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Full-Text Articles in Medicine and Health Sciences

Robotics: A Rehabilitation Modality, H. I. Krebs, B. T. Volpe Jan 2015

Robotics: A Rehabilitation Modality, H. I. Krebs, B. T. Volpe

Journal Articles

No abstract provided.


Stat5a/B Contribute To Sex Bias In Vascular Disease: A Neuroendocrine Perspective, P.B. Sehgal, Y. Yang, H. Yuan, E.J. Miller Jan 2015

Stat5a/B Contribute To Sex Bias In Vascular Disease: A Neuroendocrine Perspective, P.B. Sehgal, Y. Yang, H. Yuan, E.J. Miller

Journal Articles

No abstract provided.


Temperature Management Guidelines, J. W. Hammon, L. Shore-Lesserson, T. A. Dickinson Jan 2015

Temperature Management Guidelines, J. W. Hammon, L. Shore-Lesserson, T. A. Dickinson

Journal Articles

No abstract provided.


The Society Of Thoracic Surgeons, The Society Of Cardiovascular Anesthesiologists, And The American Society Of Extracorporeal Technology: Clinical Practice Guidelines For Cardiopulmonary Bypass-Temperature Management During Cardiopulmonary Bypass, R. Engelman, R. A. Baker, D. S. Likosky, A. Grigore, T. A. Dickinson, L. Shore-Lesserson, J. W. Hammon Jan 2015

The Society Of Thoracic Surgeons, The Society Of Cardiovascular Anesthesiologists, And The American Society Of Extracorporeal Technology: Clinical Practice Guidelines For Cardiopulmonary Bypass-Temperature Management During Cardiopulmonary Bypass, R. Engelman, R. A. Baker, D. S. Likosky, A. Grigore, T. A. Dickinson, L. Shore-Lesserson, J. W. Hammon

Journal Articles

To improve our understanding of the evidence-based literature supporting temperaturemanagement during adult cardiopulmonary bypass, The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiology and the American Society of ExtraCorporeal Technology tasked the authors to conduct a review of the peer-reviewed literature, including 1) optimal site for temperature monitoring, 2) avoidance of hyperthermia, 3) peak cooling temperature gradient and cooling rate, and 4) peak warming temperature gradient and rewarming rate. Authors adopted the American College of Cardiology/American Heart Association method for development clinical practice guidelines, and arrived at the following recommendation.


Single-Portal Arthroscopy Of The Central Compartment Of The Hip, S. Mannava, E. A. Howse, T. J. Kelsey, R. H. Barnes, A. Antunes, A. J. Stubbs Jan 2015

Single-Portal Arthroscopy Of The Central Compartment Of The Hip, S. Mannava, E. A. Howse, T. J. Kelsey, R. H. Barnes, A. Antunes, A. J. Stubbs

Journal Articles

Since hip arthroscopy has become a standard of orthopaedic practice, the indications have continued to expand as it has proved to be a helpful diagnostic, as well as therapeutic, tool. Access to the hip joint, however, remains challenging for the orthopaedic surgeon who does not routinely perform hip arthroscopy. We present a single-portal arthroscopic technique, showing the feasibility of single-portal arthroscopic access to the hip joint, as well as describing basic indications and instrumentation for single-portal hip arthroscopy. Single-portal hip arthroscopy is ideal for the patient who needs to undergo diagnostic hip arthroscopy or for treatment in patients with simple …


What Is The Prevalence And Success Of Remediation Of Emergency Medicine Residents?, M. Silverberg, M. Weizberg, T. Murano, J. L. Smith, J. C. Burkhardt, S. A. Santen Jan 2015

What Is The Prevalence And Success Of Remediation Of Emergency Medicine Residents?, M. Silverberg, M. Weizberg, T. Murano, J. L. Smith, J. C. Burkhardt, S. A. Santen

Journal Articles

INTRODUCTION: The primary objective of this study was to determine the prevalence of remediation, competency domains for remediation, the length, and success rates of remediation in emergency medicine (EM). METHODS: We developed the survey in Surveymonkey with attention to content and response process validity. EM program directors responded how many residents had been placed on remediation in the last three years. Details regarding the remediation were collected including indication, length and success. We reported descriptive data and estimated a multinomial logistic regression model. RESULTS: We obtained 126/158 responses (79.7%). Ninety percent of programs had at least one resident on remediation …


Arthroscopic Excision Of Acetabular Osteoid Osteoma: Computer Tomography-Guided Approach, C. Tamam, E. A. Howse, M. Tamam, R. H. Barnes, T. J. Kelsey, B. Perry, A. J. Stubbs Jan 2015

Arthroscopic Excision Of Acetabular Osteoid Osteoma: Computer Tomography-Guided Approach, C. Tamam, E. A. Howse, M. Tamam, R. H. Barnes, T. J. Kelsey, B. Perry, A. J. Stubbs

Journal Articles

Osteoid osteoma is a benign osteoblastic tumor that occurs in the subcortical shaft and metaphysis of the long bones of the lower extremities; however, intra-articular lesions are also possible. Intra-articular osteoid osteomas are rare, and clinical symptoms are often less specific and, thereby, may lead to misdiagnosis. The definitive treatment for osteoid osteoma is the excision of the nidus. We present the case of a 23-year-old man with a 4-year history of right anterior hip pain, subsequently diagnosed with a subarticular osteoid osteoma located in the right anterior acetabulum. Hip arthroscopic excision of the juxta-articular osteoid osteoma is presented as …


An Ongoing Search For Potential Targets And Therapies For Lethal Sepsis, G. Q. Bao, L. He, D. Lee, J. D'Angelo, H. C. Wang Jan 2015

An Ongoing Search For Potential Targets And Therapies For Lethal Sepsis, G. Q. Bao, L. He, D. Lee, J. D'Angelo, H. C. Wang

Journal Articles

Sepsis, which refers to a systemic inflammatory response syndrome resulting from a microbial infection, represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood although it is attributable to dysregulated immune responses orchestrated by innate immune cells that are sequentially released early (e.g., tumor necrosis factor(TNF), interleukin-1(IL-1), and interferon-gamma(IFN-gamma)) and late (e.g., high mobility group box 1(HMGB1)) pro-inflammatory mediators. As a ubiquitous nuclear protein, HMGB1 can be passively released from pathologically damaged cells, thereby converging infection and injury on commonly dysregulated inflammatory responses. We review evidence that supports extracellular HMGB1 as a late …


Bedside Echocardiography For Undifferentiated Hypotension: Diagnosis Of A Right Heart Thrombus, J. F. Kenny, X. Zhong, C. Brown, D. Das, B. Royall, M. Kapoor Jan 2015

Bedside Echocardiography For Undifferentiated Hypotension: Diagnosis Of A Right Heart Thrombus, J. F. Kenny, X. Zhong, C. Brown, D. Das, B. Royall, M. Kapoor

Journal Articles

A free-floating right heart thrombus is often a harbinger of a massive pulmonary embolism and must be diagnosed and treated rapidly in order to avoid significant adverse sequelae. We present the case of an 84-year-old female who presented with two days of dyspnea and was hypotensive on arrival. Bedside ultrasound was performed by the emergency physician and showed a large, mobile right heart thrombus leading to immediate administration of a thrombolytic. In this case, bedside ultrasound was utilized to help further delineate clinical care in a progressively worsening patient, leading to a potentially lifesaving treatment.


Serum Amyloid A Stimulates Pkr Expression And Hmgb1 Release Possibly Through Tlr4/Rage Receptors, W. Li, S. Zhu, J. Li, J. D'Amore, J. D'Angelo, H. Yang, P. Wang, K. J. Tracey, H. Wang Jan 2015

Serum Amyloid A Stimulates Pkr Expression And Hmgb1 Release Possibly Through Tlr4/Rage Receptors, W. Li, S. Zhu, J. Li, J. D'Amore, J. D'Angelo, H. Yang, P. Wang, K. J. Tracey, H. Wang

Journal Articles

Serum amyloid A proteins (SAAs) have been suggested as surrogate markers of sepsis, but their pathogenic roles remain poorly elucidated. Here we provide evidence to support a possible role of SAA as a pathogenic mediator of lethal sepsis. In a subset of septic patients whose serum HMGB1 levels paralleled with the clinical scores, some anti-HMGB1 antibodies detected a 12 kDa protein belonging to the SAA family. In contrast to the most abundant SAA1, human SAA induced PKR expression and HMGB1 release in the wild-type, but not TLR4/RAGE-deficient, macrophages. Pharmacological inhibition of PKR phosphorylation blocked SAA-induced HMGB1 release, suggesting an important …


Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation, A. V. Savonenko, T. Melnikova, Y. C. Wang, H. Ravert, Y. J. Gao, J. Koppel, D. Lee, P. Davies, M. G. Pomper, A. G. Horti, +6 Additional Authors Jan 2015

Cannabinoid Cb2 Receptors In A Mouse Model Of A Beta Amyloidosis: Immunohistochemical Analysis And Suitability As A Pet Biomarker Of Neuroinflammation, A. V. Savonenko, T. Melnikova, Y. C. Wang, H. Ravert, Y. J. Gao, J. Koppel, D. Lee, P. Davies, M. G. Pomper, A. G. Horti, +6 Additional Authors

Journal Articles

In Alzheimer's disease (AD), one of the early responses to A beta amyloidosis is recruitment of microglia to areas of new plaque. Microglial receptors such as cannabinoid receptor 2 (CB2) might be a suitable target for development of PET radiotracers that could serve as imaging biomarkers of A beta-induced neuroinflammation. Mouse models of amyloidosis (J20APPswe/ind and APPswe/PS1 Delta E9) were used to investigate the cellular distribution of CB2 receptors. Specificity of CB2 antibody (H60) was confirmed using J20APPswe/ind mice lacking CB2 receptors. APPswe/PS1 Delta E9 mice were used in small animal PET with a CB2-targeting radiotracer, [C-11]A836339. These studies revealed …


Achilles Tendon Rupture, S. P. Stickles, L. Friedman, M. Demarest, C. Raio Jan 2015

Achilles Tendon Rupture, S. P. Stickles, L. Friedman, M. Demarest, C. Raio

Journal Articles

No abstract provided.


Choledochal Cyst Mimicking Gallbladder With Stones In A Six-Year-Old With Right-Sided Abdominal Pain, R. Subramony, N. Kittisarapong, I. Barata, M. Nelson Jan 2015

Choledochal Cyst Mimicking Gallbladder With Stones In A Six-Year-Old With Right-Sided Abdominal Pain, R. Subramony, N. Kittisarapong, I. Barata, M. Nelson

Journal Articles

Choledochal cysts are rare but serious bile duct abnormalities are found in young children, usually during the first year of life.1 They require urgent surgical intervention due to the risk of developing cholangiocarcinoma.2 Clinicians should consider this diagnosis and perform a point-of-care ultrasound (POCUS) when a child presents to the emergency department (ED) with findings of jaundice, abdominal pain, and the presence of an abdominal mass. We present the case of a six-year-old child presenting only with abdominal pain upon arrival to our ED and was ultimately diagnosed by POCUS to have a choledochal cyst.


Have First-Year Emergency Medicine Residents Achieved Level 1 On Care-Based Milestones?, M. Weizberg, M. C. Bond, M. Cassara, C. Doty, J. Seamon Jan 2015

Have First-Year Emergency Medicine Residents Achieved Level 1 On Care-Based Milestones?, M. Weizberg, M. C. Bond, M. Cassara, C. Doty, J. Seamon

Journal Articles

BACKGROUND: Residents in Accreditation Council for Graduate Medical Education accredited emergency medicine (EM) residencies were assessed on 23 educational milestones to capture their progression from medical student level (Level 1) to that of an EM attending physician (Level 5). Level 1 was conceptualized to be at the level of an incoming postgraduate year (PGY)-1 resident; however, this has not been confirmed. OBJECTIVES: Our primary objective in this study was to assess incoming PGY-1 residents to determine what percentage achieved Level 1 for the 8 emergency department (ED) patient care-based milestones (PC 1-8), as assessed by faculty. Secondary objectives involved assessing …


Novel Mechanisms Of Herbal Therapies For Inhibiting Hmgb1 Secretion Or Action, A. H. Wu, L. He, W. Long, Q. Zhou, S. Zhu, P. Wang, S. Fan, H. Wang Jan 2015

Novel Mechanisms Of Herbal Therapies For Inhibiting Hmgb1 Secretion Or Action, A. H. Wu, L. He, W. Long, Q. Zhou, S. Zhu, P. Wang, S. Fan, H. Wang

Journal Articles

High mobility group box 1 (HMGB1) is an evolutionarily conserved protein and is constitutively expressed in virtually all types of cells. In response to microbial infections, HMGB1 is secreted from activated immune cells to orchestrate rigorous inflammatory responses. Here we review the distinct mechanisms by which several herbal components inhibit HMGB1 action or secretion, such as by modulating inflammasome activation, autophagic degradation, or endocytic uptake. In light of the reciprocal interactions between these cellular processes, it is possible to develop more effective combinational herbal therapies for the clinical management of inflammatory diseases.


Editorial Comment: Symposium: Biologics And Tissue Healing In Orthopaedics, A. Bedi, J. Dines Jan 2015

Editorial Comment: Symposium: Biologics And Tissue Healing In Orthopaedics, A. Bedi, J. Dines

Journal Articles

No abstract provided.


Minimally Invasive Scoliosis Surgery: A Novel Technique In Patients With Neuromuscular Scoliosis, V. Sarwahi, T. Amaral, S. Wendolowski, R. Gecelter, M. Gambassi, C. Plakas, B. Liao, S. Kalantre, C. Katyal Jan 2015

Minimally Invasive Scoliosis Surgery: A Novel Technique In Patients With Neuromuscular Scoliosis, V. Sarwahi, T. Amaral, S. Wendolowski, R. Gecelter, M. Gambassi, C. Plakas, B. Liao, S. Kalantre, C. Katyal

Journal Articles

Minimally invasive surgery (MIS) has been described in the treatment of adolescent idiopathic scoliosis (AIS) and adult scoliosis. The advantages of this approach include less blood loss, shorter hospital stay, earlier mobilization, less tissue disruption, and relatively less pain. However, despite these significant benefits, MIS approach has not been reported in neuromuscular scoliosis patients. This is possibly due to concerns with longer surgery time, which is further increased due to more levels fused and instrumented, challenges of pelvic fixation, size and number of incisions, and prolonged anesthesia. We modified the MIS approach utilized in our AIS patients to be implemented …


Systemic Lupus Erythematosus Is Not A Risk Factor For Poor Outcomes After Total Hip And Total Knee Arthroplasty, U. H. Shah, L. A. Mandl, C. Mertelsmann-Voss, Y. Y. Lee, M. M. Alexiades, M. P. Figgie, S. M. Goodman Jan 2015

Systemic Lupus Erythematosus Is Not A Risk Factor For Poor Outcomes After Total Hip And Total Knee Arthroplasty, U. H. Shah, L. A. Mandl, C. Mertelsmann-Voss, Y. Y. Lee, M. M. Alexiades, M. P. Figgie, S. M. Goodman

Journal Articles

OBJECTIVES: Historically, arthroplasty in systemic lupus erythematosus (SLE) patients has been less successful than for patients with osteoarthritis (OA). It is not known if SLE remains an independent risk factor for poor arthroplasty outcomes or if other factors, such as avascular necrosis (AVN), continue to play a role. METHODS: A case-control study using data from a single-institution arthroplasty registry compared SLE total hip arthroplasty (THA) and total knee arthroplasty (TKA) with OA controls matched by age, gender and presence of AVN. Baseline, two-year administrative and self-report data, and diagnosis leading to arthroplasty were evaluated. RESULTS: A total of 54 primary …


Doha Agreement Meeting On Terminology And Definitions In Groin Pain In Athletes, A. Weir, P. Brukner, E. Delahunt, J. Ekstrand, G. Lovell, T. Tyler, G. Verrall, R. J. De Vos, Z. Vuckovic, P. Holmich, +14 Additional Authors Jan 2015

Doha Agreement Meeting On Terminology And Definitions In Groin Pain In Athletes, A. Weir, P. Brukner, E. Delahunt, J. Ekstrand, G. Lovell, T. Tyler, G. Verrall, R. J. De Vos, Z. Vuckovic, P. Holmich, +14 Additional Authors

Journal Articles

Background Heterogeneous taxonomy of groin injuries in athletes adds confusion to this complicated area. Aim The 'Doha agreement meeting on terminology and definitions in groin pain in athletes' was convened to attempt to resolve this problem. Our aim was to agree on a standard terminology, along with accompanying definitions. Methods A one-day agreement meeting was held on 4 November 2014. Twenty-four international experts from 14 different countries participated. Systematic reviews were performed to give an up-to-date synthesis of the current evidence on major topics concerning groin pain in athletes. All members participated in a Delphi questionnaire prior to the meeting. …


Platelet-Rich Plasma And Other Cellular Strategies In Orthopedic Surgery, P. N. Williams, G. Moran, J. P. Bradley, N. S. Elattrache, J. S. Dines Jan 2015

Platelet-Rich Plasma And Other Cellular Strategies In Orthopedic Surgery, P. N. Williams, G. Moran, J. P. Bradley, N. S. Elattrache, J. S. Dines

Journal Articles

The use of biologics in the treatment of musculoskeletal disease has become increasingly more common as research studies continue to provide further elucidation of their mechanisms in healing. Platelet-rich plasma, patches, growth factors, and stem cells are among the many biologics under active investigation and have varying levels of success in augmenting surgical or nonoperative interventions. However, the limitations of these treatments exist, and clear guidelines for their indications and application have yet to be established. Well-designed clinical trials will help determine the appropriate future use of biologics to ensure consistent outcomes.


Pregabalin And Pain After Total Knee Arthroplasty: A Double-Blind, Randomized, Placebo-Controlled, Multidose Trial, J. T. Yadeau, Y. Lin, D. J. Mayman, E. A. Goytizolo, M. M. Alexiades, D. E. Padgett, K. G. Fields, A. K. Goon, J. Curren, G. H. Westrich, +4 Additional Authors Jan 2015

Pregabalin And Pain After Total Knee Arthroplasty: A Double-Blind, Randomized, Placebo-Controlled, Multidose Trial, J. T. Yadeau, Y. Lin, D. J. Mayman, E. A. Goytizolo, M. M. Alexiades, D. E. Padgett, K. G. Fields, A. K. Goon, J. Curren, G. H. Westrich, +4 Additional Authors

Journal Articles

BACKGROUND: Pregabalin may reduce postoperative pain and opioid use. Higher doses may be more effective, but may cause sedation and confusion. This prospective, randomized, blinded, placebo-controlled study tested the hypothesis that pregabalin reduces pain at 2 weeks after total knee arthroplasty, but increases drowsiness and confusion. METHODS: Patients (30 per group) received capsules containing pregabalin (0, 50, 100, or 150 mg); two capsules before surgery, one capsule twice a day until postoperative day (POD) 14, one on POD15, and one on POD16. Multimodal analgesia included femoral nerve block, epidural analgesia, oxycodone-paracetamol, and meloxicam. The primary outcome was pain with flexion …


Effect Of Bone Loss In Anterior Shoulder Instability, G. H. Garcia, J. N. Liu, D. M. Dines, J. S. Dines Jan 2015

Effect Of Bone Loss In Anterior Shoulder Instability, G. H. Garcia, J. N. Liu, D. M. Dines, J. S. Dines

Journal Articles

Anterior shoulder instability with bone loss can be a difficult problem to treat. It usually involves a component of either glenoid deficiency or a Hill-Sachs lesion. Recent data shows that soft tissue procedures alone are typically not adequate to provide stability to the shoulder. As such, numerous surgical procedures have been described to directly address these bony deficits. For glenoid defects, coracoid transfer and iliac crest bone block procedures are popular and effective. For humeral head defects, both remplissage and osteochondral allografts have decreased the rates of recurrent instability. Our review provides an overview of current literature addressing these treatment …


Integrating Biodegradable 3-Dimensional-Printing Into Tracheal Reconstruction, T. Goldstein, L. Smith, B. Smith, D. Grande, D. Zeltsman Jan 2015

Integrating Biodegradable 3-Dimensional-Printing Into Tracheal Reconstruction, T. Goldstein, L. Smith, B. Smith, D. Grande, D. Zeltsman

Journal Articles

No abstract provided.


Comorbid Profile Rather Than Age Determines Hip Fracture Mortality In A Nonagenarian Population, A. Graver, S. Merwin, L. Collins, N. Kohn, A. Goldman Jan 2015

Comorbid Profile Rather Than Age Determines Hip Fracture Mortality In A Nonagenarian Population, A. Graver, S. Merwin, L. Collins, N. Kohn, A. Goldman

Journal Articles

BACKGROUND: In light of poor outcomes with nonoperative management of hip fractures, orthopedic surgeons are faced with difficult decisions about which patients are too ill or too old for surgical treatment. QUESTIONS/PURPOSES: This study sought to investigate if patients over 90 years had different preoperative laboratory, clinical, and injury characteristics than younger patients with the same injury. We compared our cohort with previously published data. We wished to identify if there were pre-injury risk factors associated with 30-day mortality, which could be modified to enhance postoperative outcomes. METHODS: This is a retrospective review of 198 operatively managed hip fractures in …


Shoulder Arthroplasty: Return To Sport, M. M. Khair, J. S. Dines, D. M. Dines Jan 2015

Shoulder Arthroplasty: Return To Sport, M. M. Khair, J. S. Dines, D. M. Dines

Journal Articles

CONTEXT: Increasingly, total shoulder arthroplasty is being performed not only to treat the pain associated with glenohumeral arthritis but also to return patients to the level of activity and function they enjoyed prior to the development of arthritis. While return to sport and activity have been studied in the total knee and total hip replacement literature, it is only relatively recently that the same focus has been placed on total shoulder replacements. EVIDENCE ACQUISITION: PubMed database from the years 2000 to 2014. All studies relevant to shoulder arthroplasty and return to sport were included in the review. STUDY DESIGN: Clinical …


A Case Of Phaeohyphomycosis Caused By Exophiala Oligosperma In A Renal Transplant Patient Successfully Treated With Posaconazole, A. C. Levy, S Rehman, D.A. Sutton, K.I. Burris, D.A. Hirschwerk, N.P. Wiederhold, J. Lindner, M. Bhaskaran, H.L. Rilo, E.P. Molmenti, +3 Additional Authors Jan 2015

A Case Of Phaeohyphomycosis Caused By Exophiala Oligosperma In A Renal Transplant Patient Successfully Treated With Posaconazole, A. C. Levy, S Rehman, D.A. Sutton, K.I. Burris, D.A. Hirschwerk, N.P. Wiederhold, J. Lindner, M. Bhaskaran, H.L. Rilo, E.P. Molmenti, +3 Additional Authors

Journal Articles

No abstract provided.


Use Of Team-Based Learning Pedagogy For Internal Medicine Ambulatory Resident Teaching, S. Balwan, A. Fornari, P. Dimarzio, J. Verbsky, R. Pekmezaris, J. Stein, S. Chaudhry Jan 2015

Use Of Team-Based Learning Pedagogy For Internal Medicine Ambulatory Resident Teaching, S. Balwan, A. Fornari, P. Dimarzio, J. Verbsky, R. Pekmezaris, J. Stein, S. Chaudhry

Journal Articles

BACKGROUND: Team-based learning (TBL) is used in undergraduate medical education to facilitate higher-order content learning, promote learner engagement and collaboration, and foster positive learner attitudes. There is a paucity of data on the use of TBL in graduate medical education. Our aim was to assess resident engagement, learning, and faculty/resident satisfaction with TBL in internal medicine residency ambulatory education. METHODS: Survey and nominal group technique methodologies were used to assess learner engagement and faculty/resident satisfaction. We assessed medical learning using individual (IRAT) and group (GRAT) readiness assurance tests. RESULTS: Residents (N = 111) involved in TBL sessions reported contributing to …


Not For Industry Only: Medical Students And Office-Based Academic Detailing The Pivot (Pregnant Women Influenza Vaccine Optimization Team) Initiative, D. A. Blitz, J. R. Mallen, T. G. Kwiatkowski, J. M. Rabin, Y. D. Dlugacz, R. A. Silverman Jan 2015

Not For Industry Only: Medical Students And Office-Based Academic Detailing The Pivot (Pregnant Women Influenza Vaccine Optimization Team) Initiative, D. A. Blitz, J. R. Mallen, T. G. Kwiatkowski, J. M. Rabin, Y. D. Dlugacz, R. A. Silverman

Journal Articles

Academic detailing is a method of educational outreach that utilizes individualized encounters with physicians to broach specific medical issues in an evidence-based and quality-driven manner. Medical students utilized the matter of influenza vaccination during pregnancy as a lens through which to explore the methods of academic detailing in a community setting. Structured and customized dialogues between North Shore-LIJ affiliated obstetricians and Hofstra North Shore-LIJ medical students were conducted regarding the disparity between the proportion of providers that recommend the vaccine and the percentage of pregnant women being vaccinated annually. Ultimately the project aimed to increase vaccine-carrying rates throughout office based …


Age Influences Inflammatory Responses, Hemodynamics, And Cardiac Proteasome Activation During Acute Lung Injury, H. M. Linge, J. Y. Lee, K. Ochani, K. Koga, N. Kohn, K. Ojamaa, S. R. Powell, E. J. Miller Jan 2015

Age Influences Inflammatory Responses, Hemodynamics, And Cardiac Proteasome Activation During Acute Lung Injury, H. M. Linge, J. Y. Lee, K. Ochani, K. Koga, N. Kohn, K. Ojamaa, S. R. Powell, E. J. Miller

Journal Articles

Background: Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-dependent alterations in the responses to pulmonary challenge. The objective of this observational study was to evaluate age-dependent differences in the acute (within 6 hours) immunological and physiological responses of the heart and lung, to pulmonary challenge, that could result in increased severity. Methods: Male C57Bl/6 mice (young: 2-3 months, old: 18-20 months) were challenged intratracheally with cell wall components from …


Medically Inoperable Peripheral Lung Cancer Treated With Stereotactic Body Radiation Therapy, K. D. Kelley, D. L. Benninghoff, J. S. Stein, J. Z. Li, R. T. Byrnes, L. Potters, J. P. Knisely, H. D. Zinkin Jan 2015

Medically Inoperable Peripheral Lung Cancer Treated With Stereotactic Body Radiation Therapy, K. D. Kelley, D. L. Benninghoff, J. S. Stein, J. Z. Li, R. T. Byrnes, L. Potters, J. P. Knisely, H. D. Zinkin

Journal Articles

BACKGROUND: Lung cancer is the most frequent cause of cancer-related death in North America. There is wide variation between patients who are medically inoperable and those managed surgically. The use of stereotactic body radiotherapy (SBRT) has narrowed the gap in survival rates between operative and non-operative management for those with early stage disease. This retrospective study reports outcomes for the treatment of peripheral non-small cell lung carcinoma (NSCLC) with SBRT from a single community practice. METHODS: Sixty-seven consecutive patients (pts) with inoperable, untreated peripheral lung tumors were treated from 2010 through 2012 and included in this study. Stereotactic targeting was …