Medicine and Health Sciences Commons^™

In Silico Molecular Docking Analysis To Predict The Role Of Metal Ions In The Function Of Drug Targeted Proteins, S. M. A. Shahid, Qazi M. S. Jamal, J. M. Arif, Fahad M. Al-Khodairy, Anupam Dhasmana, Mohtashim Lohani

School of Medicine Publications

Metal ions are required for many critical functions in living systems. Scarcity of some metal ions can lead to disease. A characteristic of metals is that they easily lose electrons from the familiar elemental or metallic state to form positively charged ions which tend to be soluble in biological fluids. Role of zinc, calcium and copper ions in the catalytic mechanism of drug targeted proteins such as Farnesyltransferase, Neuraminidase and Thioredoxin are analyzed using molecular docking, respectively. The docking results show that inhibitors have low Binding, docking and internal energies with proteins in the presence of Zn, Ca and Cu …

Occupational Deprivation Or Occupational Adaptation Of Mexican Americans On Renal Dialysis, Shirley A. Wells

Occupational Therapy Faculty Publications

The aim of this study was to explore the occupational changes and perceptions experienced by Mexican Americans with end-stage renal disease (ESRD) and their families living with dialysis. In-depth interviews were conducted with 17 Mexican Americans with ESRD and 17 family members. The participants with ESRD described altered or lost activity patterns, capacities and freedoms. With a heightened awareness of death, the family members made altered occupational choices, which were consistent with their cultural values. Changes in the physical body, adhering to the dialysis regimen and environmental restrictions created barriers to occupational participation. These findings suggest that living with dialysis …

Anticancer Activity Of Cissus Quadrangularis: An In Vitro 2d Model Based Study, Saba Sheikh, Anupam Dhasmana, Sahabjada Siddiqui, Ejazul Haque

School of Medicine Publications

Cissus quadrangularis (CQ) is a perennial rambling shrub of the grape family commonly known as “Hadjora” (in Hindi) probably native to India or Sri Lanka. It is one of the valuable medicines in the Indian Traditional Systems of Medicine because of the presence of several bioactive compounds. However, in the present study we have checked its anticancer activity along with its safety profile on normal skin cells. Apart from this we have generated the spheroid HeLa culture in vitro model for analyzing the CQ extract response on the growth of HeLa tumoroid. From the present findings we have observed that …

Sequencing Strategies And Characterization Of 721 Vervet Monkey Genomes For Future Genetic Analyses Of Medically Relevant Traits, Yu S. Huang, Vasily Ramensky, Susan K. Service, Anna J. Jasinska, Yoon Jung, Oi-Wa Choi, Rita M. Cantor, Thomas D. Dyer, John Blangero

School of Medicine Publications

Background

We report here the first genome-wide high-resolution polymorphism resource for non-human primate (NHP) association and linkage studies, constructed for the Caribbean-origin vervet monkey, or African green monkey (Chlorocebus aethiops sabaeus), one of the most widely used NHPs in biomedical research. We generated this resource by whole genome sequencing (WGS) of monkeys from the Vervet Research Colony (VRC), an NIH-supported research resource for which extensive phenotypic data are available.

Results

We identified genome-wide single nucleotide polymorphisms (SNPs) by WGS of 721 members of an extended pedigree from the VRC. From high-depth WGS data we identified more than 4 …

Gratitude And Kindness: Just What The Doctor Ordered, Kathleen E. Glynn

Theses and Dissertations - UTB/UTPA

In recent years, the positive psychology movement has grown and researchers have become interested in studying overall well-being and the predictors of happiness. Previous studies have indicated that biology plays a role in determining an individual’s happiness, but this is not the only contributing factor. Thought patterns and behaviors play a key role in one’s overall wellbeing. The current study evaluated the relationship that a practice of gratitude and performing acts of kindness had on participants’ scores on happiness, gratitude and social support scales. It was predicted that individuals who performed acts of kindness and practice gratitude for one week …

Non-Communicable Diseases And Preventive Health Behaviors: A Comparison Of Hispanics Nationally And Those Living Along The Us-Mexico Border, Belinda M. Reininger, Jing Wang, Susan P. Fisher-Hoch, Alycia Boutte, Kristina Vatcheva, Joseph B. Mccormick

School of Mathematical & Statistical Sciences Faculty Publications

Background: Non-communicable diseases (NCDs) are rising among US Hispanics, but few studies have examined the preventive health behaviors for these NCDs among Hispanics. This study compared the preventive health behaviors of smoke-free living, physical activity, fruit and vegetable consumption, and avoidance of heavy alcohol use in Hispanics in the United States and Hispanics living along the US-Mexico border.

Methods: Two weighted data sets with information on Hispanic populations were analyzed: 1) the national Behavioral Risk Factor Surveillance Survey (n = 29,942) from 2009; and 2) the Cameron County Hispanic Cohort (n = 1,439) recruited from the US-Mexico border between 2008–2011. …

Diagnoses, Intervention Strategies, And Rates Of Functional Improvement In Integrated Behavioral Health Care Patients, Ana J. Bridges, Samantha J. Gregus, Juventino Hernandez Rodriguez, Arthur R. Andrews Iii, Bianca T. Villalobos, Freddie A. Pastrana, Timothy A. Cavell

Psychological Science Faculty Publications

Objective—Compared with more traditional mental health care, integrated behavioral health care (IBHC) offers greater access to services and earlier identification and intervention of behavioral and mental health difficulties. The current study examined demographic, diagnostic, and intervention factors that predict positive changes for IBHC patients.

Method—Participants were 1,150 consecutive patients (mean age = 30.10 years, 66.6% female, 60.1% Hispanic, 47.9% uninsured) seen for IBHC services at 2 primary care clinics over a 34-month period. Patients presented with depressive (23.2%), anxiety (18.6%), adjustment (11.3%), and childhood externalizing (7.6%) disorders, with 25.7% of patients receiving no diagnosis.

Results—The most commonly …

Does Maternal Asthma Contribute To Racial/Ethnic Disparities In Obstetric And Neonatal Complications?, Katrina F. Flores, Candace Robledo, Beom Seuk Hwang, Kira Leishear, Katherine Grantz, Pauline Mendola

School of Medicine Publications

Purpose

Examine whether maternal asthma contributes to racial/ethnic differences in obstetric and neonatal complications.

Methods

Data on White (n=110,603), Black (n=50,284) and Hispanic (n=38,831) singleton deliveries came from the Consortium on Safe Labor. Multi-level logistic regression models, with an interaction term for asthma and race/ethnicity, estimated within-group adjusted odds ratios (aOR) for gestational diabetes, gestational hypertension, preeclampsia, placental abruption, premature rupture of membranes, preterm delivery, maternal hemorrhage, NICU admissions, small for gestational age (SGA), apnea, respiratory distress syndrome, transient tachypnea of the newborn, anemia and hyperbilirubinemia after adjustment for clinical and demographic confounders. Non-asthmatics of the same racial/ethnic group were …

Intramembranous Bone Healing Process Subsequent To Tooth Extraction In Mice: Micro-Computed Tomography, Histomorphometric And Molecular Characterization, Andreia Espindola Vieira, Carlos Eduardo Repeke, Samuel De Barros Ferreira Junior, Priscila Maria Colavite, Cláudia Cristina Biguetti, Rodrigo Cardoso Oliveira, Gerson Francisco Assis, Rumio Taga, Ana Paula Favaro Trombone, Gustavo P. Garlet

School of Podiatric Medicine Publications

Bone tissue has a significant potential for healing, which involves a significant the interplay between bone and immune cells. While fracture healing represents a useful model to investigate endochondral bone healing, intramembranous bone healing models are yet to be developed and characterized. In this study, a micro-computed tomography, histomorphometric and molecular (RealTimePCRarray) characterization of post tooth-extraction alveolar bone healing was performed on C57Bl/6 WT mice. After the initial clot dominance (0 h), the development of a provisional immature granulation tissue is evident (7 d), characterized by marked cell proliferation, angiogenesis and inflammatory cells infiltration; associated with peaks of growth factors …

Multiblock Discriminant Analysis For Integrative Genomic Study, Mingon Kang, Dong-Chul Kim, Chunyu Liu, Jean Gao

Computer Science Faculty Publications

Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifications and transcriptional regulations have to be considered to fully exploit the knowledge of the complex human diseases as well as the genomic variants. We call the collection of the multiple heterogeneous data “multiblock data.” In this paper, we propose a novel Multiblock Discriminant Analysis (MultiDA) method that provides a new integrative genomic model for the multiblock analysis …

Plumbagin Inhibits Prostate Carcinogenesis In Intact And Castrated Pten Knockout Mice Via Targeting Pkcε, Stat3, And Epithelial-To-Mesenchymal Transition Markers, Bilal B. Hafeez, Joseph W. Fischer, Ashok Singh, Weixiong Zhong, Ala Mustafa, Louise Meske, Mohammad Ozair Sheikhani, Ajit K. Verma

School of Medicine Publications

Prostate cancer continues to remain the most common cancer and the second leading cause of cancer-related deaths in American males. The Pten deletions and/or mutations are frequently observed in both primary prostate cancers and metastatic prostate tissue samples. Pten deletion in prostate epithelium in mice results in prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma. The Pten conditional knockout mice [(Pten-loxp/loxp:PB-Cre4(+)) (Pten-KO)] provide a unique preclinical model to evaluate agents for efficacy for both the prevention and treatment of prostate cancer. We present here for the first time that dietary plumbagin, a medicinal plant-derived naphthoquinone (200 or 500 …

Analogs Of Ldl Receptor Ligand Motifs In Dengue Envelope And Capsid Proteins As Potential Codes For Cell Entry, Juan Guevara Jr., Jamie Romo Jr., Troy Mcwhorter, Natalia Valentinova Guevara

Physics & Astronomy Faculty Publications

It is established that cell entry of low density lipoprotein particles (LLPs) containing Apo B100 and Apo E is mediated by receptors and GAGs. Receptor ligand motifs, XBBBXXBX, XBBXBX, and ΨBΨXB, and mono- and bipartite NLS sequences are abundant in Apo E and Apo B100 as well as in envelope and capsid proteins of Dengue viruses 1-4 (DENV1-4). Synthetic, fluorescence-labeled peptides of sequences in DENV2 envelope protein, and DENV3 capsid that include these motifs were used to conduct a qualitative assessment of cell binding and entry capacity using …

Theory Of Mind And Inhibitory Processing Among Bilingual Mexican American Young Children, Sarah E. Stegall

Theses and Dissertations - UTB/UTPA

Bilingual children have been found to demonstrate advantages on tasks dependent in part or in whole on inhibitory processing compared to their language dominant and/or monolingual peers. This study examines relations among performance on theory of mind (ToM), inhibitory processing (FF), and performance on an ambiguous-figures (AF) tasks among monolingual and bilingual children. Participants included 135 Hispanic children ages 4.5 to 8 from predominately low-income families. Results revealed a relationship between FF and AF performance with ToM performance and found no differences in performance between monolingual, language-dominant, and balanced-bilingual children.

Urinary Phthalate Metabolite Concentrations And Blood Glucose Levels During Pregnancy, Candace A. Robledo, Jennifer D. Peck, Julie A. Stoner, Antonia M. Calafat, Hélène Carabin, Linda Cowan, Jean R. Goodman

School of Medicine Publications

Purpose: To examine associations between phthalate metabolite urinary concentrations during early pregnancy and blood glucose levels obtained at the time of screening for gestational diabetes mellitus (GDM).

Methods: Upon initiation of prenatal care, women with a mean gestational age of 12.8 weeks were recruited for a study of environmental chemical exposures (n = 110) and provided a spot urinary specimen. Blood glucose concentrations (mg/dl) were obtained from the electronic medical record for those patients who did not experience a pregnancy loss and did not transfer care to another facility prior to glucose screening (n = 72). Urinary concentrations of nine …

Physical Activity As A Behavioral Treatment In Shr Rats: An Animal Model Of Adhd, Jessica A. Martinez

Theses and Dissertations - UTB/UTPA

Attention Deficit Hyperactivity Disorder (ADHD) is a commonly diagnosed psychiatric disorder defined by inattentive, hyperactive, and/or impulsive behaviors, typically treated with medications. Physical activity has been investigated as a treatment for children with ADHD and provides the ability for the individual to use it as a lifetime treatment option. Animal models can control for many of the issues posed by using human subjects. This study investigates whether physical activity in the form of wheel running reduces hyperactivity in an animal model of ADHD, the Spontaneously Hypertensive Rats (SHR), compared to its control, Wistar Kyoto rat (WKY). Using an ABAB design, …

Correlation Of Amyloid Beta And Spatial Learning And Memory Deficits On A Thy1-App Mouse Model For Alzheimer's Disease, Amber Lynn Betz

Theses and Dissertations - UTB/UTPA

The McGill-Thy1 APP mouse is a triple transgenic model of Alzheimer disease, which has the mutant amyloid precursor protein to synergistically over-produce amyloid beta plaques. These mice exhibit visuo-spatial learning impairment at 3 months of age and memory impairment at 10-13 months of age in the Morris water maze. To extend these findings mice at 3, 5, and 7 months of age were tested on the Barnes maze. Non-Transgenic and Transgenic mice showed improvement during acquisition. However, 3 month and 5 month McGill Thy1- APP mice showed impaired acquisition learning while 7 month showed a learning and memory deficit compared …

Characterization Of Continuously Oscillating Neurons (Cons) Of The Medial Septum Of Rats, Nadia Noel Carreon

Theses and Dissertations - UTB/UTPA

Theta oscillation is the largest extracellular synchronous signal that can be recorded from the mammalian brain. It is known to influence information retention in the hippocampus, which plays a key role in declarative memory, recognition memory, working memory, and spatial memory. The theta oscillation field frequency is between 3 and 12 Hz and is present during exploratory behavior and sleep in rodents. Theta rhythm in the hippocampus is postulated to be produced by the rhythmical activity of pacemaking cells in the medial septumvertical limb of the diagonal band of Broca (MS-vDBB). Previous work in our laboratory demonstrated the existence of …

Personality Of Personal Trainers: A Study Of Perception And Preference, Andy L. Chasse

Theses and Dissertations - UTB/UTPA

This study used a personality questionnaire to address the lack of literature concerning how the general population perceives personal trainers and what qualities they desire in them. The Big Five Inventory (BFI) with two demographic items (gender and previous experience) was administered to 130 undergraduate students at The University of Texas-Pan American to determine perceived and desired characteristics. High extraversion was most commonly associated with personal trainers. High extraversion, agreeableness, and conscientiousness, as well as low neuroticism, were most desired in personal trainers. Significant differences were seen between perceived and desired means across all dimensions. Additionally, gender produced main effects …

Secondary Complications Among Person's With Spinal Cord Injury And Best Practices For Life Care Planners, Noel A. Ysasi Jr.

Theses and Dissertations - UTB/UTPA

The current study was intended to deliver life care planners with a guide as to whether or not secondary complications (SCs) should be included within the LCP, while obtaining the professional opinion of physiatrists as to the incidence rate of SCs. Each research question was designed to determine whether differences exist between life care planners (LCPs) and physiatrists in their knowledge regarding SCs while comparing their responses with empirical research. In addition, it was determined to investigate whether costs should be included in a LCP based on the reports given from certified and non-certified LCPs; even though it meets the …

Heritability Of Fractional Anisotropy In Human White Matter: A Comparison Of Human Connectome Project And Enigma-Dti Data, Peter Kochunov, Neda Jahanshad, Daniel Marcus, Anderson M. Winkler, Laura Almasy, Joanne E. Curran, Ravi Duggirala, Peter T. Fox, Rene L. Olvera, John Blangero

School of Medicine Publications

The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA …

Common Genetic Variants Influence Human Subcortical Brain Structures, Derrek P. Hibar, Jason L. Stein, Miguel E. Renteria, Alejandro Arias-Vasquez, John Blangero, Anderson M. Winkler, Joanne E. Curran, Thomas D. Dyer, Peter T. Fox, Ravi Duggirala

School of Medicine Publications

The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence …

Perception Of Cultural Competence In Nurse Practitioners, Carolina G. Huerta, Peter L. Kranz, Janice A. Maville

School of Nursing Faculty Publications

Purpose: Nurse practitioners are at the forefront in providing quality care to diverse populations and must become cognizant of the importance of cultural competence in caring for diverse patients. The purpose of this study was to examine perceptions of cultural competence and its integration in the delivery of health care in nurse practitioners practicing in a Mexican-American region of South Texas.

Methodology: A descriptive, qualitative design using grounded theory and purposive sampling was utilized for this study. Sixteen nurse practitioners, fourteen females and two males, participated in the study. Qualitative data collection was elicited through individual interviews and …

Influence Of Depression, Anxiety And Stress On Cognitive Performance In Community-Dwelling Older Adults Living In Rural Ecuador: Results Of The Atahualpa Project, Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Gladys Maestre, Hannah Gardener, Mauricio Zambrano, Clinton B. Wright

School of Medicine Publications

Aim:

To assess the relationship between cognitive status and self-reported symptoms of depression, anxiety and stress of older adults living in an underserved rural South American population.

Methods:

Community-dwelling Atahualpa residents aged ≥60 years were identified during a door-to-door census, and evaluated with the Depression Anxiety Stress Scale-21 (DASS-21) and the Montreal Cognitive Assessment (MoCA). We explored whether positivity in each of the DASS-21 axes was related to total and domain-specific MoCA performance after adjustment for age, sex and education.

Results:

A total of 280 persons (59% women; mean age, mean age 70 ± 8 years) were included. Based on …

Transcriptomic Identification Of Adh1b As A Novel Candidate Gene For Obesity And Insulin Resistance In Human Adipose Tissue In Mexican Americans From The Veterans Administration Genetic Epidemiology Study (Vages), Deidre A. Winnier, Marcel Fourcaudot, Luke Norton, Muhammad A. Abdul-Ghani, Shirley L. Hu, Thomas D. Dyer, Joanne E. Curran, John Blangero, Ravi Duggirala, Harald H. H. Goring

School of Medicine Publications

Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the risk factors obesity and insulin resistance. The goal of this study was to perform whole genome gene expression profiling in adipose tissue to detect common patterns of gene regulation associated with obesity and insulin resistance. We used phenotypic and genotypic data from 308 Mexican American participants from the Veterans Administration Genetic Epidemiology Study (VAGES). Basal fasting RNA was extracted from adipose tissue biopsies from a subset of 75 unrelated individuals, and gene expression data …

Interaction Pattern For The Complex Of B-Dnafullerene Compounds With A Set Of Known Replication Proteins Using Docking Study, Sumbul Firdaus, Anupam Dhasmana, Vandana Srivastava, Tasneem Bano, Afreen Fatima, Qazi Mohammad Sajid Jamal, Roshan Jahan, Gulshan Wadhwad, Mohtashim Lohani

School of Medicine Publications

Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications which has opened wide venues for possible human exposure to various fullerene types. Therefore, in depth knowledge of how fullerene may interfere with various cellular processes becomes quite imperative. The present study was designed to investigate how the presence of fullerene affect the binding of DNA with different enzymes involved in replication process. Different fullerenes were first docked with DNA and then binding scores of different enzymes was analyzed with fullerene docked DNA. C30, C40 & C50 once docked with DNA, reduced the binding score of …

Non-Crossover Gene Conversions Show Strong Gc Bias And Unexpected Clustering In Humans, Amy L. Williams, Giulio Genovese, Thomas D. Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Joanne E. Curran, Ravi Duggirala, John Blangero

School of Medicine Publications

Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data from 98 meioses, we identified 103 sites affected by NCO, of which 50/52 were confirmed in sequence data. Overlap with double strand break (DSB) hotspots indicates that most of the events are likely of meiotic origin. We estimate that a site is involved in a NCO at a rate of 5.9×10-6/bp/generation, consistent with sperm-typing studies, and infer that tract lengths span at least …

Evaluation Of Neurotrophic Tyrosine Receptor Kinase 2 (Ntrk2) As A Positional Candidate Gene For Variation In Estimated Glomerular Filtration Rate (Egfr) In Mexican American Participants Of San Antonio Family Heart Study, Farook Thameem, V. Saroja Voruganti, John Blangero, Anthony G. Comuzzie, Hanna E. Abboud

School of Medicine Publications

Background

The estimated glomerular filtration rate (eGFR) is a well-known measure of kidney function and is commonly used for the diagnosis and management of patients with chronic kidney disease. The inter-individual variation in eGFR has significant genetic component. However, the identification of underlying genetic susceptibility variants has been challenging. In an attempt to identify and characterize susceptibility genetic variant(s) we previously identified the strongest evidence for linkage of eGFR occurring on chromosome 9q21 in the Mexican American participants of San Antonio Family Heart Study (SAFHS). The objective of the present study was to examine whether the common genetic variants in …

Environmental Justice And Community-Based Participatory Research In Texas Borderland Colonias, Adelita G. Cantu, Margaret A. Graham, Ann V. Millard, Isidore Flores, Meaghan K. Mugleston, Iris Y. Reyes, Ester C. Carbajal

Anthropology Faculty Publications

Objective

An innovative academic-community partnership studied daily decisions in communities of mostly Spanish-speaking, low-income residents of colonias in Hidalgo County, TX, about risk of exposure to fish contaminated by PCBs at an Environment Protection Agency (EPA) Superfund site.

Design and Sample

The team used focus group interviews with colonia residents and content analysis to assess knowledge of risk related to the Superfund site, the Donna Reservoir and Canal System.

Results

(1) many lacked knowledge of the Superfund site contamination; (2) a few participants fished at the lake, knew people who did so, and consumed the catch, but most participants feared …

Association Of Insurance Status With Health Outcomes Following Traumatic Injury: Statewide Multicenter Analysis, Vatsal Chikani, Maureen Brophy, Anne Vossbrink, Khaleel Hussaini, Christopher Salvino, Jeffrey Skubic, Rogelio Martinez

School of Medicine Publications

Introduction: Recognizing disparities in definitive care for traumatic injuries created by insurance status may help reduce the higher risk of trauma-related mortality in this population. Our objective was to understand the relationship between patients' insurance status and trauma outcomes.

Methods: We collected data on all patients involved in traumatic injury from eight Level I and 15 Level IV trauma centers, and four non-designated hospitals through Arizona State Trauma Registry between January 1, 2008 and December 31, 2011. Of 109,497 records queried, we excluded 29,062 (26.5%) due to missing data on primary payer, sex, race, zip code of residence, injury severity …

Determinants Of Adherence To Living On Dialysis For Mexican Americans, Shirley A. Wells

Occupational Therapy Faculty Publications

This study explores perceptions that affect adherence behaviors among Mexican Americans living with dialysis. In-depth narrative interviews were conducted with 15 Mexican Americans with end-stage renal disease (ESRD) living on dialysis, 15 family members, and 6 health care personnel who provided care to them. Four themes emerged: (a) positive influences to adherence, (b) obstacles to adherence, (c) daily activity losses, and (d) fears about living with dialysis. From the findings, the perceptions given for non-adherence with the dialysis regimen ranged from denial of the condition, lack of pre-education, to cultural factors. Those given for adherence included prolonged life, family, and …