Medicine and Health Sciences Commons^™

Fast Blue And Cholera Toxin-B Survival Guide For Alpha-Motoneurons Labeling: Less Is Better In Young B6sjl Mice, But More Is Better In Aged C57bl/J Mice, Hasan Farid, Weston B. Gleford, Lori L. Goss, Teresa L. Garrett, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

Fast Blue (FB) and Cholera Toxin-B (CTB) are two retrograde tracers extensively used to label alpha-motoneurons (α-MNs). The overall goals of the present study were to (1) assess the effectiveness of different FB and CTB protocols in labeling α-MNs, (2) compare the labeling quality of these tracers at standard concentrations reported in the literature (FB 2% and CTB 0.1%) versus lower concentrations to overcome tracer leakage, and (3) determine an optimal protocol for labeling α-MNs in young B6SJL and aged C57Bl/J mice (when axonal transport is disrupted by aging). Hindlimb muscles of young B6SJL and aged C57Bl/J mice were intramuscularly …

The Relationship Between Insufficient Sleep And Mental Health Distress In Ohio Compared To West Virginia And New Jersey, Audrey Nourse, Alexander Winkle

Scholarship in Medicine - All Papers

Objective: To compare and establish the importance of the relationship between insufficient sleep and the frequency of mental health distress in Ohio in contrast to that in West Virginia and New Jersey in 2022. Methods: The data used included information on insufficient sleep, frequency of mental health distress, and premature death per each state studied and was collected from County Health Rankings and then analyzed using a Pearson’s correlation, one way analysis of variance, and multiple linear regression. Ohio was chosen as the reference state with New Jersey and West Virginia as comparisons based on their equivalent population s ize …

Comparing The Impact Of Food Insecurity, Access To Exercise Opportunities, And County Classification On Obesity Rates In Ohio, Ankur Parekh, Deborah Lee

Scholarship in Medicine - All Papers

Objective: We completed a study to determine how food insecurity, access to exercise opportunities, and county classification (rural or urban) impacted obesity rates in Ohio. We hypothesized that the county classification impacted obesity the most followed by food insecurity and access to exercise opportunities.

Methods: We obtained data on food insecurity, access to exercise opportunities, and obesity from County Health Rankings and county classification data from the United States Department of Agriculture Census. We analyzed correlations between obesity and food insecurity and obesity and access to exercise opportunities in both county types. We also analyzed changes in obesity rates in …

A Case Of Spontaneous Adrenal Hemorrhage In Pregnancy, Benjamin Mallicoat, Kelly Nagy, Christopher Croom

Obstetrics and Gynecology Faculty Publications

A case study looking at a 25 year old patient at 31 weeks gestation with spontaneous adrenal hemorrhage.

Novel Analysis Of The Sars-Cov-2 Genome To Identify Positive Evolutionary Selection In The Spike Protein Of Emerging Variants, Ulysses Ison

Browse all Theses and Dissertations

This thesis tests the hypothesis that the spike protein of SARV-CoV-2 is under positive evolutionary selection. A consensus nucleotide sequence was generated for the most current SARS-CoV-2 variant, XBB1.5, by performing sequence alignments of recent isolates. The consensus nucleotide sequence was translated to obtain the amino acid sequence. The amino acid and nucleotide sequences were compared to the original Wuhan-hu-1 strain to identify mutations. Forty-three mutations were identified in the spike protein, and all but two changed the amino acid. The majority of mutations were found in the receptor binding domain of the spike protein, which is the region of …

Examining Gestational Diabetes Mellitus Educational Resources: Patient And Provider Perspectives, Allison F. Peebles, Morgan E. Cooley, Rose A. Maxwell

Student Scholarship

Objective: To analyze the effectiveness of gestational diabetes mellitus (GDM) education as well as patient and provider confidence in education practices. Study

Design: Women with a diagnosis of GDM who delivered at Miami Valley Hospital were included in the study. Patients were asked to complete a questionnaire to evaluate their knowledge and confidence in managing their GDM. Providers were asked to complete a questionnaire to provide their perspective on patient education related to GDM.

Results: Patients correctly identified 66% of the correct ways that GDM affects maternal health, fetal health, and pregnancy complications. Patients felt empowered by their education and …

Addressing The Barriers To Mammography Screening In Rural And Urban Ohio Counties, Carly Perkowski, Isabelle Fox

Scholarship in Medicine - All Papers

Mammography screenings have the potential to protect individuals from the burden of cancer and can even save lives. However, in Ohio, many women are not receiving regular screenings. Recent research indicates that social determinants of health, such as income and education, can impact an individual’s ability to access mammography. Yet, we lack a comprehensive understanding of how these factors hinder an individual's ability to obtain mammography screenings, particularly in urban and rural areas of Ohio. The introduction of mammography has facilitated early detection of breast cancer in women. By identifying gaps in access to mammography and implementing changes to improve …

The Balance Between Sleep And Lifestyle: How Lifestyle Impacts Insufficient Sleep, Evan Hartman, John Monnig

Scholarship in Medicine - All Papers

Sleep insufficiency is a common but overlooked problem for many people. This is harmful because adequate sleep is important to cognitive, emotional, and physical health. This study analyzed how food environment index, smoking, physical activity, and median household income impact sleep insufficiency on an Ohio population. All data was utilized from the County Health Rankings (CHR) database. This analysis presented that the food environment index (r = -0.676, p < .001) and median household income (r = -0.743, p <.001) negatively correlated to insufficient sleep percentage. Furthermore, both adult smoking percentage (r = 0.735, p < .001) and physical inactivity (r = 0.761, p < .001) positively correlated to insufficient sleep percentage. It is also important to note that there was a significant difference between Ohio and Indiana counties (t = -12.347, p < .001), two neighboring states that both contain a mixture of urban and rural populations. Lastly, there was no significant difference between rural and urban Ohio counties (t=-1.521, p=.132). This data presents that more physical activity and less smoking may have positive benefits on sleep along with eating healthier, more nutrient dense food. Moreover, increased median household income may also positively impact sleep. Lifestyle factors such as smoking, physical activity, and increased nutritious food consumption are all avenues for patients to try to implement into their own lives to improve their sleep. Hopefully, such lifestyle modifications will improve sleep quality and thus result in an improvement in other aspects of their overall health.

Uninsurance Rates And Associated Impacts Within Urban And Rural Counties In Ohio In 2022, Anneliese M. Fisher, Megan Sharifi

Scholarship in Medicine - All Papers

Background: Rural populations comprise of 20% of the American population and 19% of those individuals are over the age of 65 (compared to 15% in urban areas).1,2 There has been an increase in discussion surrounding the social determinants of health (SDOH), and the literature shows that the SDOH often disproportionately impact individuals based on where they live, including rural areas. The rural-urban mortality rate disparity within the United States has been growing and has been attributed to levels of poverty.3 The SDOH also include access to healthcare and insurance, and insurance coverage is associated with higher healthcare access and quality.4 …

Examination Of The Role Of Adrenergic Receptor Stimulation In The Sensitization Of Neuroinflammatory-Based Depressive-Like Behavior In Isolated Guinea Pig Pups, Rachel R. Kessler, Patricia A. Schiml, Sean M. Mcgraw, Erin N. Tomlin, Mikayla J. Hoeferlin, Terrence Deak, Michael B. Hennessy

Psychology Faculty Publications

Early-life attachment disruption appears to sensitize neuroinflammatory signaling to increase later vulnerability for stress-related mental disorders, including depression. How stress initiates this process is unknown, but studies with adult rats and mice suggest sympathetic nervous system activation and/or cortisol elevations during the early stress are key. Guinea pig pups isolated from their mothers exhibit an initial active behavioral phase characterized by anxiety-like vocalizing. This is followed by inflammatory-dependent depressive-like behavior and fever that sensitize on repeated isolation. Using strategies that have been successful in adult studies, we assessed whether sympathetic nervous system activity and cortisol contributed to the sensitization process …

Factors Contributing To Adult Obesity: A Midwestern Analysis, Makul Sharma, Hop Lewis

Scholarship in Medicine - All Papers

Objective: To investigate the association between adult obesity and several health-related factors: access to healthy food, exercise opportunities, and physical inactivity in Ohio compared to other Midwestern regional states (Illinois and Iowa) in 2022

Methods: Data was obtained from a County Health Rankings Model using the Behavioral Risk Factor Surveillance System (BRFSS). Data were then weighted to reflect population distribution and then used to measure various health behaviors and health-related quality of life (RQoL) indicators.

Results: We found significantly higher rates of adult obesity in Ohio compared to Illinois and Iowa. It was also determined that adult obesity in Ohio …

The Effect Of Neighborhood Safety On Childhood Mental And Behavioral Health Problems, Courtney Kiggins, Alayna Pavol

Scholarship in Medicine - All Papers

The correlation between socioeconomic status (SES) and adverse childhood experiences (ACEs) with mental and behavioral health problems is well documented, however the connection between neighborhood safety and mental and behavioral health problems is not well understood. This study analyzes the impact of neighborhood safety on childhood mental and behavioral health outcomes. Data collected by the National Survey of Children’s Health (NSCH) was used for this study and statistically analyzed using IBM SPSS software. A strong connection was found between poverty level and childhood mental and behavioral health outcomes, where those who were more impoverished had higher percentages of children experiencing …

The Impact Of Food Insecurity On Health Outcomes, Ali El Kharsa, Gabrielle Montes

Scholarship in Medicine - All Papers

Objective: This research study aims to investigate how food insecurity in the United States has changed between 2016 and 2022 and its correlation with health outcomes by looking at the percent of reporting fair or poor health. Our study also compares healthy food access and food environment index in the US between 2016 and 2022.

Research Methods & Procedures: Paired t-tests compared the levels of food insecurity between 2016 and 2022 and compared food environment index and healthy food access in the United States between 2016 and 2022. A Pearson correlation determined the relationship between food insecurity and the percentage …

Family Medicine Editors Collaborate Towards Antiracist Publishing, Sarina Schrager, Sumi Sexton, Marjorie A. Bowman, Caroline Richardson

Population and Public Health Sciences Faculty Publications

Editors of 10 North American Family Medicine journals simultaneously published a Joint Call for Action to address systemic racism and encourage diversity, equity, inclusion and accessibility/antiracism (DEIA) initiatives in medicine and medical publishing in January 2021. The efforts of the journals since publication of the joint editorial are summarized and include working to diversify editorial teams, editorial boards and authors; enhanced content about DEIA topics; mentoring of authors who are underrepresented in medicine (URM); and presenting content related to DEIA in Family Medicine publishing at national meetings. Editors had a follow up meeting in November 2022 to continue working toward …

Effects Of Insurance Coverage On Healthcare Access And Outcomes For Children In Ohio, Haley Hurst, Patrick Ruz

Scholarship in Medicine - All Papers

Objective: Despite health insurance coverage correlating to improved child health outcomes and reduced healthcare costs, it is estimated that 8.7% of children in America lack continuous insurance. Although coverage has expanded multiple times through the Children's Health Insurance Program (CHIP) initiated in 1997, rates for child insurance vary drastically across regions of the country. In this study we investigated child insurance rates over time and by state, as well as explored the effects of having insurance and child health outcomes. To do this, we measured the association of uninsured children to primary care physician access and child mortality in the …

The Importance Of Sexual Education On Adolescent Sexual Behaviors, Ryan Hill, Jacqueline Stephens

Scholarship in Medicine - All Papers

Objective: The objective of this report is to examine how sex education for adolescents living in rural and urban settings in the states of Alabama and Ohio impacts their sexual health and behaviors.

Methods: To explore this topic, several different statistical tests were done: an independent t-test, an ANOVA test, a Pearman/Spearman correlation, a regression, and a standard correlation. The reason for these different tests was to compare the difference in the number of sexually transmitted diseases, how insurance status correlates with teenage pregnancy rates and sexually transmitted diseases, and the relationship between socioeconomic status and the rate of sexually …

Social And Environmental Factors Impact On Reading Performance In Illinois In 2020, Gisella Drouet

Scholarship in Medicine - All Papers

Objective: Reading scores, such as average literacy grade level are often used as a variable for academic success. It has been found that third grade students reading at grade level are less likely to drop out of high school. The objective of the project is to investigate average reading performance and its implications on English fluency, high school graduation and various social factors.

Methods : Social factors analyzed in this study were single-parent household, residential segregation and severe housing conditions. Illinois data analyzed was from County Health Rankings website ( https://www.countyhealthrankings.org/app/illinois/2020/measure/outcomes/1/map). This study analyzed the change in 2020 reading performance …

Examining The Impact Of Teenage Pregnancy And Its Associated Factors On High School Graduation Rates In Ohio, Eshita Garg, Empress James

Scholarship in Medicine - All Papers

Objective: Our objective is to determine the impact of teen pregnancy, and its associated factors (e.g., child poverty, single-parent households, disconnected youth) on high school graduation rates in Ohio. Introduction: Failure to complete high school often results due to a process known as educational disengagement. This process has been studied to include such factors like teenage pregnancy, which is often linked to increased absences and decreased participation in class. While studies indicate that programs should emphasize attendance and engagement, rather than teenage pregnancy prevention, we also examine factors that are commonly associated with teenage pregnancy. Such variables that contribute to …

The Impact Of Healthcare Disparities In Rural Ohio, Bailey Stammen, Sara Curtis

Scholarship in Medicine - All Papers

Rural communities in the state of Ohio face barriers to care that affect the health of the population. This paper investigates the extent to which the general state of health, life expectancy, uninsured rates, and access to primary care providers can be affected by living in a rural community and how these variables have changed over time. Data from urban and rural counties in Ohio, taken from 2016 to 2022 via the 2022 County Health Rankings, will be used to explore health-related concerns. There were significant findings of decreased general health and access to primary care providers for rural communities …

Health Disparities In Rural Kentucky Counties: Mortality Outcomes And The “Rural Penalty”, Aaron R. Tims

Scholarship in Medicine - All Papers

Objective: The object of this paper is to investigate the relationship between rurality and the national top five causes of death in Kentucky counties.

Methods: We used Spearman correlations to quantify the relationship between percent rurality and the crude death rate for heart disease, malignant neoplasia, unintentional injury, chronic lower respiratory disease, and cerebrovascular disease for each Kentucky county. We also used a Spearman correlation to compare and correlate percent rurality and mortality due to heart disease as these two factors changed between data from 2000 and 2010.

Results: Our research demonstrated statistically significant correlations between percent rurality and the …

Furosemide For Postpartum Management Of Hypertensive Disorders: A Randomized Controlled Study, Margaret J. Herr, Holly M. Johnson, Rose A. Maxwell, Zachary Candela, Sheela Barhan

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Loop diuretics have been investigated for managing postpartum hypertensive disorders, but there is currently insufficient clinical evidence pointing to any single agent. This study aims to compare blood pressure (BP) outcomes for patients with gestational hypertensive disorders receiving labetalol alone versus labetalol + furosemide during postpartum hospital stay. The primary aim was to learn if loop diuretic incorporation in conjunction with labetalol could lower the need for additional anti-hypertensive agents.

An Examination Of The Role Of Adrenergic Receptor Stimulation In Mediating The Link Between Early-Life Stress And The Sensitization Of Neuroinflammatory-Based Depressive-Like Behavior In Isolated Guinea Pig Pups, Rachel Renate Kessler

Browse all Theses and Dissertations

Early-life stress appears to sensitize neuroinflammatory signaling to increase later vulnerability for stress-related mental disorders. How stress initiates this process is unknown, but sympathetic nervous system activation during the early stress may be key. Isolated guinea pig pups display inflammatory-mediated depressive-like behavior and fever that sensitize on repeated isolation. We assessed whether sympathetic nervous system activity contributed to the sensitization process in guinea pig pups. In Experiment 1, the adrenergic agonist ephedrine, either alone or with cortisol, did not increase depressive-like behavior or fever during an initial isolation the following day. In Experiment 2, both depressive-like behavior and fever sensitized …

Prevalence And Evaluation Of Multidrug Resistance Pattern Of Pseudomonas Aeruginosa Among Critical And Non-Critical Areas At A Tertiary Care Hospital Of Multan, Romah Ishfaq, Hubza Ruatt Khan, Mehvish Javeed, Muhammad Ikrama Tanveer, Asma Ashraf

Journal of Bioresource Management

Pseudomonas aeruginosa is an extremely wide spread microorganism linked to nosocomial illnesses. Effective inspection of variations in antimicrobial resistance patterns of P. aeruginosa is vital for selecting suitable antimicrobial drugs for pragmatic treatment. The current research has been performed for assessing antimicrobial sensitivity profile of P. aeruginosa isolated as of a variety of medical specimens collected from critical and non-critical admitted patients of Nishtar Hospital, Multan. The isolates were detected utilizing standard lab practices, as well as the sensitivity was examined employing Kirby-Bauer disk diffusion method corresponding to Clinical and Laboratory Standard Institute (CLSI) recommendations 2019. Out of 373 samples, …

Does The Impact Of Arthritis On Participation In Social Activity Vary By Depression?, Mehnaaz Ali

Master of Public Health Program Student Publications

Objective As the population’s longevity is increasing over time, the number of comorbidities that individuals are suffering with are also becoming evident. The objective is to determine whether individuals living with arthritis have difficulty in social activity participation while suffering with depression. Using the 2019 National Health Interview Survey, this analysis included males and females between 18 to 85 years of age. The dependent variable was social activity participation, where it was identifying participants whether they are or are not having difficulty taking part in social activities. The primary independent variables were depression and arthritis. Other covariates included the demographics …

Epc-Exs Improve Astrocyte Survival And Oxidative Stress Through Different Uptaking Pathways In Diabetic Hypoxia Condition, Manasi Suchit Halurkar, Jinju Wang, Shuzhen Chen, Ji Chen Bihl

Pharmacology and Toxicology Faculty Publications

Background: Hyperglycemia contributes to cardiovascular complications in patients with type 2 diabetes. We confirmed that high glucose (HG) induces endothelial dysfunction and cerebral ischemic injury is enlarged in diabetic mice. Stem cell-released exosomes have been shown to protect the brain from ischemic stroke. We have previously shown that endothelial progenitor cells (EPCs)-released exosomes (EPC-EXs) can protect endothelial cells from hypoxia/reoxygenation (H/R) and HG-induced injury. Here, we aim to investigate the effects of EPC-EXs on astrocytes under H/R and HG-induced injury and whether miR-126 enriched EPC-EXs (miR126-EPC-EXs) have enhanced efficacy. Methods: EPC-EX uptake and co-localization were measured by fluorescent microscopy using …

Drug Abuse Ontology To Harness Web-Based Data For Substance Use Epidemiology Research, Usha Lokala, Francois Lamy, Raminta Daniulaityte, Manas Gaur, Amelie Gyrard, Krishnaprasad Thirunarayan, Ugur Kursuncu, Amit Sheth

Computer Science and Engineering Faculty Publications

Background: Web-based resources and social media platforms play an increasingly important role in health-related knowledge and experience sharing. There is a growing interest in the use of these novel data sources for epidemiological surveillance of substance use behaviors and trends. Objective: The key aims were to describe the development and application of the drug abuse ontology (DAO) as a framework for analyzing web-based and social media data to inform public health and substance use research in the following areas: determining user knowledge, attitudes, and behaviors related to nonmedical use of buprenorphine and illicitly manufactured opioids through the analysis of web …

Intensivist -Driven Ventilator Management Shortens Duration Of Mechanical Ventilation In Coronary Artery Bypass Graft Surgery Patients, Yonatan Dollin, Brian Elliott, Ronald J. Markert, Angela Morman, Matthew Koroscil

Internal Medicine Faculty Publications

Background Prolonged mechanical ventilation in post Coronary Artery Bypass Graft Surgery (CABG) is associated with deleterious effects including, increased ICU and hospital length of stay (LOS), infectious complications, and mortality. Standardized ventilator weaning protocols and the utilization of critical care physicians in post CABG patient care vary substantially among institutions. The purpose of this study was to evaluate if intensivist consultation in conjunction with a multidisciplinary, standardized ventilator weaning protocol improves outcomes in CABG patients. Materials and Methods We performed a single-center, retrospective, before-after cohort analysis at Miami Valley Hospital in Dayton, OH, a 970-bed community hospital. Patients were divided …

Metamotivation In Medical Students: Explaining Motivation Regulation Strategies In Medical Students, Ali Norouzi, Maryam Alizadeh, Dean Parmelee, Saharnaz Nedjat, Saiideh Norouzi, Mohammad Shariati

Medical Education Faculty Publications

BACKGROUND: Metamotivation is a process that students use to monitor their motivational states to reach their academic goals. To date, few studies have addressed the ways that medical students manage their motivational states. This study aim to identify the motivational strategies of medical students as they use the metamotivational process to monitor and control their motivational states.

MATERIALS AND METHODS: This qualitative study uses directed content analysis of the narrative responses of 18 medical students to draft an in-depth and semistructured interview protocol which were conducted through WhatsApp due to social distance restrictions of COVID-19. Data were collected, encoded, and …

Bamlanivimab Use In A Military Treatment Facility, Eric Karr, Theodore Chung, Kathryn Burtson, Ronald J. Markert, Devin Kelly

Internal Medicine Faculty Publications

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was first identified in 2019 in Wuhan, China, and has rapidly spread across the world. As of April 2021, SARS-CoV-2 has infected more than 140,000,000 and caused more than 3,000,000 deaths globally. In November 2020, the monoclonal antibody bamlanivimab was approved by the FDA for non-hospitalized patients with SARS-CoV-2 (COVID-19) who possessed risk factors for progression to severe COVID-19. This provided a treatment option that may help prevent hospitalization. Methods Patients who regularly received ambulatory care at a military treatment facility and who were …

Impact Of An Education Intervention On Covid-19 Vaccine Hesitancy In A Military Base Population, Peter C. Li, Samuel R. Theis, Devin Kelly, Col Thad Ocampo, Andrew Berglund, Damien Morgan, Ronald J. Markert, Evan Fisher, Kathryn Burtson

Internal Medicine Faculty Publications

Background: Coronavirus disease 2019 (COVID-19) vaccine hesitancy is a major impediment to achieving herd immunity and overcoming the current pandemic. Our aim was to decrease the prevalence of vaccine hesitancy through an education intervention. Method: An education intervention, consisting of a PowerPoint presentation addressing the two mRNA COVID-19 vaccine concerns/myths and a question and answer panel comprising health care providers from various specialties, was implemented to address vaccine hesitancy among personnel associated with Wright-Patterson Air Force Base through a series of virtual and in-person seminars. Participants completed a post-seminar survey as a retrospective self-assessment to identify attitudes and views surrounding …