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Articles 1 - 30 of 126
Full-Text Articles in Medicine and Health Sciences
Identification And Exploration Of The Information Needs And Information-Seeking Behaviors Of Medical-Surgical Nurses During Patient Care, Carrie Lee Gardner
Identification And Exploration Of The Information Needs And Information-Seeking Behaviors Of Medical-Surgical Nurses During Patient Care, Carrie Lee Gardner
All ETDs from UAB
Errors during the course of clinical practice are common and can lead to adverse events in hospitalized patients. Insufficient information and lack of clinician knowledge can serve as major contributing factors to the incidence of errors that occur during patient care. Nurses at the bedside need immediate access to patient specific information, at the point of care, and in an easily accessible format. There is a need for better understanding of the information needs and information-seeking behaviors of medical-surgical nurses. The purpose of this mixed-methods study was to explore the information-seeking behaviors of nurses when delivering patient care on medical-surgical …
Ca2+-Independent Phospholipase A2 Beta-Derived Lipid Signals And Osteogenesis, William Hancock
Ca2+-Independent Phospholipase A2 Beta-Derived Lipid Signals And Osteogenesis, William Hancock
All ETDs from UAB
Bone modeling can be modulated by lipid signals and arachidonic acid (AA); its cyclo-oxygenase 2 (COX2) metabolite, prostaglandin E2 (PGE2), is an important mediator of optimal bone formation. Hydrolysis of AA from membrane glycerophospholipids is catalyzed by phospholipases A2 (PLA2s). We reported that mice deficient in the Ca2+-independent PLA2beta (iPLA2β), encoded by PLA2G6, have decreased bone formation, relative to wild type (WT) mouse bones. Here, we examined at the mechanistic and molecular levels the role of iPLA2β in bone formation using bone marrow stromal cells and calvarial osteoblasts from WT and iPLA2β-deficient mice and MC3T3-E1 osteoblast precursor cell line. Our …
Sleep Following Traumatic Brain Injury: A Qualitative Descriptive Study, Rachael Marie Mumbower
Sleep Following Traumatic Brain Injury: A Qualitative Descriptive Study, Rachael Marie Mumbower
All ETDs from UAB
Introduction: Recent estimates suggest that as many as half of all survivors of Traumatic Brain Injury (TBI) may be experience sleep disturbances or disorders. Although quantitative research has resulted in a greater understanding of the prevalence, symptomology, and conditions associated with sleep, little is known regarding the sleep experiences of survivors of moderate-severe TBI, after their discharge from inpatient rehabilitation. The purpose of this qualitative descriptive study was to describe the sleep experiences of adults with moderate-severe TBI after rehabilitation. Methods: Qualitative descriptive inquiry was used to explore and describe sleep experiences of survivors of moderate-severe traumatic brain injury TBI …
Resin Infiltration Of Incipient Interproximal Caries: A 6-Month Randomized, Controlled Clinical Trial, Purvi Vaghela
Resin Infiltration Of Incipient Interproximal Caries: A 6-Month Randomized, Controlled Clinical Trial, Purvi Vaghela
All ETDs from UAB
Dental caries is the most widespread of all diseases. It causes destruction of tooth structure by dissolving the enamel first, then progressing to the dentin. While it is possible to replace carious tooth structure with invasive restorations, it is highly desirable to arrest or reverse the disease process so that the restorations can be avoided. One of the most difficult areas to clean or use preventive, non-surgical treatment is the contact area between teeth. Recently treatment with resin polymers to infiltrate enamel and dentin affected by caries has been in-troduced. The infiltration technique arrests the lesion progression by penetrating and …
Racial Disparities In The Maintenance Of Healthy Lifestyles And Their Effect On Cumulative Blood Pressure Burden And Left Ventricular Mass In African Americans And Whites: Data From The Coronary Artery Risk Development In Young Adults (Cardia) Study, John N. Booth
All ETDs from UAB
The prevalence of healthy behaviors associated with optimal blood pressure (BP) levels and reduced risk for target-organ damage and cardiovascular disease (CVD) is lower in blacks compared with whites. Randomized controlled trials provide evidence that if healthy behaviors are maintained over the lifespan, including normal body weight, moderate physical activity, limited alcohol intake, limited sodium intake, adequate potassium intake and a rich diet of fruits and vegetables and low in high-fat dairy and saturated and total fat, then high BP may be preventable. The goal of this dissertation was to assess racial differences in the maintenance of healthy behaviors and …
Contribution Of Distinct Interneuron Subclasses To Cortical Network Activity, Andrew Scott Bohannon
Contribution Of Distinct Interneuron Subclasses To Cortical Network Activity, Andrew Scott Bohannon
All ETDs from UAB
The excitatory glutamatergic output of the cerebral neocortex is tightly regulated by the release of the inhibitory neurotransmitter GABA from cortical interneurons (INs). Once viewed as a largely homogenous population, recent studies have revealed that cortical INs display a diverse range of biochemical, anatomical and physiological properties. In this work we sought to determine if differences in the physiology and connectivity patterns of identified cortical IN populations enable them to differentially contribute to network activity. Specifically, we investigated the contribution of discrete L2/3 IN groups to the generation of aberrant cortical synchrony, and the influence of HCN channels on information …
The Association Between Cancer And Risk Of Sepsis Among Whites And Blacks In The Regards Cohort, Justin Xavier Moore
The Association Between Cancer And Risk Of Sepsis Among Whites And Blacks In The Regards Cohort, Justin Xavier Moore
All ETDs from UAB
Cancer is the second leading cause of morbidity and death in the United States corresponding to more than 1.7 million incident cases and responsible for more than 550,000 deaths annually. In addition, hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to participants with no cancer history. As treatments and therapies for cancer continue to improve, the average 5-year survival is approaching 70% overall among the US population; however, to date there is very limited research that has examined the association between patients with a history of cancer and future risk of sepsis among a …
Microenvironmental Regulation And Epigenetic Control Of Glioma Pathogenesis, Nathaniel H. Boyd
Microenvironmental Regulation And Epigenetic Control Of Glioma Pathogenesis, Nathaniel H. Boyd
All ETDs from UAB
Tumor microenvironments can promote stem cell maintenance, tumor growth, and therapeutic resistance, findings linked by the tumor initiating cell hypothesis. The ischemic microenvironment characterized by low oxygen and glucose, and acidic stress occurs in both solid tumors and non-neoplastic tissue injury. Standard of care for glioblastoma (GBM) includes the chemotherapy temozolomide, which is not curative due, in part, to residual therapy-resistant brain tumor initiating cells (BTICs). Temozolomide efficacy may be increased by targeting carbonic anhydrase 9 (CAIX), a hypoxia and acidic stress responsive gene important for maintaining the altered pH gradient of tumor cells. Using patient-derived GBM xenograft cells, we …
Nadph Oxidase-Derived Superoxide Production During Coxsackie B Virus Infection Fuels Macrophage Activation To Accelerate Type 1 Diabetes, Ashley R. Burg
Nadph Oxidase-Derived Superoxide Production During Coxsackie B Virus Infection Fuels Macrophage Activation To Accelerate Type 1 Diabetes, Ashley R. Burg
All ETDs from UAB
Type 1 diabetes (T1D) is a chronic inflammatory autoimmune disease in which autoreactive T cells selectively destroy insulin-producing pancreatic β-cells. While genetic predisposition underlies susceptibility, environmental factors are proposed to play the important role of triggering the activation of autoimmunity in T1D individuals. Viral infections, particularly by Coxsackie B viruses, are highly suspected as a precipitating event. However, the exact molecular mechanism for how viral infections elicit β-cell-specific autoimmunity remains unclear. Rodent models of virus-induced T1D suggest it is through bystander activation, during which innate antiviral responses to pancreas-tropic viral infections create an inflammatory milieu that breaks the peripheral tolerance …
The Benefits Of A Vegetable Gardening Intervention For Cancer Survivors, Mallory Gamel Cases
The Benefits Of A Vegetable Gardening Intervention For Cancer Survivors, Mallory Gamel Cases
All ETDs from UAB
Due to improvements in screening and treatment, the number of cancer survivors continues to increase. Cancer survivors are at increased risk for second malignancies, comorbidities, and functional decline. All three papers draw data from Harvest for Health, a 12-month home-based vegetable gardening intervention for cancer survivors. This dissertation aimed to (1) explore changes in physical functioning and physical health-related quality of life in 44 cancer survivors aged >65 years old pooled from two iterations of Harvest for Health; (2) examine predictors of continued gardening and garden expansion 12-months post-intervention; and (3) assess the capacity of sustainability of Harvest for Health …
Improving Cognitive Predictors And Everyday Outcomes In Adults With Hiv, Shameka L. Cody
Improving Cognitive Predictors And Everyday Outcomes In Adults With Hiv, Shameka L. Cody
All ETDs from UAB
As adults age with HIV, they may encounter challenges with cognitive impairments. Perhaps, the neurobiological effects of HIV, subtle lifestyle changes, and the aging process may negatively influence cognitive functioning. Some cognitive impairments may interfere with everyday functioning and even compromise quality of life. In this dissertation, three articles were presented which focused on the overall theme of HIV and cognition. Article 1, a review of literature published in the Neurobiology of Disease, focused on how HIV affects the brain independently and the synergistic effects of HIV and aging on cognitive health. Also, the article closed with a section on …
Effects Of Maternal And Child Depressive Symptoms And Child’S Perceived Stress On Glycemic Control As Mediated By Cortisol In Prepubertal Children With Type 1 Diabetes, Sara Laubinger Davis
Effects Of Maternal And Child Depressive Symptoms And Child’S Perceived Stress On Glycemic Control As Mediated By Cortisol In Prepubertal Children With Type 1 Diabetes, Sara Laubinger Davis
All ETDs from UAB
Introduction: Type 1 diabetes (T1D) is one of the most common diseases of childhood affecting over 167,000 children under the age of 20. Despite adequate insulin regimens and concurrent treatments, many children still have trouble achieving glycemic control as evidenced by elevated HbA1c levels. Previous research indicates that parent-child interactions and parental involvement in diabetic care influence glycemic control. However, these relationships may be impaired in mothers with depressive symptoms or in children who have high levels of depressive symptoms or perceived stress. Moreover, cortisol, a stress hormone, may mediate the proposed relationships. Therefore, the purpose of this study was …
Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans
Home Healthcare And Performance: Development And Application Of A Typology For Home Health Agencies, Ronique Nechelle Evans
All ETDs from UAB
This three-paper dissertation sought to examine the existence of strategic groups in the home health industry, the application of Porter’s generic strategies (cost leader, differentiator, “stuck-in-the-middle” and both cost leader/differentiator) in identifying these groups, and the association of group membership with agency performance. The findings of this study will provide researchers and managers with a highlight of the current strategic makeup of the home health industry and its relationship with quality and financial performance. The results of this dissertation provide some evidence that strategic groups do exist in the home health industry and can be described along the basis of …
Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth
Immunoregulation During Acute And Chronic Exposure To Aspergillus Fumigatus, Jaleesa M. Garth
All ETDs from UAB
A. fumigatus is one of the most common fungal isolates with clinical disorders ranging from mild to severe. The development of Aspergillus-induced allergic and invasive fungal infections is a major health concern in several patient populations. IL-1 family members have been shown to play critical roles in host defense against A. fumigatus. IL-33, an IL-1 family member widely study in allergic and inflammatory diseases, was induced upon acute exposure to A. fumigatus. IL-33 receptor knockout mice, (Il1rl1-/-), demonstrated lower lung fungal burden in the presence of enhanced IL-1α, IL-1β, IL-6, IL-17A, IL-22, and PGE2 production. Administration of IL-33 to normal …
A Tissue Engineering Approach To The Development Of A 3d Breast Carcinoma Surrogate, Kayla Goliwas
A Tissue Engineering Approach To The Development Of A 3d Breast Carcinoma Surrogate, Kayla Goliwas
All ETDs from UAB
Tumors are three dimensional tissues consisting of malignant cells and various stromal cell populations within a volume of extracellular matrix. These components form an intricate network that influences many facets of tumor biology. Paracrine interactions between tumor cells and the surrounding microenvironment can alter drug response and impact therapeutic efficacy in vivo, yet most current in vitro models do not accurately recapitulate the stromal microenvironment or associated dimensionality of human tumors. In vitro models that are more representative of the human tumor microenvironment, including a more recapitulative dimensionality and cellular composition, have broad utility in the evaluation of mechanisms driving …
Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene
Evaluating The Genotype Phenotype Correlations In Cleidocranial Dysplasia, Stephen Lamar Greene
All ETDs from UAB
Cleidocranial dysplasia (CCD, OMIM 119600) is a rare (1 in 1,000,000) human autosomal dominant skeletal disorder with unique craniofacial and dental features caused by mutations the gene coding for transcription factor RUNX2. RUNX2 is a key master regulator of osteoblast differentiation, chondrocyte maturation and tooth formation. CCD is commonly diagnosed based on bone defects with ~90% of cases presenting with supernumerary teeth or a “third dentition”. Mouse Runx2 null models (Runx2+/-), although having similar CCD skeletal defects, do not mimic the human dental phenotype of supernumerary teeth. Instead, Runx2-/- mouse have arrested tooth formation at the cap stage. Furthermore, based …
A Prospective Randomized Clinical Trial To Compare Free Gingival Grafts And Connective Tissue Grafts Around Implants With A Lack Of Keratinized Mucosa, Jeffrey Thomas Hsu
A Prospective Randomized Clinical Trial To Compare Free Gingival Grafts And Connective Tissue Grafts Around Implants With A Lack Of Keratinized Mucosa, Jeffrey Thomas Hsu
All ETDs from UAB
A PROSPECTIVE RANDOMIZED CLINICAL TRIAL TO COMPARE FREE GINGIVAL GRAFTS AND CONNECTIVE TISSUE GRAFTS AROUND IMPLANTS WITH A LACK OF KERATINIZED MUCOSA JEFFREY T HSU PERIODONTOLOGY ABSTRACT Although evidence is equivocal regarding the need for keratinized mucosa around dental implants, the consensus among researchers and clinicians is that peri-implant keratinized mucosa is beneficial to the health and stability of the implant prosthesis. An adequate width of keratinized mucosa (WKM) provides a resistant barrier to bacterial infiltration, facilitates restorative procedures, improves esthetic outcomes, patient comfort, and ease of oral hygiene. Many surgical approaches have been used to increase WKM around dental …
Bioactive Materials: Ion Release, Flexural Strength, Secondary Caries Depth And Elemental Analysis Of Surrounding Tooth Structure, Prajakta Shreeram Kulkarni
Bioactive Materials: Ion Release, Flexural Strength, Secondary Caries Depth And Elemental Analysis Of Surrounding Tooth Structure, Prajakta Shreeram Kulkarni
All ETDs from UAB
ABSTRACT Objectives: Bioactive materials release calcium, phosphate, and fluoride which may increase tooth remineralization. But limited data is available demonstrating the superiority of bioactive or ion releasing materials compared to fluoride or no ion releasing materials. The aims of the present study are to measure and compare the calcium, fluoride, and phosphate ion release at different pH, flexural strength and caries protecting ability of the materials including the ion uptake of surrounding tooth structure. Methods: Activa, Cention N, Fuji LC II and Filtek Supreme Ultra were the restorative materials tested. Firstly, the fluoride and calcium release of these materials was …
The Role Of Hur In Astrocytes In Spinal Cord Injury, Thaddaeus Kwan
The Role Of Hur In Astrocytes In Spinal Cord Injury, Thaddaeus Kwan
All ETDs from UAB
Neuroinflammation is a defining event during the acute phase of spinal cord injury (SCI). The inflammatory cascade is initiated by activated glial cells such as astrocytes and microglia in the milieu of the injured tissue through release of pro-inflammatory cytokines, matrix metalloproteinases, and reactive oxygen species. These soluble factors produce cytotoxicity to neurons and other cells either directly or indirectly by promoting permeabilization of the blood-spinal cord barrier, edema and subsequent ischemia. These factors also serve to recruit and activate additional glia and peripheral immune cells. The mRNAs of many of these soluble factors such as TNFα, IL-1β, CXCL1, and …
A Statistical Approach To Computed Tomography Perfusion, Seth Thomas Lirette
A Statistical Approach To Computed Tomography Perfusion, Seth Thomas Lirette
All ETDs from UAB
Stroke is, and will continue to be, a pervasive problem in the both the United States and across the world, and computed tomography (CT) perfusion scanning will continue to be a first-line diagnostic tool to quantify where and how much blood flow occlusion is present in the brain. CT perfusion maps displaying several scalar perfusion parameters for each brain voxel will continue to be used by radiologists and other clinicians. The goal of this dissertation is to examine and improve upon current standards of practice concerning CT perfusion. We first exhibit how software that constructs perfusion maps can be implemented …
Autism Spectrum Disorders And Social-Ecological Models: Understanding How Context Drives Prevalence, Anne Elizabeth Brisendine
Autism Spectrum Disorders And Social-Ecological Models: Understanding How Context Drives Prevalence, Anne Elizabeth Brisendine
All ETDs from UAB
Background: While there has been significant work done to explore disparities in autism spectrum disorder (ASD) diagnoses with respect to individual characteristics, little work has been done to examine the overall system and structure of the environment in which ASD identification is made and how it is related to diagnosis and services. The purpose of this study is to better understand the social-ecological factors that impact ASD diagnoses at the population level. Methods: In the first aim of this dissertation, a tailored social ecological model was developed and examined across variables in the 2011/12 National Survey of Children’s Health. In …
A Comparative Multiyear Assessment Of Care Utilization Between Existing And Newly Enrolled Medicaid Populations Within Washington State, Preston M. Simmons
A Comparative Multiyear Assessment Of Care Utilization Between Existing And Newly Enrolled Medicaid Populations Within Washington State, Preston M. Simmons
All ETDs from UAB
A COMPARATIVE MULTIYEAR ASSESSMENT OF CARE UTILIZATION BETWEEN EXISTING AND NEWLY ENROLLED MEDICAID POPULATIONS WITHIN WASHINGTON STATE ABSTRACT The study looks at 2012 through June of 2016 Medicaid data from the Washington State Health Care Authority, comparing claims utilization for newly enrolled patients each calendar year to continuously enrolled members. Mean number of emergency department, hospital, and ambulatory (office) claims per Medicaid member are compared to ascertain if they are the same or different between the groups. Differences in the mean number of ambulatory care sensitive conditions (ACSC) were additionally assessed between those continuously and newly enrolled. The results of …
Diabetes Risk In Women: Pschosocial And Lifestyle Determinants, Sarah Katherine Sweatt
Diabetes Risk In Women: Pschosocial And Lifestyle Determinants, Sarah Katherine Sweatt
All ETDs from UAB
Type 2 diabetes (T2D) is a major public health concern. Physical inactivity, poor diet, and psychosocial distress have emerged as factors contributing to T2D. Women may be uniquely affected by these factors as obesity, physical inactivity, and the prevalence of psychosocial distress are higher in women. Additionally, polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women and increases the risk of both T2D and psychosocial distress. However, the relationship between physical activity (PA), psychosocial distress, and metabolic health is not fully understood, particularly in at risk populations such as minorities and women with PCOS. Therefore, the goal …
An Analysis Of The Relevance Of U.S. News And World Report Rankings On Admissions Outcomes And Student Placement Of Graduate Programs In Healthcare Management, William Alburn Tuttle
An Analysis Of The Relevance Of U.S. News And World Report Rankings On Admissions Outcomes And Student Placement Of Graduate Programs In Healthcare Management, William Alburn Tuttle
All ETDs from UAB
Social, economic and political influences are exerting considerable pressure on the development of universities and colleges. Such forces coupled with the growing influence of rankings are exerting a formidable impact upon higher education. The conceptual framework guiding this study was derived from the work of Spence and Signaling Theory (ST). This theory plays a vital role in societal interaction of individuals as well as how certain organizations carry out their mission. ST offers an opportunity and perspective to explore the relevance of signals associated with U.S. News and World Report (USNWR) rankings of graduate programs in healthcare management. Graduate programs …
Development And Assessment Of Nonsense Suppression Therapies To Ameliorate Disease Progression In A Nonsense Mouse Model Of Mps I Hurler Syndrome, Gwendolyn G. Gunn
Development And Assessment Of Nonsense Suppression Therapies To Ameliorate Disease Progression In A Nonsense Mouse Model Of Mps I Hurler Syndrome, Gwendolyn G. Gunn
All ETDs from UAB
Nonsense mutations introduce a premature termination codon (PTC) into the open reading frame of an mRNA resulting in premature translation termination, loss of functional protein, and rapid degradation of the mutant mRNA. Approximately 11% of human genetic disorders are attributable to a nonsense mutation. Several small molecules have been identified as potential nonsense suppression compounds. These compounds increase the frequency of PTC recognition by near-cognate aminoacyl tRNAs resulting in PTC “readthrough” and restored protein production. Mucopolysaccharidosis type I-Hurler (MPS IH) is the severe form of the autosomal recessive lysosomal storage disorder caused by mutations in the iduronidase (IDUA) gene. 60-80% …
Reciprocal Regulation Of The Α2a Adrenergic Receptor And The Amyloid Precursor Protein, Mary Alana Gannon
Reciprocal Regulation Of The Α2a Adrenergic Receptor And The Amyloid Precursor Protein, Mary Alana Gannon
All ETDs from UAB
Through widespread efferent projections, the locus coeruleus-noradrenergic (LC-NA) system supplies the cerebral cortex with norepinephrine, a key modulator of cognition. Neurodegeneration of the LC is an early hallmark of Alzheimer’s disease (AD), but despite this profound neuronal loss, there are several studies that show that NE levels actually remain stable or even elevated, especially at early stages of the disease. This indicates that the overall integrity of the NA system, rather than a loss of NE, is likely contributing to AD pathogenesis. We previously showed that activation of the α2A adrenergic receptor (α2AAR) increases amyloidogenic processing of amyloid precursor protein …
Alterations In Ubc9 Substrate Specificity Affect The Cellular Response To Dna Damage, Joshua Enyeribe Onuiri
Alterations In Ubc9 Substrate Specificity Affect The Cellular Response To Dna Damage, Joshua Enyeribe Onuiri
All ETDs from UAB
This dissertation seeks to uncover the impact of a post-translational modification, the small ubiquitin-related modifier (SUMO), on the cell response to DNA damage. Covalent modification of cellular proteins by SUMO occurs through an enzymatic cascade involving an E1 activating enzyme, an E2 conjugating enzyme, and a ligase (E3). Eukaryotic cells possess a single E1 and a single E2 for SUMO conjugation. The E2 for SUMO, Ubc9, is able to recognize and modify substrates on its own, although substrate recognition and modification are enhanced in the presence of the E3. Two independent genetic screens carried out in the budding yeast Saccharomyces …
The Effects Of Nurse-Manager Relationships And Nurse-Physician Collaboration On Nurse Intent To Leave, Phillip John Mazzuca
The Effects Of Nurse-Manager Relationships And Nurse-Physician Collaboration On Nurse Intent To Leave, Phillip John Mazzuca
All ETDs from UAB
ABSTRACT Aim. The aim of this study was to determine whether two relational aspects of the nurse work environment – perceived quality of the nurse-supervisor relationship and nurse-physician collaboration – might reduce nurse intent to leave the hospital. Background. There is a documented global shortage of nurses which is a pressing issue in U.S. hospitals. The nursing shortage has been exacerbated by a high rate of voluntary nursing turnover in U.S. hospitals which is costly and has previously been found to negatively impact patient care. Factors associated with the nursing work environment have been found to be important predictors of …
Circulating Mirnas And Human Insulin Resistance, Elizabeth Ma
Circulating Mirnas And Human Insulin Resistance, Elizabeth Ma
All ETDs from UAB
Insulin resistance (IR) is central to the pathophysiology of Type 2 diabetes (T2DM), and is a risk factor for cardiovascular disease. The mechanisms behind IR are not clear, but microRNA (miR; short, non-coding RNA strands that base-pair with mRNA to modify gene expression) have garnered interest as potential contributors. miRs have recently been shown to be detectable in the circulation, and can be taken up and regulate target genes within recipient cells. Our primary objective was to identify circulating miRs (c-miRs) that play a role in regulating systemic metabolism and participate in the pathophysiology of IR and cardiometabolic disease. Three …
Development And Pilot Testing Of A Behavioral Intervention For Chronic Pain Tailored To Individuals With Hiv, Jessica Merlin
Development And Pilot Testing Of A Behavioral Intervention For Chronic Pain Tailored To Individuals With Hiv, Jessica Merlin
All ETDs from UAB
Background. Chronic pain is a common and disabling comorbidity in individuals living with HIV. Behavioral interventions are among the most effective and safe nonpharmacologic treatments for chronic pain. However, the success of a behavioral intervention is influenced by how well it is tailored to the target population’s biological, psychological, and social context. Given well-documented psychosocial vulnerabilities among persons with HIV, it is critical to develop a behavioral intervention for chronic pain tailored to this population. Objective. To use qualitative methods to investigate patient preferences for the structure and delivery of a behavioral intervention for chronic pain in individuals with HIV. …