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Full-Text Articles in Medicine and Health Sciences

Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel Jan 2023

Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel

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Introduction: HIV (Human Immunodeficiency Virus) is a sexually transmitted infection (STI) that is still a major health issue in the United States and the world. Emerging adults are more likely to engage in risky sexual behaviors such as multiple sexual partners and unprotected sex. HIV testing contributes to ending the HIV epidemic by identifying at-risk individuals and promoting early diagnosis.Methods: Secondary data analyses of the City Health II dataset were conducted to 1) identify the association between HIV testing and risky sexual behaviors among Black/African American emerging adults ages 18-25 years living in Birmingham metro area, 2) use social network …

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Comparison Of Flexural Strength, Fracture Toughness, And Color Stability Of Cad/Cam 3d-Printed Denture Base Materials To Milled And Conventional Heat-Polymerized Materials: An In Vitro Study, Yamen Safadi Jan 2023

Comparison Of Flexural Strength, Fracture Toughness, And Color Stability Of Cad/Cam 3d-Printed Denture Base Materials To Milled And Conventional Heat-Polymerized Materials: An In Vitro Study, Yamen Safadi

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Digitalization of the design and manufacturing of complete dentures streamlines the clinical and laboratory processes and provides increased efficiency and enhanced denture quality.[1, 2] The two most common CAD/CAM techniques for denture base manufacturing are additive (3D-printing) and subtractive (milling) manufacturing. Milled denture bases have been proven to be comparable in their physical and mechanical properties to conventional heat-polymerized denture bases,[3-6] and in many studies found to be superior to 3D-printed denture bases.[7-13] However, 3D-printing offers many advantages over milling that appeal to both clinicians and dental technicians related to investment and operational costs, maintenance, speed of manufacturing, diversity of …

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Comparison Of Radiological Signs To Clinical Symptoms In Children With Jia. A Pilot Study, Shubham Sharma Jan 2023

Comparison Of Radiological Signs To Clinical Symptoms In Children With Jia. A Pilot Study, Shubham Sharma

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JIA, which stands for juvenile idiopathic arthritis, is a group of chronic inflammatory joint diseases that usually occur in children under the age of 16 and last for at least six weeks1–5. It is one of the most common chronic joint diseases in childhood1 and affects up to 150 out of every 100,000 children worldwide6. This condition has no identifiable cause and is different from adult rheumatoid arthritis. Unfortunately, JIA can have a significant negative impact on the lives of these young children, causing disability and impairing their daily activities. TMJ involvement is more common than previously believed in JIA …

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Perceptions Of Comfort And Vison In Center Distance Multifocal Contact Lenses In Non-Presbyopic Adults, D'Ajanee Smallwood Jan 2023

Perceptions Of Comfort And Vison In Center Distance Multifocal Contact Lenses In Non-Presbyopic Adults, D'Ajanee Smallwood

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Purpose: The aim of this study was to assess the subjective performance of four different multifocal contact lenses (MFCLs) amongst a population of adults excluding presbyopes. Methods: Forty-three subjects were fit with up to four different lenses (Biofinity “D” MFCL, NaturalVue MFCL, MiSight 1 Day contact lens, & Intelliwave MFCL). Information about vision and comfort were gathered using subjective assessments. Pupil size data were gathered as secondary outcome measurements. Results: There were no significant differences in ghosting, haloes, and visual clarity between larger and smaller pupils. All MFCLs had reduced overall visual clarity compared to habitual correction except for Biofinity. …

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Exercise-Driven Epigenetic And Transcriptomic Changes In An Experimental Model Of Temporal Lobe Epilepsy, Silvienne C. Sint Jago Jan 2023

Exercise-Driven Epigenetic And Transcriptomic Changes In An Experimental Model Of Temporal Lobe Epilepsy, Silvienne C. Sint Jago

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Temporal lobe epilepsy (TLE) is a neurological disease marked by recurring unprovoked seizures originating from temporal lobe structures and is frequently associated with cognitive deficits. Exercise holds promise as a therapeutic approach to alleviate seizures and cognitive impairments in TLE. However, the exact cellular and molecular mechanisms by which exercise influences pathways related to seizure activity and cognition in the context of TLE still need to be understood. Neuronal network formation relies on the regulation of gene expression, which can lead to either an increase or a decrease in the production of essential proteins involved in neuronal signaling. Genes are …

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Pathophysiological Metabolic Alteration In Lung Injury And Fibrosis, Samuel Robert Smith Jan 2023

Pathophysiological Metabolic Alteration In Lung Injury And Fibrosis, Samuel Robert Smith

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Lung injury and lung repair are two sides of the same coin, for where injury occurs, repair must follow. Lung fibrosis occurs when this repair process is dysfunctional and becomes trapped in a chronically incomplete state. The studies described here examine each side of this coin to ask the question of whether metabolism has a role in the pathophysiology of acute lung damage following severe trauma or in the chronic progression of idiopathic pulmonary fibrosis (IPF). In the first half of this work, we investigated the impact that severe lung injury and infection exert on the flux of metabolites in …

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The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith Jan 2023

The Effects Of Mobile Shielding On Scatter Radiation In The Cardiac Catheterization Laboratory, Lancer Smith

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This research evaluates the effectiveness of a Specialized Cardiac Catheterization Laboratory Shielding Device (SCCLSD) compared to traditional shielding methods in reducing occupational exposure to scattered x-rays, contributing to the ongoing enhancement of radiation safety in the cardiac catheterization laboratory (CCL) setting. The upper component of the SCCLSD comprises a mobile, transparent barrier with lead-equivalent malleable drapes designed to conform to the patient's body contours. It is height-adjustable, creating a protective shield against scatter radiation generated during CCL procedures. The lower portion of the SCCLSD replaces traditional lead-lined drapes, extending further down the table and incorporating additional shielding for staff protection.An …

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Effectiveness Of The Invisalign System For Deep Bite Correction, Jerry D. Spillers Jan 2023

Effectiveness Of The Invisalign System For Deep Bite Correction, Jerry D. Spillers

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Objective: To assess the dental and skeletal changes resulting from correction of a deep bite using Invisalign (Align Technology, Santa Clara, CA, USA).Methods: This is a retrospective case series study which analyzed pre and post treatment cephalograms for 37 adult deep bite patients. Each patient was treated by one, experi-enced clinician using the same treatment protocols. Nineteen variables, ten linear and nine angular. The Wilcoxon analysis was used to determine if there was a significant dif-ference in pre and post treatment variables. Results: Statistically significant differences (P<0.05) occurred for 14 of 19 variables. These include a decrease in Overjet (-0.97 mm), decrease in overbite (-4.07 mm), extru-sion of the upper first molar (0.47 mm), intrusion of the upper incisor (-0.67mm), extru-sion of the lower second molar (1.01 mm), lower first molar (1.20 mm), lower second premolar (1.70 mm), and lower first premolar (1.74 mm), intrusion of the lower incisor (-1.88 mm), proclination of lower incisor, (4.09 ̊), and increase in SN-MP (0.54 mm). A decrease in anterior occlusal plane (AOP) was also statistically significant. Conclusions: Invisalign is an effective treatment modality for correcting dental deep bites through posterior extrusion and anterior intrusion. Minimal skeletal changes are seen when correcting deep bites with Invisalign.

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Neuropeptide Y Overexpression In The Presence Of P23h Rhodopsin Mutation, Jean Sun Jan 2023

Neuropeptide Y Overexpression In The Presence Of P23h Rhodopsin Mutation, Jean Sun

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Neuropeptide Y (NPY), a 36-amino acid peptide, has been found to be the most abundant neuropeptide in the central nervous system, and it is widespread across mammalian species. NPY plays a dual role as a neurotransmitter and neuromodulator in the nervous system. NPY functions as a multifaceted neuromodulator through binding NPY receptors (NPYRs). NYP interacts with NPYRs and regulates various activities, such as cell growth, neurogenesis, neuroprotection, mitochondrial behaviors, food intake, anxiety, and addiction formation. In terms of NPY’s neuroprotective potential, NPY inhibits neuronal death signaling, thus preventing apoptosis, and displays anti-inflammatory and anti-oxidative effects. Additionally, it influences metabolism by …

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Social Vulnerability And Trust Associated With African American Secondary Syphilis Cases Reported In Alabama, United States, 2020-2022, Givanta Tribit Jan 2023

Social Vulnerability And Trust Associated With African American Secondary Syphilis Cases Reported In Alabama, United States, 2020-2022, Givanta Tribit

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Introduction: Syphilis is a sexually transmitted infection (STI) that can cause serious health problems, including neurological disorders, blindness, and fetal abnormalities. Routine STI screenings can help prevent its spread. Despite effective treatments, syphilis cases have risen sharply in the last decade, particularly among marginalized communities. Understanding the ecological and contextual factors contributing to syphilis incidence could inform prevention efforts and improve healthcare outcomes for all. Methods: Retrospective secondary data analyses, at the county level, from 2020 to 2022, were conducted to assess for mean differences among social vulnerability index (SVI) scores, SVI scores by four primary categories, Black Belt regional …

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Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh Jan 2023

Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh

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SENIOR EXECUTIVE EXPERIENCE AND THE PERFORMANCE OF HEALTHCARE ORGANIZATIONS JOHN P. WALSH HEALTH SERVICES ADMINISTRATION ABSTRACT The healthcare industry has become increasingly complex over the past two decades causing concern for stakeholders of hospitals and health systems regarding the future viability. Given the tumultuous times, understanding who is best suited to lead these organizations is essential. While some work has been done studying certain characteristics of the Senior Leaders of these organizations, none have looked at the relationship between the Senior Leader’s work experience comparing those with for-profit experience and those without and performance. Using Upper Echelon’s Theory as a …

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A Qualitative Descriptive Study Exploring Infertility Help-Seeking Among African American Women, Andrea G. Wells Jan 2023

A Qualitative Descriptive Study Exploring Infertility Help-Seeking Among African American Women, Andrea G. Wells

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BACKGROUND: Failure to achieve pregnancy (infertility) affects over 6 million women ages 15–44 in the United States. African American women have more difficulty getting pregnant than White women but are less likely to seek help for infertility. According to the current research, there are several factors (cost, insurance coverage, etc.) that create difficulty for women to seek help to get pregnant. However, little is known about the factors that influence or impede infertility help-seeking among African American women. The purpose of this study was to explore the barriers and facilitators to infertility help-seeking among African American women.METHODS: Factors affecting infertility …

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Select Lipid Signaling. Derived From T-Cells Is An Important Contributor To Type 1 Diabetes Development, Tayleur White Jan 2023

Select Lipid Signaling. Derived From T-Cells Is An Important Contributor To Type 1 Diabetes Development, Tayleur White

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We reported that Ca2+-independent phospholipase A2β (iPLA2) contributes to type 1 diabetes (T1D) development; however, the impact of lipid signaling from T-cells is unknown. To address this, we first administered splenocytes from NOD, NOD.iPLA2+/- (NOD.HET), or NOD.iPLA2-/- (NOD.KO) mice to 4-week-old NOD.scid recipients. As expected, T1D onset was rapid in NOD cell recipients and 100% by 12 weeks. However, onset was delayed by 1-3 weeks in NOD.HET or NOD.KO cell recipients and only 60% became diabetic, suggesting a role for T-cell iPLA2. Next, to establish importance of iPLA2 in CD4 or CD8 cells, purified cells were administered to NOD.scid mice. …

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Neighborhood Disadvantage, Sleep Quality, And Shift Work: The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Rebecca Williams Jan 2023

Neighborhood Disadvantage, Sleep Quality, And Shift Work: The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Rebecca Williams

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The first study used data (n=14,609) from the REasons for Geographic and Racial Differences in Stroke (REGARDS) to test the associations among Area Deprivation Index (ADI) and self-reported total sleep time (TST), sleep efficiency (SE), and number of restless nights within the last week. The second study (n=12,496) tested the associations among ADI, shift work status, and restlessness.Regression models were fit to examine associations between ADI and SE or TST or restlessness, as well as assess the relation between ADI and SE in clinically meaningful categories. Moderation analyses indicated whether sex or race impact the association between ADI and sleep. …

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The Role Of Tissue- And Cell-Type-Specific Expression And Regulation In Setbp1-Associated Diseases, Jordan Hailey Whitlock Jan 2023

The Role Of Tissue- And Cell-Type-Specific Expression And Regulation In Setbp1-Associated Diseases, Jordan Hailey Whitlock

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SET binding protein 1 (SETBP1) encodes a transcription factor (TF) participating in diverse cellular processes. SETBP1 is an epigenetic hub associated with variants linked to three distinct diseases. Germline variants cause rare pediatric Schinzel Giedion Syndrome (SGS) and SETBP1 haploinsufficiency disorder (SETBP1-HD), featuring multisystemic abnormalities and neurodegeneration or milder brain issues with hypotonia, respectively. On the other hand, somatic variants contribute to hematological malignancies and adult cancer. To understand tissue-specific SETBP1 mechanisms, public RNA-sequencing data from the Genotype-Tissue Expression (GTEx) project were analyzed. SETBP1 and targets were broadly expressed across 31 adult human tissues, revealing three distinct expression patterns: transcription …

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Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury Jan 2022

Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury

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Background: Significant issues of inconsistent patient services in the U.S. health system impact health outcomes and create high cost. Limitations of immobility, inefficiency, and accessibility sacrifice patient treatment, delay recovery, and escalate health risks from the lack of primary care physicians. The primary purpose of this study was to examine meVisit, a connective mobile technology, as a feasible primary care solution to address escalating health costs by reducing emergency room (ER) visits and inpatient admissions (IA). Methods: The feasibility study applied descriptive and inferential statistics to secondary data (n=4,024) and compared the two independent patient groups from the same large …

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Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton Jan 2022

Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton

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People living with HIV (PLWH) have experienced substantial increases in life expectancy, largely attributable to improvements in care such as antiretroviral therapy. As a result, there has been a concurrent increase in the development of aging-related comorbidities such as end-stage organ disease. One such comorbidity is kidney disease. Concerningly, PLWH are at disproportionately higher risk of chronic kidney disease and end-stage kidney disease (ESKD) as compared to HIV-negative counterparts. Kidney transplantation is the ideal therapy for ESKD as it is both cost-effective and provides a significant survival benefit and yet, despite excellent transplant outcomes among PLWH, access to transplantation among …

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Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber Jan 2022

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

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Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

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Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson Jan 2022

Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson

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The purpose of this dissertation is to describe critical steps in designing a usercentered mixed methods process evaluation and implement the process evaluation within an existing program. Three objectives of this dissertation include: 1) develop a conceptual framework for conducting user-centered process evaluations of web-based diet and exercise programs for middle-aged and older cancer survivors; 2) inform the design of a user-centered process evaluation by leveraging insights from “think aloud” interviews collected during the beta-testing phase of the AMPLIFY program (a webbased diet and exercise program designed to support healthy lifestyle needs of older cancer survivors); and 3) present results …

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The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson Jan 2022

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

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Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

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Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas Jan 2022

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

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of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

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Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi Jan 2022

Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi

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Intensive care unit (ICU) nurses work in a demanding environment, facing repeated encounters with trauma and ethical issues when caring for patients. Psychological stressors can include death of patients, violent acts by patients or their families, caring for suffering patients, and moral distress from performing futile care. These factors place ICU nurses at increased risk of developing post-traumatic stress disorder (PTSD). Suffering from chronic PTSD symptoms can negatively impact nurses’ psychological and physical health. There are also consequences for patients and hospitals, including increased risk for substandard care, decreased government reimbursements from poor patient satisfaction scores, and retention issues. Few …

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Impact Of Nontypeable Haemophilus Influenzae And Pseudo Aeruginosa Polymicrobial Infections On The Cystic Fibrosis Lung, Natalie R. Lindgren Jan 2022

Impact Of Nontypeable Haemophilus Influenzae And Pseudo Aeruginosa Polymicrobial Infections On The Cystic Fibrosis Lung, Natalie R. Lindgren

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Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal of the healthy nasopharynx; however, this organism can function as an opportunistic pathogen as a result of disruptions to the microbiome, as is the case in cystic fibrosis (CF) disease. People with CF experience changes in microbial residents of the respiratory tract over the course of their lifespan, seen in shifts from early-life pathogens, such as NTHi, to late-stage pathogens, such as Pseudomonas aeruginosa, that accompany a decrease in organismal diversity of the microbiome. In this work, we characterized the pathogenicity of NTHi alone and in polymicrobial respiratory infections. Using CF specific …

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The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim Jan 2022

The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim

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Protein translation (PT) is an essential cellular process playing crucial roles in growth and development. PT precipitously declines with age in multiple animal species, including humans. It has been implicitly assumed that elevated PT at young ages is beneficial to health while PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood drives aging by triggering dysfunction in protein homeostasis (proteostasis) at old ages. We propose the early-adulthood spike in PT to …

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Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc Jan 2022

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

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Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

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Optimal Antero-Posterior Position Of The Maxillary Central Incisors And Its Relationship To The Forehead In Adult Hispanic Females, Balraj Bains Jan 2022

Optimal Antero-Posterior Position Of The Maxillary Central Incisors And Its Relationship To The Forehead In Adult Hispanic Females, Balraj Bains

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Objective: The objective of this study is to investigate the relationship of forehead inclination to anteroposterior position (AP) of the maxillary central incisors in adult Hispanic females. Materials and Methods: 70 participants were recruited for this study and smiling profile photographs were taken. All images were deidentified and placed in standardized dimension of 7.5” by 6.5”, which were then added to a PowerPoint to be evaluated by a judging panel. 24 Adult Hispanic Females (AHF) made up the control group and were seen to have an optimal incisor AP position. 46 AHF were in the study group and were judged …

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The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin Jan 2022

The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin

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Statement of Problem: With the recent advent of translucent and ultra-translucent zirconia, it is unknown if this type of high-strength ceramic restoration requires adhesive cementation to enhance retention as well as the effect of surface treatment thus its clinical applicability requires further investigation. Purpose: To investigate the difference in fracture strength of translucent zirconia (5Y-Z) using different crown thickness, different cements under different surface treatment conditions. Materials and Methods: The experimental design consisted of five groups of 30 specimens each. Two different cements were utilized under different surface treatment conditions. Copings of (1.0 mm) uniform thickness were milled of 3Y-zirconia …

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Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi Jan 2022

Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

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The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …

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Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel Jan 2022

Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel

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Background: Insulin resistance is linked to the development of heart failure (HF). However, there is limited understanding of the racial differences in the association of insulin resistance with the risk of incident HF among individuals without diabetes. Objectives: In a US national cohort of Black and White participants, we sought to evaluate: 1) the relationship between insulin resistance with incident HF participants, and 2) whether there are racial differences in the association of insulin resistance with HF. Methods: We examined >16,000 participants without HF and diabetes at baseline from the REGARDS cohort. Cox regression modeling was used to assess the …

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Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski Jan 2022

Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski

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The COVID-19 pandemic has derailed normal operations in the health care delivery systems in the United States (US) and globally, providing prioritized care to patients seeking acute management of the novel coronavirus and its complications. Simultaneously, cancer screening tests have decreased, resulting in decreased rates of cancer diagnoses and referrals to oncologists. The purpose of this study was to assess time to treatment initiation (TTI) with systemic cancer therapy in patients with newly diagnosed metastatic lung cancer, metastatic lung cancer-related and total healthcare resource utilization (HCRU) and costs during the pandemic/post-pandemic period compared with the pre-pandemic period. The retrospective claims …

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