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Articles 31 - 60 of 2151
Full-Text Articles in Medicine and Health Sciences
Pheochromocytoma: A Frequent Indicator For Men 2, Claude Calmettes, Myriam Rosenberg-Gourgin, Jean Caron, Nicole Feingold
Pheochromocytoma: A Frequent Indicator For Men 2, Claude Calmettes, Myriam Rosenberg-Gourgin, Jean Caron, Nicole Feingold
Henry Ford Hospital Medical Journal
Pheochromocytoma is a frequent indicator of multiple endocrine neoplasia type 2A (MEN 2A); in the 35 French MEN 2A families in which a pheochromocytoma occurred first in some affected members, 30% of the patients had a pheochromocytoma as the first manifestation constituting 45% of all patients with pheochromocytomas. The finding of a pheochromocytoma is a strong indication for a search for medullary thyroid carcinoma and for initiating family screening.
Evaluation Of Children With Medullary Thyroid Carcinoma, Alfonso Libroia, Fabrizio Muratori, Uberta Verga, Gianleone Di Sacco, Anna Grattieri, Dario Gelli
Evaluation Of Children With Medullary Thyroid Carcinoma, Alfonso Libroia, Fabrizio Muratori, Uberta Verga, Gianleone Di Sacco, Anna Grattieri, Dario Gelli
Henry Ford Hospital Medical Journal
Early diagnosis and surgical treatment of medullary thyroid carcinoma (MTC) in children is essential to decrease the likelihood of metastatic spread. From 1981 to 1991, eight children under 18 years of age (five girls and three boys) with MTC were seen and seven underwent total thyroidectomy. Followup ranged from 14 months to 10 years after surgery. Four of the seven presented with a neck mass and elevated basal levels of calcitonin (CT). After surgery, three had recurrent disease. In the other three, the diagnosis was made after several years of screening (normal basal values of CT but increased CT levels …
Surgical Approach Of Synchronous Medullary Thyroid Carcinoma And Pheochromocytoma In Men 2 Syndrome, Georg F. W. Scheumann, Henning Dralle
Surgical Approach Of Synchronous Medullary Thyroid Carcinoma And Pheochromocytoma In Men 2 Syndrome, Georg F. W. Scheumann, Henning Dralle
Henry Ford Hospital Medical Journal
In cases with concurrent medullary thyroid carcinoma (MTC) and pheochromocytoma, discussion regarding a one-stage versus two-stage treatment strategy approach remains open. From 1975 to 1990, 11 of 25 multiple endocrine neoplasia type 2 (MEN 2) patients presented with biendocrinopathies or triendocrinopathies synchronously. All patients were treated surgically and followed subsequently in our hospital. Of the group of nine patients with concurrent MTC and pheochromocytoma, five were treated in one-stage and four in two-stage procedures. No patient had major complications intraoperatively. For the two-stage group, the total hospital stay (preoperatively and postoperatively) averaged 35 days. For the one-stage group, the total …
Pdn-21 (Katacalcin) And Chromogranin A: Tumor Markers For Medullary Thyroid Carcinoma, Friedhelm Raue, Eberhard Blind, Andreas Grauer
Pdn-21 (Katacalcin) And Chromogranin A: Tumor Markers For Medullary Thyroid Carcinoma, Friedhelm Raue, Eberhard Blind, Andreas Grauer
Henry Ford Hospital Medical Journal
The malignant C-cell releases several markets of potential clinical significance into the circulation. To determine the usefulness of these markers for management of medullary thyroid carcinoma (MTC), it is necessary to compare the usefulness of these markers with calcitonin (CT), the classical tumor marker for MTC. Measurement of serum concentrations of the peptide PDN-21 (katacalcin), a carboxyterminal cleavage product of procalcitonin. showed a high correlation with serum CT levels (r = 0.99, P < 0.01, n = 65 patients with MTC). The presence of equimolar concentrations of CT and PDN-21 (CT/PDN-21 molar ratio = 0.95 ± 0.33) indicates the peptide is cosecreted with CT. Stimulation of CT release by intravenous pentagastrin was associated with a parallel increase of PDN-21, providing further evidence of cosecretion of these two peptides. Finally, measurement of either PDN-21 or CT in selective venous catheterization specimens was useful for localization of MTC. Chromogranin A (CgA) levels were also measured in patients with MTC. Circulating levels were elevated in most patients with advanced disease. There was a moderate correlation between CgA and CT serum levels (r = 0.87, P < 0.01. n = 61 patients with MTC). Pentagastrin did not stimulate CgA, and the long half-life of CgA in the circulation did not make it possible to use this peptide for tumor localization by selective venous catheterization. We conclude that measurement of PDN-21 provides an independent assay system for diagnosis, localization, and postoperative management of MTC. whereas CgA measurement is not useful in early diagnosis of MTC and is of limited value for localization or management of progressive disease.
Somatostatin Acts Via A Pertussis Toxin-Sensitive Mechanism On Calcitonin Secretion In C-Cells, Angela Zink, Hans Scherubl, Friedhelm Raue, Reinhard Ziegler
Somatostatin Acts Via A Pertussis Toxin-Sensitive Mechanism On Calcitonin Secretion In C-Cells, Angela Zink, Hans Scherubl, Friedhelm Raue, Reinhard Ziegler
Henry Ford Hospital Medical Journal
The effect of the somatostatin analog octreotide on cAMP-mediated calcitonin (CT) secretion and cAMP accumulation in C-cells was investigated. Glucagon stimulated cAMP accumulation and CT secretion with a maximal effect at a concentration of 10-6 M. The cAMP antagonist RpcAMPs blocked the glucagon-induced CT secretion down to control levels. Therefore, no other second messengers seem to be involved in glucagon-stimulated CT secretion. Octreotide in increasing doses (10-9 to 10-6 M) inhibited cAMP accumulation and CT secretion with a maximal effect at a concentration of 10-7 (40% and 29% of control values, respectively). Pretreatment of the cells …
Oncogene And Growth Factor Expression In Men 2 And Related Tumors, Jeffrey F. Moley, Göran K. Wallin, Michele B. Brother, Michael Kim, Samuel A. Wells Jr., Garrett M. Brodeur
Oncogene And Growth Factor Expression In Men 2 And Related Tumors, Jeffrey F. Moley, Göran K. Wallin, Michele B. Brother, Michael Kim, Samuel A. Wells Jr., Garrett M. Brodeur
Henry Ford Hospital Medical Journal
Pheochromocytomas occur sporadically or in individuals affected by inherited syndromes including multiple endocrine neoplasia (MEN) type 2A and 2B, neurofibromatosis, and the von Hippel-Lindau syndrome (vHL). Medullary thyroid carcinomas (MTCs) also occur sporadically or as part of MEN 2A, MEN 2B, and familial MTC. Little is known of the molecular genetic background of these tumors. We have shown previously that activation of the N-ras, H-ras, and K-ras oncogenes does not occur in these tumors, but that deletions of the short arm of chromosome 1 are extremely common (> 60%) and may indicate loss of a suppressor gene in the chromosomal …
Role Of Insulin-Like Growth Factor-I In The Autocrine Regulation Of Cell Growth In Tt Human Medullary Thyroid Carcinoma Cells, Kuo-Pao P. Yang, Naguib A. Samaan, Yi-Fan Liang, Socorro G. Castillo
Role Of Insulin-Like Growth Factor-I In The Autocrine Regulation Of Cell Growth In Tt Human Medullary Thyroid Carcinoma Cells, Kuo-Pao P. Yang, Naguib A. Samaan, Yi-Fan Liang, Socorro G. Castillo
Henry Ford Hospital Medical Journal
Since the TT human medullary thyroid carcinoma cell line required fewer exogenous growth factors (serum), we investigated whether this line has an autocrine mechanism by examining the effects of antibodies directed toward insulin-like growth factor I (IGF-I) and its receptor on TT cell growth in serum-free conditions. Treating cells with anti-IGF-I antibody for four days reduced the cell number by more than 50% compared with a nonimmune IgG control. Furthermore, a monoclonal antibody to the IGF-I receptor suppressed DNA synthesis when determined by a [3H]thymidine incorporation assay. Exogenous IGF-I (20 ng/mL) stimulated [3H]thymidine incorporation in serum-free …
Patterns Of Neoplasia In C-Mos Transgenic Mice And Their Relevance To Multiple Endocrine Neoplasia, Nicholas Schulz, Friedrich Propst, Michael M. Rosenberg, R. Ilona Linnoila, Richard S. Paules, Douglas Schulte, George F. Vande Woude
Patterns Of Neoplasia In C-Mos Transgenic Mice And Their Relevance To Multiple Endocrine Neoplasia, Nicholas Schulz, Friedrich Propst, Michael M. Rosenberg, R. Ilona Linnoila, Richard S. Paules, Douglas Schulte, George F. Vande Woude
Henry Ford Hospital Medical Journal
We have previously described a neurological phenotype for transgenic mice carrying the c-Mos proto-oncogene. Pheochromocytomas and C-cell thyroid neoplasms occur in these transgenic lines in patterns that are similar to those seen in multiple endocrine neoplasia type 2 (MEN 2). Characterization of the pathological lesions via immunohistochemistry underscores similarities between MEN 2 and these transgenic mice. When transgenic mice that do not display the MEN 2 phenotype are crossed to a different background, the progeny display the MEN 2 phenotype. Thus the interaction of the background with the transgene is such that it can suppress tumor information. This observation bears …
Extracellular Ca2+ Sensing In C-Cells And Parathyroid Cells, Hans Scherubl, Maria Luisa Brandi, Jurgen Hescheler
Extracellular Ca2+ Sensing In C-Cells And Parathyroid Cells, Hans Scherubl, Maria Luisa Brandi, Jurgen Hescheler
Henry Ford Hospital Medical Journal
An essential function of C-cells and parathyroid cells is to monitor the extracellular Ca2+ concentration. The Ca2+-dependent secretion of calcitonin (CT) and parathyroid hormone is known to be mediated by corresponding changes in the intracellular Ca2+ concentration. To address the question of whether Ca2+ influx through voltage-dependent Ca2+ channels couples the extracellular to the intracellular Ca2+, we applied the patch clamp technique to C-cells of the rMTC 44-2 cell line and to parathyroid cells of the PT-r cell line. The rMTC cells displayed dihydropyridine-sensitive, voltage-dependent, high-threshold Ca2+ channels which allowed ion …
Biologic And Cytogenetic Characterization Of Three Human Medullary Thyroid Carcinomas In Culture, R. Pfragner, G. Wirnsberger, A. Behmel, B. Niederle, F. Längle, R. Roka, A. Mandl, P. Pürstner, J. Auner, F. Tatzber
Biologic And Cytogenetic Characterization Of Three Human Medullary Thyroid Carcinomas In Culture, R. Pfragner, G. Wirnsberger, A. Behmel, B. Niederle, F. Längle, R. Roka, A. Mandl, P. Pürstner, J. Auner, F. Tatzber
Henry Ford Hospital Medical Journal
Neuroendocrine features and cytogenetic abnormalities of one continuous cell line (MTC-SK) and two long-term cultures (GER, STAH) derived from three sporadic cases of human medullary thyroid carcinomas (MTCs) were studied. Specific neuroendocrine markers (NSE, chromogranins, calcitonin, calcitonin gene-related peptide) were identified by electron microscopy and immunocytochemistry. In situ hybridochemistry and Northern blot analysis confirmed endocrine activity. Cytogenetic studies of the cell line MTC-SK revealed three consistent marker chromosomes, t(3;10), 11p+, and 22p+. Cells of long-term cultures GER and STAH exhibited a consistent translocation t(2;18), a trisomy 7, and two consistent marker chromosomes der3 and 5p+, respectively. Recently, we have isolated …
Urban Health Care: Solutions For The 1990s, David R. Nerenz, David W. Benfer
Urban Health Care: Solutions For The 1990s, David R. Nerenz, David W. Benfer
Henry Ford Hospital Medical Journal
No abstract provided.
Urban Health Solutions In The 1990s: No Time For False Promises, Seth Foldy
Urban Health Solutions In The 1990s: No Time For False Promises, Seth Foldy
Henry Ford Hospital Medical Journal
No abstract provided.
Health Care Linkage Project: Improving Access To Care, Martha G. Ferguson, Lon Berkeley, Louis Fourcher, Belinda Guyton, Linda Ross Reiner
Health Care Linkage Project: Improving Access To Care, Martha G. Ferguson, Lon Berkeley, Louis Fourcher, Belinda Guyton, Linda Ross Reiner
Henry Ford Hospital Medical Journal
The primary objective of the Health Care Linkage Project, funded by a grant from the Chicago Community Trust, is to develop, implement, and evaluate a primary health care linkage network within the city of Chicago that creates formalized linkages between community health centers, the Chicago Department of Health clinics, and hospitals. Six linkage networks are currently operational, with an additional two sites phased in during 1991. The success of the pilot project has been demonstrated by hundreds of patients receiving primary care and ancillary services on a more timely basis, by greater coordination between the public and private sector, by …
Training The Urban Health Care Provider: One Department's First Steps, James Schindler
Training The Urban Health Care Provider: One Department's First Steps, James Schindler
Henry Ford Hospital Medical Journal
As our country faces a national crisis in health care, few have outlined plans to improve the shortage of primary care physicians. This is especially critical in urban areas where sociocultural impacts on health are large. The Department of Family Practice and Community Medicine at the University of Texas School of Medicine in Houston has begun development of a division of Urban Family Medicine to address the special training needs of the urban family practitioner. Subdivisions that have been formed focus on undergraduate curriculum, graduate educational strategies, service, and research and policy to further develop the training model.
Federal, State, And Local Partnerships In Providing Primary Care: One Urban Health Department's Endeavor With A State University Medical Center, Joy L. Getzenberg, D. Patrick Lenihan
Federal, State, And Local Partnerships In Providing Primary Care: One Urban Health Department's Endeavor With A State University Medical Center, Joy L. Getzenberg, D. Patrick Lenihan
Henry Ford Hospital Medical Journal
We describe how the federal government, the City of Chicago, and the State of Illinois worked together to increase the availability and accessibility of health care services on Chicago's underserved west side by reopening a bankrupt, federally-funded community health center. The federal government made the building available to the City which then contracted with a state university medical center to be the provider of services. This partnering has allowed the Chicago Department of Health to offer services in a previously underserved area. The University has gained an opportunity for community-based primary care teaching, as well as community relations. Patients have …
Universal Health Care For Americans, Frank Clemente
Universal Health Care For Americans, Frank Clemente
Henry Ford Hospital Medical Journal
No abstract provided.
Urban Health Care: An Integral Part Of The United States Health Care System, Sander M. Levin
Urban Health Care: An Integral Part Of The United States Health Care System, Sander M. Levin
Henry Ford Hospital Medical Journal
No abstract provided.
Public Health Care Delivery In Five U.S. Municipalities: Lessons And Implications, David G. Whiteis, J. Warren Salmon
Public Health Care Delivery In Five U.S. Municipalities: Lessons And Implications, David G. Whiteis, J. Warren Salmon
Henry Ford Hospital Medical Journal
Increasing pressures on private and public hospitals have necessitated a reassessment of urban health care delivery. Patients left unserved by stressed private hospitals have placed a greater burden on public institutions, which themselves are often old, underfunded, and in danger of closure. As policy analysts consider remedies, primary care in community-based settings has reemerged as an important component of planning. We present results of a comparative analysis of five public health care delivery systems (Boston, Dallas, Denver, Milwaukee, and Seattle), reflecting their economic, political, and cultural dynamics. Although significant differences in the relative centralization of care and reliance on community-based …
Community Health Centers: A Resource For Service And Training, Joan Hedgecock, Maria Castro, William B. Cruikshank
Community Health Centers: A Resource For Service And Training, Joan Hedgecock, Maria Castro, William B. Cruikshank
Henry Ford Hospital Medical Journal
The American Medical Student Association (AMSA) Foundation is assisting the U.S. Public Health Service in increasing the number of primary care physicians trained and committed to practice in medically underserved areas. In collaboration with the American Academy of Family Physicians, the Ambulatory Pediatrics Association, and the Society of General Internal Medicine, AMSA conducted an assessment of federally-funded residency programs to identify and describe their affiliations with federally-funded community and migrant health centers (CIMHCs). Of the 260 programs assessed and the 147 responses, 125 offer community-based training. Of these, 73 offer training in primary care centers and 39 offer training in …
Pace: A Capitated Model Towards Long-Term Care, John Shen, Ann Iverson
Pace: A Capitated Model Towards Long-Term Care, John Shen, Ann Iverson
Henry Ford Hospital Medical Journal
No abstract provided.
The Structure And Function Of Urban Pharmacies: Visits To Community Pharmacies In Inner-City Chicago, Thomas J. Reutzel, Laura A. Wilson
The Structure And Function Of Urban Pharmacies: Visits To Community Pharmacies In Inner-City Chicago, Thomas J. Reutzel, Laura A. Wilson
Henry Ford Hospital Medical Journal
Visits were made to 21 pharmacies in two poor neighborhoods on the west side of Chicago and interviews conducted with pharmacists-in-charge. The objective of the study was to provide a comprehensive description of the function, capabilities, and problems of urban pharmacy. We present results on the structure and function of these inner-city pharmacies. The pharmacies fit one of three structural forms: chain, independent, or medical center. The majority of respondents viewed the function of the inner-city pharmacy as patient-centered but also identified several barriers to effective patient communication. The results suggest that inner-city physicians and pharmacists should communicate with patients …
Urban Health And The Social Contract: Poverty, Race, And Death, H. Jack Geiger
Urban Health And The Social Contract: Poverty, Race, And Death, H. Jack Geiger
Henry Ford Hospital Medical Journal
No abstract provided.
Health Care Consortia: A Mechanism For Increasing Access For The Medically Indigent, Patricia A. Caplan, Bonnie Lefkowitz, Lynn Spector
Health Care Consortia: A Mechanism For Increasing Access For The Medically Indigent, Patricia A. Caplan, Bonnie Lefkowitz, Lynn Spector
Henry Ford Hospital Medical Journal
In response to poor coordination among health and social service providers, health care consortia have emerged in many areas of the United States. Consortia link multiple providers in a common structure to create comprehensive systems of care. They can he formally structured or informal combinations of providers that engage in coordination hut otherwise do not comprise an independent organization. The functions most common among all types of consortia are shared services and service coordination; however, a number of consortia also operate outreach/education programs. Consortia represent an innovative response to the need both for vertical integration—case management of all levels of …
Health Priorities Of The State Of Michigan, Vernice Davis Anthony
Health Priorities Of The State Of Michigan, Vernice Davis Anthony
Henry Ford Hospital Medical Journal
No abstract provided.
Moving From Health Care Research To Action, Claudia R. Baquet, Katherine Marconi, George Alexander
Moving From Health Care Research To Action, Claudia R. Baquet, Katherine Marconi, George Alexander
Henry Ford Hospital Medical Journal
Although the United States spends more on health care than any country in the world, access to that care is becoming increasingly difficult. The National Cancer Institute and other federal agencies are sponsoring innovative research for delivering effective medical services, particularly to underserved populations. Models of successful collaboration between private and public sectors concerned with health care can be adapted and implemented at the national, state, and local levels. However, other measures are needed to ensure access to adequate health care for all Americans. Minimal but effective regulations are needed to ensure quality control, reduce duplication of services, and minimize …
Mount Sinai: A Special Hospital For A Special Community, Benn Greenspan
Mount Sinai: A Special Hospital For A Special Community, Benn Greenspan
Henry Ford Hospital Medical Journal
No abstract provided.
Urban Hospitals: Their Plight And Mission, Jeffrey C. Merrill, Elliott C. Roberts, Mary Corita Heid
Urban Hospitals: Their Plight And Mission, Jeffrey C. Merrill, Elliott C. Roberts, Mary Corita Heid
Henry Ford Hospital Medical Journal
No abstract provided.
The Urban Hospital: Rediscovering Abandoned Values, Thomas W. Chapman
The Urban Hospital: Rediscovering Abandoned Values, Thomas W. Chapman
Henry Ford Hospital Medical Journal
No abstract provided.