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Alterations Of Mglur5 And Its Endogenous Regulators Norbin, Tamalin And Preso1 In Schizophrenia: Towards A Model Of Mglur5 Dysregulation, Natalie Matosin, Francesca Fernandez-Enright, Samantha J. Fung, Jeremy S. Lum, Martin Engel, Jessica L. Andrews, Xu-Feng Huang, Cynthia S. Weickert, Kelly A. Newell

Illawarra Health and Medical Research Institute

Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the molecular level in the postmortem schizophrenia brain. We assessed mGluR5 mRNA and protein levels in the dorsolateral prefrontal cortex (DLPFC) using a large cohort of schizophrenia and control subjects (n = 37/group), and additionally measured protein levels of recently discovered mGluR5 endogenous regulators, Norbin (neurochondrin), Tamalin (GRASP-1), and Preso1 (FRMPD4), which regulate mGluR5 localization, …