Medicine and Health Sciences Commons^™

Helices In Fluids And Their Applications, Eva M. Strawbridge

Biology and Medicine Through Mathematics Conference

No abstract provided.

Pk/Pd Modeling Coupled With A Phenotype-Structured Population Model For Reducing Drug Resistance, Lifeng Han

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Long-Wave Model For Film Flow Inside A Tube With Slip, Mark S. Schwitzerlett, Ihsan Topaloglu, H. Reed Ogrosky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Epithelial-Mesenchymal Transition In A 3d Multicellular Model Of Tgf-Β1 Signaling, Kristin Kim, Chris Lemmon

Biology and Medicine Through Mathematics Conference

No abstract provided.

Networking Coffee Break, Coffee

Biology and Medicine Through Mathematics Conference

No abstract provided.

Leader, Follower, And Cheater: Modeling Collective Cancer Invasion, Yi Jiang

Biology and Medicine Through Mathematics Conference

No abstract provided.

Opening Remarks, Rebecca A. Segal, Angela M. Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley

Theses and Dissertations

There is a continued need for new technology and strategies for tackling cancer and other diseases, and within the current century a novel therapeutic strategy has emerged in the realm of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifically targets and degrades disease-causing proteins via the ubiquitin-proteasome system, and has seen an explosion of research and intrigue in both academia and industry over the past two decades. The diversity of PROTAC classes based on the E3 ligase recruiting ligand and the target protein allows for a universal molecular structure that can be customized for a specific target and …

Characterizing The Effects Of Antiandrogens And Senolytics To Enhance The Therapeutic Response To Castration-Resistant Prostate Cancer, Justin M. Silverman

Theses and Dissertations

Prostate cancer is the most frequently diagnosed cancer in males and the second most common cause of cancer deaths. Androgen deprivation therapy, whether through surgical or chemical castration, is the mainstay for treatment of advanced prostate cancer; however, despite an initial response, most patients eventually develop a progressive PSA rise, and castration- sensitive prostate cancer gives rise to castration-resistant prostate cancer. The standard of care therapy includes the antiandrogens such as enzalutamide and abiraterone acetate as well as the microtubule poison, docetaxel, and various immunotherapies; however, while prostate cancer research is progressing, there continues to be a compelling need for …

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

Undergraduate Research Posters

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …

Gestational Vulnerability To Ozone Air Pollution - A Placental Story, Vishnupriya Alavala, Sarah Brent, Russell Hunter, Matthew J. Campen, Andrew Ottens

Undergraduate Research Posters

About 99% of the global population resides in areas with air pollution surpassing World Health Organization standards. Air pollution is associated with adverse neonatal health outcomes such as low fetal birth weight and an increased risk for maternal pre-eclampsia. A particularly reactive air pollutant is ozone, which forms reactive oxygen species that induce cellular damage. Research exists on the dispersion of reactive oxygen species through the bloodstream leading to fetal vulnerability during pregnancy, specifically via the placenta. Yet, placental and fetal development is a temporal process with varied susceptibility to negative gestational outcomes.

To addressing this gap, our laboratory utilized …

Respire: A Technological Tool To Navigate Mechanical Ventilation In Patient Care And Educational Settings, Swara Chokshi

Undergraduate Research Posters

Around the world, more than 20 million patients rely on mechanical ventilators annually; however, not enough individuals understand how to operate ventilators, posing a risk to the health of many. Moreover, it is increasingly difficult to determine optimal mechanical ventilator settings in a timely fashion, especially in low-resource countries and critical care areas. Respire is a mobile application that bridges this gap in a twofold manner: it is designed to assist healthcare workers around the world navigate and use mechanical ventilators effectively as well as educate the general public about mechanical ventilation. Respire offers a user-friendly yet educational interface that …

Glyphosate And Dopaminergic Neurotoxicity: Herbicide Impacts On Parkinson's Disease Development, Lojy Hozyen

Undergraduate Research Posters

Nearly one million individuals in the United States are living with Parkinson’s disease (PD). In the past two decades, the death rate from PD has risen by about 63 percent in the United States. Major findings have been made in the past five years about the potential impact of glyphosate (N-(phosphonomethyl) glycine) exposure on the onset of PD symptoms. The purpose of this meta-analysis is to provide a compiled update on the chemical and biological alterations that glyphosate imposes on the human brain. A meta-analysis was conducted to create a quantitative estimate of the connection between PD and glyphosate. Findings …

Comparing The Microbiomes Of Dental Plaques In 19th Century Ancestral Remains, Ananya Udyaver

Undergraduate Research Posters

During the construction of VCU’s Hermes A. Kontos Medical Sciences Building in April 1994, nineteenth century ancestral remains were found in an abandoned well on the Medical College of Virginia (MCV) campus. This well, now known as the East Marshall Street Well (EMSW), is thought to have been used as a disposal location for cadaver dissection for surgical and other medical waste in the past. VCU is now seeking to use DNA sequencing technology to match and assemble bones from each individual for a proper burial, uncover the cultural and historical context in which these people lived, and bring a …

Evaluation Of Spliceai For Improved Genetic Variant Classification In Inherited Ophthalmic Disease Genes, Melissa Reeves

Theses and Dissertations

ABSTRACT

EVALUATION OF SPLICEAI FOR IMPROVED GENETIC VARIANT CLASSIFICATION IN INHERITED OPHTHALMIC DISEASE GENES

By Melissa Jean Reeves, Ph.D.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2023

Major Director: Melissa Jamerson, PhD, MLS(ASCP)

Associate Professor, Department of Medical Laboratory Sciences

Inherited ophthalmic diseases impact individuals around the globe. Inherited retinal diseases (IRDs) are the leading cause of blindness in individuals aged 15 to 45. The personal, social, and economic impact of vision loss is profound. Due to individual differences, symptoms can be variable, and …

Observing Ceramide Pathway With Ferroptosis Via Mia Paca-2 Cell Treatment With Rsl3, Tazrin Rahman

Auctus: The Journal of Undergraduate Research and Creative Scholarship

Composed of sphingosine and a fatty acid, ceramides are lipid molecules that serve as key metabolic signaling molecules of a sphingolipid pathway. While it acts as a precursor of complex sphingolipids, inducing ceramide generation can cause cell stress leading to subsequent cell death via apoptosis, necrosis, and even mitophagy. With regards to cell death specifically, a novel form of regulated cell death, ferroptosis, has recently been recognized of necrotic nature. Its unique morphological features and distinct properties have been observed over the last several decades; however, the molecular features were not identifiable as pure evidence of cell death, until recently …

Boxed Lunches, Lunch

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes, Jemal Mohammed-Awel

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome, Justen Geddes

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion, Erin O. Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis, Choongseok Park, Sungwoo Ahn, Leonid Rubchinsky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Dynamics Of Usutu Virus Infection In Birds, Nora G. Heitzman-Breen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Epidemiological Assessment Of Wolbachia-Based Biocontrol For Reduction Of Dengue Morbidity, Olga Vasilieva, Oscar E. Escobar, Hector J. Martinez, Pierre-Alexandre Bliman, Yves Dumont

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mechanical Parameters Fitting For Layer-Reduced Umbilical Arteries Used For Grafting, Kun Gou

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Model Of Triple-Negative Breast Cancer In Response To Combination Chemotherapies, Angelica Davenport, Yun Lu, Carlos Gallegos, Adriana Massicano, Katherine Heinzman, Patrick Song, Anna Sorace, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Model Of Quarantine Implementation In An Animal Shelter For Canine Distemper Outbreak, Virginia Parkman, Nick Cogan

Biology and Medicine Through Mathematics Conference

No abstract provided.

Coffee Break, Coffee Break

Biology and Medicine Through Mathematics Conference

No abstract provided.

Plenary: Cardiovascular Models In Vascular Disease, Mette Olufsen

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Mathematical Model For Biological Field Effect Tranistors, Ryan M. Evans, Seulki Cho, Arvind Ballijepalli, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Using A Network Model To Control The Spread Of An Infectious Disease On A College Campus With Contact Tracing, Christopher R. Boyette

Biology and Medicine Through Mathematics Conference

No abstract provided.