Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Life Sciences & Biomedicine (3)
- Science & Technology (3)
- EXPRESSION (2)
- Research & Experimental (2)
- AUTOINFLAMMATORY DISEASES (1)
-
- Adrenal Cortex Hormones/therapeutic use;; Adrenergic beta-Antagonists/therapeutic use;; Child (1)
- Aged;; Humans;; Laryngeal Neoplasms/*pathology;; Male;; Myxoma/*pathology (1)
- Aging;; Collagen;; Extracellular matrix;; Hemangioma;; Laminin (1)
- Autoimmune inner ear disease (AIED);; Myloperoxidase (MPO);; N-Acetylcysteine (NAC);; Tumor necrosis factor alpha (TNF-alpha) (1)
- BRAIN (1)
- Biochemistry & Molecular Biology (1)
- Brachiocephalic vein;; EC-IC bypass;; Infratemporal approach;; Internal;; maxillary artery;; CAROTID-ARTERY;; ANEURYSMS;; REVASCULARIZATION;; SURGERY;; VEIN;; DISEASE;; GRAFTS;; FOSSA;; Clinical Neurology;; Surgery (1)
- Breast reconstruction;; Current practices;; Delayed breast reconstruction;; Delayed-immediate breast reconstruction;; Immediate breast reconstruction;; Postmastectomy radiation therapy (1)
- CANCER (1)
- CD4(+) T-CELLS;; DENDRITIC CELLS;; INTERLEUKIN-1 FAMILY;; SKIN;; INFLAMMATION;; DISEASE SEVERITY;; IN-VIVO;; EXPRESSION;; TOLERANCE;; IL-36;; SUPPRESSION;; Biochemistry & Molecular Biology;; Cell Biology;; Medicine (1)
- CELLS (1)
- CNS disease (1)
- CSF LEAKS (1)
- CSF flow (1)
- Combined multiportal endoscopic skull base surgery;; transnasal;; transorbital (1)
- Cytokines;; IL-36gamma;; Keratinocytes;; Papilloma;; Tlr3 (1)
- EAC = external auditory canal (1)
- FAMILY CYTOKINES (1)
- FINE-NEEDLE-ASPIRATION;; UNDETERMINED SIGNIFICANCE;; SCIENCE CONFERENCE;; FOLLICULAR LESION;; CYTOPATHOLOGY;; SYSTEM;; CYTOLOGY;; ATYPIA;; PATHOLOGISTS;; TERMINOLOGY;; Endocrinology & Metabolism (1)
- Feinstein (1)
- Fluorescence (1)
- G4-related disease;; foreign body injection;; head and neck;; immunoglobulin subtype (1)
- GUIDED SURGERY (1)
- HALOTAG (1)
- Hpv;; Langerhans cells;; T cells;; anogenital warts;; innate immunity;; natural killer cells;; recurrent respiratory papillomatosis (1)
Articles 1 - 30 of 39
Full-Text Articles in Medicine and Health Sciences
Recommendations For Head And Neck Surgical Oncology Practice In A Setting Of Acute Severe Resource Constraint During The Covid-19 Pandemic: An International Consensus., H Mehanna, Jc Hardman, Ja Shenson, Ak Abou-Foul, Mc Topf, M Alfalasi, Jyk Chan, P Chaturvedi, D Kraus, C R. Leemans, +15 Additional Authors
Recommendations For Head And Neck Surgical Oncology Practice In A Setting Of Acute Severe Resource Constraint During The Covid-19 Pandemic: An International Consensus., H Mehanna, Jc Hardman, Ja Shenson, Ak Abou-Foul, Mc Topf, M Alfalasi, Jyk Chan, P Chaturvedi, D Kraus, C R. Leemans, +15 Additional Authors
Journal Articles
No abstract provided.
Autoimmune Inner Ear Disease Patient-Associated 28-Kda Proinflammatory Il-1 Beta Fragment Results From Caspase-7 Mediated Cleavage In Vitro, S. Pathak, A. Vambutas
Autoimmune Inner Ear Disease Patient-Associated 28-Kda Proinflammatory Il-1 Beta Fragment Results From Caspase-7 Mediated Cleavage In Vitro, S. Pathak, A. Vambutas
Journal Articles
No abstract provided.
An Oxygen-Rich Atmosphere Or Systemic Fluoxetine Extend The Time To Respiratory Arrest In A Rat Model Of Obstructive Apnea, S. Mooney, R. Kollmar, R. Gurevich, J. Tromblee, A. Banerjee, K. Sundaram, J. B. Silverman, M. Stewart
An Oxygen-Rich Atmosphere Or Systemic Fluoxetine Extend The Time To Respiratory Arrest In A Rat Model Of Obstructive Apnea, S. Mooney, R. Kollmar, R. Gurevich, J. Tromblee, A. Banerjee, K. Sundaram, J. B. Silverman, M. Stewart
Journal Articles
© 2019 Elsevier Inc. Audiogenic seizure-prone mice can be protected from seizure-associated death by exposure to an oxygen atmosphere or treatment with selective serotonergic reuptake inhibitors (SSRIs). We have shown previously in a rat model that epileptic seizure activity can spread through brainstem areas to cause sufficient laryngospasm for obstructive apnea and that the period of seizure-associated obstructive apnea can last long enough for respiratory arrest to occur. We hypothesized that both the oxygen-rich atmosphere and SSRIs function by prolonging the time to respiratory arrest, thus ensuring that seizure activity stops before the point of respiratory arrest to allow recovery …
A Near-Infrared Probe For Non-Invasively Monitoring Cerebrospinal Fluid Flow By F-18-Positron Emitting Tomography And Fluorescence, H. Guo, H. Kommidi, C. C. Lekaye, J. Koutcher, M. S. Judenhofer, S. R. Cherry, A. P. Wu, O. Akin, M. M. Souweidane, R. Ting, +2 Additional Authors
A Near-Infrared Probe For Non-Invasively Monitoring Cerebrospinal Fluid Flow By F-18-Positron Emitting Tomography And Fluorescence, H. Guo, H. Kommidi, C. C. Lekaye, J. Koutcher, M. S. Judenhofer, S. R. Cherry, A. P. Wu, O. Akin, M. M. Souweidane, R. Ting, +2 Additional Authors
Journal Articles
No abstract provided.
A New Office-Based Procedure For Treatment Of Snoring: The S.I.Le.N.C.E. Study., M. Friedman, M. B. Gillespie, F. A. Shabdiz, D. H. Hiltzik, T. A. Meyer, J. Ahn, P. J. Catalano, N. J. Joseph
A New Office-Based Procedure For Treatment Of Snoring: The S.I.Le.N.C.E. Study., M. Friedman, M. B. Gillespie, F. A. Shabdiz, D. H. Hiltzik, T. A. Meyer, J. Ahn, P. J. Catalano, N. J. Joseph
Journal Articles
Objective:Demonstrate the safety and effectiveness of palatal foreshortening and stiffening in reducing snoring severity in nonobstructive sleep apnea (non-OSA) patients complaining of chronic disruptive snoring. Methods:In a US-based 8-center, open-label, prospective, single-arm cohort study, 52 consenting adults with chronic disruptive snoring (snoring impacting a patient's life and causing patient or bed partner to seek medical intervention) were treated via office-based placement of resorbable, bidirectional, barbed suture implants into the soft palate under local anesthesia. Prior to intervention, home sleep tests (HSTs) were performed to rule out OSA and to document snoring noise level. Both subject and their bed/sleep partners (also …
How Can We Improve Antidepressant Adherence In The Management Of Depression? A Targeted Review And 10 Clinical Recommendations., M. Solmi, A. Miola, G. Croatto, G. Pigato, A. Favaro, M. Fornaro, M. Berk, L. Smith, C. U. Correll, A. F. Carvalho, +2 Additional Authors
How Can We Improve Antidepressant Adherence In The Management Of Depression? A Targeted Review And 10 Clinical Recommendations., M. Solmi, A. Miola, G. Croatto, G. Pigato, A. Favaro, M. Fornaro, M. Berk, L. Smith, C. U. Correll, A. F. Carvalho, +2 Additional Authors
Journal Articles
Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence is common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with poor adherence, interventions that promote antidepressant adherence, pharmacological aspects related to antidepressant adherence, and formulates 10 clinical recommendations to optimize antidepressant adherence. Patient-related factors associated with antidepressant non-adherence include younger age, psychiatric and medical comorbidities, cognitive impairment, and substance use disorders. Prescriber behavior-related factors include neglecting medical and family histories, selecting poorly tolerated antidepressants, or complex antidepressant regimens. Multi-disciplinary interventions targeting both patient and prescriber, aimed at improving antidepressant …
Consortium Of Otolaryngology Journal Editors: Collegiality And Contributions, R. T. Sataloff, R. Chandra, E. W. Fisher, D. Goldenberg, E. Y. Hanna, J. Johnson, D. W. Kennedy, D. H. Kraus, J. H. Krouse, D. B. Welling, +12 Additional Authors
Consortium Of Otolaryngology Journal Editors: Collegiality And Contributions, R. T. Sataloff, R. Chandra, E. W. Fisher, D. Goldenberg, E. Y. Hanna, J. Johnson, D. W. Kennedy, D. H. Kraus, J. H. Krouse, D. B. Welling, +12 Additional Authors
Journal Articles
No abstract provided.
Seizures Induce Obstructive Apnea In Dba/2j Audiogenic Seizure-Prone Mice: Lifesaving Impact Of Tracheal Implants, R. Irizarry, D. Sukato, R. Kollmar, S. Schild, J. Silverman, K. Sundaram, S. Stephenson, M. Stewart
Seizures Induce Obstructive Apnea In Dba/2j Audiogenic Seizure-Prone Mice: Lifesaving Impact Of Tracheal Implants, R. Irizarry, D. Sukato, R. Kollmar, S. Schild, J. Silverman, K. Sundaram, S. Stephenson, M. Stewart
Journal Articles
Wiley Periodicals, Inc. © 2020 International League Against Epilepsy The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. We hypothesized that DBA/2J mice, which display lethal audiogenic seizures, would be protected from death by implanting a tracheal T-tube as a surrogate airway. In a 2 × 2 design, mice were implanted with either open or closed tracheal T-tubes and treated with either low-dose ketamine/xylazine to …
A Fluorescent, [F-18]-Positron-Emitting Agent For Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting In Adoptively Transferred, Genetically Modified Cells, H. Guo, H. Kommidi, Y. Vedvyas, J. E. Mccloskey, W. Zhang, N. Chen, F. Nurili, A. P. Wu, H. B. Sayman, R. Ting, +4 Additional Authors
A Fluorescent, [F-18]-Positron-Emitting Agent For Imaging Prostate-Specific Membrane Antigen Allows Genetic Reporting In Adoptively Transferred, Genetically Modified Cells, H. Guo, H. Kommidi, Y. Vedvyas, J. E. Mccloskey, W. Zhang, N. Chen, F. Nurili, A. P. Wu, H. B. Sayman, R. Ting, +4 Additional Authors
Journal Articles
No abstract provided.
Rhyme Awareness In Children With Normal Hearing And Children With Cochlear Implants: An Exploratory Study., L. Jing, K. Vermeire, A. Mangino, C. Reuterskiöld
Rhyme Awareness In Children With Normal Hearing And Children With Cochlear Implants: An Exploratory Study., L. Jing, K. Vermeire, A. Mangino, C. Reuterskiöld
Journal Articles
Phonological awareness is a critical component of phonological processing that predicts children's literacy outcomes. Phonological awareness skills enable children to think about the sound structure of words and facilitates decoding and the analysis of words during spelling. Past research has shown that children's vocabulary knowledge and working memory capacity are associated with their phonological awareness skills. Linguistic characteristics of words, such as phonological neighborhood density and orthography congruency have also been found to influence children's performance in phonological awareness tasks. Literacy is a difficult area for deaf and hard of hearing children, who have poor phonological awareness skills. Although cochlear …
Open Access: Is There A Predator At The Door?, R. Chandra, E. W. Fisher, T. M. Jones, D. W. Kennedy, D. H. Kraus, J. H. Krouse, M. J. Link, L. R. Lustig, B. W. O'Malley, R. Youngs, +8 Additional Authors
Open Access: Is There A Predator At The Door?, R. Chandra, E. W. Fisher, T. M. Jones, D. W. Kennedy, D. H. Kraus, J. H. Krouse, M. J. Link, L. R. Lustig, B. W. O'Malley, R. Youngs, +8 Additional Authors
Journal Articles
No abstract provided.
Efficacy Of A Non-Invasive Middle Ear Aeration Device In Children With Recurrent Otitis Media: A Randomized Controlled Trial Protocol, T. Tham, L. Rahman, P. Costantino
Efficacy Of A Non-Invasive Middle Ear Aeration Device In Children With Recurrent Otitis Media: A Randomized Controlled Trial Protocol, T. Tham, L. Rahman, P. Costantino
Journal Articles
© 2018 The Authors Acute otitis media (AOM) represents a significant disease burden in the pediatric population. Besides vaccinations, there are no robust measures of reducing incidence of AOM in this age-group. This is a randomized controlled clinical trial evaluating the efficacy of a non-invasive middle ear aeration device, the EarPopper device (EP). We aim to investigate the reduction of episodes AOM in children with recurrent otitis media. The control arm will be observational. The intervention arm will have the EP used. The primary endpoint is incidence of AOM. The secondary endpoints are hazard ratio of time to AOM, proportion …
Thyroseq V3 Molecular Profiling For Tailoring The Surgical Management Of Hürthle Cell Neoplasms., S. Pearlstein, A. H. Lahouti, E. Opher, Y. E. Nikiforov, D. B. Kuriloff
Thyroseq V3 Molecular Profiling For Tailoring The Surgical Management Of Hürthle Cell Neoplasms., S. Pearlstein, A. H. Lahouti, E. Opher, Y. E. Nikiforov, D. B. Kuriloff
Journal Articles
Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite …
International Consensus (Icon) On Treatment Of Sudden Sensorineural Hearing Loss, M. Marx, E. Younes, S. S. Chandrasekhar, J. Ito, S. Plontke, S. O'Leary, O. Sterkers
International Consensus (Icon) On Treatment Of Sudden Sensorineural Hearing Loss, M. Marx, E. Younes, S. S. Chandrasekhar, J. Ito, S. Plontke, S. O'Leary, O. Sterkers
Journal Articles
© 2018 Elsevier Masson SAS Sudden sensorineural hearing loss (SSNHL) is a common and alarming symptom that often prompts an urgent visit to an ENT specialist. Treatment of SSNHL remains one of the most problematic issues for contemporary otorhinolaryngology: although many meta-analyses and national guidelines have been issued, management is not standardized in terms of medical treatment, and duration and route of administration. We present several methodological suggestions for the study of treatments for SSNHL. These were developed from the existing level of evidence of the main treatments used in SSNHL by experts who convened at the IFOS 2017 ENT …
Frequency-Place Map For Electrical Stimulation In Cochlear Implants: Change Over Time, K. Vermeire, D. M. Landsberger, P. H. Van De Heyning, M. Voormolen, A. Kleine Punte, R. Schatzer, C. Zierhofer
Frequency-Place Map For Electrical Stimulation In Cochlear Implants: Change Over Time, K. Vermeire, D. M. Landsberger, P. H. Van De Heyning, M. Voormolen, A. Kleine Punte, R. Schatzer, C. Zierhofer
Journal Articles
The relationship between the place of electrical stimulation from a cochlear implant and the corresponding perceived pitch remains uncertain. Previous studies have estimated what the pitch corresponding to a particular location should be. However, perceptual verification is difficult because a subject needs both a cochlear implant and sufficient residual hearing to reliably compare electric and acoustic pitches. Additional complications can arise from the possibility that the pitch corresponding to an electrode may change as the auditory system adapts to a sound processor. In the following experiment, five subjects with normal or near-to-normal hearing in one ear and a cochlear implant …
Transmucosal Bleomycin For Tongue Lymphatic Malformations, E. W. Cerrati, T. M. O., D. Binetter, Y. Bernstein, M Waner
Transmucosal Bleomycin For Tongue Lymphatic Malformations, E. W. Cerrati, T. M. O., D. Binetter, Y. Bernstein, M Waner
Journal Articles
No abstract provided.
Diagnosis And Management Of Infantile Hemangioma, D. H. Darrow, A. K. Greene, A. J. Mancini, A. J. Nopper, T. M. O
Diagnosis And Management Of Infantile Hemangioma, D. H. Darrow, A. K. Greene, A. J. Mancini, A. J. Nopper, T. M. O
Journal Articles
Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its …
Comparative Analysis Of The Extracellular Matrix Composition In Proliferating And Involuted Infantile Hemangiomas, H. Park, H. Park, H. Y. Chung, T. M. O, M. Waner
Comparative Analysis Of The Extracellular Matrix Composition In Proliferating And Involuted Infantile Hemangiomas, H. Park, H. Park, H. Y. Chung, T. M. O, M. Waner
Journal Articles
BACKGROUND: Changes in the composition of the extracellular matrix (ECM) occur between the proliferating and involuted phases of infantile hemangiomas (IH), and are associated with angiogenic growth. We examined the composition of the ECM in proliferating and involuted IHs and assessed correlations between the composition of the ECM and whether the IH was in the proliferating or the involuted phase. METHODS: We evaluated IH samples from a cohort of patients who had five proliferating IHs and five involuted IHs. The following ECM molecules were analyzed using enzyme-linked immunosorbent assays and immunohistochemistry: laminin, fibronectin, collagen type I, collagen type II, and …
Probable Immunoglobulin Subtype-G4-Related Disease In The Head And Neck From Foreign Body Injection: A Case Report, M. J. Highstein, J. Mallen, T. Tham, T. Brennan, A. Boubour, E. Opher, V. Wolf, P. Singh, P. Costantino
Probable Immunoglobulin Subtype-G4-Related Disease In The Head And Neck From Foreign Body Injection: A Case Report, M. J. Highstein, J. Mallen, T. Tham, T. Brennan, A. Boubour, E. Opher, V. Wolf, P. Singh, P. Costantino
Journal Articles
Introduction Immunoglobulin subtype G4-related disease (IgG4-RD) is a fibroinflammatory disease of unknown etiology, with manifestations involving nearly every organ system. Its association with foreign bodies is not established. Here, we present a novel case of IgG4-RD in response to foreign body injection. Case Description A 58-year-old woman presented with history of persistent left facial pain, xerophthalmia, blurred vision, and trismus. The patient's medical history was significant for left-sided temporomandibular joint (TMJ) reconstruction with silicone injection into the joint. Magnetic resonance imaging revealed a lesion in the left skull base. Biopsies demonstrated the cardinal histopathological features of IgG4-RD. The patient was …
Surgeon Motivations Behind The Timing Of Breast Reconstruction In Patients Requiring Postmastectomy Radiation Therapy, M. Lee, E. Reinertsen, E. Mcclure, S. Liu, L. Kruper, N. Tanna, J. Brian Boyd, J. W. Granzow
Surgeon Motivations Behind The Timing Of Breast Reconstruction In Patients Requiring Postmastectomy Radiation Therapy, M. Lee, E. Reinertsen, E. Mcclure, S. Liu, L. Kruper, N. Tanna, J. Brian Boyd, J. W. Granzow
Journal Articles
OBJECTIVES: Although postmastectomy radiation therapy (PMRT) has been shown to reduce breast cancer burden and improve survival, PMRT may negatively influence outcomes after reconstruction. The goal of this study was to compare current opinions of plastic and reconstructive surgeons (PRS) and surgical oncologists (SO) regarding the optimal timing of breast reconstruction for patients requiring PMRT. METHODS: Members of the American Society of Plastic Surgeons (ASPS), the American Society of Breast Surgeons (ASBS), and the Society of Surgical Oncology (SSO) were asked to participate in an anonymous web-based survey. Responses were solicited in accordance to the Dillman method, and they were …
Presurgical Ct Evaluation Of Congenital Aural Atresia, V. T. Nguyen, G. Paek, J. Hu, L. P. Smith
Presurgical Ct Evaluation Of Congenital Aural Atresia, V. T. Nguyen, G. Paek, J. Hu, L. P. Smith
Journal Articles
Congenital aural atresia occurs in approximately 1 in 10,000‐20,000 births and may be surgically repaired if the middle ear malformation is limited in character. External auditory canal atresia is difficult to repair surgically, with significant risks and complications. Surgical candidacy in congenital aural atresia is based on multiple factors, central to which are the anatomy of the temporal bone and audiometric findings. High-resolution multidetector CT is the imaging technique of choice for anatomy delineation, although there are some specific indications for MR imaging in presurgical assessment. Various CT grading systems have been developed to determine surgical candidacy and are described …
Poly(I:C) Induces Controlled Release Of Il-36gamma From Keratinocytes In The Absence Of Cell Death, A. A. Rana, A. V. Lucs, J. Devoti, L. Blanc, J. Papoin, R. Wu, C. J. Papayannakos, A. Abramson, V. R. Bonagura, B. M. Steinberg
Poly(I:C) Induces Controlled Release Of Il-36gamma From Keratinocytes In The Absence Of Cell Death, A. A. Rana, A. V. Lucs, J. Devoti, L. Blanc, J. Papoin, R. Wu, C. J. Papayannakos, A. Abramson, V. R. Bonagura, B. M. Steinberg
Journal Articles
The epithelium is part of an integrated immune system where cytokines, toll-like receptors and their ligands, and extracellular vesicles play a crucial role in initiating an innate immune response. IL-36gamma is a pro-inflammatory member of the IL-1 family that is mainly expressed by epithelial cells, but regulation of its expression and release are only beginning to be understood. Previous studies reported that IL-36gamma is abundant in recurrent respiratory papillomatosis, a rare but devastating disease caused by human papillomaviruses (HPV) types 6 and 11, in which papillomas recurrently grow in and block the airway. Despite the overexpression of IL-36gamma, papilloma tissues …
Giant Cell Tumor Of The Larynx Treated By Surgery And Adjuvant Denosumab: Case Report And Review Of The Literature, A. E. Yancoskie, D. K. Frank, J. E. Fantasia, S. Savona, N. Eiseler, I. Reder, L. B. Kahn
Giant Cell Tumor Of The Larynx Treated By Surgery And Adjuvant Denosumab: Case Report And Review Of The Literature, A. E. Yancoskie, D. K. Frank, J. E. Fantasia, S. Savona, N. Eiseler, I. Reder, L. B. Kahn
Journal Articles
Giant cell tumor of the larynx (GCTL) is a rare entity; only 34 cases have been reported in the literature. We report a case of GCTL in a 46 year-old male presenting clinical, radiographic, histological and therapeutic features. Previously reported cases are also reviewed.
Oncologic Outcomes After Transoral Robotic Surgery : A Multi-Institutional Study, J. R. De Almeida, R. Li, J. S. Magnuson, R. V. Smith, E. Moore, G. Lawson, M. Remacle, I. Ganly, D. H. Kraus, F. C. Holsinger, +12 Additional Authors
Oncologic Outcomes After Transoral Robotic Surgery : A Multi-Institutional Study, J. R. De Almeida, R. Li, J. S. Magnuson, R. V. Smith, E. Moore, G. Lawson, M. Remacle, I. Ganly, D. H. Kraus, F. C. Holsinger, +12 Additional Authors
Journal Articles
IMPORTANCE: Large patient cohorts are necessary to validate the efficacy of transoral robotic surgery (TORS) in the management of head and neck cancer. OBJECTIVES: To review oncologic outcomes of TORS from a large multi-institutional collaboration and to identify predictors of disease recurrence and disease-specific mortality. DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of records from 410 patients undergoing TORS for laryngeal and pharyngeal cancers from January 1, 2007, through December 31, 2012, was performed. Pertinent data were obtained from 11 participating medical institutions. INTERVENTIONS: Select patients received radiation therapy and/or chemotherapy before or after TORS. MAIN OUTCOMES AND MEASURES: Locoregional …
The Macrophage Inhibitor Cni-1493 Blocks Metastasis In A Mouse Model Of Ewing Sarcoma Through Inhibition Of Extravasation, A. J. Hesketh, C. Maloney, C. A. Behr, M. C. Edelman, R. D. Glick, Y. Al-Abed, M. Symons, S. Z. Soffer, B. M. Steinberg
The Macrophage Inhibitor Cni-1493 Blocks Metastasis In A Mouse Model Of Ewing Sarcoma Through Inhibition Of Extravasation, A. J. Hesketh, C. Maloney, C. A. Behr, M. C. Edelman, R. D. Glick, Y. Al-Abed, M. Symons, S. Z. Soffer, B. M. Steinberg
Journal Articles
Metastatic Ewing Sarcoma carries a poor prognosis, and novel therapeutics to prevent and treat metastatic disease are greatly needed. Recent evidence demonstrates that tumor-associated macrophages in Ewing Sarcoma are associated with more advanced disease. While some macrophage phenotypes (M1) exhibit anti-tumor activity, distinct phenotypes (M2) may contribute to malignant progression and metastasis. In this study, we show that M2 macrophages promote Ewing Sarcoma invasion and extravasation, pointing to a potential target of anti-metastatic therapy. CNI-1493 is a selective inhibitor of macrophage function and has shown to be safe in clinical trials as an anti-inflammatory agent. In a xenograft mouse model …
The Relationship Between Insertion Angles, Default Frequency Allocations, And Spiral Ganglion Place Pitch In Cochlear Implants, D. M. Landsberger, M. Svrakic, J. T., Jr. Roland, M. Svirsky
The Relationship Between Insertion Angles, Default Frequency Allocations, And Spiral Ganglion Place Pitch In Cochlear Implants, D. M. Landsberger, M. Svrakic, J. T., Jr. Roland, M. Svirsky
Journal Articles
OBJECTIVES: Commercially available cochlear implant systems attempt to deliver frequency information going down to a few hundred Hertz, but the electrode arrays are not designed to reach the most apical regions of the cochlea, which correspond to these low frequencies. This may cause a mismatch between the frequencies presented by a cochlear implant electrode array and the frequencies represented at the corresponding location in a normal-hearing cochlea. In the following study, the mismatch between the frequency presented at a given cochlear angle and the frequency expected by an acoustic hearing ear at the corresponding angle is examined for the cochlear …
Immune Dysregulation In Patients Persistently Infected With Human Papillomaviruses 6 And 11, A. V. Lucs, J. A. Devoti, L. Hatam, A. Afzal, A. L. Abramson, B. M. Steinberg, V. R. Bonagura
Immune Dysregulation In Patients Persistently Infected With Human Papillomaviruses 6 And 11, A. V. Lucs, J. A. Devoti, L. Hatam, A. Afzal, A. L. Abramson, B. M. Steinberg, V. R. Bonagura
Journal Articles
Human Papillomaviruses (HPVs) 6 and 11 are part of a large family of small DNA viruses, some of which are commensal. Although much of the population can contain or clear infection with these viruses, there is a subset of individuals who develop persistent infection that can cause significant morbidity and on occasion mortality. Depending on the site of infection, patients chronically infected with these viruses develop either recurrent, and on occasion, severe genital warts or recurrent respiratory papillomas that can obstruct the upper airway. The HPV-induced diseases described are likely the result of a complex and localized immune suppressive milieu …
N-Acetylcysteine Attenuates Tumor Necrosis Factor Alpha Levels In Autoimmune Inner Ear Disease Patients, S. Pathak, C. Stern, A. Vambutas
N-Acetylcysteine Attenuates Tumor Necrosis Factor Alpha Levels In Autoimmune Inner Ear Disease Patients, S. Pathak, C. Stern, A. Vambutas
Journal Articles
Autoimmune inner ear disease (AIED) is a poorly understood disease marked by bilateral, rapidly progressive hearing loss triggered by unknown stimuli, which is corticosteroid responsive in 60 % of patients. Although the mechanism of the disease is not precisely understood, a complex interaction of cytokines is believed to contribute toward the inflammatory disease process and hearing loss. Previously, we showed the role of TNF-alpha in steroid-sensitive and IL-1beta in steroid-resistant immune-mediated hearing loss. N-Acetylcysteine (NAC), a broad spectrum antioxidant, has been effective in other autoimmune disorders. Other studies have shown NAC to have a protective adjunct role in human idiopathic …
Measurement Of Cochlear Implant Electrode Position From Intraoperative Post-Insertion Skull Radiographs: A Validation Study, M. Svrakic, D. R. Friedmann, P. M. Berman, A. J. Davis, J. T., Jr. Roland, M. A. Svirsky
Measurement Of Cochlear Implant Electrode Position From Intraoperative Post-Insertion Skull Radiographs: A Validation Study, M. Svrakic, D. R. Friedmann, P. M. Berman, A. J. Davis, J. T., Jr. Roland, M. A. Svirsky
Journal Articles
OBJECTIVE: To validate a method of measuring angular depth of insertion (aDOI) as well as positional depth of each electrode contact in a cochlear implant by using intraoperative postinsertion skull radiographs. STUDY DESIGN: Retrospective review. SETTING: Tertiary referral center. PATIENTS: Intraoperative postinsertion radiographs obtained from 18 cochlear implant recipients were chosen for analysis. One high-resolution computer tomography scan of the head with the electrode in place was also analyzed. One cadaveric temporal bone with an inserted electrode provided additional data for analysis. INTERVENTION: aDOI and position of each electrode contact were measured from the radiographs using readily available software. High-resolution …
Multiportal Combined Transorbital And Transnasal Endoscopic Resection Of Fibrous Dysplasia, T. Tham, P. Costantino, M. Bruni, D. Langer, J. Boockvar, P. Singh
Multiportal Combined Transorbital And Transnasal Endoscopic Resection Of Fibrous Dysplasia, T. Tham, P. Costantino, M. Bruni, D. Langer, J. Boockvar, P. Singh
Journal Articles
Introduction Historically, access to the anterior skull base was achieved with open procedures. The paradigms to this approach were challenged with the advent of minimally disruptive endoscopic surgical techniques and supporting technology. The next step in the evolution of minimally disruptive surgery was the combination of multiportal endoscopic surgery. Results The patient was an 18-year-old man who presented with right-sided proptosis. Further diagnostic tests revealed a fibrous dysplasia (FD) occupying the skull base and orbit. The lesion was successfully resected. Conclusions The location of the tumor in this case was challenging, in which surgeons at some centers would have opted …