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Articles 4471 - 4500 of 5204

Full-Text Articles in Medicine and Health Sciences

Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins Jan 1999

Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins

Department of Psychology: Faculty Publications

Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on single-trial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1–3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both …

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“I Know I Know It, I Know I Saw It” : The Stability Of The Confidence–Accuracy Relationship Across Domains, Brian H. Bornstein, Douglas J. Zickafoose Jan 1999

“I Know I Know It, I Know I Saw It” : The Stability Of The Confidence–Accuracy Relationship Across Domains, Brian H. Bornstein, Douglas J. Zickafoose

Department of Psychology: Faculty Publications

If the relationship between confidence and accuracy extended across domains, then one could assess performance in a known domain and use it to estimate performance in another domain. The stability of the confidence- accuracy relationship across the domains of eyewitness memory and general knowledge was investigated. The major findings of Experiment 1 were that in both domains participants were overconfident, yet more confident on correct than on incorrect responses, and that the degrees of overconfidence, calibration, and resolution in the 2 domains were positively correlated. Experiment 2 replicated these findings and showed that feedback about overconfidence reduced overall confidence levels …

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Introduction, Dan Bernstein Jan 1999

Introduction, Dan Bernstein

Department of Psychology: Faculty Publications

This volume is about motivation and gender. The chapters outline recent research and conceptual analysis related to four important motivational constructs-sexuality, emotion, competition, and aggression. In each case the author has examined the relation between the motivational construct and gender; the chapters describe those relations and analyze their origins and implications. There are two primary ideas that connect these accounts of gender and motivation: the authors generally report great diversity within gender groups in the degree to which these motivational characteristics are found, and they note that there is much to be considered in exactly how these motivational constructs are …

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Common Parasites, Diseases And Injuries Of Freshwater Fishes In The Northwest Territories And Nunavut, D. B. Stewart, L. M. J. Bernier Jan 1999

Common Parasites, Diseases And Injuries Of Freshwater Fishes In The Northwest Territories And Nunavut, D. B. Stewart, L. M. J. Bernier

Zoonotics and Wildlife Disease: Publications

This booklet gives basic information on common parasites, diseases and injuries of fish harvested from fresh water in the Northwest Territories and Nunavut (Canada). It answers some of the more common questions asked by Aboriginal, domestic, sport and commercial harvesters, and by fisheries researchers. It is not an in depth treatment of fish health. Parasites that are uncommon or too small to be seen with the naked eye and diseases that are poorly known are not discussed. Relatively little research has been conducted on fish parasites in the region, less still on fish diseases and injuries.

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The Human Ehrlichioses In The United States, Jennifer H. Mcquiston, Christopher D. Paddock, Robert C. Holman, James E. Childs Jan 1999

The Human Ehrlichioses In The United States, Jennifer H. Mcquiston, Christopher D. Paddock, Robert C. Holman, James E. Childs

Zoonotics and Wildlife Disease: Publications

The emerging tick-borne zoonoses human monocytic ehrlichiosis (HME) and human granulocytic ehrlichiosis (HGE) are underreported in the United States. From 1986 through 1997, 1,223 cases (742 HME, 449 HGE, and 32 not ascribed to a specific ehrlichial agent) were reported by state health departments. HME was most commonly reported from southeastern and southcentral states, while HGE was most often reported from northeastern and upper midwestern states. The annual number of reported cases increased sharply, from 69 in 1994 to 364 in 1997, coincident with an increase in the number of states making these conditions notifiable. From 1986 through 1997, 827 …

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Long-Term Studies Of Hantavirus Reservoir Populations In The Southwestern United States: A Synthesis, James N. Mills, Thomas G. Ksiazek, C.J. Peters, James E. Childs Jan 1999

Long-Term Studies Of Hantavirus Reservoir Populations In The Southwestern United States: A Synthesis, James N. Mills, Thomas G. Ksiazek, C.J. Peters, James E. Childs

Zoonotics and Wildlife Disease: Publications

A series of intensive, longitudinal, mark-recapture studies of hantavirus infection dynamics in reservoir populations in the southwestern United States indicates consistent patterns as well as important differences among sites and host-virus associations. All studies found a higher prevalence of infection in older (particularly male) mice; one study associated wounds with seropositivity. These findings are consistent with horizontal transmission and transmission through fighting between adult male rodents. Despite very low rodent densities at some sites, low-level hantavirus infection continued, perhaps because of persistent infection in a few long-lived rodents or periodic reintroduction of virus from neighboring populations. Prevalence of hantavirus antibody …

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Diagnosis Of Human Ehrlichiosis By Pcr Assay Of Acute-Phase Serum, James A. Comer, William L. Nicholson, John W. Sumner, James G. Olson, James E. Childs Jan 1999

Diagnosis Of Human Ehrlichiosis By Pcr Assay Of Acute-Phase Serum, James A. Comer, William L. Nicholson, John W. Sumner, James G. Olson, James E. Childs

Zoonotics and Wildlife Disease: Publications

A PCR assay of 43 acute-phase serum samples was evaluated as a method for early detection of human granulocytic ehrlichiosis (HGE) and determination of etiology when serologic testing is inconclusive. Sequenceconfirmed products of the HGE agent were amplified from three individuals residing or having exposure history in Minnesota or Wisconsin, and similarly confirmed products from Ehrlichia chaffeensis were amplified from three individuals from Florida or Maryland. Etiology, as determined by PCR and serology, was the same whenever there was a fourfold difference between the maximum titers of antibodies to both antigens, indicating that presumptive determination of etiology may be based …

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Dusky-Footed Wood Rats (Neotoma Fuscipes) As Reservoirs Of Granulocytic Ehrlichiae (Rickettsiales: Ehrlichieae) In Northern California, William L. Nicholson, Martin B. Castro, Vicki L. Kramer, John W. Sumner, James E. Childs Jan 1999

Dusky-Footed Wood Rats (Neotoma Fuscipes) As Reservoirs Of Granulocytic Ehrlichiae (Rickettsiales: Ehrlichieae) In Northern California, William L. Nicholson, Martin B. Castro, Vicki L. Kramer, John W. Sumner, James E. Childs

Zoonotics and Wildlife Disease: Publications

Dusky-footed wood rats (Neotoma fuscipes) and Peromyscus sp. mice (P. maniculatus and P. truei) were collected from one site in Placer County, one site in Santa Cruz County, and two sites in Sonoma County in northern California. Serum or plasma samples from 260 rodents were tested for antibodies to the agent of human granulocytic ehrlichiosis. Of these, samples from 25 wood rats (34% of those tested) and 10 (8%) Peromyscus sp. mice were found to be seropositive, but only those from one site. PCR assays targeting the groESL heat shock operon were conducted on all seropositive …

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Outcome Of Diagnostic Tests Using Samples From Patients With Culture-Proven Human Monocytic Ehrlichiosis: Implications For Surveillance, James E. Childs, John W. Sumner, William L. Nicholson, Robert F. Massung, Steven M. Standaert, Christopher D. Paddock Jan 1999

Outcome Of Diagnostic Tests Using Samples From Patients With Culture-Proven Human Monocytic Ehrlichiosis: Implications For Surveillance, James E. Childs, John W. Sumner, William L. Nicholson, Robert F. Massung, Steven M. Standaert, Christopher D. Paddock

Zoonotics and Wildlife Disease: Publications

We describe the concordance among results from various laboratory tests using samples derived from nine culture-proven cases of human monocytic ehrlichiosis (HME) caused by Ehrlichia chaffeensis. A class-specific indirect immunofluorescence assay for immunoglobulin M (IgM) and IgG, using E. chaffeensis antigen, identified 44 and 33% of the isolation-confirmed HME patients on the basis of samples obtained at initial clinical presentation, respectively; detection of morulae in blood smears was similarly insensitive (22% positive). PCR amplifications of ehrlichial DNA targeting the 16S rRNA gene, the variable-length PCR target gene, and the groESL operon were positive for whole blood specimens obtained …

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Hidden Mortality Attributable To Rocky Mountain Spotted Fever: Immunohistochemical Detection Of Fatal, Serologically Unconfirmed Disease, James E. Childs, Patricia W. Greer, Tara L. Ferebee, Joseph Singleton Jr., Don B. Mckechnie, Tracee A. Treadwell, John W. Krebs, Matthew J. Clarke, Robert C. Holman, James G. Olson, Christopher D. Paddock, Sherif R. Zaki Jan 1999

Hidden Mortality Attributable To Rocky Mountain Spotted Fever: Immunohistochemical Detection Of Fatal, Serologically Unconfirmed Disease, James E. Childs, Patricia W. Greer, Tara L. Ferebee, Joseph Singleton Jr., Don B. Mckechnie, Tracee A. Treadwell, John W. Krebs, Matthew J. Clarke, Robert C. Holman, James G. Olson, Christopher D. Paddock, Sherif R. Zaki

Zoonotics and Wildlife Disease: Publications

Rocky Mountain spotted fever (RMSF) is the most severe tickborne infection in the United States and is a nationally notifiable disease. Since 1981, the annual case-fatality ratio for RMSF has been determined from laboratory-confirmed cases reported to the Centers for Disease Control and Prevention (CDC). Herein, a description is given of patients with fatal, serologically unconfirmed RMSF for whom a diagnosis of RMSF was established by immunohistochemical (IHC) staining of tissues obtained at autopsy. During 1996-1997, acute-phase serum and tissue samples from patients with fatal disease compatible with RMSF were tested at the CDC. As determined by indirect immunofluorescence assay, …

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Search For The Ebola Virus Reservoir In Kikwit, Democratic Republic Of The Congo: Reflections On A Vertebrate Collection, Herwig Leirs, James N. Mills, John W. Krebs, James E. Childs, Dudu Akaibe, Neal Woollen, George Ludwig, Clarence J. Peters, Thomas G. Ksiazek Jan 1999

Search For The Ebola Virus Reservoir In Kikwit, Democratic Republic Of The Congo: Reflections On A Vertebrate Collection, Herwig Leirs, James N. Mills, John W. Krebs, James E. Childs, Dudu Akaibe, Neal Woollen, George Ludwig, Clarence J. Peters, Thomas G. Ksiazek

Zoonotics and Wildlife Disease: Publications

A 3-month ecologic investigation was done to identify the reservoir of Ebola virus following the 1995 outbreak in Kikwit, Democratic Republic of the Congo. Efforts focused on the fields where the putative primary case had worked but included other habitats near Kikwit. Samples were collected from 3066 vertebrates and tested for the presence of antibodies to Ebola (subtype Zaire) virus: All tests were negative, and attempts to isolate Ebola virus were unsuccessful. The investigation was hampered by a lack of information beyond the daily activities of the primary case, a lack of information on Ebola virus ecology, which precluded the …

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Population Dynamics Of A Naturally Occurring Heterogeneous Mixture Of Borrelia Burgdorferi Clones, Erick K. Hofmeister, Gregory E. Glass, James E. Childs, David H. Persing Jan 1999

Population Dynamics Of A Naturally Occurring Heterogeneous Mixture Of Borrelia Burgdorferi Clones, Erick K. Hofmeister, Gregory E. Glass, James E. Childs, David H. Persing

Zoonotics and Wildlife Disease: Publications

Two unique isolates of Borrelia burgdorferi, differing in plasmid content and outer surface protein C expression, were cultured on sequential captures of a single free-living Peromyscus leucopus mouse and were examined for differences in transmissibility. Both isolates were transmissible from inoculated C.B-17 mice to larval Ixodes scapularis ticks and, subsequently, from infected nymphal ticks to C3H/HeJ mice. Plasmid and protein analyses suggested that the original isolates were a mixed population of B. burgdorferi, and cloning by limiting dilution resulted in the identification of two clonal groups. In addition to being heterogeneous in plasmid and genomic macrorestriction analyses, the …

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Isolation Of A New Subspecies, Bartonella Vinsonii Subsp. Arupensis, From A Cattle Rancher: Identity With Isolates Found In Conjunction With Borrelia Burgdorferi And Babesia Microti Among Naturally Infected Mice, David F. Welch, Karen C. Carroll, Erick K. Hofmeister, David H. Persing, Denise A. Robison, Arnold G. Steigerwalt, Don J. Brenner Jan 1999

Isolation Of A New Subspecies, Bartonella Vinsonii Subsp. Arupensis, From A Cattle Rancher: Identity With Isolates Found In Conjunction With Borrelia Burgdorferi And Babesia Microti Among Naturally Infected Mice, David F. Welch, Karen C. Carroll, Erick K. Hofmeister, David H. Persing, Denise A. Robison, Arnold G. Steigerwalt, Don J. Brenner

Zoonotics and Wildlife Disease: Publications

Bacteremia with fever due to a novel subspecies of Bartonella vinsonii was found in a cattle rancher. The subspecies shared major characteristics of the genus Bartonella in terms of most biochemical features and cellular fatty acid profile, but it was distinguishable from other subspecies of B. vinsonii by good growth on heart infusion agar supplemented with X factor and by its pattern of enzymatic hydrolysis of peptide substrates. DNA relatedness studies verified that the isolate belonged to the genus Bartonella and that it was genotypically related to B. vinsonii. The highest level of relatedness was observed with recently characterized …

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Oral Transmission And Early Lymphoid Tropism Of Chronic Wasting Disease PrpRes In Mule Deer Fawns (Odocoileus Hemionus), Christina J. Sigurdson, Elizabeth S. Williams, Michael W. Miller, Terry R. Spraker, Katherine I. O'Rourke, Edward A. Hoover Jan 1999

Oral Transmission And Early Lymphoid Tropism Of Chronic Wasting Disease PrpRes In Mule Deer Fawns (Odocoileus Hemionus), Christina J. Sigurdson, Elizabeth S. Williams, Michael W. Miller, Terry R. Spraker, Katherine I. O'Rourke, Edward A. Hoover

Zoonotics and Wildlife Disease: Publications

Mule deer fawns (Odocoileus hemionus) were inoculated orally with a brain homogenate prepared from mule deer with naturally occurring chronic wasting disease (CWD), a prion-induced transmissible spongiform encephalopathy. Fawns were necropsied and examined for PrPres, the abnormal prion protein isoform, at 10, 42, 53, 77, 78 and 80 days post-inoculation (p.i.) using an immunohistochemistry assay modified to enhance sensitivity. PrPres was detected in alimentarytract- associated lymphoid tissues (one or more of the following: retropharyngeal lymph node, tonsil, Peyer’s patch and ileocaecal lymph node) as early as 42 days p.i. and in all fawns examined thereafter …

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Prp Genotypes Of Captive And Free-Ranging Rocky Mountain Elk (Cervus Elaphus Nelsoni) With Chronic Wasting Disease, Katherine I. O'Rourke, T. E. Besser, M. W. Miller, T. F. Cline, T. R. Spraker, A. L. Jenny, M. A. Wild, G. L. Zebarth Jan 1999

Prp Genotypes Of Captive And Free-Ranging Rocky Mountain Elk (Cervus Elaphus Nelsoni) With Chronic Wasting Disease, Katherine I. O'Rourke, T. E. Besser, M. W. Miller, T. F. Cline, T. R. Spraker, A. L. Jenny, M. A. Wild, G. L. Zebarth

Zoonotics and Wildlife Disease: Publications

The PrP gene encodes the putative causative agent of the transmissible spongiform encephalopathies (TSEs), a heterogeneous group of fatal, neurodegenerative disorders including human Creutzfeldt–Jakob disease, bovine spongiform encephalopathy, ovine scrapie and chronic wasting disease (CWD) of North American deer and elk. Polymorphisms in the PrP gene are associated with variations in relative susceptibility, pathological lesion patterns, incubation times and clinical course of TSEs of humans, mice and sheep. Sequence analysis of the PrP gene from Rocky Mountain elk showed only one amino acid change (Met to Leu at cervid codon 132). Homozygosity for Met at the corresponding polymorphic site (Met …

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Family Cluster Of Rocky Mountain Spotted Fever, James E. Childs, Timothy F. Jones, Allen S. Craig, Christopher D. Paddock, Don B. Mckechnie, Sherif R. Zaki, William Schaffner Jan 1999

Family Cluster Of Rocky Mountain Spotted Fever, James E. Childs, Timothy F. Jones, Allen S. Craig, Christopher D. Paddock, Don B. Mckechnie, Sherif R. Zaki, William Schaffner

Zoonotics and Wildlife Disease: Publications

Soon after a patient from Tennessee died of Rocky Mountain spotted fever (RMSF), several family members developed symptoms suggestive of the disease and were treated presumptively for RMSF. Fifty-four persons visiting the index patient's home were interviewed; serum samples were collected from 35. Three additional cases of RMSF were confirmed, all of which occurred in firstdegree relatives. Time spent at the family home and going into the surrounding woods were significantly associated with developing antibodies to Rickettsia rickettsii. Ticks were collected and examined for rickettsiae by polymerase chain reaction analysis. Because hyperendemic foci and family clusters of RMSF can …

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Molecular Cloning And Characterization Of The Ehrlichia Chaffeensis Variable-Length Pcr Target: An Antigen-Expressing Gene That Exhibits Interstrain Variation, John W. Sumner, James E. Childs, Christopher D. Paddock Jan 1999

Molecular Cloning And Characterization Of The Ehrlichia Chaffeensis Variable-Length Pcr Target: An Antigen-Expressing Gene That Exhibits Interstrain Variation, John W. Sumner, James E. Childs, Christopher D. Paddock

Zoonotics and Wildlife Disease: Publications

A clone expressing an immunoreactive protein with an apparent molecular mass of 44 kDa was selected from an Ehrlichia chaffeensis Arkansas genomic library by probing with anti-E. chaffeensis hyperimmune mouse ascitic fluid. Nucleotide sequencing revealed an open reading frame (ORF) capable of encoding a 198-aminoacid polypeptide. The ORF contained four imperfect, direct, tandem 90-bp repeats. The nucleotide and deduced amino acid sequences did not show close homologies to entries in the molecular databases. PCR with primers whose sequences matched the sequences flanking the ORF was performed with DNA samples extracted from cell cultures infected with nine different isolates of E. …

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Serologic Testing For Human Granulocytic Ehrlichiosis At A National Referral Center, James A. Comer, William L. Nicholson, James G. Olson, James E. Childs Jan 1999

Serologic Testing For Human Granulocytic Ehrlichiosis At A National Referral Center, James A. Comer, William L. Nicholson, James G. Olson, James E. Childs

Zoonotics and Wildlife Disease: Publications

An indirect immunofluorescence assay (IFA) was used to identify patients with antibodies reactive to the human granulocytic ehrlichiosis (HGE) agent. Serum samples collected from clinically ill individuals were submitted to the Centers for Disease Control and Prevention by physicians via state health departments from throughout the United States and tested against a panel of ehrlichial and rickettsial pathogens. Antibodies reactive to the HGE agent were detected in 142 (8.9%) of 1,602 individuals tested. There were 19 confirmed and 59 probable (n = 78) cases of HGE as defined by seroconversion or a fourfold or higher titer to the HGE agent …

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Bacterial Toxins: Friends Or Foes?, Clare K. Schmitt, Karen C. Meysick, Alison D. O'Brien Jan 1999

Bacterial Toxins: Friends Or Foes?, Clare K. Schmitt, Karen C. Meysick, Alison D. O'Brien

Uniformed Services University of the Health Sciences

Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes. These toxins, which affect eukaryotic cells by a variety of means, include Staphylococcus aureus α-toxin, Shiga toxin, cytotoxic necrotizing factor type 1, Escherichia coli heat-stable toxin, botulinum and tetanus neurotoxins, and S. aureus toxic-shock syndrome toxin. For each, we discuss the information available on its synthesis and structure, mode of action, and contribution to virulence. We also review the role certain toxins have played in unraveling signal pathways in eukaryotic cells and summarize …

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Gender Differences In The Relationships Among Ses, Family History Of Alcohol Disorders And Alcohol Dependence, Geoffrey M. Curran, Scott F. Stoltenberg, Elizabeth M. Hill, Sharon A. Mudd, Frederic C. Blow, Robert A. Zucker Jan 1999

Gender Differences In The Relationships Among Ses, Family History Of Alcohol Disorders And Alcohol Dependence, Geoffrey M. Curran, Scott F. Stoltenberg, Elizabeth M. Hill, Sharon A. Mudd, Frederic C. Blow, Robert A. Zucker

Department of Psychology: Faculty Publications

Objective: Potential moderator and mediator roles of several measures of socioeconomic status (SES) were investigated for the relationship between a family history of alcoholism( FH) and alcohol dependence symptoms in adulthood. Method: These analyses were performed with a sample of 931 men and 385 women participating in studies at the Alcohol Research Center, University of Michigan. Hierarchical multiple regression equations were used to assess whether SES mediated and moderated relationships between FH and alcohol dependence symptoms. Results: In general, measures of SES (education, occupation, personal and household income) were more important predictors of alcohol dependence symptoms among men, while FH …

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Monitoring Of Transmission Of Tuberculosis Between Wild Boars And Cattle: Genotypical Analysis Of Strains By Molecular Epidemiology Techniques, Andrea Serraino, Giulia Marchetti, Valeria Sanguinetti, Maria Cristina Rossi, Renato Giulio Zanoni, Lidia Catozzi, Alessandra Bandera, Walter Dini, Walter Mignone, Fabio Franzetti, Andrea Gori Jan 1999

Monitoring Of Transmission Of Tuberculosis Between Wild Boars And Cattle: Genotypical Analysis Of Strains By Molecular Epidemiology Techniques, Andrea Serraino, Giulia Marchetti, Valeria Sanguinetti, Maria Cristina Rossi, Renato Giulio Zanoni, Lidia Catozzi, Alessandra Bandera, Walter Dini, Walter Mignone, Fabio Franzetti, Andrea Gori

Michigan Bovine Tuberculosis Bibliography and Database

An epidemiological survey for the monitoring of bovine tuberculosis transmission was carried out in western Liguria, a region in northern Italy. Fifteen Mycobacterium bovis strains were isolated from 63 wild boar samples (62 from mandibular lymph nodes and 1 from a liver specimen). Sixteen mediastinal lymph nodes of 16 head of cattle were collected, and 15 Mycobacterium bovis strains were subsequently cultured. All M. bovisstrains isolated from cattle and wild boars were genotyped by spoligotyping and by restriction fragment length polymorphism (RFLP) analysis with the IS6110 and IS1081 probes. All M. bovis strains showed the typical spoligotype characterized by …

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Veterinary And Biomedical Sciences: 1999 Annual Report Jan 1999

Veterinary And Biomedical Sciences: 1999 Annual Report

School of Veterinary and Biomedical Sciences: Information and History

VBMS Personnel
VBMS Postdoctoral Research Associates
Awards and Recognition
Committee Assignments
Teaching Program
Graduate Program
Great Plains Veterinary Educational Center (GPVEC)
Research Program
Extension Program
Nebraska Veterinary Diagnostic Laboratory Systems (NVDLS)
Grants
Publications
Presentations
Selected Committees, Editorial and Other Appointments
Departmental Budget Summaries
Nebraska Agricultural Statistics
Appendix

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American Indians And Crime, Lawrence A. Greenfeld, Steven K. Smith Jan 1999

American Indians And Crime, Lawrence A. Greenfeld, Steven K. Smith

United States Public Health Resources

This report represents a compilation and new analysis of data on the effects and consequences of violent crime among American Indians. The report uses data from a wide variety of sources, including statistical series maintained by the Bureau of Justice Statistics (BJS), the FBI, and the Bureau of the Census. Data are reported from American Indian crime victims on how they were affected by the victimization and about who victimized them. The report also includes the first BJS estimates of the total number of American Indians under the custody or supervision of the justice system.
The findings reveal a disturbing …

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Hepatitis C Virus And Other Flaviviridae Viruses Enter Cells Via Low Density Lipoprotein Receptor, Vincent Agnello, György Ábel, Mutasim Elfahal, Glenn B. Knight, Qing-Xiu Zhang Jan 1999

Hepatitis C Virus And Other Flaviviridae Viruses Enter Cells Via Low Density Lipoprotein Receptor, Vincent Agnello, György Ábel, Mutasim Elfahal, Glenn B. Knight, Qing-Xiu Zhang

United States Public Health Resources

Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus Cyhepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by low density lipoprotein (LDL) receptors on cultured cells by several lines of evidence: by the demonstration that endocytosis of these virus correlated with LDL receptor activity, by complete inhibition of detectable endocytosis by anti-LDL receptor antibody, by inhibition with anti-apolipoprotein E and -apolipoprotein B antibodies, by chemical methods abrogating lipoproteinyLDL receptor interactions, and by inhibition with the endocytosis inhibitor phenylarsine oxide. Confirmatory evidence was provided by the lack of detectable LDL receptor on cells known …

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Preventing Hepatitis B And Hepatitis C Virus Infections In End-Stage Renal Disease Patients: Back To Basics, Scott Kellerman, Miriam Alter Jan 1999

Preventing Hepatitis B And Hepatitis C Virus Infections In End-Stage Renal Disease Patients: Back To Basics, Scott Kellerman, Miriam Alter

United States Public Health Resources

In this issue of HEPATOLOGY, Mathurin et al. report the results of a 10-year retrospective study of kidney transplant recipients that compared rates of patient and graft survival among patients with and without chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.1 Following this cohort of patients at intervals of 5 and 10 years, the investigators found a statistically significant decrease in survival in the HBV-infected group at both 5 and 10 years and a similar decrease at 10 years in the HCV-infected group. The findings of this study underscore the importance of preventing these infections in …

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Development Of A Model Of Natural Infection With Mycobacterium Bovis In White-Tailed Deer, Mitchell V. Palmer, Diana L. Whipple, Steven C. Olsen Jan 1999

Development Of A Model Of Natural Infection With Mycobacterium Bovis In White-Tailed Deer, Mitchell V. Palmer, Diana L. Whipple, Steven C. Olsen

Michigan Bovine Tuberculosis Bibliography and Database

The objective of this study was to develop a suitable experimental model of natural Mycobacterium bovis infection in white-tailed deer (Odocoileus virginianus), describe the distribution and character of tuberculous lesions, and to examine possible routes of disease transmission. In October 1997, 10 mature female white-tailed deer were inoculated by intratonsilar instillation of 2 3 103 (low dose) or 2 3 105 (high dose) colony forming units (CFU) of M. bovis. In January 1998, deer were euthanatized, examined, and tissues were collected 84 to 87 days post inoculation. Possible routes of disease transmission were evaluated by culture of nasal, …

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Can Large Dsdna-Containing Viruses Provide Information About The Minimal Genome Size Required To Support Life?, James L. Van Etten Jan 1999

Can Large Dsdna-Containing Viruses Provide Information About The Minimal Genome Size Required To Support Life?, James L. Van Etten

James Van Etten Publications

The genomes of a few viruses, such as Bacillus megaterium phage G (670 kb) and the chlorella viruses (330 to 380 kb), are larger than the predicted minimal genome size required to support life (ca. 320 kb). A comparison of the 256 proteins predicted to be required for life with the putative 376 proteins encoded by chlorella virus PBCV-1, as well as those encoded by other large viruses, indicates that viruses lack many of these “essential” genes. Consequently, it is unlikely that viruses will aid in determining the minimal number and types of genes required for life. However, viruses may …

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Observations On Animal And Human Health During The Outbreak Of Mycobacterium Bovis In Game Farm Wapiti In Alberta, P. Nick Nation, E. Anne Fanning, H. Bim Hopf, Terry L. Church Jan 1999

Observations On Animal And Human Health During The Outbreak Of Mycobacterium Bovis In Game Farm Wapiti In Alberta, P. Nick Nation, E. Anne Fanning, H. Bim Hopf, Terry L. Church

Michigan Bovine Tuberculosis Bibliography and Database

This report describes and discusses the history, clinical, pathologic, epidemiologic, and human health aspects of an outbreak of Mycobacterium bovis infection in domestic wapiti in Alberta between 1990 and 1993, shortly after legislative changes allowing game farming. The extent and seriousness of the outbreak of M. bovis in wapiti in Alberta was not fully known at its onset. The clinical findings in the first recognized infected wapiti are presented and the postmortem records for the herd in which the animal resided are summarized. Epidemiologic findings from the subsequent field investigation are reviewed, the results of recognition and investigation of human …

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A Comparison Of Wildlife Control And Cattle Vaccination As Methods For The Control Of Bovine Tuberculosis, R. R. Kao, M. G. Roberts Jan 1999

A Comparison Of Wildlife Control And Cattle Vaccination As Methods For The Control Of Bovine Tuberculosis, R. R. Kao, M. G. Roberts

Michigan Bovine Tuberculosis Bibliography and Database

The Australian brushtail possum is the major source of infection for new cases of bovine tuberculosis in cattle in New Zealand. Using hypothetical values for the cost of putative cattle and possum Tb vaccines, the relative efforts required to eradicate Tb in cattle using possum culling, possum vaccination or cattle vaccination are compared. For realistic assumed costs for 1080 poison bait, possum culling is found to be a cost-effective strategy compared to cattle vaccination if the required control area is below 13 ha per cattle herd, while possum vaccination is cost-effective for control areas of less than 3 ha per …

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Thirteen-Lined Ground Squirrel (Sciuridae: Spermophilus Tridecemlineatus) Antipredator Vigilance: Monitoring The Sky For Aerial Predators, Cody L. Arenz, Daniel Leger Jan 1999

Thirteen-Lined Ground Squirrel (Sciuridae: Spermophilus Tridecemlineatus) Antipredator Vigilance: Monitoring The Sky For Aerial Predators, Cody L. Arenz, Daniel Leger

Department of Psychology: Faculty Publications

Despite the success of antipredator vigilance research, the specific focus of this vigilance has been difficult to determine. We have previously shown that thirteen-lined ground squirrels (Spermophilus tridecemlineatus) increase their vigilance when their lateral field of view is obstructed. In this paper, we describe an experiment in which we attempt to determine the predator class for which this vigilance is directed. Using six differentially occluded Plexiglas foraging boxes with hinged “eaves,” we were able to obstruct the squirrels’ view of the sky while not obstructing their view of terrestrial threats. In general, across the box types, when their …

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