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Articles 421 - 450 of 2396
Full-Text Articles in Medicine and Health Sciences
Ibrutinib Restores Immune Cell Numbers And Function In First-Line And Relapsed/Refractory Chronic Lymphocytic Leukemia, I. G. Solman, L. K. Blum, H. Y. Hoh, T. J. Kipps, J. A. Burger, J. C. Barrientos, S. O'Brien, S. P. Mulligan, N. E. Kay, A. Mongan, +4 Additional Authors
Ibrutinib Restores Immune Cell Numbers And Function In First-Line And Relapsed/Refractory Chronic Lymphocytic Leukemia, I. G. Solman, L. K. Blum, H. Y. Hoh, T. J. Kipps, J. A. Burger, J. C. Barrientos, S. O'Brien, S. P. Mulligan, N. E. Kay, A. Mongan, +4 Additional Authors
Journal Articles
© 2020 The Authors Ibrutinib positively modulates many T-cell subsets in chronic lymphocytic leukemia (CLL). To understand ibrutinib's effects on the broader landscape of immune cell populations, we comprehensively characterized changes in circulating counts of 21 immune blood cell subsets throughout the first year of treatment in patients with relapsed/refractory (R/R) CLL (n = 55, RESONATE) and previously untreated CLL (n = 50, RESONATE-2) compared with untreated age-matched healthy donors (n = 20). Ibrutinib normalized abnormal immune cell counts to levels similar to those of age-matched healthy donors. Ibrutinib significantly decreased pathologically high circulating B cells, regulatory T cells, effector/memory …
A Comprehensive Review Of Contemporary Literature For Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer And Their Toxicity, C. S. Lee, S. Sharma, E. Miao, C. Mensah, K. Sullivan, N. Seetharamu
A Comprehensive Review Of Contemporary Literature For Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer And Their Toxicity, C. S. Lee, S. Sharma, E. Miao, C. Mensah, K. Sullivan, N. Seetharamu
Journal Articles
© 2020 Lee et al. Mutations in the epidermal growth factor receptor (EGFR) are common amongst those with non-small cell lung cancer and represent a major factor in treatment decisions, most notably in the advanced stages. Small molecule tyrosine kinase inhibitors (TKIs) that target the EGFR, such as erlotinib, gefitinib, icotinib, afatinib, dacomitinib and osimertinib, have all shown to be effective in this setting. Osimertinib, a third-generation EGFR TKI, is a favorable option, but almost all patients develop resistance at some time point. There are no effective treatment options for patients who progress on osimertinib, but ongoing trials will hopefully …
A Randomized,Double-Blind,Placebo-Controlled, Phaseiistudy Of Regorafenib Versus Placebo In Advanced/Metastatic,Treatment-Refractoryliposarcoma: Results From Thesarc024study, R. F. Riedel, K. Ballman, Y. Lu, S. Attia, E. T. Loggers, K. N. Ganjoo, M. B. Livingston, W. Chow, J. Wright, R. G. Maki, +10 Additional Authors
A Randomized,Double-Blind,Placebo-Controlled, Phaseiistudy Of Regorafenib Versus Placebo In Advanced/Metastatic,Treatment-Refractoryliposarcoma: Results From Thesarc024study, R. F. Riedel, K. Ballman, Y. Lu, S. Attia, E. T. Loggers, K. N. Ganjoo, M. B. Livingston, W. Chow, J. Wright, R. G. Maki, +10 Additional Authors
Journal Articles
No abstract provided.
Menstruation: Science And Society, H. O. Critchley, E. Babayev, S. E. Bulun, S. Clark, I. Garcia-Grau, P. K. Gregersen, A. Kilcoyne, J. Y. Kim, C. N. Metz, L. G. Griffith, +11 Additional Authors
Menstruation: Science And Society, H. O. Critchley, E. Babayev, S. E. Bulun, S. Clark, I. Garcia-Grau, P. K. Gregersen, A. Kilcoyne, J. Y. Kim, C. N. Metz, L. G. Griffith, +11 Additional Authors
Journal Articles
© 2020 The Authors Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been hampered by a lack of understanding of basic uterine and menstrual physiology. Menstrual health is an integral part of overall health because between menarche and menopause, most women menstruate. Yet for tens of millions of women around the world, menstruation regularly and often catastrophically disrupts their physical, mental, and social well-being. Enhancing our understanding of the underlying phenomena involved in menstruation, abnormal uterine bleeding, and other menstruation-related disorders will move us closer to the goal of personalized care. …
Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors
Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors
Journal Articles
© 2019 The Authors Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls …
Treating Covid-19 Positive Cancer Patients With Radiation Therapy: A Case Report From Epicenter Of The Pandemic., B. Parashar, L. Lee, C. Madu, A. Narayana, L. Potters
Treating Covid-19 Positive Cancer Patients With Radiation Therapy: A Case Report From Epicenter Of The Pandemic., B. Parashar, L. Lee, C. Madu, A. Narayana, L. Potters
Journal Articles
The coronavirus disease 2019 (SARS-Cov-2 or COVID-19) pandemic has resulted in unprecedented clinical challenges across the globe. Outcomes of patients with this infection are likely dependent on underlying comorbidities that predict worse outcome in older patients. However, it is unknown whether COVID-19 infected cancer patients receiving radiation therapy (RT) have any different outcome than non-infected patients. We present the first series from our center of COVID-19 infected patients who received RT for malignancy, their outcome, and toxicities.
Society Of Behavior Medicine (Sbm) Urges Congress To Ensure Affordable Care Act Coverage Of Prostate Cancer Screening Support Services For High-Risk Men, K. Watson, J. Buscemi, M. Fitzgibbon, M. Murray, A. Murphy, M. Abern, P. Gann, J. B. Levi, M. Diefenbach, R. A. Winn, +1 Additional Author
Society Of Behavior Medicine (Sbm) Urges Congress To Ensure Affordable Care Act Coverage Of Prostate Cancer Screening Support Services For High-Risk Men, K. Watson, J. Buscemi, M. Fitzgibbon, M. Murray, A. Murphy, M. Abern, P. Gann, J. B. Levi, M. Diefenbach, R. A. Winn, +1 Additional Author
Journal Articles
© Society of Behavioral Medicine 2019. All rights reserved. For permissions, please e-mail: [email protected]. Prostate cancer (PCa) disproportionately affects African American men. Early detection reduces risk of mortality. The United States Preventive Services Task Force (USPSTF) issued an updated recommendation statement on serum Prostate Specific Antigen (PSA)-based screening for PCa. Specifically, in 2012, the USPSTF recommended against PSA-based screening due to risk for overdiagnosis and overtreatment. However, the updated 2018 guidelines recommend consideration of screening for certain at risk men and revised the recommendation rating from "D" to "C." This new guideline recommends providers to educate high-risk men on the …
Accuracy Of Noninvasive Fibrosis Scoring Systems In African American And White Patients With Nonalcoholic Fatty Liver Disease, H. K. Marella, Y. K. Reddy, Y. Jiang, S. Ganguli, P. S. Podila, P. D. Snell, A. J. Kovalic, G. Cholankeril, A. K. Singal, S. K. Satapathy, +2 Additional Authors
Accuracy Of Noninvasive Fibrosis Scoring Systems In African American And White Patients With Nonalcoholic Fatty Liver Disease, H. K. Marella, Y. K. Reddy, Y. Jiang, S. Ganguli, P. S. Podila, P. D. Snell, A. J. Kovalic, G. Cholankeril, A. K. Singal, S. K. Satapathy, +2 Additional Authors
Journal Articles
No abstract provided.
Contract Negotiation Skills: A Workshop For Women In Medicine, A. M. Simone, M. Simone, L. Block, N. Lavine
Contract Negotiation Skills: A Workshop For Women In Medicine, A. M. Simone, M. Simone, L. Block, N. Lavine
Journal Articles
© 2020 Simone et al. Introduction: Contract negotiation is a high-stakes interaction, yet most physicians are never taught negotiation skills. Studies suggest that women, as compared with men, display a lower propensity to initiate negotiations and negotiate less competitively, highlighting a need for training to help level the playing field for female physicians. Methods: We devised a learner-centered workshop for female physicians that included a mini-didactic on negotiation principles, a question-and-answer time with a lawyer, an interactive role-play on contract negotiation style, and guided reflection. The workshop was intended for women in medicine from the level of medical student to …
Lung Nodule Management Practice Patterns - A Survey Of Indian Physicians, V. Mehta, P. Makkar, K. Bhatia, S. Mehta, S. Raoof
Lung Nodule Management Practice Patterns - A Survey Of Indian Physicians, V. Mehta, P. Makkar, K. Bhatia, S. Mehta, S. Raoof
Journal Articles
No abstract provided.
Covid-19 Induced Myocarditis: A Rare Cause Of Heart Failure., Q. Z. Iqbal, M. A. Haider, S. B. A. Sattar, M. Hanif, I. Javid
Covid-19 Induced Myocarditis: A Rare Cause Of Heart Failure., Q. Z. Iqbal, M. A. Haider, S. B. A. Sattar, M. Hanif, I. Javid
Journal Articles
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing lung injury has been well documented in the literature recently. They do so primarily by binding to the membrane-bound form of angiotensin-converting enzyme 2 (ACE-2) receptors. However, since these receptors are also expressed in the heart and blood vessels, coronavirus can also cause damage to these organs by binding to the ACE-2 receptors. A typical case of coronavirus disease 2019 (COVID-19) usually presents with respiratory symptoms like cough and shortness of breath accompanied by fever. The literature regarding this pandemic has been growing and now we know very well that the effect …
Preoperative Nuclear Stress Testing In The Very Old Patient Population, A. N. Makaryus, J. N. Makaryus, J. A. Diamond
Preoperative Nuclear Stress Testing In The Very Old Patient Population, A. N. Makaryus, J. N. Makaryus, J. A. Diamond
Journal Articles
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. BACKGROUND Elderly patients awaiting moderate to high-risk surgery may undergo nuclear stress testing (NST) in order to evaluate their cardiovascular risk. The prognostic utility of such testing in the very elderly (≥ 85 years) has yet to be fully evaluated. Octogenarians and nonogenarians frequently have a number of concurrent conditions including a high rate of coronary disease, and therefore the prognostic value of NST for their preoperative risk assessment has been questioned. Our evaluation assesses the ability of nuclear stress testing to predict peri-operative cardiac outcomes in …
Diagnostic And Treatment Utility Of Echocardiography In The Management Of The Cardiac Patient, A. Khalili, J. Drummond, N. Ramjattan, R. Zeltser, A. N. Makaryus
Diagnostic And Treatment Utility Of Echocardiography In The Management Of The Cardiac Patient, A. Khalili, J. Drummond, N. Ramjattan, R. Zeltser, A. N. Makaryus
Journal Articles
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. BACKGROUND Echocardiograms are an incredibly useful diagnostic tool due to their lack of harmful radiation, the relative ease and speed with which they can be performed, and their almost ubiquitous availability. Unfortunately, the advantages that support the use of echocardiography can also lead to the overuse of this technology. We sought to evaluate the physician perceived impact echocardiography has on patient management. AIM To evaluate the physician perceived impact echocardiography has on patient management. METHODS Surveys were distributed to the ordering physician for echocardiograms performed at our …
Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, H. Rhythm, +14 Additional Authors
Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, H. Rhythm, +14 Additional Authors
Journal Articles
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), started in the city of Wuhan late in 2019. Within a few months, the disease spread toward all parts of the world and was declared a pandemic on March 11, 2020. The current health care dilemma worldwide is how to sustain the capacity for quality services not only for those suffering from COVID-19 but also for non-COVID-19 patients, all while protecting physicians, nurses, and other allied health care workers.
Cytokine Storm Of A Different Flavor: The Different Cytokine Signature Of Sars-Cov2 The Cause Of Covid-19 From The Original Sars Outbreak., D. O. Griffin, A. Jensen, M. Khan, J. Chin, K. Chin, J. Saad, R. Parnell, C. Awwad, D. Patel
Cytokine Storm Of A Different Flavor: The Different Cytokine Signature Of Sars-Cov2 The Cause Of Covid-19 From The Original Sars Outbreak., D. O. Griffin, A. Jensen, M. Khan, J. Chin, K. Chin, J. Saad, R. Parnell, C. Awwad, D. Patel
Journal Articles
We present a case series of three patients with COVID-19 who had a cytokine panel which revealed elevation of interleukin-6 (IL-6), but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8) in contrast to the cytokine signature described in Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS). We also documented evidence of a compromised T-cell IFN-gamma response in two of these patients.
Spontaneous Pneumothorax As A Complication Of Covid-19 Pneumonia: A Case Report., L. Perice, Z. Roit, I. Llovera, M. G. Flanagan-Kundle
Spontaneous Pneumothorax As A Complication Of Covid-19 Pneumonia: A Case Report., L. Perice, Z. Roit, I. Llovera, M. G. Flanagan-Kundle
Journal Articles
INTRODUCTION:Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2. It typically presents with respiratory symptoms such as fevers, cough, and shortness of breath. As the number of cases increases, however, COVID-19 is being increasingly recognized as being associated with a variety of other respiratory pathologies. CASE REPORT:We present the case of a 59-year-old man with COVID-19 pneumonia who acutely decompensated after having been on the medicine floor for two weeks. He was found to have a tension pneumothorax. This was treated with a needle decompression followed by a chest tube insertion. The patient subsequently recovered …
Electrophysiology Practice During Covid-19 Pandemic: A New York Tertiary Hospital Experience, D. Anca, O. Reyes, R. L. Mitra, L. M. Epstein, L. Shore-Lesserson
Electrophysiology Practice During Covid-19 Pandemic: A New York Tertiary Hospital Experience, D. Anca, O. Reyes, R. L. Mitra, L. M. Epstein, L. Shore-Lesserson
Journal Articles
© 2020 Elsevier Inc. As hospitals became overwhelmed during the Covid-19 pandemic in March-May in New York, Cardiology and Electrophysiology (EP) departments rapidly developed protocols for case selection as well modifying the practice of managing the cases. Recommendations by the AHA/HRS as well as American Society of Anesthesiology (ASA) were considered in the multidisciplinary collaborative approach to patient care and personnel safety and the anesthesiology team had an integral role in developing protocols for workflow, care, recovery and transport during these challenging times.
Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang
Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang
Journal Articles
No abstract provided.
Oscillatory Bursting As A Mechanism For Temporal Coupling And Information Coding, I. Tal, S. Neymotin, S. Bickel, P. Lakatos, C. E. Schroeder
Oscillatory Bursting As A Mechanism For Temporal Coupling And Information Coding, I. Tal, S. Neymotin, S. Bickel, P. Lakatos, C. E. Schroeder
Journal Articles
© Copyright © 2020 Tal, Neymotin, Bickel, Lakatos and Schroeder. Even the simplest cognitive processes involve interactions between cortical regions. To study these processes, we usually rely on averaging across several repetitions of a task or across long segments of data to reach a statistically valid conclusion. Neuronal oscillations reflect synchronized excitability fluctuations in ensembles of neurons and can be observed in electrophysiological recordings in the presence or absence of an external stimulus. Oscillatory brain activity has been viewed as sustained increase in power at specific frequency bands. However, this perspective has been challenged in recent years by the notion …
Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin
Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin
Journal Articles
© Copyright © 2020 Kwak, Kim, Lee, Kim, Son and Shin. Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-dependent secretion pathway; however, some proteins, including a few danger-associated molecular patterns (DAMPs), are secreted via non-classical ER/Golgi-independent secretion pathways. The evolutionarily conserved high mobility group box1 (HMGB1) is a ubiquitous nuclear protein that can be released by almost all cell types. HMGB1 lacks signal peptide and utilizes diverse non-canonical secretion mechanisms for its extracellular export. Although the post-translational modifications of HMGB1 were demonstrated, the oxidation of HMGB1 and secretion mechanisms are not highlighted yet. We currently investigated that …
Man With Foot Pain, B. Hahn, D. Langhan, D. Miller, J. Greenstein
Man With Foot Pain, B. Hahn, D. Langhan, D. Miller, J. Greenstein
Journal Articles
No abstract provided.
Are We Responding Effectively To Bone Mineral Density Loss And Fracture Risks In People With Epilepsy?, A. S. Miller, V. Ferastraoaru, V. Tabatabaie, T. R. Gitlevich, R. Spiegel, S. R. Haut
Are We Responding Effectively To Bone Mineral Density Loss And Fracture Risks In People With Epilepsy?, A. S. Miller, V. Ferastraoaru, V. Tabatabaie, T. R. Gitlevich, R. Spiegel, S. R. Haut
Journal Articles
© 2020 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. Objective: A 2007 study performed at Montefiore Medical Center (Bronx, NY) identified high prevalence of reduced bone density in an urban population of patients with epilepsy and suggested that bone mineralization screenings should be regularly performed for these patients. We conducted a long-term follow-up study to determine whether bone mineral density (BMD) loss, osteoporosis, and fractures have been successfully treated or prevented. Methods: In the current study, patients from the 2007 study who had two dual-energy absorptiometry (DXA) scans performed at least …
Fetal Loss And Malformations In The Monead Study Of Pregnant Women With Epilepsy, K. J. Meador, P. B. Pennell, R. C. May, L. Van Marter, T. F. Mcelrath, C. Brown, E. E. Gerard, L. Kalayjian, S. Hwang, R. H. Finnell, +7 Additional Authors
Fetal Loss And Malformations In The Monead Study Of Pregnant Women With Epilepsy, K. J. Meador, P. B. Pennell, R. C. May, L. Van Marter, T. F. Mcelrath, C. Brown, E. E. Gerard, L. Kalayjian, S. Hwang, R. H. Finnell, +7 Additional Authors
Journal Articles
No abstract provided.
Dorsal Root Ganglion Stimulation Lead Fracture Within The Superficial Fascial Layers In 4 Cases, K. B. Chapman, K. V. Patel, N. Van Helmond, G. C. Chien
Dorsal Root Ganglion Stimulation Lead Fracture Within The Superficial Fascial Layers In 4 Cases, K. B. Chapman, K. V. Patel, N. Van Helmond, G. C. Chien
Journal Articles
We present 4 cases of dorsal root ganglion stimulation lead fracture. In these cases, the surgical technique involved (1) traversing fascial layers for placement of leads via a Tuohy needle in the upper low back, (2) subcutaneous tunneling from the implantable pulse generator site to the lead puncture site without dissecting below the superficial fascial plane at the puncture site, and (3) connection of the lead/extension with the generator. All fractures occurred adjacent to the original lead puncture site. These cases suggest lead entrapment within the membranous fascial plane, with tension on a thin lead, is a mechanism underlying lead …
Unilateral Dorsal Root Ganglion Stimulation Lead Placement With Resolution Of Bilateral Lower Extremity Symptoms In Diabetic Peripheral Neuropathy., K. B. Chapman, B. W. Van Roosendaal, N. Van Helmond, T. A. Yousef
Unilateral Dorsal Root Ganglion Stimulation Lead Placement With Resolution Of Bilateral Lower Extremity Symptoms In Diabetic Peripheral Neuropathy., K. B. Chapman, B. W. Van Roosendaal, N. Van Helmond, T. A. Yousef
Journal Articles
Dorsal root ganglion stimulation (DRG-S) is a form of neuromodulation that can target specific dermatomes to obtain better coverage of the distal extremity. Previously proposed mechanisms of action for DRG-S focused on the dorsal root ganglion (DRG) itself, without consideration of orthodromic effects in the dorsal horn and antidromic effects on the nerve root and sympathetic chain. Diabetic peripheral neuropathy (DPN) is an axonal neuropathy that affects around half of all patients with diabetes mellitus, causing severe pain and sensory impairment in the distal extremities. We present a case of a patient with DPN in both feet, in addition to …
Diagnostic Value Of Electroencephalography With Ten Electrodes In Critically Ill Patients, M. B. Westover, K. Gururangan, M. S. Markert, B. N. Blond, S. Lai, S. Benard, S. Bickel, L. J. Hirsch, J. Parvizi
Diagnostic Value Of Electroencephalography With Ten Electrodes In Critically Ill Patients, M. B. Westover, K. Gururangan, M. S. Markert, B. N. Blond, S. Lai, S. Benard, S. Bickel, L. J. Hirsch, J. Parvizi
Journal Articles
No abstract provided.
Acthar Gel (Repository Corticotropin Injection) For Persistently Active Sle: Study Design And Baseline Characteristics From A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial, A. D. Askanase, E. Zhao, J. Zhu, E. Connolly-Strong, R. A. Furie
Acthar Gel (Repository Corticotropin Injection) For Persistently Active Sle: Study Design And Baseline Characteristics From A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial, A. D. Askanase, E. Zhao, J. Zhu, E. Connolly-Strong, R. A. Furie
Journal Articles
© 2020 Author(s). Objective SLE is a chronic inflammatory autoimmune disease characterised by the excessive production of autoantibodies, immune complexes and proinflammatory cytokines. Repository corticotropin injection (RCI) is a naturally sourced complex mixture of adrenocorticotropic hormone analogues and other pituitary peptides. RCI is approved by the US Food and Drug Administration for use during an exacerbation or as maintenance therapy in select cases of SLE. This paper discusses the design and baseline characteristics of a multicentre, double-blind, randomised, placebo-controlled, 24-week clinical trial evaluating the effect of RCI in reducing disease activity for patients with persistently active SLE despite moderate-dose corticosteroid …
Chagas Disease In The New York City Metropolitan Area., C. Zheng, O. Quintero, E. K. Revere, M. B. Oey, F. Espinoza, Y. A. Puius, D. Ramirez-Baron, C. R. Salama, L. F. Hidalgo, H. B. Tanowitz, +5 Additional Authors
Chagas Disease In The New York City Metropolitan Area., C. Zheng, O. Quintero, E. K. Revere, M. B. Oey, F. Espinoza, Y. A. Puius, D. Ramirez-Baron, C. R. Salama, L. F. Hidalgo, H. B. Tanowitz, +5 Additional Authors
Journal Articles
Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chagas disease among the medical community in the United States is poor. Methods:We review our experience managing 60 patients with Chagas disease in hospitals throughout the New York City metropolitan area and describe screening, clinical manifestations, EKG findings, imaging, and treatment. Results:The most common country of origin of our patients was El Salvador (n …
In Response To Na Et Al.’S Long-Term Mortality Of Patients Discharged From The Hospital After Successful Critical Care: Do We Need More Comprehensive Data?, A. M. Esquinas, H. M. Karim, B. Mina
In Response To Na Et Al.’S Long-Term Mortality Of Patients Discharged From The Hospital After Successful Critical Care: Do We Need More Comprehensive Data?, A. M. Esquinas, H. M. Karim, B. Mina
Journal Articles
No abstract provided.
Erythropoiesis-Stimulating Agent Treatment In Patients With Covid-19., S. Fishbane, J. S. Hirsch
Erythropoiesis-Stimulating Agent Treatment In Patients With Covid-19., S. Fishbane, J. S. Hirsch
Journal Articles
No abstract provided.