Medicine and Health Sciences Commons^™

Genetic Microheterogeneity And Phenotypic Variation Of Helicobacter Pylori Arginase In Clinical Isolates, Justin Hovey, Emily Watson, Melanie Langford, Ellen Hildebrandt, Sangeetha Bathala, Jeffrey Bolland, Domenico Spadafora, George Mendz, David Mcgee

School of Biological Sciences: Faculty Publications

Background: Clinical isolates of the gastric pathogen Helicobacter pylori display a high level of genetic macro- and microheterogeneity, featuring a panmictic, rather than clonal structure. The ability of H. pylori to survive the stomach acid is due, in part, to the arginase-urease enzyme system. Arginase (RocF) hydrolyzes L-arginine to L-ornithine and urea, and urease hydrolyzes urea to carbon dioxide and ammonium, which can neutralize acid.

Results: The degree of variation in arginase was explored at the DNA sequence, enzyme activity and protein expression levels. To this end, arginase activity was measured from 73 minimally-passaged clinical isolates and six laboratory-adapted strains …

Protostrongylid Parasites And Pneumonia In Captive And Wild Thinhorn Sheep (Ovis Dalli), Emily J. Jenkins, A. M. Veitch, Susan J. Kutz, T. K. Bollinger, J. M. Chirino-Trejo, B. T. Elkin, K. H. West, Eric P. Hoberg, L. Polley

Harold W. Manter Laboratory of Parasitology: Faculty Publications

We describe health significance of protostrongylid parasites (Parelaphostrongylus odocoilei and Protostrongylus stilesi) and other respiratory pathogens in more than 50 naturally infected Dall’s sheep (Ovis dalli dalli) from the Mackenzie Mountains, Northwest Territories (1998–2002) as well as in three Stone’s sheep (O. d. stonei) experimentally infected with P. odocoilei (2000–2002). Histological lesions in the brain and distribution of P. odocoilei in the muscles of experimentally and naturally infected sheep were consistent with a previously hypothesized ‘‘central nervous system to muscle’’ pattern of migration for P. odocoilei. Dimensions of granulomas associated with eggs of …

Lupine Allergy: Not Simply Cross-Reactivity With Peanut Or Soy, Kim A. B. M. Peeters, Julie A. Nordlee, André H. Penninks, Lingyun Chen, Richard E. Goodman, Carla A. F. M. Bruijnzeel-Koomen, Sue L. Hefle, Steve L. Taylor, André C. Knulst

Department of Food Science and Technology: Faculty Publications

Background: Reports of lupine allergy are increasing as its use in food products increases. Lupine allergy might be the consequence of cross-reactivity after sensitization to peanut or other legumes or de novo sensitization. Lupine allergens have not been completely characterized.

Objectives: We sought to identify allergens associated with lupine allergy, evaluate potential cross-reactivity with peanut, and determine eliciting doses (EDs) for lupine allergy by using double-blind, placebo-controlled food challenges.

Methods: Six patients with a history of allergic reactions to lupine flour were evaluated by using skin prick tests, CAP tests, and double-blind, placebo-controlled food challenges. Three of …

Chlorophacinone Baiting For Belding’S Ground Squirrels, Craig A. Ramey, George H. Matschke, Richard M. Engeman

United States Department of Agriculture Wildlife Services: Staff Publications

The efficacy of using 0.01% chlorophacinone on steam-rolled oat (SRO) groats applied in CA alfalfa by spot-baiting/hand baiting around burrow entrances (~11.5 g) to control free-ranging Belding's ground squirrels (Spermophilus beldingi) were compared in 6 randomly assigned square treatment units (TUs). Four TUs were given the rodenticide and 2 treated with placebo bait. Each TU was a 0.4 ha square surrounded by a similarly treated 5.5 ha square buffer zone. Baits were applied on May 13 and re-applied, on May 20 and May 22, after 7 days of un-forecasted cool wet weather greatly reduced their above ground activity. Pesticide (EPA …

Grânulos De Amido E Fitólitos Em Cálculos Dentários Humanos: Contribuição Ao Estudo Do Modo De Vida E Subsistência De Grupos Sambaquianos Do Litoral Sul Do Brasil, Verônica Wesolowski, Sheila Maria Ferraz Mendonça De Souza, Karl Reinhard, Gregório Ceccantini

Karl Reinhard Publications

Este artigo tem por objetivo apresentar os resultados da recuperação e análise de micro-vestígios vegetais retidos em cálculos dentários de grupos de pescadores-coletores do litoral sul do Brasil. Apresenta também os resultados das relações mantidas entre grânulos de amido e cárie, e entre fitólitos e desgaste dentário.

Através da dissolução química de cálculos dentários foram recuperados microvestígios vegetais em todos os indivíduos estudados. Foi evidenciado o consumo de alimentos amiláceos em todas as séries esqueléticas estudadas, demonstrando independência entre dieta com aporte de produtos vegetais e utilização de cerâmica. Foram encontrados resultados sugestivos de padrões de escolha de alimentos diferenciados …

Depression Vulnerability Within Smoking Research: How Accurate Are One-Item Screening Items?, Dennis E. Mcchargue, Jessica Werth Cook

Department of Psychology: Faculty Publications

Epidemiological and large scale treatment studies within smoking research have utilized many one-item screening items to examine the influence of current depressive symptoms on smoking behavior and quitting. Little is known about that concurrent validity of screening items that may reflect depression vulnerability independent of current symptoms. The present paper evaluated the concurrent validity of two one-item screening items that were essential for diagnosing past episodes of major depression. Screening questions were administered to seventy seven nicotine dependent participants via a telephone screening interview. Smokers then returned to the laboratory for a comprehensive structured assessment of depressive vulnerability. Vulnerability measures …

Effect Of Impulsivity On Cardiovascular And Subjective Reactivity To Smoking Cues, Neal Doran, Dennis E. Mcchargue, Bonnie Spring

Department of Psychology: Faculty Publications

Individuals with high levels of impulsivity are more likely to smoke and may have greater difficulty quitting than other smokers. Although the specific mechanisms mediating this relationship are not explicitly known, one candidate is disproportionate cigarette craving in response to environmental smoking cues. We assessed the effect of impulsivity on three measures of cue reactivity. Regular smokers (n=75) were exposed to a smoking cue and a neutral cue in 2 counterbalanced experimental sessions. Cigarette craving, heart rate (HR), and mean arterial pressure (MAP) were used to index cue reactivity. More impulsive smokers exhibited a disproportionate response to the …

Acculturative Stress, Social Support, And Coping: Relations To Psychological Adjustment Among Mexican American College Students, Lisa J. Crockett, Maria I. Iturbide, Rosalie A. Torres Stone, Meredith Mcginley, Marcela Raffaelli, Gustavo Carlo

Department of Psychology: Faculty Publications

This study examined the relations between acculturative stress and psychological functioning, as well as the protective role of social support and coping style, in a sample of 148 Mexican American college students (67% female, 33% male; mean age = 23.05 years, SD = 3.33). In bivariate analyses, acculturative stress was associated with higher levels of anxiety and depressive symptoms. Moreover, active coping was associated with better adjustment (lower depression), whereas avoidant coping predicted poorer adjustment (higher levels of depression and anxiety). Tests of interaction effects indicated that parental support and active coping buffered the effects of high acculturative stress on …

How Do I Feel About The Behavior? The Interplay Of Affective Associations With Behaviors And Cognitive Beliefs As Influences On Physical Activity Behavior, Marc T. Kiviniemi, Amy M. Voss-Humke, April L. Seifert

Department of Psychology: Faculty Publications

Individuals have affective associations with health behaviors. In other domains such associations have been shown to influence behavior, but affective associations with health behaviors are not included in current health decision-making models. The authors examined whether affective associations with exercise predicted individuals’ activity behavior and, if so, how they interfaced with other decision-making constructs to influence behavior. Adult participants (N = 433) reported their current physical activity behavior and affective associations with physical activity. Health belief model and theory of planned behavior constructs were also assessed. More positive affective associations with activity significantly predicted greater activity behavior. Moreover, the …

Multilevel Models For Examining Individual Differences In Within-Person Variation And Covariation Over Time, Lesa Hoffman

Department of Psychology: Faculty Publications

Heterogeneity of variance may be more than a statistical nuisance—it may be of direct interest as a result of individual differences. In studies of short-term fluctuation, individual differences may relate to the magnitude of within-person variation as well as to level of an outcome or its covariation with other processes. Although models for heterogeneous variances have been utilized in group contexts (i.e., dispersion models), they are not usually applied in examinations of intraindividual variation. This work illustrates how an extension of the multilevel model for heterogeneous variances can be used to examine individual differences in level, between- and within-person covariation, …

On The Use Of Multilevel Modeling As An Alternative To Items Analysis In Psycholinguistic Research, Lawrence Locker Jr., Lesa Hoffman, James A. Bovaird

Department of Psychology: Faculty Publications

The use of multilevel modeling is presented as an alternative to separate item and subject ANOVAs (F₁ x F₂) in psycholinguistic research. Multilevel modeling is commonly utilized to model variability arising from the nesting of lower level observations within higher level units (e.g., students within schools, repeated measures within individuals). However, multilevel models can also be used when two random factors are crossed at the same level, rather than nested. The current work illustrates the use of the multilevel model for crossed random effects within the context of a psycholinguistic experimental study, in which both subjects …

Concordance Of Self-Report And Informant Assessment Of Emotional Well-Being In Nursing Home Residents With Dementia, Ann M. Kolanowski, Lesa Hoffman, Scott M. Hofer

Department of Psychology: Faculty Publications

The emotional well-being of persons with dementia is an aspect of their quality of life. We examined the stability of informant-rated and self-reported emotion, and the influence of mental status and physical dependence on ratings; we modeled concordance between ratings at both the within- and between-person levels of analysis. We used multilevel modeling to examine data collected over 12 days from 31 nursing home residents. We found significant within-person variation in both informant-rated and self-reported emotion, such that between 40% and 60% of the overall variance in each occurred within persons. We found little correspondence between or within persons between …

Child Sexual Abuse, David J. Hansen, Kathryn R. Wilson

Department of Psychology: Faculty Publications

Although definitions can vary across legal, clinical, and research contexts, sexual abuse is commonly defined as sexual acts between a youth and an older person (e.g., by 5 years or more) in which the dominance of the older person is used to exploit or coerce the youth. Behaviors may include noncontact (e.g., exposure) and contact (e.g., intercourse) offenses.

When Quantity Trumps Number: Discrimination Experiments In Cotton-Top Tamarins (Saguinus Oedipus) And Common Marmosets (Callithrix Jacchus), Jeffrey R. Stevens, Justin N. Wood, Marc D. Hauser

Department of Psychology: Faculty Publications

The capacity for non-linguistic, numerical discrimination has been well characterized in non-human animals, with recent studies providing careful controls for nonnumerical confounds such as continuous extent, density, and quantity. More poorly understood are the conditions under which animals use numerical versus nonnumerical quantification, and the nature of the relation between these two systems. Here we test whether cotton- top tamarins and common marmosets can discriminate between two quantities on the basis of the amount of food rather than on number. In three experiments, we show that when choosing between arrays containing different numbers and sizes of food objects, both species …

Will They Tell? Weapons Reporting By Middle-School Youth, Eve M. Brank, Jennifer L. Woolard, Veda E. Brown, Mark Fondacaro, Jennifer L. Luescher, Ramona G. Chinn, Scott A. Miller

Department of Psychology: Faculty Publications

Adding to the body of research that describes students who will bring weapons to school, the current research examined middle-school students’ willingness to report when they know someone has a weapon at school. The sample included 1,957 sixth, seventh, and eighth graders from 27 schools in five states. Overall, a majority of students indicated that they would be willing to report; however, there were significant effects for the conditions of reporting (such as anonymity) and effects for some demographic characteristics. Furthermore, students who perceived adult or parental involvement in their lives were more willing to report. In contrast, students with …

Childhood Psychological Maltreatment And Quality Of Marriage: The Mediating Role Of Psychological Distress, Andrea R. Perry, David K. Dilillo, James Peugh

Department of Psychology: Faculty Publications

This study examined the role of adult psychological distress in mediating associations between childhood psychological maltreatment and marital satisfaction in a sample of 65 newlywed couples. Results indicated that a significant linkage between psychological maltreatment (including emotional abuse and emotional neglect) and marital satisfaction was eliminated when accounting for global psychological distress, hostility, and depression in the overall sample. These findings were moderated by gender, such that for men, the long-term cOl'relates of emotional abuse were mediated by broad psychological distress and paranoia. Conversely, for women, relations between emotional abuse and emotional neglect and later marital satisfaction were mediated by …

Towards An Understanding Of The Process And Mechanisms Of Change In Cognitive Behavioral Therapy: Linking Innovative Methodology With Fundamental Questions [Editorial], Adele Hayes, Debra A. Hope, Sarah Hayes

Department of Psychology: Faculty Publications

There is now consistent evidence to support the efficacy of cognitive-behavior therapy (CBT) to reduce clinical symptoms and improve quality of life across a variety of clinical problems (Butler, Chapman, Formen, & Beck, 2006). This outcome research typically relies on a pretreatment-posttreatment design and follow-up assessments at fixed intervals beyond post-test. These outcome studies have been important in answering questions about if a treatment works and, to some extent, for whom it works. However, these designs provide much less information about the mechanisms of treatment—why or how an intervention works. There has been a resurgence of interest in studying …

Development And Pilot Testing Of An Omega-3 Fatty Acid Food Frequency Questionnaire, Paula K. Ritter-Gooder, Nancy M. Lewis, Kimberly Barber-Heidal, Megan Waltz-Hill

Department of Nutrition and Health Sciences: Faculty Publications

Omega-3 fatty acids are essential to health and provide cardio-protective benefits. To estimate omega-3 fatty acid dietary intake, we developed a semi-quantitative food frequency questionnaire (FFQ) and pilot tested its reliability and validity in a convenience sample of cardiac patients in the Midwest. The FFQ was developed using the USDA Nutrient Database for Standard Reference and the ESHA Food Processor, ESHA Research, Salem, Oregon. Three 24-h recalls and two administrations of the FFQ two weeks apart were obtained by a dietitian by phone and home visit from 28 volunteers. Pearson correlation was used to assess the association between food recalls …

Linking Self-Regulation And Risk Proneness To Risky Sexual Behavior: Pathways Through Peer Pressure And Early Substance Use, Lisa J. Crockett, Marcela Raffaelli, Yuh-Ling Shen

Department of Psychology: Faculty Publications

The linkages between self-regulation in childhood, risk proneness in early adolescence, and risky sexual behavior in mid-adolescence were examined in a cohort of children (N = 518) from the National Longitudinal Survey of Youth. The possible mediating role of two early adolescent variables (substance use and negative peer pressure) was also examined. Self-regulation was assessed by maternal report at ages 8–9, and risk proneness, comprising aspects of sensation seeking and decision making, was assessed by adolescent self-report at ages 12–13. Structural equation models predicting risky sexual behavior at ages 16–17 indicated that self-regulation operated partly through early adolescent substance use, …

Transfusion-Associated Transmission Of West Nile Virus, United States 2003 Through 2005, Susan P. Montgomery, Jennifer A. Brown, Matthew Kuehnert, Theresa L. Smith, Nicholas Crall, Robert S. Lanciotti, Alexandre Macedo De Oliveira, Thomas Boo, Anthony A. Marfin, 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team

Zoonotics and Wildlife Disease: Publications

BACKGROUND: National blood donation screening for West Nile virus (WNV) started in June 2003, after the documentation of WNV transfusion-associated transmission (TAT) in 2002.

STUDY DESIGN AND METHODS: Blood donations were screened with investigational nucleic acid amplification assays in minipool formats. Blood collection agencies (BCAs) reported screening results to state and local public health authorities. Donor test results and demographic information were forwarded to CDC via ArboNET, the national electronic arbovirus surveillance system. State health departments and BCAs also reported suspect WNV TATs to CDC, which investigated these reports to confirm WNV infection in blood transfusion recipients in the absence …

Transfusion-Associated Transmission Of West Nile Virus, United States 2003 Through 2005, Susan P. Montgomery, Jennifer A. Brown, Matthew Kuehnert, Theresa L. Smith, Nicholas Crall, Robert S. Lanciotti, Alexandre Macedo De Oliveira, Thomas Boo, Anthony A. Marfin, 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team

United States Public Health Resources

BACKGROUND: National blood donation screening for West Nile virus (WNV) started in June 2003, after the documentation of WNV transfusion-associated transmission (TAT) in 2002.
STUDY DESIGN AND METHODS: Blood donations were screened with investigational nucleic acid amplification assays in minipool formats. Blood collection agencies (BCAs) reported screening results to state and local public health authorities. Donor test results and demographic information were forwarded to CDC via ArboNET, the national electronic arbovirus surveillance system. State health departments and BCAs also reported suspect WNV TATs to CDC, which investigated these reports to confirm WNV infection in blood transfusion recipients in the absence …

Measuring Attentional Ability In Older Adults: Development And Psychometric Evaluation Of Driverscan, Lesa Hoffman, Yang Xiangdong, James A. Bovaird, Susan E. Embretson

Department of Psychology: Faculty Publications

Although deficits in visual attention are often postulated as an important component of many declines in cognitive processing and functional outcomes in older adults, surprisingly little emphasis has been placed on evaluating psychometric instruments with which individual differences in visual attention ability can be assessed. This article reports the development and beginning psychometric evaluation of DriverScan, a change detection measure of attentional search for older adults. A constrained graded response model is used to approximate response speed and accuracy with categories of immediate, delayed, or no response. DriverScan items are shown to have excellent reliability over the studied sample, and …

A Dyadic Examination Of Daily Health Symptoms And Emotional Well-Being In Late-Life Couples, Jeremy B. Yorgason, David Almeida, Shevaun D. Neupert, Avron Spiro Iii, Lesa Hoffman

Department of Psychology: Faculty Publications

This study investigated the link between daily health symptoms and spousal emotional well-being in a sample of 96 older dyads. Higher negative mood and lower positive mood were associated with spousal symptoms in couples wherein husbands or wives reported higher average levels of symptoms. For wives, partner effects were moderated by husbands’ marital satisfaction and illness severity. Specifically, higher husband marital satisfaction and illness severity were associated with higher negative mood and lower positive mood for wives on days where husbands reported higher symptom levels. In their work with later-life families, practitioners and educators should address long-term and daily health-related …

Clinical Registered Dietitians, Employers, And Educators Are Interested In Advanced Practice Education And Professional Doctorate Degrees In Clinical Nutrition, Annalynn Skipper, Nancy M. Lewis

Department of Nutrition and Health Sciences: Faculty Publications

A subset of registered dietitians (RDs) is known to practice at an advanced level, but a clear educational pathway supporting advanced medical nutrition therapy practice has not been identified. Thus, an electronic survey was designed to investigate interest of clinical RDs, employers, and educators in advanced practice competencies and professional doctorate degree programs in clinical nutrition. Usable responses were obtained from 440 of 978 (45%) RDs, 61 of 107 (57%) employers, and 76 of 114 (67%) educators. Mean interest (5 = very interested, 1 = very uninterested) in obtaining advanced practice education was highest among RDs (3.93 ±1.01) and was …

Job Applicants’ Testing And Organizational Perceptions: The Effects Of Test Information And Attitude Strength, Andrew L. Noon

Department of Psychology: Dissertations, Theses, and Student Research

This quasi-experimental study examined job applicants’ organizational perceptions prior to and immediately after completing pre-employment assessments, and after the hiring decision was announced. Participants were actual applicants (N = 262) for non-exempt level data processing positions at a medium-size Midwestern insurance company. As part of the selection process, applicants completed both a cognitive ability test and a personality inventory. Information about the tests was used as a manipulation. Approximately half of the participants received information prior to completing the assessments that explained the tests’ content, job relatedness, and validity, and a description of the testing process, while the other …

Anti-Capsular Antibodies Activate Killing Of Escherichia Coli O8:K87 By The Alternate Complement Pathway In Porcine Serum, N. M. Clark, E. M. Berberov, M. Wang, Rodney A. Moxley

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterotoxigenic Escherichia coli (ETEC) strains that produce K88 (F4) ⁺ fimbria are important causes of diarrhea and post-diarrheal septicemia in swine. ETEC O8:K87, a serotype represented by a number of these strains, is typically serum resistant. Strain-specific antibodies are known to activate alternative C pathway-mediated killing of other serum-resistant E. coli [Hill, A.W., Shears, A.L., Hibbitt, K.G., 1978. The requirement of specific antibody for the killing of E. coli by the alternate complement pathway in bovine serum. Immunology 34, 131–136], but their antigenic targets have not been determined. We tested the hypothesis that anti-K87 antibodies activate alternative pathway-mediated killing of …

Bringing Evidence-Based Child Mental Health Services To The Schools: General Issues And Specific Populations, Carrie Masia-Warner, Douglas W. Nangle, David J. Hansen

Department of Psychology: Faculty Publications

Epidemiological research indicates a high prevalence of psychiatric disorders among children and adolescents. Approximately 21% of children and adolescents, ages 9 to 17, have a diagnosable psychiatric disorder (Costello et al., 1996; Shaffer et al., 1996; U.S. Public Health Service, 2000), and additional youngsters experience social and emotional difficulties that do not meet symptom criteria for a disorder but cause considerable distress and impairment in functioning. Unfortunately, there is a significant gap between the many youth who are in need of treatment and those who actually receive menfal health care (Burns et al., 1995; Leaf et al., 1996). According to …

Acculturation Status And Heavy Alcohol Use Among Mexican American College Students: Investigating The Moderating Role Of Gender, Byron L. Zamboanga, Marcela Raffaelli, Nicholas J. Horton

Department of Psychology: Faculty Publications

We examined whether gender moderates the association between acculturation and heavy alcohol use. The sample consisted of 126 Mexican American college students (Mean age = 24.7 years; 57% female) who completed self-report measures of heavy alcohol use, acculturation status (global acculturation and ethnic identity), and relevant control variables (age, peer alcohol use). Multivariable regression revealed that higher levels of ethnic identity were associated with greater frequency of heavy alcohol among men. Conversely, neither measure of acculturation was associated with heavy alcohol use among women. These findings suggest that interventions for Latino/a students should consider the role of culturally relevant variables …

Development Of A Gis-Based, Real-Time Internet Mapping Tool For Rabies Surveillance, Jesse D. Blanton, Arie Manangan, Jamie Manangan, Cathleen A. Hanlon, Dennis Slate, Charles E. Rupprecht

Zoonotics and Wildlife Disease: Publications

Background: Oral rabies vaccination programs have been implemented to control the spread of wildlife rabies in the United States. However, current surveillance systems are inadequate for the efficient management and evaluation of these large scale vaccine baiting programs. With this in mind, a GIS-based rabies surveillance database and Internet mapping application was created. This surveillance system, RabID, provides a new resource for the rapid mapping and dissemination of data on animal rabies cases in relation to unaffected, enzootic, and baited areas where current interventions are underway.

Results: RabID is a centralized database for diagnostic and demographic information collected by local, …

Sub-Typing Of Prrsv Isolates By Means Of Measurement Of Cross-Neutralization Reactions, Fernando A. Osorio

School of Veterinary and Biomedical Sciences: Faculty Publications

The degree of similitude or closeness between two different isolates or strains of PRRSV is very important for deciding which strains should be used for immunization, by either vaccinating with commercial vaccines or attempting to stabilize a herd with planned wt PRRSV infection. As previously known for certain important viral diseases, such as in Foot and Mouth Disease, the reciprocal (cross-) neutralization titers between two strains may be of utmost importance to establish the degree of similarity or difference between these. There is currently a void of methods that would allow distinguishing or grouping strains of PRRSV in a manner …