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Articles 31 - 54 of 54
Full-Text Articles in Medicine and Health Sciences
Investigation Of Optimized Prompt Gamma Detection Strategy For Real-Time Bragg Peak Tracking In Proton Radiation Therapy, Melek Zarifi, Yujin Qi, Susanna Guatelli, Brian F. Hutton, Anatoly B. Rosenfeld
Investigation Of Optimized Prompt Gamma Detection Strategy For Real-Time Bragg Peak Tracking In Proton Radiation Therapy, Melek Zarifi, Yujin Qi, Susanna Guatelli, Brian F. Hutton, Anatoly B. Rosenfeld
Illawarra Health and Medical Research Institute
Prompt gamma (PG) ray signal from proton radiation has been proposed for in vivo beam range verification to provide unique real-time tracking of the Bragg Peak (BP) during proton therapy (PT) delivery. In this study, we investigate possible strategies to optimize PG detection for BP tracking in proton radiation therapy. Extensive Geant4 Monte Carlo (MC) simulations have been used to study the energy spectral, spatial and timing characteristics of PG emission signal from 200 MeV proton pencil beam irradiations with water and PMMA phantoms. These include their relationship with the position of the BP and the background of the neutron …
Multipotent Caudal Neural Progenitors Derived From Human Pluripotent Stem Cells That Give Rise To Lineages Of The Central And Peripheral Nervous System, Mark Denham, Kouichi Hasegawa, Trevelyan Menheniott, Benjamin Rollo, Dongcheng Zhang, Shelley Hough, Abdullah Alshawaf, Fabia Febbraro, Samiramis Ighaniyan, Jessie Leung, David A. Elliott, Donald F. Newgreen, Martin F. Pera, Mirella Dottori
Multipotent Caudal Neural Progenitors Derived From Human Pluripotent Stem Cells That Give Rise To Lineages Of The Central And Peripheral Nervous System, Mark Denham, Kouichi Hasegawa, Trevelyan Menheniott, Benjamin Rollo, Dongcheng Zhang, Shelley Hough, Abdullah Alshawaf, Fabia Febbraro, Samiramis Ighaniyan, Jessie Leung, David A. Elliott, Donald F. Newgreen, Martin F. Pera, Mirella Dottori
Illawarra Health and Medical Research Institute
The caudal neural plate is a distinct region of the embryo that gives rise to major progenitor lineages of the developing central and peripheral nervous system, including neural crest and floor plate cells. We show that dual inhibition of the glycogen synthase kinase 3β and activin/nodal pathways by small molecules differentiate human pluripotent stem cells (hPSCs) directly into a preneuroepithelial progenitor population we named "caudal neural progenitors" (CNPs). CNPs coexpress caudal neural plate and mesoderm markers, and, share high similarities to embryonic caudal neural plate cells in their lineage differentiation potential. Exposure of CNPs to BMP2/4, sonic hedgehog, or FGF2 …
Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments And Disruptions To Gabaergic Signaling In Mice, Martin Engel, Peta Snikeris, Andrew M. Jenner, Tim Karl, Xu-Feng Huang, Elisabeth T. Frank
Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments And Disruptions To Gabaergic Signaling In Mice, Martin Engel, Peta Snikeris, Andrew M. Jenner, Tim Karl, Xu-Feng Huang, Elisabeth T. Frank
Illawarra Health and Medical Research Institute
Background: Substantial evidence from human post-mortem and genetic studies has linked the neurotrophic factor neuregulin 1 (NRG1) to the pathophysiology of schizophrenia. Genetic animal models and in vitro experiments have suggested that altered NRG1 signaling, rather than protein changes, contributes to the symptomatology of schizophrenia. However, little is known about the effect of NRG1 on schizophrenia-relevant behavior and neurotransmission (particularly GABAergic and glutamatergic) in adult animals. Method: To address this question, we treated adult mice with the extracellular signaling domain of NRG1 and assessed spontaneous locomotor activity and acoustic startle response, as well as extracellular GABA, glutamate, and …
Bardoxolone Methyl: A Potential Therapeutic For The Prevention Of Anti-Psychotic Drug-Induced Obesity?, Danielle Camer, Christopher Bell, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Bardoxolone Methyl: A Potential Therapeutic For The Prevention Of Anti-Psychotic Drug-Induced Obesity?, Danielle Camer, Christopher Bell, Yinghua Yu, Alexander M. Szabo, Francesca Fernandez-Enright, Hoang Lan Chi Dinh, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Abstract of a presentation.
Area-Level Socioeconomic Gradients In Overweight And Obesity In A Community-Derived Cohort Of Health Service Users - A Cross-Sectional Study, Andrew D. Bonney, Darren J. Mayne, Bryan D. Jones, Lawrence Bott, Stephen Andersen, Peter Caputi, Kathryn M. Weston, Donald C. Iverson
Area-Level Socioeconomic Gradients In Overweight And Obesity In A Community-Derived Cohort Of Health Service Users - A Cross-Sectional Study, Andrew D. Bonney, Darren J. Mayne, Bryan D. Jones, Lawrence Bott, Stephen Andersen, Peter Caputi, Kathryn M. Weston, Donald C. Iverson
Illawarra Health and Medical Research Institute
Background Overweight and obesity lead to higher probability of individuals accessing primary care but adiposity estimates are rarely available at regional levels to inform health service planning. This paper analyses a large, community-derived clinical database of objectively measured body mass index (BMI) to explore relationships with area-level socioeconomic disadvantage for informing regional level planning activities. Materials and Methods The study included 91776 adults who had BMI objectively measured between 1 July 2009 and 30 June 2011 by a single pathology provider. Demographic data and BMI were extracted and matched to 2006 national census socioeconomic data using geocoding. Adjusted odds-ratios for …
Prenatal Polyic And Lps Exposure Alters Serotonin Transporter And 5-Ht2a Receptor Binding Densities In Rodents: Implications For Schizophrenia, Yinghua Yu, Rory Watsford, Christopher Bell, Zehra Boz, Hongqin Wang, Xu-Feng Huang
Prenatal Polyic And Lps Exposure Alters Serotonin Transporter And 5-Ht2a Receptor Binding Densities In Rodents: Implications For Schizophrenia, Yinghua Yu, Rory Watsford, Christopher Bell, Zehra Boz, Hongqin Wang, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Abstract of a poster presentation.
Separation And Identification Of Phosphatidylcholine Regioisomers By Combining Liquid Chromatography With A Fusion Of Collision-And Ozone-Induced Dissociation, Rachel Kozlowski, Todd W. Mitchell, Stephen J. Blanksby
Separation And Identification Of Phosphatidylcholine Regioisomers By Combining Liquid Chromatography With A Fusion Of Collision-And Ozone-Induced Dissociation, Rachel Kozlowski, Todd W. Mitchell, Stephen J. Blanksby
Illawarra Health and Medical Research Institute
The differentiation of closely related lipid isomers is increasingly important to our evolving understanding of lipid biochemistry but it is equally challenging to contemporary chromatographic and mass spectral analyses. Recently, we described a novel ion-activation approach based on combining collision- with ozone-induced dissociation (CID/OzID) for the identification of the relative acyl chain substitution positions in glycerophospholipids. Here we demonstrate, for the first time, that CID/OzID can be effectively combined with reversed-phase chromatography to enable the separation and unambiguous identification of regioisomeric pairs of phosphatidylcholines that differ only in the arrangement of acyl chains on the glycerol backbone.
18 Ghz Electromagnetic Field Induces Permeability Of Gram-Positive Cocci, The Hong Phong Nguyen, Yury Shamis, Rodney J. Croft, Andrew J. Wood, Robert L. Mcintosh, Russell Crawford, Elena Ivanova
18 Ghz Electromagnetic Field Induces Permeability Of Gram-Positive Cocci, The Hong Phong Nguyen, Yury Shamis, Rodney J. Croft, Andrew J. Wood, Robert L. Mcintosh, Russell Crawford, Elena Ivanova
Illawarra Health and Medical Research Institute
The effect of electromagnetic field (EMF) exposures at the microwave (MW) frequency of 18 GHz, on four cocci, Planococcus maritimus KMM 3738, Staphylococcus aureus CIP 65.8T, S. aureus ATCC 25923 and S. epidermidis ATCC 14990T, was investigated. We demonstrate that exposing the bacteria to an EMF induced permeability in the bacterial membranes of all strains studied, as confirmed directly by transmission electron microscopy (TEM), and indirectly via the propidium iodide assay and the uptake of silica nanospheres. The cells remained permeable for at least nine minutes after EMF exposure. It was shown that all strains internalized 23.5 nm nanospheres, whereas …
Fatty Acid Composition Of The Anterior Cingulate Cortex Indicates A High Susceptibility To Lipid Peroxidation In Parkinson's Disease, Sarah K. Abbott, Andrew M. Jenner, Adena S. Spiro, Marijka Batterham, Glenda M. Halliday, Brett Garner
Fatty Acid Composition Of The Anterior Cingulate Cortex Indicates A High Susceptibility To Lipid Peroxidation In Parkinson's Disease, Sarah K. Abbott, Andrew M. Jenner, Adena S. Spiro, Marijka Batterham, Glenda M. Halliday, Brett Garner
Illawarra Health and Medical Research Institute
Background: Oxidative stress contributes to Parkinson's disease (PD) etiology. Although previous studies have focused on sources of free radical formation in brain regions affected by PD, less is known regarding changes in lipid composition and the implications for susceptibility to peroxidation. Objective: To assess fatty acid profiles from control and PD tissues that are susceptible to PD pathology but devoid of severe destruction. Methods: We used gas chromatography methods to assess fatty acid profiles from control (n = 10) and PD (n = 9) postmortem tissues. We focused on the anterior cingulate cortex (ACC), a region that accumulates alpha-synuclein, but …
Cognitive Differences In Schizophrenia On Long-Term Treatments With Clozapine, Risperidone And Typical Antipsychotics, Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Chong Sheng Song, Yinghua Yu, Xu-Feng Huang
Cognitive Differences In Schizophrenia On Long-Term Treatments With Clozapine, Risperidone And Typical Antipsychotics, Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Chong Sheng Song, Yinghua Yu, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Cognitive deficits are a core feature of schizophrenia. There is ongoing debate on whether cognition is affected by antipsychotic drugs (APDs). This study examined the effect of long-term treatment with APDs on cognition in schizophrenia. Cognitive function was assessed in 418 patients with schizophrenia on long-term treatment with APDs (215 on clozapine, 91 on risperidone and 112 on typical APDs) and 159 healthy controls using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Schizophrenia symptomatology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found that cognitive test scores were significantly lower in all patients compared …
Is B-Type Natriuretic Peptide A Risk Factor For Heart Failure In Patients Treated With Bardoxolone Methyl?, Danielle Camer, Xu-Feng Huang
Is B-Type Natriuretic Peptide A Risk Factor For Heart Failure In Patients Treated With Bardoxolone Methyl?, Danielle Camer, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Letter to the Editor, comment on article entitled "Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl" by Chin et al in the Journal of Cardiac Failure.
Preimplantation Exposure To Bisphenol A And Triclosan May Lead To Implantation Failure In Humans, Mu Yuan, Ming-Zhu Bai, Xu-Feng Huang, Yue Zhang, Jing Liu, Min-Hao Hu, Wei-Qian Zheng, Fan Jin
Preimplantation Exposure To Bisphenol A And Triclosan May Lead To Implantation Failure In Humans, Mu Yuan, Ming-Zhu Bai, Xu-Feng Huang, Yue Zhang, Jing Liu, Min-Hao Hu, Wei-Qian Zheng, Fan Jin
Illawarra Health and Medical Research Institute
Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and triclosan (TCS), are mass-produced and are widespread.They both have estrogenic properties and similar chemical structures and pharmacokinetic features and have been detected in human fluids and tissues. Clinical evidence has suggested a positive association between BPA exposure and implantation failure in IVF patients. Studies inmouse models have suggested that preimplantation exposure to BPA and TCS can lead to implantation failure. This paper reviews the relationship between preimplantation exposure to BPA and TCS and implantation failure and discusses the …
Roquin Binds Microrna-146a And Argonaute2 To Regulate Microrna Homeostasis, Monika Srivastava, Guowen Duan, Nadia J. Kershaw, Vicki Athanasopoulos, Janet H. Yeo, Toyoyuki Ose, Desheng Hu, Simon H. Brown, Slobodan Jergic, Hardip R. Patel, Alvin Pratama, Sashika Richards, Anil Verma, E Yvonne Jones, Vigo Heissmeyer, Thomas Preiss, Nicholas E. Dixon, Mark M. Chong, Jeffrey J. Babon, Carola Vinuesa
Roquin Binds Microrna-146a And Argonaute2 To Regulate Microrna Homeostasis, Monika Srivastava, Guowen Duan, Nadia J. Kershaw, Vicki Athanasopoulos, Janet H. Yeo, Toyoyuki Ose, Desheng Hu, Simon H. Brown, Slobodan Jergic, Hardip R. Patel, Alvin Pratama, Sashika Richards, Anil Verma, E Yvonne Jones, Vigo Heissmeyer, Thomas Preiss, Nicholas E. Dixon, Mark M. Chong, Jeffrey J. Babon, Carola Vinuesa
Illawarra Health and Medical Research Institute
Roquin is an RNA-binding protein that prevents autoimmunity and inflammation via repression of bound target mRNAs such as inducible costimulator (Icos). When Roquin is absent or mutated (Roquinsan), Icos is overexpressed in T cells. Here we show that Roquin enhances Dicer-mediated processing of pre-miR-146a. Roquin also directly binds Argonaute2, a central component of the RNA-induced silencing complex, and miR-146a, a microRNA that targets Icos mRNA. In the absence of functional Roquin, miR-146a accumulates in T cells. Its accumulation is not due to increased transcription or processing, rather due to enhanced stability of mature miR-146a. This is associated with decreased 3′ …
Metabotropic Glutamate Receptor 5, And Its Trafficking Molecules Norbin And Tamalin, Are Increased In The Ca1 Hippocampal Region Of Subjects With Schizophrenia, Natalie Matosin, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Martin Engel, Xu-Feng Huang, Kelly A. Newell
Metabotropic Glutamate Receptor 5, And Its Trafficking Molecules Norbin And Tamalin, Are Increased In The Ca1 Hippocampal Region Of Subjects With Schizophrenia, Natalie Matosin, Francesca Fernandez-Enright, Jeremy S. Lum, Jessica L. Andrews, Martin Engel, Xu-Feng Huang, Kelly A. Newell
Illawarra Health and Medical Research Institute
Metabotropic glutamate receptor 5 (mGluR5) is involved in hippocampal-dependent learning and memory, which are processes disrupted in schizophrenia. Recent evidence from human genetic and animal studies suggests that the regulation of mGluR5, including its interaction with trafficking molecules, may be altered in the disorder. However there have been no investigations of hippocampal mGluR5 or mGluR5 trafficking molecules in the postmortem schizophrenia brain to confirm this. In the present study, we investigated whether protein expression of mGluR5, as well as Norbin and Tamalin (modulators of mGluR5 signalling and trafficking), might be altered in the schizophrenia brain, using postmortem samples from the …
Prenatal Infection Promotes Olanzapine-Induced Obesity In Rats: Implications For Antipsychotic-Induced Obesity In Schizophrenia, Xu-Feng Huang, Christopher Bell, Hongqin Wang, Zehra Boz, Yinghua Yu
Prenatal Infection Promotes Olanzapine-Induced Obesity In Rats: Implications For Antipsychotic-Induced Obesity In Schizophrenia, Xu-Feng Huang, Christopher Bell, Hongqin Wang, Zehra Boz, Yinghua Yu
Illawarra Health and Medical Research Institute
Abstract of a poster presentation.
Differential Cognitive And Behavioural Impacts Of Lps And Polyi:C Prenatal Infections On Adult Female Offspring, Christopher Bell, Hongqin Wang, Xu-Feng Huang, Yinghua Yu
Differential Cognitive And Behavioural Impacts Of Lps And Polyi:C Prenatal Infections On Adult Female Offspring, Christopher Bell, Hongqin Wang, Xu-Feng Huang, Yinghua Yu
Illawarra Health and Medical Research Institute
Abstract of a poster presentation.
Teasaponin Improves Leptin Sensitivity In The Prefrontal Cortex Of Obese Mice, Yinghua Yu, Yizhen Wu, Alexander M. Szabo, Sen Wang, Shijia Yu, Qing Wang, Xu-Feng Huang
Teasaponin Improves Leptin Sensitivity In The Prefrontal Cortex Of Obese Mice, Yinghua Yu, Yizhen Wu, Alexander M. Szabo, Sen Wang, Shijia Yu, Qing Wang, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Scope Obesity impairs cognition, and the leptin-induced increase of brain-derived neurotrophic factor (BDNF) and neurogenesis. Tea consumption improves cognition and increases brain activation in the prefrontal cortex. Methods and results This study examined whether teasaponin, an active ingredient in tea, could improve memory and central leptin effects on neurogenesis in the prefrontal cortex of obese mice, and in vitro in cultured prefrontal cortical neurons. Teasaponin (10 mg/kg, intraperitoneal) for 21 days improved downstream leptin signaling (JAK2 and STAT3), and leptin's effect on BDNF, in the prefrontal cortex of high-fat diet (HFD) fed mice. Prefrontal cortical neurons were cultured with teasaponin …
Clusterin Seals The Ocular Surface Barrier In Mouse Dry Eye, Aditi Bauskar, Wendy J. Mack, Jerome Mauris, Pablo Argüeso, Martin Heur, Barbara A. Nagel, Grant R. Kolar, Martin E. Gleave, Takahiro Nakamura, Shigeru Kinoshita, Janet Moradian-Oldak, Noorjahan Panjwani, Stephen Pflugfelder, Mark R. Wilson, M Elizabeth Fini, Shinwu Jeong
Clusterin Seals The Ocular Surface Barrier In Mouse Dry Eye, Aditi Bauskar, Wendy J. Mack, Jerome Mauris, Pablo Argüeso, Martin Heur, Barbara A. Nagel, Grant R. Kolar, Martin E. Gleave, Takahiro Nakamura, Shigeru Kinoshita, Janet Moradian-Oldak, Noorjahan Panjwani, Stephen Pflugfelder, Mark R. Wilson, M Elizabeth Fini, Shinwu Jeong
Illawarra Health and Medical Research Institute
Dry eye is a common disorder caused by inadequate hydration of the ocular surface that results in disruption of barrier function. The homeostatic protein clusterin (CLU) is prominent at fluid-tissue interfaces throughout the body. CLU levels are reduced at the ocular surface in human inflammatory disorders that manifest as severe dry eye, as well as in a preclinical mouse model for desiccating stress that mimics dry eye. Using this mouse model, we show here that CLU prevents and ameliorates ocular surface barrier disruption by a remarkable sealing mechanism dependent on attainment of a critical all-or-none concentration. When the CLU level …
High Fat Diet-Induced Obesity Increases The Formation Of Colon Polyps Induced By Azoxymethane In Mice, Jiezhong Chen, Xu-Feng Huang
High Fat Diet-Induced Obesity Increases The Formation Of Colon Polyps Induced By Azoxymethane In Mice, Jiezhong Chen, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Background: Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet. Methods: In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice. Results: We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 times of polyps compared to the low fat fed mice (P<0.05). Although the DR mice tended to have more polyps than the low-fat diet fed mice, this was not statistically significant. The DIO mice could have an increased polyp formation due to obesity-related cancer risk factors and different gene expression from DR mice. Conclusions: DIO mice could be used as an appropriate model for studying obesity-associated colon cancer; however DR mice are not suitable because they don't show any significant weight gains to indicate obesity. Keywords: Obesity-associated colon cancer; high-fat diet; diet-induced obesity (DIO); diet resistant (DR); polyp; animal model
Challenges And Opportunities In Stigma For Psychiatrists: An Analysis Of Effective Coping Mechanisms To Reduce Stigma Associated With Mental Illnesses, M Rajasuriya, Sunera M. Fernando, U Gunawardhana
Challenges And Opportunities In Stigma For Psychiatrists: An Analysis Of Effective Coping Mechanisms To Reduce Stigma Associated With Mental Illnesses, M Rajasuriya, Sunera M. Fernando, U Gunawardhana
Illawarra Health and Medical Research Institute
Stigma leads to discrimination of the patient, family, health care providers and services. A workshop-type qualitative analysis was conducted with a panel of 40 psychiatrists to attempt to apply evidence based anti-stigma strategies to five given hypothetical case vignettes. Various combinations of protest, education and challenge strategies were selected as effective by the panel. The analysis also revealed a number of stigmatising beliefs related to psychiatry as a profession and behaviour of patients. Psychiatrists themselves need to change such beliefs as part of reducing stigma related to mental illnesses.
Bardoxolone Methyl Prevents Mesenteric Fat Deposition And Inflammation In High-Fat Diet Mice, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Hongqin Wang, Xu-Feng Huang
Bardoxolone Methyl Prevents Mesenteric Fat Deposition And Inflammation In High-Fat Diet Mice, Chi H. L Dinh, Alexander M. Szabo, Yinghua Yu, Danielle Camer, Hongqin Wang, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Mesenteric fat belongs to visceral fat. An increased deposition of mesenteric fat contributes to obesity associated complications such as type 2 diabetes and cardiovascular diseases. We have investigated the therapeutic effects of bardoxolone methyl (BARD) on mesenteric adipose tissue of mice fed a high-fat diet (HFD). Male C57BL/6J mice were administered oral BARD during HFD feeding (HFD/BARD), only fed a high-fat diet (HFD), or fed low-fat diet (LFD) for 21 weeks. Histology and immunohistochemistry were used to analyse mesenteric morphology and macrophages, while Western blot was used to assess the expression of inflammatory, oxidative stress, and energy expenditure proteins. Supplementation …
Bardoxolone Methyl Prevents The Development And Progression Of Cardiac And Renal Pathophysiologies In Mice Fed A High-Fat Diet, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Hongqin Wang, Chi H. L Dinh, Xu-Feng Huang
Bardoxolone Methyl Prevents The Development And Progression Of Cardiac And Renal Pathophysiologies In Mice Fed A High-Fat Diet, Danielle Camer, Yinghua Yu, Alexander M. Szabo, Hongqin Wang, Chi H. L Dinh, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Obesity caused by the consumption of a high-fat (HF) diet is a major risk factor for the development of associated complications, such as heart and kidney failure. A semi-synthetic triterpenoid, bardoxolone methyl (BM) was administrated to mice fed a HF diet for 21 weeks to determine if it would prevent the development of obesity-associated cardiac and renal pathophysiologies. Twelve week old male C57BL/6J mice were fed a lab chow (LC), HF (40% fat), or a HF diet supplemented with 10 mg/kg/day BM in drinking water. After 21 weeks, the left ventricles of hearts and cortex of kidneys of mice were …
Feasibility Of A Community-Based Interdisciplinary Lifestyle Intervention Trial On Weight Loss (The Healthtrack Study), Linda C. Tapsell, Rebecca L. Thorne, Marijka Batterham, Joanna Russell, Joseph Ciarrochi, Gregory E. Peoples, Maureen A. Lonergan, Allison Martin
Feasibility Of A Community-Based Interdisciplinary Lifestyle Intervention Trial On Weight Loss (The Healthtrack Study), Linda C. Tapsell, Rebecca L. Thorne, Marijka Batterham, Joanna Russell, Joseph Ciarrochi, Gregory E. Peoples, Maureen A. Lonergan, Allison Martin
Illawarra Health and Medical Research Institute
Aim The aim of this study was to test the feasibility and acceptability of a novel interdisciplinary intervention on weight loss. Methods A 3-month parallel, blinded, randomised controlled trial compared the effects of an interdisciplinary model of care (individualised interdisciplinary advice delivered through dietitians) with control (general advice on diet and physical activity delivered by primary care nurses). The primary outcome was assessing feasibility and acceptability of the protocol, with secondary outcomes including body weight, clinical, dietary, physical activity and psychological variables. Results Twenty-four participants were randomised and 21 included in the final analysis. The recruitment rate was 42% (24/57) …
Whole Transcriptome Of The Venom Gland From Urodacus Yaschenkoi Scorpion, Karen S. Luna Ramirez, Veronica Quintero-Hernandez, Víctor Rivelino Juarez-Gonzalez, Lourival D. Possani
Whole Transcriptome Of The Venom Gland From Urodacus Yaschenkoi Scorpion, Karen S. Luna Ramirez, Veronica Quintero-Hernandez, Víctor Rivelino Juarez-Gonzalez, Lourival D. Possani
Illawarra Health and Medical Research Institute
Australian scorpion venoms have been poorly studied, probably because they do not pose an evident threat to humans. In addition, the continent has other medically important venomous animals capable of causing serious health problems. Urodacus yaschenkoi belongs to the most widely distributed family of Australian scorpions (Urodacidae) and it is found all over the continent, making it a useful model system for studying venom composition and evolution. This communication reports the whole set of mRNA transcripts produced by the venom gland. U. yaschenkoi venom is as complex as its overseas counterparts. These transcripts certainly code for several components similar to …