Medicine and Health Sciences Commons^™

Aha/Acc Guidelines For Preventing Heart Attack And Death In Patients With Atherosclerotic Cardiovascular Disease: 2001 Update - A Statement For Healthcare Professionals From The American Heart Association And The American College Of Cardiology, Sidney C. Smith Jr., Steven N. Blair, Robert O. Bonow, Lawrence M. Brass, Manuel D. Cerqueira, Kathleen Dracup, Valentin Fuster, Antonio M. Gotto, Scott M. Grundy, Nancy Houston-Miller, Alice Jacobs, Daniel Jones, Ronald M. Krauss, Lori Mosca, Ira S. Ockene, Richard C. Pasternak, Thomas A. Pearson, Marc A. Pfeffer, Rodman K. Starke, Kathryn A. Taubert

Faculty Publications

No abstract provided.

Embryonic Stem Cell Research As An Ethical Issue: On The Emptiness Of Symbolic Value, Kevin Quinn

Faculty Publications

The ability to generate a wide variety of stem cell lines (in relatively renewable tissue cultures) opens up a whole new world of breathtaking possibilities for science and medicine. The possibilities include: "in vitro studies of normal embryo-genesis, human gene discovery, and drug and teratogen testing and as a renewable source of cells for tissue transplantation, cell replacement, and gene therapies." But it also opens up a world of complications.

Human EG and ES cells must be recovered from aborted fetuses or live embryos. Because primordial gonadal tissue is removed from fetuses after their death, the derivation of EO cells …

Risk Factors And Gender Differentials For Death Among Children Hospitalized With Diarrhoea In Bangladesh, Amal K. Mitra, Mohammad M. Rahman, George J. Fuchs

Faculty Publications

To identify risk factors for death among children with diarrhoea, a cohort of 496 children, aged less than 5 years, admitted to the intensive care unit of a diarrhoeal disease hospital in Bangladesh, was studied during November 1992-June 1994, Clinical and laboratory records of children who died and of those who recovered in the hospital were compared, Deaths were significantly higher among those who had altered consciousness, hypoglycaemia, septicaemia, paralytic ileus, toxic colitis, necrotizing enterocolitis, haemolytic-uraemic syndrome, invasive or persistent diarrhoea, dehydration, electrolyte imbalances, and malnutrition, Females experienced a 2-fold higher risk of death than males (p=0.003). Several indices of …

Proteolytic Enzymes In The Marine Bacterium Pseudoalteromonas Atlantica: Post-Secretional Activation And Effects Of Environmental Conditions, Monica Hoffman, Alan W. Decho

Faculty Publications

Production and activities of cellular and extracellular proteolytic enzymes associated with the marine bacterium Pseudoalteromonas atlantica were examined in response to physiological state and changing environmental variables under laboratory conditions. Enzymes evidenced by zymography were metalloproteases, as defined by substrate preference and susceptibility to inhibitors (EDTA and 1, 10-phenanthroline). Distinct bands (i.e. molecular-weight [MW] size classes) of enzymes were isolated from within cellular and extracellular compartments. Susceptibility of extracellular enzymes to environmental stressors was related, in part, to the MW size classes of the enzymes. While all bands of enzymes showed some degree of inhibition when pH was decreased, the …

Biomedical Research Leaders: Report On Needs, Opportunities, Difficulties, Education And Training, And Evaluation, Samuel H. Wilson, Deborah Brown, Jay Moskowitz, Dan Hurley, David Brown, David Brown, Byron J. Bailey, Michael Mcclain, Marilyn Misenhimer, Judith Buckalew, Thomas Burks

Faculty Publications

The National Association of Physicians for the Environment (NAPE) has assumed a leadership role in protecting environmental health in recent years. The Committee of Biomedical Research Leaders was convened at the recent NAPE Leadership Conference: Biomedical Research and the Environment held on 1–2 November 1999, at the National Institutes of Health, Bethesda, Maryland. This report summarizes the discussion of the committee and its recommendations. The charge to the committee was to raise and address issues that will promote and sustain environmental health, safety, and energy efficiency within the biomedical community. Leaders from every important research sector (industry laboratories, academic health …

The Use Of Uniaxial And Triaxial Accelerometers To Measure Children's "Free-Play" Physical Activity, Alise E. Ott, Russell R. Pate, Stewart G. Trost, Dianne S. Ward, Ruth P. Saunders

Faculty Publications

In order to effectively measure the physical activity of children, objective monitoring devices must be able to quantify the intermittent and nonlinear movement of free play. The purpose of this study was to investigate the validity of the Computer Science and Applications (CSA) uniaxial accelerometer and the TriTrac-R3D triaxial accelerometer with respect to their ability to measure 8 "free-play" activities of different intensity. The activities ranged from light to very vigorous in intensity and included activities such as throwing and catching, hopscotch, and basketball. Twenty-eight children, ages 9 to 11, wore a CSA and a heart rate monitor while performing …

The Integrity Of Death: Resolving Dilemmas In Medicine, Larry I. Palmer

Faculty Publications

No abstract provided.

Children's Understanding Of The Concept Of Physical Activity, Stewart G. Trost, Angela M. Morgan, Ruth P. Saunders, Gwen A. Felton, Dianne S. Ward, Russell R. Pate

Faculty Publications

This study evaluated 4th-grade students' understanding of the concept of physical activity and assessed the effects of two interventions to enhance the students' understanding of this concept. Students were randomly assigned to 1 of 3 conditions: the video group (n=40) watched a 5-min video describing physical activity; the verbal group (n=42) listened to a generic description of physical activity; the control group received no instruction (n=45). Students completed a 17-item checklist testing their understanding of the concept of physical activity. Compared to controls, students in the verbal and video group demonstrated significantly higher checklist …

Comparison Of A Dietary Record Using Reported Portion Size Versus Standard Portion Size For Assessing Nutrient Intake, Desiree C. Welten, Ruth A. Carpenter, R. Sue Mcpherson, Suzanne Brodney, Deirdre Douglass, James B. Kampert, Steven N. Blair

Faculty Publications

Objective: Because the percentage of missing portion sizes was large in the Aerobics Center Longitudinal Study (ACLS), careful consideration of the accuracy of standard portion sizes was necessary. The purpose of the present study was to investigate the consequences of using standard portion size instead of reported portion sizes on subjects' nutrient intake.

Methods: In 2307 men and 411 women, nutrient intake calculated from a 3-day dietary record using reported portion sizes was compared with nutrient intake calculated from the same record in which standard portion sizes were substituted for reported portion sizes.

Results: The standard portion sizes provided significantly …

Low Fasting Plasma Glucose Level As A Predictor Of Cardiovascular Disease And All-Cause Mortality, Ming Wei, Larry W. Gibbons, Tedd L. Mitchell, James B. Kampert, Michael P. Stern, Steven N. Blair

Faculty Publications

Background - Although medical textbooks usually classify fasting plasma glucose <70 or 80 mg/dL (<3.89 or 4.44 mmol/L) as abnormal, the prognosis for patients with low fasting plasma glucose is unclear.

Methods and Results - We conducted prospective cohort studies among 40,069 men and women to investigate the association between fasting plasma glucose levels and cardiovascular disease and all-cause mortality. We documented a U-shaped relation between fasting plasma glucose and mortality. In addition to diabetes and impaired fasting glucose levels, low fasting plasma glucose levels were also associated with high morality. After multivariate adjustment for age, sex, study population, ethnicity, current smoking status, high blood pressure, total cholesterol, body mass index, triglycerides, history of cardiovascular disease and cancer, and a family …

Teaching The Ethics Of Biology, David Harris Phd, Carol K. Johansen

Faculty Publications

Discusses the basic principles of ethics and ethical decision making as applied to biology. Ethical issues associated with biology; Theoretical basis of ethical decision-making; Models of ethical decision-making; Social implications of scientific experimentation and discovery.

Using The Levels Of Family Involvement Model With Religious Professionals, Dale R. Hawley, Carla M. Dahl

Faculty Publications

Serving as a religious professional is a complex task with a wide variety of demands and responsibilities. This variety contributes to a professional identity that requires the fulfillment of a number of roles. The Levels of Family Involvement (LFI) model (W. J. Doherty, 1995) offers a structure for helping clergy ascertain which roles may be most beneficial to a family in a given set of circumstances, as well as which roles are beyond their training and mission. The LFI is offered as a guideline for helping clergy select modes of intervention and identify areas for personal and professional development. Case …

Managing Phantom Pain With Drugs, Shelly Jensen Reed

Faculty Publications

Reed offers advice on how to manage and prevent pain that exists in a limb that doesn't. More than 70 percent of amputees suffer from stump and phantom limb pain years after amputation.

Correlates Of Physical Activity In Male And Female Youth, Timothy Bungum, Marsha Dowda, Anne T. Weston, Stewart G. Trost, Russell R. Pate

Faculty Publications

This study examined associations between psychosocial factors and physical activity in a group of youth (n=520). Students completed the Previous Day Physical Activity Recall and a survey of potential determinants of physical activity. Regression analyses of intentions to be physically active revealed that enjoyment and self-efficacy predicted intentions for both males and females. Attitudes predicted moderate to vigorous activity (MVPA), and enjoyment and self-efficacy predicted vigorous activity (VPA) for males. Self-efficacy predicted both MVPA and VPA for females. The findings suggest that intervention programs targeted at youth should include developmentally appropriate activities that are fun and promote physical …

Alcohol, Tobacco, And Pharmaceutical Industry Funding: Considerations For Organizations Serving Lesbian, Gay, Bisexual And Transgender Communities, Laurie A. Drabble

Faculty Publications

Emerging research suggests that alcohol, tobacco and drug-related problems may be higher in lesbian and gay communities than in the population as a whole. At the same time, alcohol, tobacco and pharmaceutical industries have increased marketing strategies that are targeted specifically to lesbian and gay communities. Lesbian, Gay, Bisexual and Transgender (LGBT) and HTV/AIDS organizations, often marginalized and under-funded, have frequently faced significant challenges in funding programs and special events. These organizations are often the very same groups needed to promote and support effective substance abuse countermeasures in LGBT communities. Agency leaders, community members, and substance abuse prevention advocates all …

Is Malnutrition Declining? An Analysis Of Changes In Levels Of Childhood Malnutrition Since 1980, Mercedes De Onis, Edward A. Frongillo Jr., Monika Blo¨ Ssner

Faculty Publications

Nutritional status is the best global indicator of well-being in children. Although many surveys of children have been conducted since the 1970s, lack of comparability between them has made it difficult to monitor trends in child malnutrition.

Cross-sectional data from 241 nationally representative surveys were analysed in a standard way to produce comparable results of low height-for-age (stunting). Multilevel modelling was applied to estimate regional and global trends from 1980 to 2005.

The prevalence of stunting has fallen in developing countries from 47% in 1980 to 33% in 2000 (i.e. by 40 million), although progress has been uneven according to …

Moderate Intensity Exercise Training Improves Cardiorespiratory Fitness In Women, J. David Branch, Russell R. Pate, Sharon P. Bourque

Faculty Publications

Among women, there is an increased prevalence of sedentary lifestyle and less participation in physical activity at levels recommended by the Surgeon General. As a result, women have been identified as a target group in public health initiatives to increase physical activity. The health-related benefits of habitual, moderate intensity physical activity are well documented in the epidemiological literature, but less is known about the effect of such physical activity on cardiorespiratory fitness. Our hypothesis was that moderate and vigorous exercise training regimens of similar estimated energy expenditure would result in similar changes in cardiorespiratory fitness. Eighteen sedentary premenopausal women with …

An Investigation Of The Effects Of Subthalamic Nucleus Stimulation On Acoustic Measures Of Voice, Christopher Dromey, Rajeev Kumar, Anthony E. Lang, Andres M. Lozano

Faculty Publications

Summary: Seven patients with Parkinson’s disease were implanted with deep brain stimulators to provide chronic electrical stimulation to the subthalamic nucleus bilaterally. Acoustic recordings and neurologic assessments were undertaken before surgery in the medication-off and medication-on conditions and after surgery with and without electrical stimulation in the medication off and medication-on conditions. The data showed significant improvements in limb motor performance in response to medication before surgery and when the subthalamic nucleus was stimulated after surgery. Six months after surgery, there were small but statistically significant increases in sound pressure level and fundamental frequency variability in response to stimulation in …

Cardiovascular Disease Prevention By Sports: Myth Or Reality?, Maria João C. A. Almeida, Steven N. Blair

Faculty Publications

Low levels of physical activity and fitness substantially increase risk of several chronic diseases, reduce longevity, and lead to loss of function. The strength and relation of inactivity to health problems and the high prevalence of sedentary habits in most countries of the world make lack of exercise a major public health problem. Fortunately, there is now good consensus regarding public health recommendations for physical activity from many important medical, scientific, and public health organizations. Recent research on physical activity interventions provides additional approaches to helping sedentary adults become more physically active.

The Treatment Of Essential Voice Tremor With Botulinum Toxin A: A Longitudinal Case Report, Christopher Dromey, Paul Warrick, Jonathan Irish, Lisa Durkin

Faculty Publications

Summary: The purpose of this study was to evaluate the effects of bilateral botulinum toxin injection into the thyroarytenoid (TA) muscles of a patient with essential voice tremor. Acoustic and aerodynamic data were collected weekly over a 16-week period. Flexible nasolaryngoscopy was performed prior to injection and 2, 6, 10, and 16 weeks post injection. Perceptual analyses of the acoustic and nasolaryngoscopic data were performed. A reduction in frequency tremor and, to a lesser extent, amplitude tremor was observed during the 1-10 week period. Estimated laryngeal resistance decreased after injection and was accompanied in perceptual measures by a reduction in …

Botulinum Toxin For Essential Tremor Of The Voice With Multiple Anatomical Sites Of Tremor: A Crossover Design Study Of Unilateral Versus Bilateral Injection, Christopher Dromey, Paul Warrick, Jonathan C. Irish, Lisa Durkin, Anthony Parkiam, Anthony Lang

Faculty Publications

Objectives/Hypothesis: To evaluate the relative efficacy of unilateral and bilateral injections of botulinum toxin injection (BOTOX) in the treatment of essential tremor of the voice (ETV). Study Design: Prospective open-label crossover study. Methods: Patients referred to the Neurolaryngology Clinic at Toronto General Hospital with a diagnosis of ETV were eligible for the study. Patients were sequentially as-signed to receive BOTOX as either a bilateral 2.5-U or a unilateral 15-U electromyography-guided injection, followed by the alternative injection 16 to 18 weeks later. Acoustic, aerodynamic, and nasopharyngoscopic data were collected approximately 2, 6, 10, and16 weeks after each injection. Patients were asked …

Personal Values And Work Satisfaction Of Registered Nurses Working In Hospitals, Marie M. Prothero, Elaine S. Marshall, Donna M. Fosbinder, Leland J. Hendrix

Faculty Publications

Personal values are increasingly recognized as important factors in work environments, including health care systems (Cameron & Whetten, 1995; Covey, Merrill, & Merrill, 1995; Fagermoen, 1997). The personal values of nursing students have been explored (Eddy, Elfrink, Weis, & Schank, 1994; Sivberg & Petersson, 1997) as have those of nurses, in the context of work design (Koerner, 1993 ). Factors of nurses' work satisfaction have also been studied extensively (Avallone & Gibbon, 1998; Brown, Naughton, & Nolan, 1998; Johnston,1997; Kangas, Kee, & McKee-Waddle,1999; Seymour & Buscherhof,1990). However, little is known about the personal values of nurses as they relate to …

Tracking Of Physical Activity, Physical Inactivity, And Health-Related Physical Fitness In Rural Youth, Russell R. Pate, Stewart G. Trost, Marsha Dowda, Alise E. Ott, Dianne S. Ward, Ruth P. Saunders, Gwen A. Felton

Faculty Publications

This study examined the tracking of selected measures of physical activity, inactivity, and fitness in a cohort of rural youth. Students (N=181, 54.7% female, 63.5% African American) completed test batteries during their fifth- (age=10.7±0.7 years), sixth-, and seventh-grade years. The Previous Day Physical Activity Recall (PDPAR) was used to assess 30-min blocks of vigorous physical activity (VPA), moderate-to-vigorous physical activity (MVPA), TV watching and other sedentary activities, and estimated energy expenditure (EE). Fitness measures included the PWC 170 cycle ergometer test, strength tests, triceps skinfold thickness, and BMI. Intraclass correlation coefficients (ICCs) for VPA, MVPA, and after-school EE …

Validity Of The Previous Day Physical Activity Recall (Pdpar) In Fifth-Grade Children, Stewart G. Trost, Dianne S. Ward, Ben Mcgraw, Russell R. Pate

Faculty Publications

This study evaluated the validity of the Previous Day Physical Activity Recall (PDPAR) self-report instrument in quantifying after-school physical activity behavior in fifth-grade children. Thirty-eight fifth-grade students (mean age, 10.8 ± 0.1; 52.6%; female; 26.3% African American) from two urban elementary schools completed the PDPAR after wearing a CSA WAM 7164 accelerometer for a day. The mean within-subject correlation between self-reported MET level and total counts for each 30-min block was 0.57 (95% C.I., 0.51-0.62). Self-reported mean MET level during the after-school period and the number of 30-min blocks with activity rated at > 6 METs were significantly correlated with the …

Patient And Care Giver Perceptions Of Cancer Pain Control, Patricia Rushton, Sherry Brown

Faculty Publications

PURPOSE: This study measured the perceptions of Utah cancer patients and cargivers concerning knowledge about and adequacy of pharmacologic cancer pain control. METHODS: A descriptive survey was used. Questionnaires were sent to cancer patients and caregivers surveying their knowledge about and perceptions of the adequacy of pharmacologic cancer pain control. RESULTS: The study had a 52% response rate (259 of 500). Eighty five percent (219 of 259) of the respondents stated they had no cancer pain. CLINICAL IMPLICATIONS: Cancer literature indicated that much cancer pain is not effectively controlled. The majority of the respondents of this study reported no pain. …

Dietary Assimilation Of Cadmium Associated With Bacterial Exopolymer Sediment Coatings By The Estuarine Amphipod Leptocheirus Plumulosus: Effects Of Cd Concentration And Salinity, Christian E. Schlekat, Alan W. Decho, G. Thomas Chandler

Faculty Publications

Bacterial extracellular substances (also known as exopolysaccharides, or EPS) may serve as vectors for trophic transfer of metals in benthic systems because these ubiquitous sediment coatings can sorb high concentrations of toxic metals, and because many benthic invertebrates assimilate EPS sediment coatings upon ingestion. We conducted 3 sets of experiments to determine the assimilative bioavailability of EPS-associated Cd to the benthic amphipod Leptocheirus plumulosus as a function of Cd concentration and salinity. Bioavailability was measured as L. plumulosus Cd assimilation efficiency (AE) from EPS-coated silica (EPS●Si) and from uncoated silica (NC●Si) using modified pulse-chase methods with the gamma-emitting radioisotope ^{109 …}

A Comparison Of The Use Of Tympanic, Axillary, And Rectal Thermometers In Infants, Russell Wilshaw, Renea L. Beckstrand, Dawn Waid, Bruce Schaallje

Faculty Publications

This study examined the relationship between three instruments used in measuring tympanic, axillary, and rectal temperatures in infants less than 1 year of age. Temperatures were measured by Oto-temp Pedi Q tympanic thermometers, Becton Dickinson axillary thermometer, and rectal thermometers. A convience sample of 5 infants less than 90 day and 54 greater than 90 days with fever, as well as 34 infants less than 90 days and 27 infants greater than 90 days without fever were studied. Correlations of infants less than 90 days and greater 90 days of age, as well as differences between infant temperature with and …

Health And Educational Outcomes Of Children Who Experienced Severe Neonatal Medical Complications, Timothy B. Smith, Glenna C. Boyce, Glendon Castro

Faculty Publications

To determine the long-term developmental and educational outcomes of a sample of low birthweight infants with intraventricular hemorrhage (IVH), developmental assessments and interviews were conducted eight years after the initiation of an early intervention project. At the time of the follow-up, 62% of children were experiencing some developmental or behavior problems, with visual impairments, cerebral palsy, and attention deficits occurring most frequently. Grade of IVH and the number of days spent in the neonatal intensive care unit were the best predictors of later developmental delays. The sample also scored below average on school achievement; approximately 30% of those in school …

Development And Testing Of A Quantitative Food Frequency Questionnaire For Use In Gujarat, India, James R. Hébert, Prakash C. Gupta, Ramesh B. Bhonsle, Pesi N. Sinor, Hemali Mehta, Fali S. Mehta

Faculty Publications

Objective: To develop and test a quantitative, interviewer-administered food frequency questionnaire (FFQ) to ascertain nutrient intakes of individuals in northern India. Design: A 92-item FFQ was developed based on food use and market surveys of the study area. A validation study was conducted consisting of 24-h diet recalls (24HR) administered on 6 randomly selected days over 1 year. Two FFQs were administered, one each at the beginning and end of the 1-year period. FFQ and 24HR-derived nutrient scores were compared using correlation and regression analyses and by computing differences between nutrient intakes estimated by the two methods. Setting: Rural villages …

Acoustic And Perceptual Improvements In Tracheoesophageal Voice Using A Neck Strap, Christopher Dromey, Carol Kapusta-Shemie

Faculty Publications

Tracheoesophageal (TE) speech, which relies on pulmonary air directed through a one-way valve from the trachea to the esophagus, has become an effective means of voice restoration for many alaryngeal speakers. Whereas the success rate for TE speech has been reported to reach 80% to 90%, complications are not uncommon. In a few cases, pouching of the neck at the level of the neoglottis has been observed. This has previously been reported to negatively affect functional communication, and has been associated with a flaccid or hypnotic vibratory segment. The application of pressure, either manually or by way of a neck …