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Articles 1531 - 1560 of 2232
Full-Text Articles in Medicine and Health Sciences
Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael
Targeting Protein Kinases To Manage Or Prevent Alzheimer’S Disease, Manal A. Nael
Electronic Theses and Dissertations
Due to the pressing need for new disease-modifying drugs for Alzheimer’s disease (AD), new treatment strategies and alternative drug targets are currently being heavily researched. One such strategy is to modulate protein kinases such as cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase-3 (GSK-3α and GSK-3β), and the protein kinase RNA-like endoplasmic reticulum kinase (PERK). AD intervention by reduction of amyloid beta (Aβ) levels is also possible through development of protein kinase C-epsilon (PKC-ϵ) activators to recover α-secretase levels and decrease toxic Aβ levels, thereby restoring synaptogenesis and cognitive function. In this way, we aim to develop …
The Acute And Chronic Muscle Adaptations Following Six Weeks Of "No Load" And Traditional High Load Resistance Training, Brittany Counts
The Acute And Chronic Muscle Adaptations Following Six Weeks Of "No Load" And Traditional High Load Resistance Training, Brittany Counts
Electronic Theses and Dissertations
Muscle growth is postulated to occur through mechanisms initiated by local muscle tension. This appears to be true, independent of the external load, provided sufficient tension is achieved. PURPOSE: The purpose of this study was to remove the influence of an external load and compare the acute and chronic muscle adaptations of “No Load” training to traditional High Load training. METHODS: Thirteen participants completed six weeks of thrice weekly unilateral elbow flexion exercise. Using a within subject design, each arm was designated to either the No Load or the High Load (70% one repetition maximum) condition. The No Load condition …
Prehabilitation (Prehab): Prevention In Motion, Billie Russell
Prehabilitation (Prehab): Prevention In Motion, Billie Russell
Electronic Theses and Dissertations
Cardiovascular disease is the leading cause of death for U.S. adults. It adds greater than $100 billion to U.S. health care costs annually. Rates of morbidity, mortality, and economic burden of the disease could be dramatically reduced with improvements in sedentary behaviors among adults with coronary artery disease (CAD). A regular commitment to moderate physical activity can reduce ischemic heart events up to 50%. Although the benefits of physical activity are well-known for individuals with coronary artery disease, an estimated 70% of this population remains relatively sedentary. Hospital-based cardiac rehabilitation programs are the single secondary prevention option offered to improve …
The Role Of Sod1 Acetylation In Neurodegeneration, Michael Kaliszewski
The Role Of Sod1 Acetylation In Neurodegeneration, Michael Kaliszewski
Electronic Theses and Dissertations
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting motor neurons. Cu, Zn superoxide dismutase (SOD1), a cytoplasmic free radical scavenging enzyme, is mutated in familial ALS (fALS) and post-translational modification of the wild-type protein has been associated with sporadic ALS (sALS). Proteomic studies indicate that SOD1 is acetylated at Lys123; however, the role of this modification remains unknown. To investigate its function, we generated antibodies for Lys123-acetylated SOD1 (Ac-K123 SOD1). Sod1 deletion in Sod1-/- mice, K123 mutation, or preabsorption with Ac-K123 peptide suppressed immunoreactivity, confirming antibody specificity. In the normal central nervous system, Ac-K123 SOD1 maps to glutamatergic …
Evaluation Of Echogenicity Within And Between Ultrasonographic Images Of The Vastus Lateralis, Alyssa Varanoske
Evaluation Of Echogenicity Within And Between Ultrasonographic Images Of The Vastus Lateralis, Alyssa Varanoske
Electronic Theses and Dissertations
PURPOSE: The purpose of this study was to examine the echo intensity (EI) values of different ultrasound (US) images of the vastus lateralis (VL) using panoramic imaging in the transverse plane (PTI) and still imaging in the longitudinal plane (SLI). Secondary purposes of this study were to examine VL homogeneity and to determine relationships between subcutaneous adipose tissue thickness (SubQ) adjacent to the muscle and EI. METHODS: Twenty-four recreationally trained collegiate males (20.2 ± 1.6 years; height: 178.1 ± 6.6 cm; weight: 82.2 ± 13.4 kg) participated in this investigation. EI, cross-sectional area (CSA), muscle thickness (MT), and SubQ of …
The Influence Of Perceived Organizational Support, Perceived Coworker Support & Debriefing On Work-Related Compassion Satisfaction, Burnout, And Secondary Traumatic Stress In Florida Public Safety Personnel, Anastasia Miller
Electronic Theses and Dissertations
The purpose of this study was to examine the relationships between perceived organizational support, perceived coworker support, and debriefing on the one hand, and compassion satisfaction, burnout, and secondary traumatic stress on the other hand in Florida law enforcement, fire, emergency medical services, and dispatch public safety workers. In order to explore the relationships between these constructs, the research questions examined the relationships of the work environment of Florida public safety by administering surveys gauging perceived organizational support, perceived coworker support, psychological resilience, and debriefing activities that the personnel participate in. The Professional Quality of Life: Compassion Satisfaction and Compassion …
Biophysical Sources Of 1/F Noises In Neurological Tissue, Alan Paris
Biophysical Sources Of 1/F Noises In Neurological Tissue, Alan Paris
Electronic Theses and Dissertations
High levels of random noise are a defining characteristic of neurological signals at all levels, from individual neurons up to electroencephalograms (EEG). These random signals degrade the performance of many methods of neuroengineering and medical neuroscience. Understanding this noise also is essential for applications such as real-time brain-computer interfaces (BCIs), which must make accurate control decisions from very short data epochs. The major type of neurological noise is of the so-called 1/f-type, whose origins and statistical nature has remained unexplained for decades. This research provides the first simple explanation of 1/f-type neurological noise based on biophysical fundamentals. In addition, noise …
Evaluation And Enhancement Of Physical Stability Of Amorphous Solid Dispersions, Xin Feng
Evaluation And Enhancement Of Physical Stability Of Amorphous Solid Dispersions, Xin Feng
Electronic Theses and Dissertations
A major concern during formulation development has been to enhance the dissolution rate and bioavailability of poorly water-soluble drugs.[1],[2] The amorphous forms of APIs have attracted considerable attention as the amorphous forms tend to exhibit significantly higher levels of supersaturation in aqueous media when compared to the crystalline forms.[3],[4] For drugs which bioavailability is limited by aqueous solubility (biopharmaceutical classification system (BCS) class II drugs), which is a significant number of recently discovered drug candidates, the improved solubility may lead to enhanced bioavailability.[5-7] Oral absorption of APIs depends on two broad, but crucial, events, namely drug solubilization and gastrointestinal permeation.[8] …
Exploring New Chemical Entities From Traditional Medicine: Docking, Synthesis And Specific Bioactivities, Chinni Yalamanchili
Exploring New Chemical Entities From Traditional Medicine: Docking, Synthesis And Specific Bioactivities, Chinni Yalamanchili
Electronic Theses and Dissertations
Traditional medical systems contributed significantly to medicine with a number of their phytochemicals found to possess good biological properties. Recently, Dr. Youyou Tu was awarded the Nobel Prize (2015) for her discovery/isolation of Artemisinin from the TCM plant Artemisia annua. Our first aim is to identify active phytochemicals against botulinum neurotoxin A (BoNT/A), and diabetes from Ayurveda and TCM, respectively, by using in silico, in vitro and in vivo approaches. In our second aim, we wanted to enantioselectively synthesize scalable quantities of phytoestrogenic isoflavans such as equol and sativan. The following three chapters summarize results of the three research goals. …
Physical Activity Initiatives: Implications For Physical Activity Promotion, Allison Lea Nooe
Physical Activity Initiatives: Implications For Physical Activity Promotion, Allison Lea Nooe
Electronic Theses and Dissertations
The Exercise is Medicine (EiM) initiative and the National Physical Activity Plan (NPAP) are structured to promote an increase of physical activity at the population level. The primary vision of the EiM initiative is the assessment and prescription of exercise in a primary care clinical setting. The NPAP is a document presenting evidenced-based strategies and tactics across 8 different societal sectors that create opportunity for increased physical activity. Both initiatives offer valuable strategies in promoting physical activity among American citizens. However, little empirical research on these initiatives has been evaluated. Study I is entitled,Perceptions of the Exercise is Medicine®Initiative in …
Bone Mineral Density, Preventative Behaviors And Risk Factors In African American And Caucasian Mother-Daughter Pairs, Mary Haskins Haskins
Bone Mineral Density, Preventative Behaviors And Risk Factors In African American And Caucasian Mother-Daughter Pairs, Mary Haskins Haskins
Electronic Theses and Dissertations
It is expected that by 2030, elderly minorities will comprise 20.2 million of the total 72.8 million population of Americans over 65 years (pollard, 2013). For African American women over the age of 50, 5% have osteoporosis and an estimated 35% have low bone mass (nof, n.d.). It is estimated that while over 40% of African American women over 80 years meet criteria for treatment, yet less than 12% are actually treated (Cauley, 2011). Striking disparities exist between African American and Caucasian women's likelihood for dual-energy x-ray absorptiometry (dxa) referral, the measurement tool that is used to diagnosis osteoporosis. (Hamrick, …
Evaluating Moral Distress, Moral Distress Residue And Moral Courage In Oncology Nurses, Lolita Melhado
Evaluating Moral Distress, Moral Distress Residue And Moral Courage In Oncology Nurses, Lolita Melhado
Electronic Theses and Dissertations
Purpose: To examine relationships between moral distress, moral distress residue, and moral courage and to determine which nurse characteristics are predictive of moral distress and moral courage. Methods: The study used a mixed methods cross-sectional correlation design and qualitative content analysis to investigate oncology nurses' characteristics and relationships between moral distress, moral distress residue, and moral courage. A convenience sample of 187 oncology nurses working in inpatient and outpatient settings was recruited through the national Oncology Nursing Society in the Southeastern United States. Hamric's 21-item Moral Distress Scale-Revised (MDS-R) and Sekerka et al. 15-item Professional Moral Courage Scale (PMCS) supplemented …
Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha
Novel Approaches For Ungual And Trans-Ungual Delivery Of Drugs, Avadhesh Singh Kushwaha
Electronic Theses and Dissertations
Topical therapy is commonly used for the treatment of nail diseases such as onychomycosis and nail psoriasis due to less severe side effects, non-invasiveness, direct drug delivery at the site of infection, patient compliance and lower cost of treatment. However, topical treatment is limited due to poor permeability and hard nature of nail plate. The main objective of first project was to investigate the penetrability of apremilast into and across the nail plate, folloby the preparation of a novel nail lacquer formulation to improve its ungual and trans-ungual permeation for the treatment of nail psoriasis. Dexpanthenol and salicylic acid were …
Sedentary Behavior-Inducing Randomized Control Intervention On Various Health-Related Outcomes In Active, Young Adults, Meghan Edwards
Sedentary Behavior-Inducing Randomized Control Intervention On Various Health-Related Outcomes In Active, Young Adults, Meghan Edwards
Electronic Theses and Dissertations
An expansive body of literature has established the positive effects of physical activity on a number of health-related outcomes, including chronic disease prevention (both physiological and psychological). In addition to growing information regarding the benefits of physical activity, recent research has suggested the need to focus future studies on the effects of sedentary behavior (independent of physical activity) on one’s wellbeing. The majority of existing research on sedentary behavior, however, has used cross-sectional study designs. The few experimental studies on sedentary behavior have primarily focused on minimizing prolonged sedentary behavior among inactive individuals, rather than inducing sedentary behavior. We hypothesized …
Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu
Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu
Electronic Theses and Dissertations
Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in drug products with inferior therapeutic efficacy and unacceptable clinical safety profile. Topical cream formulations may possess numerous quality attributes that can affect the permeation of the drug through skin and consequently therapeutic efficacy. CQAs of topical formulations are often aimed at characterizing either the physicochemical properties of APIs or bulk characteristics of the formulation itself. Solvent systems constitute a …
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil
Electronic Theses and Dissertations
Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …
Examining The Association Between Leisure Coping Strategies And Mental Health Among College Students, Karolyne Helen Rehner
Examining The Association Between Leisure Coping Strategies And Mental Health Among College Students, Karolyne Helen Rehner
Electronic Theses and Dissertations
No abstract provided.
Biological And Psychosocial Risk Factors Of Stroke In African Americans Enrolled In The Jackson Heart Study (Jhs), Sasikiran Nunna
Biological And Psychosocial Risk Factors Of Stroke In African Americans Enrolled In The Jackson Heart Study (Jhs), Sasikiran Nunna
Electronic Theses and Dissertations
Objectives: the objective of this study is to estimate the impact of biological, psychosocial and other risk factors on stroke in African Americans enrolled in the JHS and determine the population attributable risk of risk factors. Methods: this study used a nested case control design. Cases were patients with stroke during the follow up period. Corresponding controls were selected from subjects who are alive at that time period and who are at risk of stroke by matching on the person-years spent in the cohort. Odds ratios (OR) and population attributable risks (PAR) were calculated to understand the association of risk …
Structural And Functional Characterization Of Enzymes Of A Novel Group Of Tryptophylquinone Cofactor Containing Oxidases, Esha Sehanobish
Structural And Functional Characterization Of Enzymes Of A Novel Group Of Tryptophylquinone Cofactor Containing Oxidases, Esha Sehanobish
Electronic Theses and Dissertations
Protein-derived cofactors are redox and catalytic centers that are generally formed by the posttranslational modifications of one or more amino acids. An important class of these cofactors are the quinones derived from tyrosine and tryptophan. Amongst redox proteins, it has been known till now that oxidases either contain a flavin or a tyrosylquinone cofactor, whereas tryptophylquinone ones are present within the dehydrogenases. In recent times, oxidases from a marine bacterium, Marinomonas mediterranea, have been shown to possess the latter. This study involves the characterization of two such proteins, lysine-?-oxidase (LodA) and glycine oxidase (GoxA). They have been reported to contain …
Political, Economic, And Health Determinants Of Tuberculosis Incidence, Ashley Rutherford
Political, Economic, And Health Determinants Of Tuberculosis Incidence, Ashley Rutherford
Electronic Theses and Dissertations
The epidemiologic transition has shifted major causes of mortality from infectious disease to chronic disease; however, infectious diseases are again re-emerging as a major global concern (Diamond, 1997; Karlen, 1995; McNeil, 1976). This research aimed to identify potential areas of infectious disease influence that are not health-related in order to help governments and policymakers establish new policies, correct current policies, or further address these issues in order to effectively prevent and combat infectious disease. This study employed a retrospective, cross-sectional, non-experimental design via structural equation modeling (SEM) and examined tuberculosis incidence rates at the country-level. Secondary data from open-source, international …
The Mauc Gene Encodes A Versatile Signal Sequence And Redox Protein That Can Be Utilized In Native And Non-Native Protein Expression And Electron Trnasfer Systems, Brian Dow
Electronic Theses and Dissertations
The redox-active type 1 copper site of amicyanin is composed of a single copper ion that is coordinated by two histidines, a methionine, and a cysteine residue. This redox site has a potential of +265 mV at pH7.5. Over ten angstroms away from the copper site resides a tryptophan residue whose fluorescence is quenched by the copper. The effects of the tryptophan on the electron transfer (ET) properties were investigated by site-directed mutagenesis. Lessons learned about the hydrogen bonding network of amicyanin from the aforementioned study were attempted to be used as a model to increase the stability of another …
The Reproducibility And Validity Of Using The Dmax Method To Predict Physical Working Capacity At Fatigue Threshold, Joshua Riffe
The Reproducibility And Validity Of Using The Dmax Method To Predict Physical Working Capacity At Fatigue Threshold, Joshua Riffe
Electronic Theses and Dissertations
Although the original (ORG) physical working capacity at fatigue threshold (PWCFT) assessment has demonstrated strong reliability and sensitivity to training and/or nutritional interventions, limitations may exist regarding the method of PWCFT estimation. However, a relatively new mathematical method, called Dmax, has been shown to be objective and reliable when estimating metabolic and neuromuscular fatigue thresholds. To date, however, no study has examined whether the Dmax method for estimating the work rate at PWCFT is similar to the ORG method. PURPOSE: The purpose of this study is to evaluate the reliability and validity of the Dmax-EMG method for estimating and tracking …
Perceived Readiness To Transition To Adult Health Care For Youth With Cystic Fibrosis And Congruence With Their Caregivers' Views, Valerie Lapp
Electronic Theses and Dissertations
Youth with cystic fibrosis must gradually assume considerable self-care management skills in order to optimize longevity and quality of life, and healthcare providers and caregivers play a role in youth gradually assuming these skills. The purpose of this study was to determine how youth with cystic fibrosis perceive their self-care management skills required for transition to adult healthcare, the relationship between age and skill acquisition, youth and caregiver congruence on perceived transition readiness, and frequency of transition discussion with provider. In this descriptive, correlational, cross-sectional design, 58 youth ages 14-22 rated their skill ability in managing cystic fibrosis using the …
Preschool Attendance: A Parental And Teacher Perspective Of Barriers And Behaviors Using Grounded Theory Research, Anne Meoli
Electronic Theses and Dissertations
Background: Preschool children from single-parent households with lower socioeconomic status (SES) are absent from preschool at rates higher than any other group. Some children are chronically absent, missing more than 10% of the school year. The phenomenon of preschool attendance related to behaviors, practices, and parental decision making associated with health and illness in lower SES households has not been previously studied using grounded theory methodology. Aim: The purpose of this study was to explore decision making related to supporting attendance in a preschool of 67 children (aged 3 to 4 years) with primarily low-income, single parents and preschool teachers …
Role Of Klf8-Cxcr4 Signaling In Breast Cancer Metastasis, Debarati Mukherjee
Role Of Klf8-Cxcr4 Signaling In Breast Cancer Metastasis, Debarati Mukherjee
Electronic Theses and Dissertations
Krüppel-like factor 8 (KLF8) has been strongly implicated in breast cancer metastasis. However, the underlying mechanisms remain largely unknown. In this study we report a novel signaling from KLF8 to C-X-C cytokine receptor type 4 (CXCR4) in breast cancer. Overexpression of KLF8 in MCF-10A cells induced CXCR4 expression at both mRNA and protein levels. This induction was well correlated with increased Boyden chamber migration, matrigel invasion and transendothelial migration (TEM) of the cells towards the ligand CXCL12. On the other hand, knockdown of KLF8 in MDA-MB-231 cells reduced CXCR4 expression associated with decreased cell migration, invasion and TEM towards CXCL12. …
An Evaluation Of Anxiety Following Substance Abuse Withdrawal And Assessment Of Somatic Treatments Presently Available With A Focus On Cranial Electrotherapy Stimulation, Janet Hutchison
Electronic Theses and Dissertations
Addictive disorders/substance use disorders (SUDS) affect almost everyone in the United States, either directly or indirectly. The cost of substance abuse to the social and economic structure in the United States is huge. Anxiety is one of the most frequently mentioned symptoms which lead to relapse during the early weeks of recovery due to neurohormonal changes in the limbic system as well as cortisol production which occur during this time. Present research in the treatment of anxiety in substance abuse and long term recovery is focused on genetics and pharmaceuticals, however most pharmaceuticals produce sedation. Additional therapies in early recovery, …
Mathematical Modeling Of Heart Rate Deflection Point In Relation To Respiratory Compensation And Treadmill Running Performance, Kayla Baker
Electronic Theses and Dissertations
Heart rate deflection point (HRDP), identified as the second breakpoint in the "intensity / heart rate" relationship, is indicative of the anaerobic threshold (AT). This point can be determined via bi-segmental linear regression (2SEG) or through use of the maximal distance model (D-max); however, the relationship between these methods has yet to be investigated 2. Purpose: To compare the use of 2SEG and D-max methods to determine HRDP and to examine the relationship between these values with a metabolic threshold, respiratory compensation point (RCP), as well as running performance [5,000 meter treadmill time trial (5Ktime)]. Methods: Nineteen recreationally active men …
The Effect Of The Patient Protection And Affordable Care Act On The Medicare Part D Coverage Gap As Reflected In Diabetes Medication Adherence., Jennifer A. Forristal
The Effect Of The Patient Protection And Affordable Care Act On The Medicare Part D Coverage Gap As Reflected In Diabetes Medication Adherence., Jennifer A. Forristal
Electronic Theses and Dissertations
This dissertation involves an evaluation of the effect of the Patient Protection and Affordable Care Act (ACA) on diabetic medication adherence for mail order utilizers over 6 years as the Medicare Part D coverage gap begins to close. The study had 3 objectives: 1) to evaluate diabetes medication adherence of health plan members before they reach the coverage gap and then while they are in the coverage gap, 2) to compare diabetes medication adherence between two similar groups with differing benefit structures, one group with a gap in coverage as opposed to a group with no benefit changes within the …
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Mechanisms And Intervention Strategies For Alcohol And Hiv-Antiretroviral Therapy-Induced Liver Injury., Hridgandh Donde
Electronic Theses and Dissertations
Chronic alcohol consumption is a leading cause of liver disease and liver-related death worldwide. Alcoholic liver disease includes, hepatic steatosis, steatohepatitis and ultimately fibrosis and cirrhosis. Emerging evidence has established the important role of the “gut-liver” axis in the development of alcoholic liver disease (ALD). Our recent work indicated that chronic alcohol induced perturbations in the gut microbiome and consequent changes in fatty acids have a major impact on the development of intestinal barrier dysfunction and ALD. The aim of this study was to investigate whether treatment with tributyrin - a butyrate prodrug results in protection against ALD in terms …
Comparison Of Digital Scanning And Polyvinyl Siloxane Impression Techniques By Dmd Students : Instructional Efficiency And Attitudes Toward Technology., Alexander M. Marti
Comparison Of Digital Scanning And Polyvinyl Siloxane Impression Techniques By Dmd Students : Instructional Efficiency And Attitudes Toward Technology., Alexander M. Marti
Electronic Theses and Dissertations
The aim of this research was compare the ability of dental students to learn an digital scanner (3M LAVA) and material-based (PVS) impression techniques and to determine attitudes and preferences towards each. D2 dental students (n=25) were recruited and instructed on the use of 3M LAVA and PVS techniques using three pedagogic methods: 1) video lecture (P1), 2) investigator-led demonstration (P2), and 3) independent clinical exercise (P3). The amount of time for each pedagogic method was measured, averaged (± s.d.) and compared using Wilcoxon Signed-Ranks tests. A pre- and post-test was administered assessing their attitudes towards both techniques using a …