Medicine and Health Sciences Commons^™

The Perceptions Of Stereotypes Of People Who Stutter In Hispanic University Students, Ruth Crutchfield, Xiaohui Wang

Communication Sciences & Disorders Faculty Publications and Presentations

The purpose of this study was to obtain data regarding how stutterers are perceived in Hispanic populations in order to identify whether stereotypes exist across cultures. This investigation was completed in order to repeat and amplify previously completed research projects that have used the Bipolar Semantic Scale and have revealed correlations between the presence of stuttering and negative feelings and reactions. University students were surveyed utilizing the Bipolar Semantic Scale which provides information regarding how stutterers are perceived. When comparing the findings of this project that deals primarily with Hispanic population to the previous studies that were completed on non-Hispanic …

Thsd1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation In The Pathogenesis Of Intracranial Aneurysm And Subarachnoid Hemorrhage, Teresa Santiago-Sim, Xiaoqian Fang, Morgan L. Hennessy, Stephen V. Nalbach, Steven R. Depalma, Ming Sum Lee, Steven C. Greenway, Barbara Mcdonough, Georgene W. Hergenroeder

School of Medicine Publications and Presentations

Background and Purpose

A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage (SAH). This study seeks to define a specific gene whose mutation leads to disease.

Methods

More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was performed on a large family, revealing a segregating THSD1 mutation. THSD1 was sequenced in other probands and controls. Thsd1 loss-of-function studies in zebrafish and mice were used for in vivo analyses, and functional studies performed using an in vitro endothelial cell model.

Results

A nonsense mutation in THSD1 (thrombospondin type-1 domain-containing …

Genetic Variants In Kcnj11, Tcf7l2 And Hnf4a Are Associated With Type 2 Diabetes, Bmi And Dyslipidemia In Families Of Northeastern Mexico: A Pilot Study, Hugo Leonid Gallardo-Blanco, Jesus Zacarias Villarreal-Perez, Ricardo Martin Cerda-Flores, Andres Figueroa

Computer Science Faculty Publications and Presentations

The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low‑density lipoprotein (LDL), very LDL (VLDL), high‑density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 …

False Positives On Neuropsychological Measures Of Effort Among Bilingual Neurologically Intact Mexican Americans, Arnoldo Amador Jr.

Theses and Dissertations

The present study examines the performance of bilingual Mexican Americans on neuropsychological measures of effort in language and visual-perceptual formats. Optimal/suboptimal effort cutoff scores derived from monolingual English Speakers were used to test participants divided by language of administration and bilingual groupings based upon Spanish-English difference scores on the Woodcock Munoz Language Survey-Revised Picture Vocabulary subtest. Participants produced more false positives (misidentification of suboptimal effort) on the Reliable Digit Span, a language formatted measure, and similar rates of false positives on visual-perceptual effort measures: Test of Memory Malingering and the Dot Counting Test as compared to established rates using monolingual …

Evaluating Practicum Student's' Therapeutic Effectiveness Using Solution Focused Brief Therapy With Mexican American Clients: A Single Case Design, Krystle L. Ortega

Theses and Dissertations

The purpose of this study is to examine the effectiveness of a practicum counseling experience on client therapeutic outcomes using Solution Focused Brief Therapy with Mexican American clients. We implemented a small series (N = 3) single-case research design to assess the effectiveness of SFBT for increasing hope and decreasing clinical symptoms. Clients’ clinical areas of functioning and clinically significant change will be evaluated using the Outcome Questionnaire -45.2 whereas hope will be assessed using The Trait Hope Scale. The results of this study will ultimately help researchers in counseling education, counselors, supervisors, and students by providing an outcome …

A Principal Component Meta-Analysis On Multiple Anthropometric Traits Identifies Novel Loci For Body Shape, Janina S. Ried, Janina Jeff M., Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jennifer L. Bragg-Gresham, Jennifer E. Huffman, Tarunveer S. Ahluwalia, Gemma Cadby, Niina Eklund, John Blangero

School of Medicine Publications and Presentations

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. …

Multidimensional Heritability Analysis Of Neuroanatomical Shape, Tian Ge, Martin Reuter, Anderson M. Winkler, Avram J. Holmes, Phil H. Lee, Lee S. Tirrell, Joshua L. Roffman, Randy L. Buckner, Jordan W. Smoller, Mert R. Sabuncu

School of Medicine Publications and Presentations

In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining the genetic underpinnings of brain features, behaviour and disease. For example, shape measurements derived from brain MRI scans are multidimensional geometric descriptions of brain structure and provide an alternate class of phenotypes that remains largely unexplored in genetic studies. Here we extend the concept of heritability to multidimensional traits, and present the first comprehensive analysis of the heritability of neuroanatomical shape measurements across an ensemble of brain structures based on genome-wide SNP and MRI data from 1,320 unrelated, young and healthy individuals. …

Cucurbitacin D Exhibits Potent Anticancer Activity In Cervical Cancer, Mohammed Sikander, Bilal B. Hafeez, Shabnam Malik, Abdulrhman Alsayari, Fathi T. Halaweish, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications and Presentations

In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein. Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in …

Lack Of Association Between Slc30a8 Variants And Type 2 Diabetes In Mexican American Families, Hemant Kulkarni, Manju Mamtani, Juan M. Peralta, Vincent P. Diego, Thomas D. Dyer, Harald H. H. Goring, Laura Almasy, Sarah Williams-Blangero, Michael C. Mahaney, Ravindranath Duggirala, Joanne E. Curran, John Blangero

School of Medicine Publications and Presentations

SLC30A8 encodes zinc transporter 8 which is involved in packaging and release of insulin. Evidence for the association of SLC30A8 variants with type 2 diabetes (T2D) is inconclusive. We interrogated single nucleotide polymorphisms (SNPs) around SLC30A8 for association with T2D in high-risk, pedigreed individuals from extended Mexican American families. This study of 118 SNPs within 50 kb of the SLC30A8 locus tested the association with eight T2D-related traits at four levels: (i) each SNP using measured genotype approach (MGA); (ii) interaction of SNPs with age and sex; (iii) combinations of SNPs using Bayesian Quantitative Trait Nucleotide (BQTN) analyses; and (iv) …

Decisions, Decisions: Factors That Influence A Patient's Medical Tourism Choices, Louis K. Falk, Thomas J. Prinsen

Communication Faculty Publications and Presentations

In the digital age, the amount of information and sources concerning Medical Tourism is overwhelming. Knowledge is power in an era of healthcare uncertainty. As health care options have grown in global proportions, it has become more difficult for potential patients to locate the material necessary to make informed decisions or to even know which factors to consider during their information search. Individual financial circumstances vary greatly. This paper suggests how medical tourism makes financial sense for many patients and payers. Proximity and culture play roles in that medical tourists may prefer locations that are not too far from home. …

Faster Permutation Inference In Brain Imaging, Anderson M. Winkler, Gerard R. Ridgway, Gwenaëlle Douaud, Thomas E. Nichols, Stephen M. Smith

School of Medicine Publications and Presentations

Permutation tests are increasingly being used as a reliable method for inference in neuroimaging analysis. However, they are computationally intensive. For small, non-imaging datasets, recomputing a model thousands of times is seldom a problem, but for large, complex models this can be prohibitively slow, even with the availability of inexpensive computing power. Here we exploit properties of statistics used with the general linear model (GLM) and their distributions to obtain accelerations irrespective of generic software or hardware improvements. We compare the following approaches: (i) performing a small number of permutations; (ii) estimating the p-value as a parameter of a negative …

Constrained Multivariate Association With Longitudinal Phenotypes, Phillip E. Melton, Juan M. Peralta, Laura Almasy

School of Medicine Publications and Presentations

The incorporation of longitudinal data into genetic epidemiological studies has the potential to provide valuable information regarding the effect of time on complex disease etiology. Yet, the majority of research focuses on variables collected from a single time point. This aim of this study was to test for main effects on a quantitative trait across time points using a constrained maximum-likelihood measured genotype approach. This method simultaneously accounts for all repeat measurements of a phenotype in families. We applied this method to systolic blood pressure (SBP) measurements from three time points using the Genetic Analysis Workshop 19 (GAW19) whole-genome sequence …

Finding Potential Cis-Regulatory Loci Using Allele-Specific Chromatin Accessibility As Weights In A Kernel-Based Variance Component Test, Juan M. Peralta, Marcio A. Almeida, Lawrence J. Abraham, Eric K. Moses, John Blangero

School of Medicine Publications and Presentations

We present a novel approach to detect potential cis-acting regulatory loci that combines the functional potential, an empirical DNase-seq based estimate of the allele-specificity of DNase-I hypersensitivity sites, with kernel-based variance component association analyses against expression phenotypes. To test our method we used public ENCODE whole genome DNase-I sequencing data, from a single sample, to estimate the functional potentials of the subset of 10,552 noncoding heterozygous single-nucleotide polymorphisms (SNPs) that were also present in the Genetic Analysis Workshop 19 (GAW19) family-based data set. We then built two covariance kernels, one nonweighted and one weighted by the functional potentials, and …

Structural Equation Model Of Disability In Low Back Pain, Brittany L. Melton, Murad Moqbel, Saddam Kanaan, Neena K. Sharma

Information Systems Faculty Publications and Presentations

Study Design—The effects of participant characteristics along with descriptions of pain, and psychological involvement, such as fear avoidance, were assessed using structural equation modeling to identify relationships between these factors and disability as a result of low back pain.

Objective—The aim of this study was to evaluate the relationship between factors related to pain description, participants’ characteristics, psychological involvement and disability through structural equation modeling.

Summary of Background Data—Low back pain is a complex multifactorial condition that can lead to disability. Understanding which factors contribute to disability and how those factors interact is important for predicting and …

Lack Of Interaction Between Erbb2 And Insulin Receptor Substrate Signaling In Breast Cancer, Sarah M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert Dearth, Adrian V. Lee

Biology Faculty Publications and Presentations

Background: ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signaling. For example, ErbB2 inhibitors can block IGF-induced signaling while, conversely, IGF1R inhibitors can inhibit ErbB2 action. ErbB receptors can bind and phosphorylate insulin receptor substrates (IRS) and this may be critical for ErbBmediated anti-estrogen resistance in breast cancer. Herein, we examined crosstalk between ErbB2 and IRSs using cancer cell lines and transgenic mouse models.

Methods: MMTV-ErbB2 and MMTV-IRS2 transgenic mice were crossed to create hemizygous MMTV-ErbB2/MMTVIRS2 bigenic mice. Signaling crosstalk …

Novel Genetic Loci Underlying Human Intracranial Volume Identified Through Genome-Wide Association, Hieab Hh Adams, Derrek P. Hibar, Vincent Chouraki, Jason L. Stein, Paul A. Nyquist, Miguel E. Rentería, Stella Trompet, John Blangero, Joanne E. Curran, Ravi Duggirala, Harald Hh Goring

School of Medicine Publications and Presentations

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci …

Genetic Analysis Workshop 19: Methods And Strategies For Analyzing Human Sequence And Gene Expression Data In Extended Families And Unrelated Individuals, Corinne D. Engelman, Celia M T Greenwood, Julia N. Bailey, Rita M. Cantor, Jack W. Kent Jr, Inke R. König, Justo Lorenzo Bermejo, Phillip E. Melton, Stephanie A. Santorico, Laura Almasy

School of Medicine Publications and Presentations

Genetic Analysis Workshop 19 provided a platform for developing and evaluating statistical methods to analyze whole-genome sequence and gene expression data from a pedigree-based sample, as well as whole-exome sequence data from a large cohort of unrelated individuals. In this article we present an overview of the data sets, the GAW experience, and summaries of the contributions arranged into nine methodological themes.

Health Care, The Arab Spring And After, Sonia Alianak

Political Science Faculty Publications and Presentations

This study analyzes the effect of health care on Middle Eastern countries on the eve of and soon after the Arab Spring. It posits that countries that were most stable were the healthiest ones; countries which underwent revolutions were the unhealthiest ones; whereas countries that settled for reforms were moderate in health. It presents a hypothesis, the Inverted Funnel Model Hypothesis, that states that as the level of health care of a country rises so does its stability, which in turn leads to better health care as if down an inverted funnel to hypothetical maximums of both health care and …

N-Acetylcysteine In Combination With Igf-1 Enhances Neuroprotection Against Proteasome Dysfunction-Induced Neurotoxicity In Sh-Sy5y Cells, Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

School of Medicine Publications and Presentations

Ubiquitin proteasome system (UPS) dysfunction has been implicated in the development of many neuronal disorders, including Parkinson’s disease (PD). Previous studies focused on individual neuroprotective agents and their respective abilities to prevent neurotoxicity following a variety of toxic insults. However, the effects of the antioxidant N-acetylcysteine (NAC) on proteasome impairment-induced apoptosis have not been well characterized in human neuronal cells. The aim of this study was to determine whether cotreatment of NAC and insulin-like growth factor-1 (IGF-1) efficiently protected against proteasome inhibitor-induced cytotoxicity in SH-SY5Y cells. Our results demonstrate that the proteasome inhibitor, MG132, initiates poly(ADP-ribose) polymerase (PARP) cleavage, caspase …

Systematically Characterizing Dysfunctional Long Intergenic Noncoding Rnas In Multiple Brain Regions Of Major Psychosis, Jing Hu, Jinyuan Xu, Lin Pang, Hongying Zhao, Feng Li, Yulan Deng, Ling Liu, Yujia Lan, Xinxin Zhang, Chun Xu

Health & Biomedical Sciences Faculty Publications and Presentations

Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed “major psychosis”. Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their molecular mechanism in pathogenesis of SZ and BD. Here, we performed RNA sequencing on 82 postmortem brain tissues from three brain regions (orbitofrontal cortex (BA11), anterior cingulate cortex (BA24) and dorsolateral prefrontal cortex (BA9)) of patients with SZ and BD and control subjects, generating over one billion reads. We characterized lincRNA transcriptome in the three brain regions and identified 20 …

Distribution Of Six Polymorphisms In Two Communities With A Historical High Incidence Of Diabetes And Obesity In Yucatan, Mexico, Miriam Givisay Domínguez-Cruz, María De Lourdes Muñoz, Armando Totomoch-Serra, María Guadalupe García-Escalante, Nina Valadez-González, Doris Pinto-Escalante, Alvaro Diaz-Badillo

School of Medicine Publications and Presentations

Aims: Maya ancestry populations from Yucatan have exhibited a high prevalence of diabetes and obesity; consequently, the aim of this study was to determine the allelic and genotype frequencies of six polymorphisms associated with diabetes and obesity in two Maya populations.

Place and Duration of Study: Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del IPN; Laboratorios de Genética y Hematología, Centro de Investigaciones Regionales “Dr. Hideyo Noguchi”, Universidad Autónoma de Yucatán between September 2014 and March 2016.

Methodology: Healthy individuals with Maya ancestry were recruited in small rural and urban communities from Yucatan. Six …

Methylation Of Socs3 Is Inversely Associated With Metabolic Syndrome In An Epigenome-Wide Association Study Of Obesity, Omar Ali, Diana Cerjak, Jack W. Kent Jr, Roland James, John Blangero, Melanie A. Carless, Yi Zhang

School of Medicine Publications and Presentations

Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10-7) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a …

The Genetic Architecture Of Type 2 Diabetes, Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton, Joanne E. Curran, Satish Kumar, John Blangero, Ravi Duggirala

School of Medicine Publications and Presentations

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping …

Novel Somatic Copy Number Alteration Identified For Cervical Cancer In The Mexican American Population, Alireza Torabi, Javier Ordonez, Brenda Bin Su, Laura Palmer, Chunxiang Mao, Katherine E. Lara, Lewis P. Rubin, Chun Xu

Health & Biomedical Sciences Faculty Publications and Presentations

Cervical cancer affects millions of Americans, but the rate for cervical cancer in the Mexican American is approximately twice that for non-Mexican Americans. The etiologies of cervical cancer are still not fully understood. A number of somatic mutations, including several copy number alterations (CNAs), have been identified in the pathogenesis of cervical carcinomas in non-Mexican Americans. Thus, the purpose of this study was to investigate CNAs in association with cervical cancer in the Mexican American population. We conducted a pilot study of genome-wide CNA analysis using 2.5 million markers in four diagnostic groups: reference (n = 125), low grade dysplasia …

Preterm Birth And Air Pollution: Critical Windows Of Exposure For Women With Asthma, Pauline Mendola, Maeve Wallace, Beom Seuk Hwang, Danping Liu, Candace Robledo, Tuija Männistö

School of Medicine Publications and Presentations

Background: Ambient air pollutants may increase preterm birth (PTB) risk, but critical exposure windows are uncertain. The interaction of asthma and pollutant exposure is rarely studied.

Objective: We sought to assess the interaction of maternal asthma and air pollutant exposures in relation to PTB risk.

Methods: Electronic medical records for 223,502 US deliveries were linked with modified Community Multiscale Air Quality model outputs. Logistic regression with generalized estimating equations estimated the odds ratio and 95% CIs for PTB on the basis of the interaction of maternal asthma and particulate matter with aerodynamic diameter of less than 2.5 microns and particulate …

Reproductive Health Knowledge Among African American Women Enrolled In A Clinic-Based Randomized Controlled Trial To Reduce Psychosocial And Behavioral Risk, Project Dc-Hope, Uba Backonja, Candace Robledo, Maeve Wallace, Katrina F. Flores, Michele Kiely

School of Medicine Publications and Presentations

Background: Washington, DC, has among the highest rates of sexually transmitted infections and unintended pregnancy in the United States. Increasing women's reproductive health knowledge may help to address these reproductive health issues. This analysis assessed whether high-risk pregnant African American women in Washington, DC, who participated in an intervention to reduce behavioral and psychosocial risks had greater reproductive health knowledge than women receiving usual care.

Methods: Project DC-HOPE was a randomized, controlled trial that included pregnant African American women in Washington, DC, recruited during prenatal care (PNC). Women in the intervention group were provided reproductive health education and received tailored …

Psma Targeted Docetaxel-Loaded Superparamagnetic Iron Oxide Nanoparticles For Prostate Cancer, Prashanth K. B. Nagesh, Nia R. Johnson, Vijaya K. N. Boya, Pallabita Chowdhury, Shadi F. Othman, Vahid Khalilzad-Sharghi, Bilal B. Hafeez, Aditya Ganju, Sheema Khan, Stephen Behrman, Nadeem Zafar, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

School of Medicine Publications and Presentations

Docetaxel (Dtxl) is currently the most common therapeutic option for prostate cancer (PC). However, adverse side effects and problems associated with chemo-resistance limit its therapeutic outcome in clinical settings. A targeted nanoparticle system to improve its delivery to and activity at the tumor site could be an attractive strategy for PC therapy. Therefore, the objective of this study was to develop and determine the anti-cancer efficacy of a novel docetaxel loaded, prostate specific membrane antigen (PSMA) targeted superparamagnetic iron oxide nanoparticle (SPION) (J591-SPION-Dtxl) formulation for PC therapy. Our results showed the SPION-Dtxl formulation exhibits an optimal particle size and zeta …

Cordycepin Promotes Apoptosis By Modulating The Erk-Jnk Signaling Pathway Via Dusp5 In Renal Cancer Cells, Jung-Hoo Hwang, Jong Cheon Joo, Dae Joon Kim, Eunbi Jo, Hwa-Seung Yoo, Kyung-Bok Lee, Soo Jung Park, Ik-Soon Jang

School of Medicine Publications and Presentations

Constitutive activation of extracellular signal regulated kinase (ERK)-Jun NH2-terminal kinase (JNK) signaling commonly occurs in tumors. The activation of ERK promotes cell proliferation, whereas that of JNK induces cell apoptosis. However, the apoptotic mechanism of ERK-JNK signaling in cancer is not well understood. Recently, we identified that apoptosis and activation of the JNK signaling pathway were induced after cordycepin treatment in human renal cancer, suggesting that JNK signaling might contribute to TK-10 cell apoptosis. We investigated the apoptotic effects of cordycepin by evaluating the activation of the ERK-JNK signaling pathway in renal cancer TK-10 cells. We found that cordycepin downregulated …

Genome-Wide Significant Loci For Addiction And Anxiety, Karen Hodgson, Laura Almasy, Emma E. M. Knowles, Jack W. Kent Jr., Joanne E. Curran, Thomas D. Dyer, Harald H. H. Goring, Rene L. Olvera, Peter T. Fox, Godfrey D. Pearlson, J. H. Krystal, Ravindranath Duggirala, John Blangero, David C. Glahn

School of Medicine Publications and Presentations

Background

Psychiatric comorbidity is common among individuals with addictive disorders, with patients frequently suffering from anxiety disorders. While the genetic architecture of comorbid addictive and anxiety disorders remains unclear, elucidating the genes involved could provide important insights into the underlying etiology.

Methods

Here we examine a sample of 1284 Mexican-Americans from randomly selected extended pedigrees. Variance decomposition methods were used to examine the role of genetics in addiction phenotypes (lifetime history of alcohol dependence, drug dependence or chronic smoking) and various forms of clinically relevant anxiety. Genome-wide univariate and bivariate linkage scans were conducted to localize the chromosomal regions influencing …

A Study On The Effect Of Higher Education Branding On Student's College Decision, David E. Garcia

Theses and Dissertations

All around us we are inundated by brand marketing. Logos and labels with trademarks surround our lives. With marketing being part of our society, higher education institutions have created a brand marketing scheme all their own. This new form of branding has caused many students to make their decision based on the logo, mascot or social lifestyle. The purpose of this study was to test whether attitudinal brand loyalty has a statistically significant effect on college decision through academic and athletic factors. Based on multiple regression analysis, results show that attitudinal brand loyalty does have a significant effect on college …