Medicine and Health Sciences Commons^™

Department Of Surgery Update, August 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Regulated Phosphorylation Of The K-Cl Cotransporter Kcc3 Is A Molecular Switch Of Intracellular Potassium Content And Cell Volume Homeostasis, Norma C. Adragna, Nagendra B. Ravilla, Peter K. Lauf, Gulnaz Begum, Arjun R. Khanna, Dandan Sun, Kristopher K. Kahle

Pharmacology and Toxicology Faculty Publications

The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease (RVD), resulting in K+ and Cl− efflux via activation of K+ channels, volume-regulated anion channels (VRACs), and the K+-Cl− cotransporters, including KCC3. Here, we show genetic alanine (Ala) substitution at threonines (Thr) 991 and 1048 in the KCC3a isoform carboxyl-terminus, preventing inhibitory phosphorylation at these sites, not only significantly up-regulates KCC3a activity up to 25-fold in normally inhibitory isotonic conditions, but is also accompanied by reversal of activity of the …

Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity In The ∆7 Sma Mouse, Vicki L. Mcgovern, Aurelie Massoni-Laporte, Xueyong Wang, Thanh T. Le, Hao T. Le, Mark M. Rich, Arthur H. M. Burghes

Neuroscience, Cell Biology & Physiology Faculty Publications

Spinal muscular atrophy is caused by loss of the SMN1 gene and retention of SMN2. TheSMN2 copy number inversely correlates with phenotypic severity and is a modifier of disease outcome. The SMN2 gene essentially differs from SMN1 by a single nucleotide in exon 7 that modulates the incorporation of exon 7 into the final SMN transcript. The majority of the SMN2transcripts lack exon 7 and this leads to a SMN protein that does not effectively oligomerize and is rapidly degraded. However theSMN2 gene does produce some full-length SMN and theSMN2 copy number along with how …

The Cutting Edge Summer 2015, Wright State University Department Of Surgery

The Cutting Edge Newsletter

A twelve page newsletter created by the Department of Surgery documenting current affairs of the department. This issue contains features such as faculty news, information on general surgery residencies, a list of scholarly activity, special lectures, and more.

Department Of Surgery Update, July 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Department Of Surgery Update, June 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A three page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Predictive Performance Of A Vancomycin Population Pharmacokinetic Model In Neonates, Chris Stockmann, Adam L. Hersh, Jessica K. Roberts, Jiraganya Bhongsatiern, E. Kent Korgenski, Michael G. Spigarelli, Catherine M.T. Sherwin, Adam Frymoyer

Pediatrics Faculty Publications

Introduction

The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-resistant Staphylococcus aureus (MRSA) infections. Utilization of population pharmacokinetic models and Bayesian methods offers the potential for developing individualized therapeutic approaches. To meet this need, a neonatal vancomycin population pharmacokinetic model was recently published. The current study sought to externally evaluate the predictive performance and generalizability of this model.

Methods

A retrospective chart review of neonates who received vancomycin and had ≥1 peak and ≥1 trough concentrations at five Intermountain Healthcare neonatal intensive care …

The Significance Of Macrocephaly Or Enlarging Head Circumference In Infants With The Triad: Further Evidence Of Mimics Of Shaken Baby Syndrome, David Miller, Patrick Barnes, Marvin E. Miller

Pediatrics Faculty Publications

Infants with the triad (neurologic dysfunction, subdural hematoma [SDH], and retinal hemorrhage) are often diagnosed as victims of shaken baby syndrome. Medical conditions/predisposing factors to developing the triad are often dismissed: short falls, birth-related SDH that enlarges, macrocephaly, sinus/cortical vein thrombosis, and others. Six infants with the triad are described in which child abuse was diagnosed, but parents denied wrongdoing. All 6 had either macrocephaly or enlarging head circumference, which suggested medical explanations. Three infants incurred short falls, 1 had a difficult delivery in which there was likely a rebleed of a birth-related SDH, 1 had a spontaneous SDH associated …

The Effect Of Positive And Negative Reinforcement On Sixth Graders’ Mental Math Performance, Tess Greene, Amber Todd

Medical Education Faculty Publications

We examined the relationship between different forms of reinforcement and subjects’ mathematical performance. Thirty sixth-grade students were asked to mentally calculate answers to fraction problems, while holding a heart rate monitor, after receiving a positive, negative, or neutral form of reinforcement. While the results suggest that any motivation, positive or negative, may result in higher grades, the positive reinforcement group displayed the largest gain. However, the results were not statistically significant, though the trend was consistent with prior research. The heart rates of the positively-reinforced group were significantly lower than those of the negatively-reinforced and control groups. These results suggest …

Department Of Surgery Update, May 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A five page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, pictures of the new interns for 2015-2016, scholarly activity and more.

Flight Physician - May, 2015, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A seventeen page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

Ohio Academy Of Medical History Annual Meeting Program, April 25, 2015, Ohio Academy Of Medical History

Annual Conference Programs

This program is from the annual meeting of the Ohio Academy of Medical History held on April 25, 2015 at Lloyd Library and Museum in Cincinnati, Ohio. The program details the events and presentations of the meeting.

Birth Of A Collection: The Vesalius Trust Collection Of Art In The Service Of Science, Marcia Hartsock, Anna Heran, Tina Schott

Annual Conference Presentations, Papers, and Posters

No abstract provided.

125th Anniversary Of The Ohio State University College Of Dentistry, Robert B. Stevenson

Annual Conference Presentations, Papers, and Posters

No abstract provided.

James Gillray, Thomas Rowlandson And Company: Medical Caricaturists Untamed, Jim Hennessy

Annual Conference Presentations, Papers, and Posters

No abstract provided.

Irreversible Electroporation Of Malignant Lesions: An Institution Experience, Benjamin Bates, Minia Hellan, Shannon Kauffman, James R. Ouellette

Department of Surgery Faculty Publications

Background: Irreversible electroporation (IRE) is a tumor ablation technique where short, high-voltage pulses are applied to tumors to permeabilize the cell membranes. Since no thermal energy is created, it can be used near vital structures. We report our experience in a wide array of anatomic locations and on diverse oncologic processes.

Methods: We performed a retrospective review of all IRE cases performed at our institution from September 2010 to September 2013. Patients were evaluated for peri-operative morbidity, mortality, and oncologic outcome.

Results: Twenty-seven patients underwent IRE during 16 laparotomies and 12 CT guided percutaneous procedures. Anatomic locations: 9 liver, 7 …

Wright State University's Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts From Friday, April 10, 2015, Wright State University Office Of Undergraduate Research And Stemm Activities

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's fifth annual Celebration of Research, Scholarship and Creative Activities on April 10, 2015.

No Oasis In The Desert: Identification And Implications Of The Food Desert Around An Urban Ohio Hospital, R. J. Sontag

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

Montgomery County, Ohio’s diabetes prevalence outpaces the nation, and the incidence of adult obesity approaches 1/3. Access to healthy food in the impoverished neighborhood surrounding Dayton’s Good Samaritan Hospital, the site of the Family Medicine residency, is important when educating about health lifestyle. The purpose of this project was to determine whether the area was a food desert and to evaluate the implications of the label.

Woodrow Wilson’S Ideological War: American Intervention In Russia, 1918-1920, Shane Hapner

Best Integrated Writing

Shane Hapner analyzes the effects of Woodrow Wilson’s principle of self-determination on American intervention in Russia from 1918-1920 in this essay written for the Integrated Writing course HST 4220: Soviet Union, taught by Dr. Seam Pollock at Wright State University.

Circular Thinking: An Original Analysis Of Lord Of The Flies, John Callon

Best Integrated Writing

John Callon examines traits of circular thinking and imagery in William Golding’s Lord of the Flies in this essay written for the Integrated Writing course ENG 4560: Capstone in Integrated Language Arts Curriculum, taught by Dr. Nancy Mack at Wright State University.

Are The Main Institutional Changes That Created The “Business Man” Still Relevant?, Hayden Joblin

Best Integrated Writing

Hayden Joblin examines the forces driving the evolution of the modern business man and whether those still have relevance in this essay written for the Integrated Writing course EC 3190: Institutional Economics, taught by Dr. Hee Young Shin at Wright State University.

Identifying Genes Involved In Suppression Of Tumor Formation In The Planarian Schmidtea Mediterranea, Erin Dorsten

Best Integrated Writing

Erin Dorsten makes a proposal for a scientific study of experiments to identify genes involved in protecting an organism with negligible senescence from tumor formation in this piece written for the Integrated Writing course BIO 4020: Current Literature: Biology of Regeneration, taught by Labib Rouhana at Wright State University.

The Barb Report, Elizabeth Schoppelrei

Best Integrated Writing

Elizabeth Schoppelrei explores issues of sexuality, kindness, masculinity, discrimination, and respect in this short story written for the Integrated Writing course ENG 4830: Advanced Fiction Writing Seminar, taught by Dr. Erin Flanagan at Wright State University.

How To Recover From The Great Recession And Reduce The Government Debt, Hunter Cregger

Best Integrated Writing

Hunter Cregger proposes how to recover from the Great Recession of the 2000s and reduce government debt in this essay written for the Integrated Writing course EC 2050: Principles of Macroeconomics, taught by Dr. Hee Young Shin at Wright State University.

Inter-Tribal Disunity: An Analysis Of Inter-Tribal Conflict During The Black Hawk War Of 1832, Megan Bailey

Best Integrated Writing

Megan Bailey explores the effects of inter-tribal disunity and conflict on the Black Hawk War of 1832 in this essay written for the Integrated Writing course HST 3000: Introduction to Historical Analysis, taught by Dr. Noeleen McIlvenna at Wright State University.

Effects Of Caffeine And Vitamin E On Wisconsin Fast Plant, Sarah Ferguson

Best Integrated Writing

Sarah Ferguson examines the effects of caffeine and vitamin E on the growth of Wisconsin Fast Plant in this piece written for the Integrated Writing course BIO 3450: Concepts of Biology I for Early and Middle Childhood Education, taught by Mr. Len Kenyon at Wright State University.

Best Integrated Writing 2015 - Complete Edition

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. The journal is published annually by the Wright State University Department of English Language and Literatures.

Proceedings - Wright State University Boonshoft School Of Medicine Seventh Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Seventh Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 8, 2015.

Department Of Surgery Update, April 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Flight Physician - March, 2015, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

An eleven page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.