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Virginia Commonwealth University

Life Sciences

Bile acids

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Full-Text Articles in Medicine and Health Sciences

The Role Of Sphingosine Kinase 2 In Alcoholic Liver Disease, Eric K. Kwong Jan 2019

The Role Of Sphingosine Kinase 2 In Alcoholic Liver Disease, Eric K. Kwong

Theses and Dissertations

Alcoholic liver disease (ALD) is one of the most common liver diseases worldwide characterized by the accumulation of lipids within the liver, inflammation and the possibility of progressing to cirrhosis and liver failure. More importantly, there are currently no effective treatments for ALD and liver transplantation remains the only therapeutic option for end-stage liver disease. Previous studies have shown that ALD is a result of a combination of endoplasmic reticulum (ER) stress, lipid metabolism dysregulation and inflammation. It has been previously reported that alcohol disrupts gut microbiota homeostasis and causes increased endotoxins that contribute to the pathology of ALD. However, …


The Scaffolding Protein Iqgap1 Promotes Hepatic Proliferation And Protects The Liver From Injury, Hanna Erickson, Sayeepriyadarshini Anakk Jan 2017

The Scaffolding Protein Iqgap1 Promotes Hepatic Proliferation And Protects The Liver From Injury, Hanna Erickson, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.


Bile Acids Contribute To The Gender-Biased Incidence Of Hcc, Megan E. Patton, Sherwin H. Kelekar, Rhishikesh Thakare, Yazen Alnouti, Sayeepriyadarshini Anakk Jan 2017

Bile Acids Contribute To The Gender-Biased Incidence Of Hcc, Megan E. Patton, Sherwin H. Kelekar, Rhishikesh Thakare, Yazen Alnouti, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.