiety Excluded.' Corrected Tables are shown below with corrected numbers in bold. Tables S1-S5 in the …

Management Of Acute Pancreatitis In The Pediatric Population: A Clinical Report From The North American Society For Pediatric Gastroenterology, Hepatology And Nutrition Pancreas Committee., M. Abu-El-Haija, S. Kumar, J. A. Quiros, K. Balakrishnan, B. Barth, S. Bitton, J. F. Eisses, E. J. Foglio, V. Fox, V. D. Morinville, +10 Additional Authors

Journal Articles

BACKGROUND:Although the incidence of acute pancreatitis (AP) in children is increasing, management recommendations rely on adult published guidelines. Pediatric-specific recommendations are needed. METHODS:The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas committee performed a MEDLINE review using several preselected key terms relating to management considerations in adult and pediatric AP. The literature was summarized, quality of evidence reviewed, and statements of recommendations developed. The authorship met to discuss the evidence, statements, and voted on recommendations. A consensus of at least 75% was required to approve a recommendation. RESULTS:The diagnosis of pediatric AP should follow the published INternational Study …

Metabolic Obesity Phenotypes And Risk Of Colorectal Cancer In Postmenopausal Women., G. C. Kabat, M. Y. Kim, M. Stefanick, G. Y. F. Ho, D. S. Lane, A. O. Odegaard, M. S. Simon, J. W. Bea, J. Luo, T. E. Wassertheil-Smoller

Journal Articles

Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR-a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-

Joint Representation Of Spatial And Phonetic Features In The Human Core Auditory Cortex, P. Patel, L. K. Long, J. L. Herrero, A. D. Mehta, N. Mesgarani

Journal Articles

No abstract provided.

The Influence Of Insurance Type On Stage At Presentation, Treatment, And Survival Between Asian American And Non-Hispanic White Lung Cancer Patients, A. Tantraworasin, E. Taioli, B. Liu, R. M. Flores, A. J. Kaufman

Journal Articles

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. The effect of insurance type on lung cancer diagnosis, treatment, and survival in Asian patients living in the United States is still under debate. We have analyzed this issue using the Surveillance, Epidemiology, and End Results database. There were 102,733 lung cancer patients age 18–64 years diagnosed between 2007 and 2013. Multilevel regression analysis was performed to identify the association between insurance types, stage at diagnosis, treatment modalities, and overall mortality in Asian and non-Hispanic White (NHW) patients. Clinical characteristics were significantly different between Asian and NHW …

Liver Cancer Disparities In New York City: A Neighborhood View Of Risk And Harm Reduction Factors, G. R. Kamath, E. Taioli, N. N. Egorova, J. M. Llovet, P. V. Perumalswami, J. J. Weiss, M. Schwartz, S. Ewala, N. A. Bickell

Journal Articles

© 2018 Kamath, Taioli, Egorova, Llovet, Perumalswami, Weiss, Schwartz, Ewala and Bickell. Introduction: Liver cancer is the fastest increasing cancer in the United States and is one of the leading causes of cancer-related death in New York City (NYC), with wide disparities among neighborhoods. The purpose of this cross-sectional study was to describe liver cancer incidence by neighborhood and examine its association with risk factors. This information can inform preventive and treatment interventions. Materials and methods: Publicly available data were collected on adult NYC residents (n = 6,407,022). Age-adjusted data on liver and intrahepatic bile duct cancer came from the …

Prevalence, Comorbidity, And Correlates Of Psychiatric And Substance Use Disorders And Associations With Hiv Risk Behaviors In A Multisite Cohort Of Women Living With Hiv, J. A. Cook, J. K. Burke-Miller, P. J. Steigman, R. M. Schwartz, N. A. Hessol, J. Milam, D. J. Merenstein, K. Anastos, E. T. Golub, M. H. Cohen

Journal Articles

© 2018, The Author(s). We used the World Health Organization’s Composite International Diagnostic Interview to determine the prevalence, comorbidity, and correlates of lifetime and 12-month behavioral health disorders in a multisite cohort of 1027 women living with HIV in the United States. Most (82.6%) had one or more lifetime disorders including 34.2% with mood disorders, 61.6% with anxiety disorders, and 58.3% with substance use disorders. Over half (53.9%) had at least one 12-month disorder, including 22.1% with mood disorders, 45.4% with anxiety disorders, and 11.1% with substance use disorders. Behavioral health disorder onset preceded HIV diagnosis by an average of …

Controversies On Lung Cancers Manifesting As Part-Solid Nodules., R. Yip, K. Li, L. Liu, D. Xu, K. Tam, D. F. Yankelevitz, E. Taioli, B. Becker, C. I. Henschke

Journal Articles

PURPOSE: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs).

METHODS: PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs

RESULTS: Twenty studies reported on PSNs

CONCLUSION: A clear definition of the upper limit of solid component of a PSN is needed to avoid …

Gender Differences In Pain Experience And Treatment After Motor Vehicle Collisions: A Secondary Analysis Of The Crash Injury Study, T. E. Madsen, S. Mclean, W. Zhai, S. Linnstaedt, M. C. Kurz, R. Swor, P. Hendry, D. Peak, D. Lee, F. Beaudoin, +4 Additional Authors

Journal Articles

No abstract provided.

Implementation Of An Emergency Medicine Research Associates Program: Sharing 20 Years Of Experience, B. Abar, V. Derienzo, J. Glick, N. Wood, M. N. Shah, S. Schneider, D. Adler

Journal Articles

© 2018 Abar et al. Introduction: The use of research associates (RA) programs to facilitate study enrollment in the emergency department was initiated during the mid-1990s. The University of Rochester Medical Center (URMC) was an early adopting site for this model, which has experienced considerable growth and development over the past 20 years. Methods: Our goal was to detail the Emergency Department Research Associates (EDRA) program processes developed at the URMC that has led to our program’s sustainability and productivity. These processes, and the lessons learned during their development, can assist institutions seeking to establish an RA program or refine …

Correction To: The Toxicology Investigators Consortium Case Registry—The 2017 Annual Report., L. A. Farrugia, S. H. Rhyee, S. L. Campleman, B. Judge, L. Kao, A. Pizon, L. Porter, A. M. Riederer, N. Majlesi, A. Zosel, +89 Additional Authors

Journal Articles

No abstract provided.

Epidemiology Of Injuries In Tennis Players, M. C. Fu, T. S. Ellenbecker, P. A. Renstrom, G. S. Windler, D. M. Dines

Journal Articles

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of review: To review the recent literature regarding the epidemiology of tennis injuries at all levels of play, and to discuss recent findings in injury surveillance by the Association of Tennis Professionals (ATP). Recent findings: Following the release of a consensus statement in 2009 calling for standardized documentation and analysis of tennis-related injuries, multiple studies have been published describing longitudinal injury incidences at Grand Slam tournaments and the Davis Cup. Recent efforts by the ATP have further elucidated injury patterns on tour. There have also been recent high-quality studies …

Comparative Effectiveness Of A Technology-Facilitated Depression Care Management Model In Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes Of A Large Clinical Trial., S. Wu, K. Ell, H. Jin, I. Vidyanti, C. P. Chou, P. J. Lee, S. Gross-Schulman, L. M. Sklaroff, M. Richman, J. Guterman, +20 Additional Authors

Journal Articles

BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers.

OBJECTIVE: The aim of this study was to compare 6-month outcomes of a technology-facilitated care model with a usual care model and a supported care model that involved team-based …

Long Head Of Biceps Tendon Management: A Survey Of The American Shoulder And Elbow Surgeons, K. T. Corpus, G. H. Garcia, J. N. Liu, D. M. Dines, S. J. O’Brien, J. S. Dines, S. A. Taylor

Journal Articles

© 2017, Hospital for Special Surgery. Background:: Management of symptomatic long head of biceps tendon (LHBT) pathology remains a source of debate. Questions/Purposes:: The purpose of this study was to identify consensus trends for the treatment of LHBT pathology among specialists. Methods:: A survey was distributed to members of the American Shoulder and Elbow Society (ASES), consisting of three sections—demographics, case scenarios, and general LHBT pathology management. Cases presented common clinical scenarios, and surgeons reported their management preferences. Consensus responses were defined as > 50% of participants giving a single response. Results:: One hundred and forty-two of 417 (34%) surgeons completed …

Management Of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis, A. Malhotra, X. Wu, H. P. Forman, C. C. Matouk, D. Gandhi, P. Sanelli

Journal Articles

© 2017 American Medical Association. All rights reserved. Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs. Design, Setting, and Participants: …

Nuclear Medicine Imaging In Fever Of Unknown Origin: The New Paradigm, C. J. Palestro, C. Love

Journal Articles

No abstract provided.

Endoscopic Proximal Adductor Lengthening For Chronic Adductor-Related Groin Pain, S. Bharam, P. V. Bhagat, M. C. Spira, D. A. Klein

Journal Articles

© 2018 Arthroscopy Association of North America Proximal adductor injuries are relatively common groin injuries in athletes. Various tenotomy techniques have been described including open, partial, and percutaneous approaches. Current techniques help most athletes return to sport; however, many develop adductor weakness. Moreover, the procedures lack full visualization of the tendon and do not allow for return to athletes’ preinjury level of play. We describe an endoscopic z-lengthening of the proximal adductor tendon with the potential to minimize complications associated with open procedures such as incisional pain and neurovascular injury while affording a more complete tenotomy than current percutaneous techniques. …

Neuroimaging Of Meckel’S Cave In Normal And Disease Conditions, A. Malhotra, L. Tu, V. B. Kalra, X. Wu, A. Mian, R. Mangla, E. Michaelides, P. Sanelli, D. Gandhi

Journal Articles

© 2018, The Author(s). Abstract: Meckel’s cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel’s cave; (2) to …

Open Access: Is There A Predator At The Door?, R. Chandra, E. W. Fisher, T. M. Jones, D. W. Kennedy, D. H. Kraus, J. H. Krouse, M. J. Link, L. R. Lustig, B. W. O'Malley, R. Youngs, +8 Additional Authors

Journal Articles

No abstract provided.

Thyroseq V3 Molecular Profiling For Tailoring The Surgical Management Of Hürthle Cell Neoplasms., S. Pearlstein, A. H. Lahouti, E. Opher, Y. E. Nikiforov, D. B. Kuriloff

Journal Articles

Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite …

Promoting Sustainability In Quality Improvement: An Evaluation Of A Web-Based Continuing Education Program In Blood Pressure Measurement., L. Block, S. J. Flynn, L. A. Cooper, C. Lentz, T. Hull, K. B. Dietz, R. T. Boonyasai

Journal Articles

BACKGROUND: The accuracy of blood pressure measurement is variable in office-based settings. Even when staff training programs are effective, knowledge and skills decay over time, supporting the need for ongoing staff training. We evaluated whether a web-based continuing education program in blood pressure measurement reinforced knowledge and skills among clinical staff and promoted sustainability of an existing quality improvement program.

METHODS: Medical assistants and nurses at six primary care clinics within a health system enrolled in a 30-min online educational program designed to refresh their knowledge of blood pressure measurement. A 20-question pre- and post-intervention survey addressed learners' knowledge and …

Gene-Level Association Analysis Of Systemic Sclerosis: A Comparison Of African-Americans And White Populations, O. Y. Gorlova, Y. Li, I. Gorlov, J. Ying, W. V. Chen, S. Assassi, J. D. Reveille, P. K. Gregersen, A. T. Lee, D. Khanna, M. D. Mayes, +22 Additional Authors

Journal Articles

© 2018 Gorlova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The White …

Dynamic Hydrostatic Pressure Regulates Nucleus Pulposus Phenotypic Expression And Metabolism In A Cell Density-Dependent Manner, B. S. Shah, N. O. Chahine

Journal Articles

© 2018 by ASME. Dynamic hydrostatic pressure (HP) loading can modulate nucleus pulposus (NP) cell metabolism, extracellular matrix (ECM) composition, and induce transformation of notochordal NP cells into mature phenotype. However, the effects of varying cell density and dynamic HP magnitude on NP phenotype and metabolism are unknown. This study examined the effects of physiological magnitudes of HP loading applied to bovine NP cells encapsulated within three-dimensional (3D) alginate beads. Study 1: seeding density (1 M/mL versus 4 M/mL) was evaluated in unloaded and loaded (0.1 MPa, 0.1 Hz) conditions. Study 2: loading magnitude (0, 0.1, and 0.6 MPa) applied …

Smoking Is The Most Significant Modifiable Lung Cancer Risk Factor In Systemic Lupus Erythematosus, S. Bernatsky, R. Ramsey-Goldman, M. Petri, M. B. Urowitz, D. D. Gladman, P. R. Fortin, E. H. Yelin, E. Ginzler, C. Aranow, A. E. Clarke, +9 Additional Authors

Journal Articles

Copyright © 2018 The Journal of Rheumatology. All rights reserved. Objective. To assess lung cancer risk in systemic lupus erythematosus (SLE), relative to demographics, drug exposures, smoking, and disease activity. Methods.We analyzed data from 14 SLE cohorts. We calculated adjusted HR estimates for lung cancer in SLE, relative to demographics, smoking, time-dependent medication exposures, and cumulative disease activity [mean adjusted SLE Disease Activity Index (SLEDAI) scores]. This project was approved by the ethics boards of all participating institutions, including the Institutional Review Board of the McGill University Health Centre. The ethics approval number for the Cancer Risk study is GEN-06-031. …

New Insights Into The Function Of Rab Gtpases In The Context Of Exosomal Secretion, L. Blanc, M. Vidal

Journal Articles

© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group © 2017, © Lionel Blanc and Michel Vidal. In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, the function of extracellular vesicles is far from clear, especially due to the disparity of released vesicles by cells. Basically, one must consider vesicles budding from the cell plasma membrane (ectosomes) and vesicles released upon fusion of an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report and discuss here the possibility that different routes regulated by …

No Improvement In Long-Term Survival Over Time For Chronic Lymphocytic Leukemia Patients In Stereotyped Subsets #1 And #2 Treated With Chemo(Immuno)Therapy, P. Baliakas, M. Mattsson, A. Hadzidimitriou, E. Minga, A. Agathangelidis, L. A. Sutton, L. Scarfo, Z. Davis, N. Chiorazzi, K. Stamatopoulos, +30 Additional Authors

Journal Articles

No abstract provided.

Somatic Cll Mutations Occur At Multiple Distinct Hematopoietic Maturation Stages: Documentation And Cautionary Note Regarding Cell Fraction Purity, S. Marsilio, H. Khiabanian, G. Fabbri, S. Vergani, C. Scuoppo, E. Montserrat, E. J. Shpall, M. Hadigol, K. R. Rai, N. Chiorazzi, +4 Additional Authors

Journal Articles

No abstract provided.

Genetic Background May Contribute To The Latitude-Dependent Prevalence Of Dermatomyositis And Anti-Tif1-Γ Autoantibodies In Adult Patients With Myositis, J. E. Parkes, S. Rothwell, A. Oldroyd, H. Chinoy, J. A. Lamb, I. E. Lundberg, F. W. Miller, P. K. Gregersen, G. Marder, Z. E. Betteridge, +25 Additional Authors

Journal Articles

© 2018 The Author(s). Background: The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultraviolet (UV) light towards the equator. In this study, we investigated whether differing genetic background in populations could contribute to this distribution of DM. Methods: Case data derived from the MYOGEN (Myositis Genetics Consortium) Immunochip study (n = 1769) were used to model the association of DM prevalence and DM-specific autoantibodies with latitude. Control data (n = 9911) were used to model the relationship of human …

Hydroxychloroquine Prescription Trends And Predictors For Excess Dosing Per Recent Ophthalmology Guidelines, A. M. Jorge, R. B. Melles, Y. Zhang, N. Lu, S. K. Rai, L. H. Young, K. H. Costenbader, R. Ramsey-Goldman, C. Aranow Md, H. Choi, +6 Additional Authors

Journal Articles

© 2018 The Author(s). Background: Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight (ABW)-based dosing. However, contemporary HCQ prescribing trends in the UK remain unknown. Methods: We examined a UK general population database to investigate HCQ dosing between 2007 and 2016. We studied trends of excess HCQ dosing per ophthalmology guidelines (defined by exceeding 6.5 mg/kg of IBW and 5.0 mg/kg of ABW) and determined their independent predictors using multivariable logistic regression analyses. Results: Among 20,933 new HCQ users (78% female), the …

Methods For High-Dimensonal Analysis Of Cells Dissociated From Cyropreserved Synovial Tissue, L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. Mcgeachy, J. D. Turner, P. K. Gregersen, R. Furie, B. Diamond, M. Mcmahon, +81 Additional Authors

Journal Articles

© 2018 The Author(s). Background: Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to deconstruct autoimmune pathology by examining cells within target tissues through multiple high-dimensional assays. Robust standardized protocols need to be developed before cellular phenotypes at a single cell level can be effectively compared across patient samples. Methods: Multiple clinical sites collected cryopreserved synovial tissue fragments from arthroplasty and synovial biopsy in a 10% DMSO solution. Mechanical and enzymatic dissociation parameters were optimized for viable cell …