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Letter: Surgical Management Of Brain Tumor Patients In The Covid-19 Era, Be Zacharia, Dg Eichberg, Me Ivan, S Hanft, Ja Boockvar, H Isildak, A Mansouri, Rj Komotar, Rs D'Amico Jan 2020

Letter: Surgical Management Of Brain Tumor Patients In The Covid-19 Era, Be Zacharia, Dg Eichberg, Me Ivan, S Hanft, Ja Boockvar, H Isildak, A Mansouri, Rj Komotar, Rs D'Amico

Journal Articles

No abstract provided.


Telemedicine For Outpatient Neurosurgical Oncology Care: Lessons Learned For The Future During The Covid-19 Pandemic., Lc Daggubati, Dg Eichberg, Me Ivan, S Hanft, A Mansouri, Rj Komotar, Rs D'Amico, Be Zacharia Jan 2020

Telemedicine For Outpatient Neurosurgical Oncology Care: Lessons Learned For The Future During The Covid-19 Pandemic., Lc Daggubati, Dg Eichberg, Me Ivan, S Hanft, A Mansouri, Rj Komotar, Rs D'Amico, Be Zacharia

Journal Articles

No abstract provided.


Negative Sars-Cov-2 Antibody Testing Following Covid-19 Infection In Two Ms Patients Treated With Ocrelizumab, Jr Thornton, A Harel Jan 2020

Negative Sars-Cov-2 Antibody Testing Following Covid-19 Infection In Two Ms Patients Treated With Ocrelizumab, Jr Thornton, A Harel

Journal Articles

No abstract provided.


Neurological Manifestations Of Covid-19 (Sars-Cov-2): A Review, Mu Ahmed, M Hanif, Mj Ali, Ma Haider, D Kherani, Gm Memon, Ah Karim, A Sattar Jan 2020

Neurological Manifestations Of Covid-19 (Sars-Cov-2): A Review, Mu Ahmed, M Hanif, Mj Ali, Ma Haider, D Kherani, Gm Memon, Ah Karim, A Sattar

Journal Articles

No abstract provided.


Cerebrovascular Complications Of Covid-19, J. M. Katz, R. B. Libman, J. J. Wang, P. Sanelli, C. G. Filippi, M. Gribko, S. V. Pacia, R. I. Kuzniecky, S. Najjar, S. Azhar Jan 2020

Cerebrovascular Complications Of Covid-19, J. M. Katz, R. B. Libman, J. J. Wang, P. Sanelli, C. G. Filippi, M. Gribko, S. V. Pacia, R. I. Kuzniecky, S. Najjar, S. Azhar

Journal Articles

No abstract provided.


Central Nervous System Complications Associated With Sars-Cov-2 Infection: Integrative Concepts Of Pathophysiology And Case Reports, S. Najjar, A. Najjar, D. J. Chong, B. K. Pramanik, C. Kirsch, R. Kuzniecky, S. Pacia, S. Azhar Jan 2020

Central Nervous System Complications Associated With Sars-Cov-2 Infection: Integrative Concepts Of Pathophysiology And Case Reports, S. Najjar, A. Najjar, D. J. Chong, B. K. Pramanik, C. Kirsch, R. Kuzniecky, S. Pacia, S. Azhar

Journal Articles

No abstract provided.


Acute Seizures Occurring In Association With Sars-Cov-2, S. T. Hwang, A. A. Ballout, U. Mirza, A. N. Sonti, A. Husain, C. Kirsch, R. Kuzniecky, S. Najjar Jan 2020

Acute Seizures Occurring In Association With Sars-Cov-2, S. T. Hwang, A. A. Ballout, U. Mirza, A. N. Sonti, A. Husain, C. Kirsch, R. Kuzniecky, S. Najjar

Journal Articles

© Copyright © 2020 Hwang, Ballout, Mirza, Sonti, Husain, Kirsch, Kuzniecky and Najjar. Seizures are an infrequent and serious neurological complication of SARS-CoV-2 infection, with limited data describing the etiology and the clinical context in which these occur or the associated electrographic and imaging findings. This series details four cases of seizures occurring in patients with COVID-19 with distinct time points, underlying pathology, and proposed physiological mechanisms. An enhanced understanding of seizure manifestations in COVID-19 and their clinical course may allow for earlier detection and improved patient management.


The Influence Of Migraine On Driving: Current Understanding, Future Directions, And Potential Implications Of Findings, S. J. Tepper, S. D. Silberstein, N. L. Rosen, R. B. Lipton, E. B. Dennehy, S. A. Dowsett, E. Doty Jan 2020

The Influence Of Migraine On Driving: Current Understanding, Future Directions, And Potential Implications Of Findings, S. J. Tepper, S. D. Silberstein, N. L. Rosen, R. B. Lipton, E. B. Dennehy, S. A. Dowsett, E. Doty

Journal Articles

© 2019 Eli Lilly and Company. Headache: The Journal of Head and Face Pain published by Wiley Periodicals, Inc. on behalf of American Headache Society Objective: To review the published findings relevant to migraine and driving performance, with an intent to encourage discussion on research which may broaden understanding in this area and help educate healthcare providers and their patients. Background: Motor vehicle crashes result in more than 35,000 deaths and more than 2 million injuries annually in the United States. Migraine is one of the most prevalent diseases in the world, and many symptoms associated with migraine attacks have …


Diagnostic Value Of Electroencephalography With Ten Electrodes In Critically Ill Patients, M. B. Westover, K. Gururangan, M. S. Markert, B. N. Blond, S. Lai, S. Benard, S. Bickel, L. J. Hirsch, J. Parvizi Jan 2020

Diagnostic Value Of Electroencephalography With Ten Electrodes In Critically Ill Patients, M. B. Westover, K. Gururangan, M. S. Markert, B. N. Blond, S. Lai, S. Benard, S. Bickel, L. J. Hirsch, J. Parvizi

Journal Articles

No abstract provided.


Are We Responding Effectively To Bone Mineral Density Loss And Fracture Risks In People With Epilepsy?, A. S. Miller, V. Ferastraoaru, V. Tabatabaie, T. R. Gitlevich, R. Spiegel, S. R. Haut Jan 2020

Are We Responding Effectively To Bone Mineral Density Loss And Fracture Risks In People With Epilepsy?, A. S. Miller, V. Ferastraoaru, V. Tabatabaie, T. R. Gitlevich, R. Spiegel, S. R. Haut

Journal Articles

© 2020 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. Objective: A 2007 study performed at Montefiore Medical Center (Bronx, NY) identified high prevalence of reduced bone density in an urban population of patients with epilepsy and suggested that bone mineralization screenings should be regularly performed for these patients. We conducted a long-term follow-up study to determine whether bone mineral density (BMD) loss, osteoporosis, and fractures have been successfully treated or prevented. Methods: In the current study, patients from the 2007 study who had two dual-energy absorptiometry (DXA) scans performed at least …


Fetal Loss And Malformations In The Monead Study Of Pregnant Women With Epilepsy, K. J. Meador, P. B. Pennell, R. C. May, L. Van Marter, T. F. Mcelrath, C. Brown, E. E. Gerard, L. Kalayjian, S. Hwang, R. H. Finnell, +7 Additional Authors Jan 2020

Fetal Loss And Malformations In The Monead Study Of Pregnant Women With Epilepsy, K. J. Meador, P. B. Pennell, R. C. May, L. Van Marter, T. F. Mcelrath, C. Brown, E. E. Gerard, L. Kalayjian, S. Hwang, R. H. Finnell, +7 Additional Authors

Journal Articles

No abstract provided.


Incorporating Remote Electrical Neuromodulation (Ren) Into Usual Care Reduces Acute Migraine Medication Use: An Open-Label Extension Study, M. J. Marmura, T. Lin, D. Harris, A. Ironi, N. L. Rosen Jan 2020

Incorporating Remote Electrical Neuromodulation (Ren) Into Usual Care Reduces Acute Migraine Medication Use: An Open-Label Extension Study, M. J. Marmura, T. Lin, D. Harris, A. Ironi, N. L. Rosen

Journal Articles

© Copyright © 2020 Marmura, Lin, Harris, Ironi and Rosen. Background: A recent randomized controlled study showed that 66.7% (66/99) and 37.4% (37/99) of people undergoing remote electrical neuromodulation (REN), a novel non-pharmacological migraine treatment, achieve pain relief and pain freedom, respectively, at 2 h post-treatment. The participants who completed the 6-weeks double-blind phase of this study were offered to participate in an open-label extension (OLE) with an active REN device. Objective: This study investigated the clinical use of REN, focusing on its potential in reducing the use of acute migraine medications. Methods: The parent study for this open-label extension …


Tdp-43 Is Elevated In Plasma Neuronal-Derived Exosomes Of Patients With Alzheimer’S Disease, N. Zhang, D. Gu, M. Meng, M. L. Gordon Jan 2020

Tdp-43 Is Elevated In Plasma Neuronal-Derived Exosomes Of Patients With Alzheimer’S Disease, N. Zhang, D. Gu, M. Meng, M. L. Gordon

Journal Articles

© Copyright © 2020 Zhang, Gu, Meng and Gordon. Background: Recently, TDP-43 has been recognized as a common proteinopathy in the “oldest old” and a neuropathological comorbidity in patients with Alzheimer’s disease (AD). However, since it has a low concentration in cerebrospinal fluid, the presence of TDP-43 in AD is rarely investigated in vivo. Methods: Twenty-four patients with amyloid PET confirmed AD and 15 healthy controls (HCs) were included in this study. TDP-43 level in plasma neuronal-derived exosomes (NDEs) was measured by enzyme-linked immunosorbent assay. Results: TDP-43 level was elevated in patients with AD compared with HCs (median 1.08 ng/ml, …


Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang Jan 2020

Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang

Journal Articles

No abstract provided.


Oscillatory Bursting As A Mechanism For Temporal Coupling And Information Coding, I. Tal, S. Neymotin, S. Bickel, P. Lakatos, C. E. Schroeder Jan 2020

Oscillatory Bursting As A Mechanism For Temporal Coupling And Information Coding, I. Tal, S. Neymotin, S. Bickel, P. Lakatos, C. E. Schroeder

Journal Articles

© Copyright © 2020 Tal, Neymotin, Bickel, Lakatos and Schroeder. Even the simplest cognitive processes involve interactions between cortical regions. To study these processes, we usually rely on averaging across several repetitions of a task or across long segments of data to reach a statistically valid conclusion. Neuronal oscillations reflect synchronized excitability fluctuations in ensembles of neurons and can be observed in electrophysiological recordings in the presence or absence of an external stimulus. Oscillatory brain activity has been viewed as sustained increase in power at specific frequency bands. However, this perspective has been challenged in recent years by the notion …


Significance Of Blood And Cerebrospinal Fluid Biomarkers For Alzheimer's Disease: Sensitivity, Specificity And Potential For Clinical Use, C. D'Abramo, L. D'Adamio, L. Giliberto Jan 2020

Significance Of Blood And Cerebrospinal Fluid Biomarkers For Alzheimer's Disease: Sensitivity, Specificity And Potential For Clinical Use, C. D'Abramo, L. D'Adamio, L. Giliberto

Journal Articles

No abstract provided.


Mesial Temporal Resection Following Long-Term Ambulatory Intracranial Eeg Monitoring With A Direct Brain-Responsive Neurostimulation System, L. J. Hirsch, E. A. Mirro, V. Salanova, T. C. Witt, C. N. Drees, M. Brown, R. W. Lee, N. Sotudeh, R. I. Kuzniecky, M. J. Morrell, +21 Additional Authors Jan 2020

Mesial Temporal Resection Following Long-Term Ambulatory Intracranial Eeg Monitoring With A Direct Brain-Responsive Neurostimulation System, L. J. Hirsch, E. A. Mirro, V. Salanova, T. C. Witt, C. N. Drees, M. Brown, R. W. Lee, N. Sotudeh, R. I. Kuzniecky, M. J. Morrell, +21 Additional Authors

Journal Articles

No abstract provided.


Deep Brain Stimulation For Refractory Obsessive-Compulsive Disorder (Ocd): Emerging Or Established Therapy?, H. Wu, M. Hariz, V. Visser-Vandewalle, L. Zrinzo, V. A. Coenen, S. A. Sheth, C. Bervoets, M. Naesstrom, M. Schulder, B. Nuttin, +45 Additional Authors Jan 2020

Deep Brain Stimulation For Refractory Obsessive-Compulsive Disorder (Ocd): Emerging Or Established Therapy?, H. Wu, M. Hariz, V. Visser-Vandewalle, L. Zrinzo, V. A. Coenen, S. A. Sheth, C. Bervoets, M. Naesstrom, M. Schulder, B. Nuttin, +45 Additional Authors

Journal Articles

No abstract provided.


Fusiform Superior Cerebellar Artery Aneurysm Treated With Flow Diversion: A Case Report, Y. Serulle, D. Khatri, J. Fletcher, A. Pappas, A. Heidbreder, D. Langer, R. A. Ortiz Jan 2020

Fusiform Superior Cerebellar Artery Aneurysm Treated With Flow Diversion: A Case Report, Y. Serulle, D. Khatri, J. Fletcher, A. Pappas, A. Heidbreder, D. Langer, R. A. Ortiz

Journal Articles

© 2020 Published by Scientific Scholar on behalf of Surgical Neurology International. Background: Fusiform aneurysms of the distal superior cerebellar artery are rare and challenging to treat. Due to the rarity of these lesions, there is little consensus regarding their management. Treatment options have traditionally included parent artery sacrifice with either an endovascular approach or microsurgical clipping. Given the small diameter of the superior cerebellar artery, flow diversion has not been typically considered as a viable treatment option for these aneurysms. Case Description: A 67-year-old female presented complaining of severe sudden onset headache. Noncontrast head CT demonstrated no intracranial hemorrhage. …


Response To Misused And Misleading: 100% Response Rate To Galcanezumab In Patients With Episodic Migraine, N. Rosen, E. Pearlman, D. Ruff, K. Day, A. J. Nagy Jan 2019

Response To Misused And Misleading: 100% Response Rate To Galcanezumab In Patients With Episodic Migraine, N. Rosen, E. Pearlman, D. Ruff, K. Day, A. J. Nagy

Journal Articles

No abstract provided.


Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar Jan 2019

Editorial: Recent Advances In Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, Autoimmune Encephalopathy, And Mild Encephalitis, K. Bechter, D. Brown, S. Najjar

Journal Articles

No abstract provided.


Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni Jan 2019

Tele-Monitored Tdcs Rehabilitation: Feasibility, Challenges And Future Perspectives In Parkinson's Disease, A. Cucca, K. Sharma, S. Agarwal, A. S. Feigin, M. C. Biagioni

Journal Articles

© 2019 The Author(s). Transcranial direct current stimulation (tDCS) is a modality of non-invasive brain stimulation involving the application of low amplitude direct current via surface electrodes on the scalp. tDCS has been studied in healthy populations and in multiple brain disorders and has the potential to be a treatment for several neuropsychiatric conditions by virtue of its capability of influencing cognitive, motor and behavioral processes. tDCS is a generally safe technique when performed within standardized protocols in research or clinical settings. Furthermore, tDCS portability, high acceptability and user-friendly interface makes it highly appealing for telemedicine practices. The term "telemedicine" …


Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher Jan 2019

Sex-Related Differences In Homebound Advanced Parkinson's Disease Patients, L. Nwabuobi, W. Barbosa, M. Sweeney, S. Oyler, T. Meisel, A. Di Rocco, J. Chodosh, J. E. Fleisher

Journal Articles

No abstract provided.


Altered Dynamics Of Visual Contextual Interactions In Parkinson's Disease., M. I. Vanegas, A. Blangero, J. E. Galvin, A. Di Rocco, A. Quartarone, M. F. Ghilardi, S. P. Kelly Jan 2019

Altered Dynamics Of Visual Contextual Interactions In Parkinson's Disease., M. I. Vanegas, A. Blangero, J. E. Galvin, A. Di Rocco, A. Quartarone, M. F. Ghilardi, S. P. Kelly

Journal Articles

Over the last decades, psychophysical and electrophysiological studies in patients and animal models of Parkinson's disease (PD), have consistently revealed a number of visual abnormalities. In particular, specific alterations of contrast sensitivity curves, electroretinogram (ERG), and visual-evoked potentials (VEP), have been attributed to dopaminergic retinal depletion. However, fundamental mechanisms of cortical visual processing, such as normalization or "gain control" computations, have not yet been examined in PD patients. Here, we measured electrophysiological indices of gain control in both space (surround suppression) and time (sensory adaptation) in PD patients based on steady-state VEP (ssVEP). Compared with controls, patients exhibited a significantly …


Correction To: Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments (Vol 12, 56, 2019), M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors Jan 2019

Correction To: Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments (Vol 12, 56, 2019), M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors

Journal Articles

No abstract provided.


Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors Jan 2019

Sequencing And Curation Strategies For Identifying Candidate Glioblastoma Treatments, M. O. Frank, T. Koyama, K. Rhrissorrakrai, N. Robine, F. Utro, A. Emde, B. Chen, J. Boockvar, A. Demopoulos, R. B. Darnell, +39 Additional Authors

Journal Articles

No abstract provided.


Ieeg-Bids, Extending The Brain Imaging Data Structure Specification To Human Intracranial Electrophysiology, C. Holdgraf, S. Appelhoff, S. Bickel, K. Bouchard, S. D'Ambrosio, O. David, O. Devinsky, B. Dichter, A. Flinker, D. Hermes, +29 Additional Authors Jan 2019

Ieeg-Bids, Extending The Brain Imaging Data Structure Specification To Human Intracranial Electrophysiology, C. Holdgraf, S. Appelhoff, S. Bickel, K. Bouchard, S. D'Ambrosio, O. David, O. Devinsky, B. Dichter, A. Flinker, D. Hermes, +29 Additional Authors

Journal Articles

No abstract provided.


Consensus Statement From The International Consensus Meeting On The Role Of Decompressive Craniectomy In The Management Of Traumatic Brain Injury: Consensus Statement, P. J. Hutchinson, A. G. Kolias, T. Tajsic, A. Adeleye, A. T. Aklilu, T. Apriawan, A. H. Bajamal, E. J. Barthelemy, J. S. Ullman, F. Servadei, +41 Additional Authors Jan 2019

Consensus Statement From The International Consensus Meeting On The Role Of Decompressive Craniectomy In The Management Of Traumatic Brain Injury: Consensus Statement, P. J. Hutchinson, A. G. Kolias, T. Tajsic, A. Adeleye, A. T. Aklilu, T. Apriawan, A. H. Bajamal, E. J. Barthelemy, J. S. Ullman, F. Servadei, +41 Additional Authors

Journal Articles

No abstract provided.


Prehospital Factors Associated With Discharge Outcomes: Baseline Data From The Andhra Pradesh Traumatic Brain Injury Project, K. Ram, K. Varaprasad, M. K. Krishna, N. Kannan, V. Sundar, M. Joseph, V. D. Sinha, D. Shukla, R. K. Narayan, M. S. Vavilala, +2 Additional Authors Jan 2019

Prehospital Factors Associated With Discharge Outcomes: Baseline Data From The Andhra Pradesh Traumatic Brain Injury Project, K. Ram, K. Varaprasad, M. K. Krishna, N. Kannan, V. Sundar, M. Joseph, V. D. Sinha, D. Shukla, R. K. Narayan, M. S. Vavilala, +2 Additional Authors

Journal Articles

© 2019 The Authors Objective: Strategies to improve traumatic brain injury (TBI) outcomes in India are ill defined. The objective of this study was to examine baseline prehospital (PH) factors associated with outcomes from the Andhra Pradesh Traumatic Brain Injury Project. Methods: We conducted a prospective observational cohort study of adult patients with TBI admitted to the primary referral hospital. Modes of injury, prehospital care and transport, and factors associated with increased in-hospital mortality were evaluated. Poisson regression with robust error variance and adjusted attributable risk percent estimates determined factors associated with outcomes. Results: A total of 447 adults (38% …


Noninvasive Sub-Organ Ultrasound Stimulation For Targeted Neuromodulation, V. Cotero, Y. Fan, T. Tsaava, A. M. Kressel, I. Hancu, T. R. Coleman, S. Zanos, K. J. Tracey, S. S. Chavan, C. Puleo, +10 Additional Authors Jan 2019

Noninvasive Sub-Organ Ultrasound Stimulation For Targeted Neuromodulation, V. Cotero, Y. Fan, T. Tsaava, A. M. Kressel, I. Hancu, T. R. Coleman, S. Zanos, K. J. Tracey, S. S. Chavan, C. Puleo, +10 Additional Authors

Journal Articles

© 2019, The Author(s). Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Next, hepatic U/S stimulation is shown to modulate pathways that regulate blood glucose and is as effective as VNS in suppressing the hyperglycemic effect …