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Articles 4291 - 4320 of 5204

Full-Text Articles in Medicine and Health Sciences

The Environment Of Child Maltreatment: Contextual Factors And The Development Of Psychopathology, Debra B. Hecht, David J. Hansen Sep 2001

The Environment Of Child Maltreatment: Contextual Factors And The Development Of Psychopathology, Debra B. Hecht, David J. Hansen

Department of Psychology: Faculty Publications

Some professionals have hypothesized that the observed problems in children who have been maltreated may actually be a result of the combination of risk factors surrounding the child, including but not limited to direct results of the abuse itself. This article examines the complexity of hypothesized pathways to poor adjustment after physical and sexual abuse. The literature on the impact of major risk factors associated with maltreatment is reviewed in an attempt to clarify the potential contributions of these contextual variables on the development of psychopathology in physically and sexually abused children. The implications this analysis may yield for prevention, …

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Maternal And Child Reports Of Behavioral Compensation In Response To Safety Equipment Usage, David Dilillo, George Tremblay Aug 2001

Maternal And Child Reports Of Behavioral Compensation In Response To Safety Equipment Usage, David Dilillo, George Tremblay

Department of Psychology: Faculty Publications

Objective: To assess maternal and child risk compensation behaviors in response to several commonly used safety measures.

Methods: We administered a previously validated self-report measure of risk tolerance to a total of 151 mothers and their children in grades 3–7. Mothers indicated the level of risk they would permit their child to assume; children were questioned regarding the degree of physical risk they would typically assume while unsupervised by an adult. Participating families were randomly assigned to conditions in which safety equipment either was or was not present during assessments of risk tolerance.

Results: Mothers who viewed the stimulus materials …

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‘She’S 16 Years Old And There’S Boys Calling Over To The House’: An Exploratory Study Of Sexual Socialization In Latino Families, Marcela Raffaelli, Lenna L. Ontai Jul 2001

‘She’S 16 Years Old And There’S Boys Calling Over To The House’: An Exploratory Study Of Sexual Socialization In Latino Families, Marcela Raffaelli, Lenna L. Ontai

Department of Psychology: Faculty Publications

Compared to other ethnic groups in the USA, Latino populations are at high risk for negative sexual outcomes, including unplanned pregnancy and HIV/AIDS infection. The goal of this study was to explore the role of cultural beliefs and values in sexual socialization by focusing on the family socialization of adolescent romantic and sexual behavior described by 22 Latina/Hispanic women who took part in in-depth individual interviews. Four broad themes were explored: parental concerns regarding dating, family communication about sexual issues, family rules about dating, and actual dating and sexual experiences. Consistent with traditional cultural views, female romantic involvement outside of …

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Serotonin Transporter Promoter Polymorphism Genotype Is Associated With Behavioral Disinhibition And Negative Affect In Children Of Alcoholics, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Scott F. Stoltenberg, Hiram E. Fitzgerald, Robert A. Zucker Jul 2001

Serotonin Transporter Promoter Polymorphism Genotype Is Associated With Behavioral Disinhibition And Negative Affect In Children Of Alcoholics, Geoffrey R. Twitchell, Gregory L. Hanna, Edwin H. Cook, Scott F. Stoltenberg, Hiram E. Fitzgerald, Robert A. Zucker

Department of Psychology: Faculty Publications

Background: Serotonergic (5-HT) dysfunction has been implicated in the etiology of both behavioral disinhibition (BD) and negative affect (NA). This work extends our previous finding of relationships between whole blood 5-HT and both BD and NA in pubescent, but not prepubescent, children of alcoholics and continues examination of a hypothesized role of 5-HT dysfunction in alcoholism risk. The long and short (L and S) variants of the 5-HT transporter gene-linked polymorphic region (5-HTTLPR) are responsible for differing transcriptional efficiencies in 5-HT uptake. Although associations have been found between the SS 5-HTTLPR genotype and severe alcoholism and neuroticism, recent reports describe …

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Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta Jul 2001

Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Bacteria of the genus Mycobacterium are gram-positive, acid- fast organisms that include a number of significant human and animal pathogens. Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiological agent of a severe gastroenteritis in ruminants, known as Johne’s disease. H. A. Johne and L. Frothingham initially reported the disease in Germany in 1894. However, it was not until 1910 that F. W. Trowt successfully fulfilled Koch’s postulates by growing M. paratuberculosis in the laboratory and reproducing the disease in experimentally infected cattle (46, 148). Johne’s disease is prevalent in domestic animals worldwide and has significant impact on …

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Advancing Scientific Discourse In The Controversy Surrounding The Comprehensive System For The Rorschach: A Rejoinder To Meyer (2000), James M. Wood, M. Teresa Nezworski, William J. Stejskal, Sena Garven Jun 2001

Advancing Scientific Discourse In The Controversy Surrounding The Comprehensive System For The Rorschach: A Rejoinder To Meyer (2000), James M. Wood, M. Teresa Nezworski, William J. Stejskal, Sena Garven

Department of Psychology: Faculty Publications

A recent commentary by Meyer (2000) in the Journal of Personality Assessment alleged that Rorschach critic Wood and his colleagues had intentionally published information that they knew to be in error. To substantiate this contention, Meyer’s commentary published information that was part of the peer review process at another journal. In this rejoinder, we present factual information that shows we have consistently acted in good faith. This rejoinder suggests that the scientific debate regarding the Comprehensive System for the Rorschach is unlikely to be advanced by speculating about the intentions of Rorschach critics, or by publishing information from the peer …

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Advancing Scientific Discourse In The Controversy Surrounding The Comprehensive System For The Rorschach: A Rejoinder To Meyer (2000), James M. Wood, M. Teresa Nezworski, William J. Stejskal, Sena Garven Jun 2001

Advancing Scientific Discourse In The Controversy Surrounding The Comprehensive System For The Rorschach: A Rejoinder To Meyer (2000), James M. Wood, M. Teresa Nezworski, William J. Stejskal, Sena Garven

Department of Psychology: Faculty Publications

A recent commentary by Meyer (2000) in the Journal of Personality Assessment alleged that Rorschach critic Wood and his colleagues had intentionally published information that they knew to be in error. To substantiate this contention, Meyer’s commentary published information that was part of the peer review process at another journal. In this rejoinder, we present factual information that shows we have consistently acted in good faith. This rejoinder suggests that the scientific debate regarding the Comprehensive System for the Rorschach is unlikely to be advanced by speculating about the intentions of Rorschach critics, or by publishing information from the peer …

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Child Sexual Abuse In Asian American Families: An Examination Of Cultural Factors That Influence Prevalence, Identification, And Treatment, Kristine T. Futa, Eugenia Hsu, David J. Hansen Jun 2001

Child Sexual Abuse In Asian American Families: An Examination Of Cultural Factors That Influence Prevalence, Identification, And Treatment, Kristine T. Futa, Eugenia Hsu, David J. Hansen

Department of Psychology: Faculty Publications

Child sexual abuse affects thousands of families each year. Issues pertaining to the prevalence, identification, and treatment of sexual abuse have been relatively well explored in the literature as they pertain to the dominant European American culture. These issues, however, are still relatively unexplored in terms of how sexual abuse affects Asian American families and the Asian American community. We review the relevant literature in Asian American families. These matters are explored in the context of Asian American values such as collectivity, conformity, inconspicuousness, middle position virtue, shame, self-control, and fatalism. Attitudes toward family, sexuality, and the mental health system …

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The Effects Of Limiting Punitive Damage Awards, Edith Greene, David Coon, Brian H. Bornstein Jun 2001

The Effects Of Limiting Punitive Damage Awards, Edith Greene, David Coon, Brian H. Bornstein

Department of Psychology: Faculty Publications

In response to concerns that jury awards in tort cases are excessive and unpredictable, nearly every state legislature has enacted some version of tort reform that is intended to curb extravagant damage awards. One of the most important and controversial reforms involves capping (or limiting) the maximum punitive damage award. We conducted a jury analogue study to assess the impact of this reform. In particular, we examined the possibility that capping punitive awards would cause jurors to inflate their compensatory awards to satisfy their desires to punish the defendant, particularly in situations where the defendant’s conduct was highly reprehensible. Relative …

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Getting What They Came For: How Power Influences The Dynamics And Outcomes Of Interpersonal Interaction., Mark Snyder, Marc T. Kiviniemi May 2001

Getting What They Came For: How Power Influences The Dynamics And Outcomes Of Interpersonal Interaction., Mark Snyder, Marc T. Kiviniemi

Department of Psychology: Faculty Publications

Many social interactions are indelibly tinged by issues of power and of power differences. Consider some common social interactions: First, imagine a job candidate going in for an interview with a potential employer. Next, consider a teacher meeting new students on the first day of class. Then, imagine two people meeting for a first date. Finally, imagine two college roommates meeting for the first time at the beginning of the semester. Each of these scenarios contains at least two common features, which together set the stage for the arguments that are offered in this chapter. First, each scenario involves a …

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Multidisciplinarity And Cognitive Science, Barbara Von Eckardt May 2001

Multidisciplinarity And Cognitive Science, Barbara Von Eckardt

Department of Psychology: Faculty Publications

The aim of Schunn, Crowley and Okada’s (1998) study is to address the question of whether the current state of cognitive science, as represented by Cognitive Science and the Cognitive Science Society, “reflects the multidisciplinary ideals of its foundation.” To properly interpret and respond to their results, we need to ask a prior question: What is cognitive science’s multidisciplinary ideal? There are at least two conceptions—a “localist” conception, which seems to be implicit in Schunn, Crowley and Okada’s discussion, and a “holist” conception. I argue that while both have been endorsed by some cognitive scientists, there are reasons for preferring …

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Interpersonal Functioning Among Women Reporting A History Of Childhood Sexual Abuse: Empirical Findings And Methodological Issues, David Dilillo May 2001

Interpersonal Functioning Among Women Reporting A History Of Childhood Sexual Abuse: Empirical Findings And Methodological Issues, David Dilillo

Department of Psychology: Faculty Publications

A subset of research exploring the long-term impact of child sexual abuse (CSA) has examined the adult interpersonal functioning of female survivors. The present review discusses empirical findings and critical methodological issues related to this important but often overlooked aspect of adult adjustment. Though characterized by several methodological limitations, this literature, as a whole, suggests that early sexual abuse represents a risk factor for a range of interpersonal dysfunction among female survivors, including problems with intimate partner relations, disturbed sexual functioning, and difficulties in the parental role. Suggested methodological improvements for future research include new approaches to the measurement of …

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Experimental Deer-To-Deer Transmission Of Mycobacterium Bovis, Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters May 2001

Experimental Deer-To-Deer Transmission Of Mycobacterium Bovis, Mitchell V. Palmer, Diana L. Whipple, W. Ray Waters

Michigan Bovine Tuberculosis Bibliography and Database

Objective—To determine whether Mycobacterium bovis can be transmitted from experimentally infected deer to uninfected in-contact deer.

Animals—Twenty-three 6-month-old white-tailed deer.

Procedure—On day 0, M bovis (2 X 108 colony-forming units) was administered by intratonsillar instillation to 8 deer; 3 control deer received saline (0.9% NaCl) solution. Eight in-contact deer were comingled with inoculated deer from day 21. On day 120, inoculated deer were euthanatized and necropsied. On day 180, 4 in-contact deer were euthanatized, and 4 new incontact deer were introduced. On day 360, all in-contact deer were euthanatized. Rectal, oral, and nasal swab specimens and …

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Rationality In Medical Decision Making: A Review Of The Literature On Doctors’ Decision-Making Biases, Brian H. Bornstein, A. Christine Emler Apr 2001

Rationality In Medical Decision Making: A Review Of The Literature On Doctors’ Decision-Making Biases, Brian H. Bornstein, A. Christine Emler

Department of Psychology: Faculty Publications

The objectives of this study were to describe ways in which doctors make suboptimal diagnostic and treatment decisions, and to discuss possible means of alleviating those biases, using a review of past studies from the psychological and medical decision-making literatures. A number of biases can affect the ways in which doctors gather and use evidence in making diagnoses. Biases also exist in how doctors make treatment decisions once a defi nitive diagnosis has been made. These biases are not peculiar to the medical domain but, rather, are manifestations of suboptimal reasoning to which people are susceptible in general. None the …

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Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales Apr 2001

Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales

School of Veterinary and Biomedical Sciences: Faculty Publications

A 30% decrease in osmolarity stimulated 3H-taurine, 3H-GABA and glutamate (followed as 3H-D-aspartate) efflux from rat hippocampal slices. 3H-taurine efflux was activated rapidly but inactivated slowly. It was decreased markedly by 100 μM 5-nitro-(3-phenylpropylamino) benzoic acid (NPPB) and 600 μM niflumic acid and inhibited strongly by tyrphostins AG18, AG879 and AG112 (25–100 μM), suggesting a tyrosine kinase-mediated mechanism. Hyposmolarity activated the mitogen-activated protein kinases (MAPK) extracellular-signal-related kinase-1/2 (ERK1/ERK2) and p38, but blockade of this reaction did not affect 3H-taurine efflux. Hyposmosis also activated phosphatidyl-inositide 3-kinase (PI3K) and its prevention by wortmannin (100 nM) essentially abolished …

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Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde Apr 2001

Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde

School of Veterinary and Biomedical Sciences: Faculty Publications

In the summer of 1996, we screened 18,931 calves in 128 beef herds located in five US states for persistent bovine viral diarrhea virus (BVDV) infection. Of these, 76 herds were randomly selected from the client database of collaborating veterinary practices, and 52 herds were suspected by the collaborating veterinarians to have BVDV infection based on history or clinical signs. Serum was obtained from each calf in the cooperating herds prior to 4 months of age and tested for the presence of BVDV by microtiter virus isolation. Information about each of the herds (including management practices, vaccination history, and breeding- …

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Between- Or Within-Culture Variation? Culture Group As A Moderator Of The Relations Between Individual Differences And Resource Allocation Preferences, Gustavo Carlo, Scott C. Roesch, George P. Knight, Silvia H. Koller Apr 2001

Between- Or Within-Culture Variation? Culture Group As A Moderator Of The Relations Between Individual Differences And Resource Allocation Preferences, Gustavo Carlo, Scott C. Roesch, George P. Knight, Silvia H. Koller

Department of Psychology: Faculty Publications

Recent theoretical discussion of the influence of between- and within-culture factors on social behaviors suggests that both approaches may be useful. The present study was designed to investigate the joint influence of sociocultural (between-group) and individual (within-group) factors on resource allocation preferences. Brazilian (n = 166) and European-American (n = 99) children with ages ranging from 37 to 140 months were administered a resource allocation task, which consisted of distributing rewards to themselves or to an acquaintance. As expected, individualistic resource allocation preferences decreased with age, whereas competitive and cooperative resource allocation preferences increased with age. Culture group, the task-specific …

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Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers Apr 2001

Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers

School of Veterinary and Biomedical Sciences: Faculty Publications

A 17-year-old male captive West African dwarf crocodile (Osteolaemus tetraspis subsp. tetraspis) died 1 month after fighting with a penmate. Abrasions were present on the head and mandible. Necropsy revealed a vegetative valvular lesion of the left atrioventricular valve, miliary foci of necrosis in the endocardium and myocardium, multiple duodenal and rectal ulcers, and serous atrophy of body fat. Stenotrophomonas maltophilia was isolated in pure culture from lung, liver, and kidney. Gram-negative bacilli were seen histologically in the valvular lesion and in foci of necrosis in the myocardium, liver, spleen, pancreas, kidney, and intestine. Septic thrombi in multiple …

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Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones Apr 2001

Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500–1503, 2000).The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to …

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Individual Differences In Rat Locomotor Activity Are Diminished By Nicotine Through Stimulation Of Central Nicotinic Acetylcholine Receptors, Rick A. Bevins, Joyce Besheer Mar 2001

Individual Differences In Rat Locomotor Activity Are Diminished By Nicotine Through Stimulation Of Central Nicotinic Acetylcholine Receptors, Rick A. Bevins, Joyce Besheer

Department of Psychology: Faculty Publications

An increasing body of research has focused on isolating factors that predict or alter individual differences in the behavioral and neural processes mediating the effects of abused drugs. Within this framework, the current report assessed individual differences and the locomotor effect of nicotine. Rats were screened for activity induced by a novel environment. Rats, which were more active to initial environment exposure, remained more active even after seven additional 30-min exposures to the same environment. Treatment with nicotine-di-D tartrate (1 mg/kg, sc) disrupted this effect. This nicotine disruption of individual differences occurred whether nicotine suppressed locomotor activity (initial administration) or …

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Environmental Familiarization In Rats: Differential Effects Of Acute And Chronic Nicotine, Rick A. Bevins, Jana Koznarova, Tracy J. Armiger Mar 2001

Environmental Familiarization In Rats: Differential Effects Of Acute And Chronic Nicotine, Rick A. Bevins, Jana Koznarova, Tracy J. Armiger

Department of Psychology: Faculty Publications

If an environment is familiar, rats will interact more with a novel object than if the environment is unfamiliar. In two experiments we used this behavioral tendency to assess the effects of nicotine on environmental familiarization (i.e., an elevated platform). As expected, rats given 2 min of exposure to the platform on 2 consecutive days (familiarization phase) interacted more with a novel object in a subsequent test than rats that had not experienced the platform until the test day. During the familiarization phase acute pretreatment with nicotine (0.6 and 1.8 mg/kg, subcutaneous) 10 min before platform exposure interfered with familiarization …

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An Exploration Of Factors Related To Deviant Sexual Arousal Among Juvenile Sex Offenders, William D. Murphy, Mary R. Haynes, David Dilillo, Elaine Steere Mar 2001

An Exploration Of Factors Related To Deviant Sexual Arousal Among Juvenile Sex Offenders, William D. Murphy, Mary R. Haynes, David Dilillo, Elaine Steere

Department of Psychology: Faculty Publications

To date, there has been limited literature on the measurement of sexual arousal in adolescent sex offenders. The data that exist have been somewhat mixed in terms of factors related to deviant sexual arousal in this group. The present study, with 71 adolescent sex offenders, investigates the relationship between offender and offense characteristics, including gender of victim, history of sexual abuse, history of physical abuse, race, and interactions between these factors in the prediction of physiologically measured sexual arousal to deviant and nondeviant stimulus categories. A number of variables significantly predicted sexual arousal. The most consistent predictors were gender of …

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A Closer Look At The Nature Of Intimate Partner Violence Reported By Women With A History Of Child Sexual Abuse, David Dilillo, Dawn Giuffre, George C. Tremblay, Lizette Peterson Feb 2001

A Closer Look At The Nature Of Intimate Partner Violence Reported By Women With A History Of Child Sexual Abuse, David Dilillo, Dawn Giuffre, George C. Tremblay, Lizette Peterson

Department of Psychology: Faculty Publications

This study provides an examination of violence occurring in the couple relationships of female survivors of childhood sexual abuse (CSA). Participants were 240 low-income women, 113 of whom (47%) reported some history of CSA. Compared with non–sexually abused women, those who had experienced CSA reported that their couple relationships were more likely to have involved several severe forms of violence, including hitting, kicking, and beating. Comparisons of the directional patterns of partner violence revealed that a greater proportion of CSA survivors’ relationships had involved at least one incident of both man-to-woman and woman-to-man aggression. An unexpected finding was that a …

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Escherichia Coli O157:H7 In Free-Ranging Deer In Nebraska, David G. Renter, Jan M. Sargeant, Scott E. Hygnstrom, Jeff D. Hoffmann, Jerry R. Gillespie Jan 2001

Escherichia Coli O157:H7 In Free-Ranging Deer In Nebraska, David G. Renter, Jan M. Sargeant, Scott E. Hygnstrom, Jeff D. Hoffmann, Jerry R. Gillespie

School of Natural Resources: Faculty Publications

In order to determine the prevalence and distribution of the human pathogen, Escherichia coli O157:H7, in free-ranging deer, hunters were asked to collect and submit fecal samples from deer harvested during a regular firearm season (14–22 November 1998). Prior to the season, 47% of the hunters with permits in the southeastern Nebraska (USA) study area indicated a willingness to participate in the study. Approximately 25% of successful hunters in the area submitted deer fecal samples. Escherichia coli O157:H7 was cultured from four (0.25%) of 1,608 total samples submitted. All of the fecal samples that were properly identified (1,426) and all …

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Infections With Ehrlichia Chaffeensis And Ehrlichia Ewingii In Persons Coinfected With Human Immunodeficiency Virus, Christopher D. Paddock, Scott M. Folk, G. Merrill Shore, Linda J. Machado, Mark M. Huycke, Leonard N. Slater, Allison M. Liddell, Richard S. Buller, Gregory A. Storch, Thomas P. Monson, David Rimland, John W. Sumner, Joseph Singleton, Karen C. Bloch, Yi-Wei Tang, Steven M. Standaert, James E. Childs Jan 2001

Infections With Ehrlichia Chaffeensis And Ehrlichia Ewingii In Persons Coinfected With Human Immunodeficiency Virus, Christopher D. Paddock, Scott M. Folk, G. Merrill Shore, Linda J. Machado, Mark M. Huycke, Leonard N. Slater, Allison M. Liddell, Richard S. Buller, Gregory A. Storch, Thomas P. Monson, David Rimland, John W. Sumner, Joseph Singleton, Karen C. Bloch, Yi-Wei Tang, Steven M. Standaert, James E. Childs

Zoonotics and Wildlife Disease: Publications

The clinical course and laboratory valuation of 21 patients coinfected with human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis caused by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. chaffeensis or E. ewingii. Twenty patients were male, and the median CD4+ T lymphocyte count was 137 cells/μL. Exposures to infecting ticks were linked to recreational pursuits, occupations, and peridomestic activities. For 8 patients, a diagnosis of ehrlichiosis was not considered until ≥4 days after presentation. Severe manifestations occurred more frequently …

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Prospective Assesment Of The Etiology Of Acute Febrile Illness After A Tick Bite In Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic-Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle Jan 2001

Prospective Assesment Of The Etiology Of Acute Febrile Illness After A Tick Bite In Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic-Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle

Zoonotics and Wildlife Disease: Publications

A prospective study established the etiology of febrile illnesses in residents of Slovenia that occurred within 6 weeks after a tick bite. A combination of laboratory and clinical criteria identified 64 (49.2%) of 130 patients as having confirmed, probable, or possible cases of tickborne disease during 1995 and 1996. Of the 130 patients, 36 (27.7%) had laboratory evidence of tickborne encephalitis, all of whom had clinically confirmed disease. Evidence of infection with Borreliab urgdorfersie sensu lato was identified in 26 patients; 10 (7.7%) had confirmed Lyme borreliosis. Of 22 patients with evidence of Ehrlichiap hagocytophila infection, 4 (3.1%) had confirmed …

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Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs Jan 2001

Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs

Zoonotics and Wildlife Disease: Publications

Epidemiologic and clinical characteristics of fatal and nonfatal cases of Rocky Mountain spotted fever (RMSF) were compared to identify risk factors for death caused by this disease. Confirmed and probable RMSF cases reported through US national surveillance for 1981- 1998 were analyzed. Among 6388 RMSF patients, 213 died (annual case-fatality rate, 3M; range, 4.9 % in 1982 to 1.1 % in 1996). Use of tetracycline-class antibiotics for treatment of RMSF increased significantly in the 1990s, compared with use in the 1980s. Older patients, patients treated with chloramphenicol only, patients for whom tetracycline antibiotics were not the primary therapy, and patients …

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Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke Jan 2001

Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes. This study determined the distribution and biochemical properties of PrP cellular (PrP-C) and the distribution of PrP scrapie (PrP-Sc) in reproductive, placental, and selected fetal tissues and fetal fluids in sheep. Glycosylated, N-terminally truncated, proteinase K-sensitive PrP-C with apparent molecular masses of 23–37 kDa was present in reproductive, placental, and fetal tissues and fetal fluids. PrP-C was low or undetectable in intercotyledonary chorioallantois, …

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Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin Jan 2001

Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin

Zoonotics and Wildlife Disease: Publications

Following diagnosis of scrapie in a clinically suspect Suffolk sheep, 7 clinically normal flockmates were purchased by the Pennsylvania Department of Agriculture to determine their scrapie status using an immunohistochemical procedure. Two of the 7 euthanized healthy sheep had positive immunohistochemical staining of the prion protein of scrapie (PrP-Sc) in their brains, nictitating membranes, and tonsils. The PrP-Sc was localized in the areas of the brain where, histopathologically, there was neurodegeneration and astrocytosis. The PrP-Sc occurred within germinal centers of the affected nictitating membranes and tonsils and was located in the cytoplasm of the dendrite-like cells, lymphoid cells, and macrophages. …

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Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin Jan 2001

Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin

Zoonotics and Wildlife Disease: Publications

To determine the transmissibility of chronic wasting disease (CWD) to cattle and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of CWD in cattle, 13 calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Between 24 and 27 months postinoculation, 3 animals became recumbent and were euthanized. Gross necropsies revealed emaciation in 2 animals and a large pulmonary abscess in the third. Brains were examined for protease-resistant prion protein (PrPres) by immunohistochemistry and Western blotting and for scrapie-associated fibrils (SAFs) by negative-stain electron microscopy. Microscopic …

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