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Chronic Betahistine Co-Treatment Reverses Olanzapine's Effects On Dopamine D2 But Not 5-Ht2a/2c Bindings In Rat Brains, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Chronic Betahistine Co-Treatment Reverses Olanzapine's Effects On Dopamine D2 But Not 5-Ht2a/2c Bindings In Rat Brains, Jiamei Lian, Xu-Feng Huang, Nagesh B. Pai, Chao Deng
Illawarra Health and Medical Research Institute
Olanzapine is widely prescribed for treating schizophrenia and other mental disorders, although it leads to severe body weight gain/obesity. Chronic co-treatment with betahistine has been found to significantly decrease olanzapine-induced weight gain; however, it is not clear whether this co-treatment affects the therapeutic effects of olanzapine. This study investigated the effects of chronic treatment of olanzapine and/or betahistine on the binding density of the serotonergic 5-HT2A (5-HT2AR) and 5-HT2C (5-HT2CR) receptors, 5-HT transporter (5-HTT), and dopaminergic D2 receptors (D2R) in the brain regions involved in antipsychotic efficacy, including the prefrontal cortex (PFC), cingulate cortex (Cg), nucleus accumbens (NAc), and caudate …
Differential Effects Of Short- And Long-Term Antipsychotic Treatment On The Expression Of Neuregulin-1 And Erbb4 Receptors In The Rat Brain, Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huang
Differential Effects Of Short- And Long-Term Antipsychotic Treatment On The Expression Of Neuregulin-1 And Erbb4 Receptors In The Rat Brain, Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic treatment has different effects on the expression of NRG1 and ErbB4 receptors. Female Sprague-Dawley rats were treated orally with either aripiprazole (0.75 mg/kg), haloperidol (0.1 mg/kg), olanzapine (0.5 mg/kg), or vehicle, 3 times/day for 1 or 12 weeks. Western blotting was performed to examine the expression of NRG1 isoforms (135 kDa, 70 kDa and 40 kDa) and ErbB4 receptors. Both 1-week haloperidol and olanzapine treatment increased NRG1-70 kDa …