Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

University of Nebraska - Lincoln

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 3481 - 3510 of 5204

Full-Text Articles in Medicine and Health Sciences

Brown Dog Tick: Vector For Rocky Mountain Spotted Fever, Craig Levy Feb 2008

Brown Dog Tick: Vector For Rocky Mountain Spotted Fever, Craig Levy

Zoonotics and Wildlife Disease: Publications

The brown dog tick, Rhipicephalus sanguineus (Acari: Ixodidae), feeds primarily on dogs and until recently was not known to vector Rocky Mountain spotted fever (RMSF). In 2003–2004, fourteen cases of RMSF in humans occurred in eastern Arizona in the absence of known vectors, the Rocky Mountain wood tick, Dermacentor andersoni, and American dog tick, Dermacentor variabilis. However, health officials found brown dog ticks to be very abundant in areas associated with human cases, and the Centers for Disease Control and Prevention (CDC) implicated that the brown dog tick was responsible for transmitting RMSF. Brown dog ticks occur throughout the United …

Go to article

Does Gender Moderate Associations Among Impulsivity And Health-Risk Behaviors?, Scott F. Stoltenberg, Brian D. Batien, Denis G. Birgenheir Feb 2008

Does Gender Moderate Associations Among Impulsivity And Health-Risk Behaviors?, Scott F. Stoltenberg, Brian D. Batien, Denis G. Birgenheir

Department of Psychology: Faculty Publications

The present study explores the relations among gender, impulsivity and three health-risk behaviors relevant to young adults (tobacco use, alcohol problems and gambling problems) in a sample of 197 college-age individuals. We sought to determine whether impulsivity is associated with health-risk behaviors in the same ways for men and women. For tobacco use and gambling problems, men were at higher risk than women, and impulsivity was not significantly associated with higher risk. Higher levels of motor impulsivity in men accounted for a significant amount of the gender difference in risk for alcohol problems. That is, impulsivity as measured by the …

Go to article

Introducing Point Mutations Into The Atgs Of The Putative Open Reading Frames Of The Hsv-1 Gene Encoding The Latency Associated Transcript (Lat) Reduces Its Anti-Apoptosis Activity, Dale Carpenter, Gail A. Henderson, Chinhui Hsiang, Nelson Osorio, Lbachir Benmohamed, Clinton J. Jones, S L. Wechsler Feb 2008

Introducing Point Mutations Into The Atgs Of The Putative Open Reading Frames Of The Hsv-1 Gene Encoding The Latency Associated Transcript (Lat) Reduces Its Anti-Apoptosis Activity, Dale Carpenter, Gail A. Henderson, Chinhui Hsiang, Nelson Osorio, Lbachir Benmohamed, Clinton J. Jones, S L. Wechsler

School of Veterinary and Biomedical Sciences: Faculty Publications

The herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) gene has anti-apoptosis activity that directly or indirectly enhances the virus’s reactivation phenotype in small animal models. The first 1.5 kb of the primary 8.3 kb LAT is sufficient and some or all of it is necessary for LAT’s anti-apoptosis in transient transfection assays and for LAT’s ability to enhance the reactivation phenotype. Based on LAT’s genomic sequence, the first 1.5 kb contains eight potential open reading frames (ORFs) defined as an ATG followed by an in frame termination codon. In this study, point mutations were introduced into the …

Go to article

Lactic Acid Bacteria Cultures That Inhibit Food-Borne Pathogens: U.S. Patent No. Us 7,323,166 B2, Mindy M. Brashears, Divya Jaroni Jan 2008

Lactic Acid Bacteria Cultures That Inhibit Food-Borne Pathogens: U.S. Patent No. Us 7,323,166 B2, Mindy M. Brashears, Divya Jaroni

School of Veterinary and Biomedical Sciences: Faculty Publications

The present invention provides methods and compositions for preventing or inhibiting human food-borne pathogens in animals, and methods for increasing feed efficiency in animals by administering to the animal effective amounts of probiotic lactic acid producing bacteria. Further provided are feed compositions comprising probiotic lactic acid producing bacteria. A preferred probiotic lactic acid producing bacteria is Lactobacillus acidophilus strain ATCC accession number PTA-5249. This bacterial strain inhibits nalidixic acid-resistant Escherichia coli 0157:H7.

Go to article

In Situ Measurement Of Three-Dimensional Ion Densities In Focused Femtosecond Pulses, James Strohaber, Cornelis J. Uiterwaal Jan 2008

In Situ Measurement Of Three-Dimensional Ion Densities In Focused Femtosecond Pulses, James Strohaber, Cornelis J. Uiterwaal

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

We image spatial distribution of xenon ions in the focus of a laser beam of ultrashort, intense pulses in all three dimensions, with a resolution of three by twelve microns in the two transverse directions. This allows for studying ionization processes without spatially averaging ion yields. Our in situ ion imaging is also useful to analyze focal intensity profiles and to investigate the transverse modal purity of tightly focused beams of complex light. As an example, the intensity profile of a Hermite-Gaussian beam mode HG recorded with ions is found to be in good agreement with optical images.

Go to article

Differential Role Of Nadp+ And Nadph In The Activity And Structure Of Gdp-D-Mannose 4,6-Dehydratase From Two Chlorella Viruses, Floriana Fruscione, Laura Sturla, Garry Duncan, James L. Van Etten, Paola Valbuzzi, Antonio De Flora, Eleonopra Di Zanni, Michela Tonetti Jan 2008

Differential Role Of Nadp+ And Nadph In The Activity And Structure Of Gdp-D-Mannose 4,6-Dehydratase From Two Chlorella Viruses, Floriana Fruscione, Laura Sturla, Garry Duncan, James L. Van Etten, Paola Valbuzzi, Antonio De Flora, Eleonopra Di Zanni, Michela Tonetti

James Van Etten Publications

GDP-D-mannose 4,6-dehydratase (GMD) is a key enzyme involved in the synthesis of 6-deoxyhexoses in prokaryotes and eukaryotes. Paramecium bursaria chlorella virus-1 (PBCV-1) encodes a functional GMD, which is unique among characterized GMDs because it also has a strong stereospecific NADPH-dependent reductase activity leading to GDP-D-rhamnose formation (Tonetti, M., Zanardi, D., Gurnon, J., Fruscione, F., Armirotti, A., Damonte, G., Sturla, L., De Flora, A., and Van Etten, J.L. (2003) J. Biol. Chem. 278, 21559–21565). In the present study we characterized a recombinant GMD encoded by another chlorella virus, Acanthocystis turfacea chlorella virus 1 (ATCV-1), demonstrating that it has the expected dehydratase …

Go to article

Assessing Risk Of Reoffending In Adolescents Who Have Committed A Sexual Offense: The Accuracy Of Clinical Judgments After Completion Of Risk Assessment Instruments, Natasha Elkovitch, Jodi L. Viljoen, Mario J. Scalora, Daniel Ullman Jan 2008

Assessing Risk Of Reoffending In Adolescents Who Have Committed A Sexual Offense: The Accuracy Of Clinical Judgments After Completion Of Risk Assessment Instruments, Natasha Elkovitch, Jodi L. Viljoen, Mario J. Scalora, Daniel Ullman

Department of Psychology: Faculty Publications

As courts often rely on clinicians when differentiating between sexually abusive youth at a low versus high risk of reoffense, understanding factors that contribute to accuracy in assessment of risk is imperative. The present study built on existing research by examining (1) the accuracy of clinical judgments of risk made after completing risk assessment instruments, (2) whether instrument- informed clinical judgments made with a high degree of confidence are associated with greater accuracy, and (3) the risk assessment instruments and subscales most predictive of clinical judgments. Raters assessed each youth’s (n = 166) risk of reoffending after completing the SAVRY …

Go to article

Juries And Eyewitnesses, Cindy Laub, Brian H. Bornstein Jan 2008

Juries And Eyewitnesses, Cindy Laub, Brian H. Bornstein

Department of Psychology: Faculty Publications

The role of an eyewitness can be extremely important in the legal system, as eyewitness testimony and eyewitness identifications play a major role in the prosecution of a criminal defendant. Often the courts are left to rely solely on an eyewitness because there is no other physical evidence. This leaves the jury to rely on a witness’s testimony. Jurors are asked to determine the credibility of an eyewitness at trial when rendering a verdict, and jurors have been found to place more emphasis on eyewitness testimony than on any other kind of evidence. However, there are numerous documented cases of …

Go to article

A Review Of The Tripartite Model For Understanding The Link Between Anxiety And Depression In Youth, Emily R. Anderson, Debra A. Hope Jan 2008

A Review Of The Tripartite Model For Understanding The Link Between Anxiety And Depression In Youth, Emily R. Anderson, Debra A. Hope

Department of Psychology: Faculty Publications

Although research from numerous investigations indicates that there is substantial overlap in anxiety and depressive symptoms and comorbid diagnoses in youth, these constructs can be adequately differentiated. Clark and Watson [Clark, L. A. & Watson, D., (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxonomic implications. Journal of Abnormal Psychology, 100: 316-336] proposed a tripartite model to account for the symptom overlap and diagnostic comorbidity between anxiety and depression. This tripartite model posits that anxiety and depression share a common component of negative affect, but can be differentiated by low positive affect associated with depression and high …

Go to article

Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro Jan 2008

Amphetamine Selectively Enhances Avoidance Responding To A Less Salient Stimulus In Rats, Ming Li, Wei He, Rebecca Munro

Department of Psychology: Faculty Publications

This preclinical study examined the psychological processes affected by amphetamine that contribute to human psychosis. Using a novel avoidance conditioning paradigm involving two conditioned stimuli (CS) with varied salience, we found that acute amphetamine (1.5 mg/ kg, i.p.) selectively enhanced avoidance responding to a less salient stimulus, but not to a salient one. These findings suggest that elevated dopaminergic activity selectively enhances the attributions of motivational salience to a less salient stimulus, a process that may bear relevance to the development of human delusional thoughts.

Go to article

Signs For The Future Of Civil Justice Research, Brian H. Bornstein Jan 2008

Signs For The Future Of Civil Justice Research, Brian H. Bornstein

Department of Psychology: Faculty Publications

The chapters in the present volume [Civil Juries and Civil Justice (New York: Springer, 2008)] provide a number of signs for the future of civil justice research. Many of the signs are favorable and point to continued fruitful collaborations between legal and psychological researchers on pressing topics in the justice arena with important policy implications; yet the contributions also highlight several gaps in the literature, data limitations, and false steps. In other words, some of the signs are not-so-favorable, and there is still much work to be done. In this concluding commentary, I identify the major portents for the …

Go to article

Ecological Factors Associated With West Nile Virus Transmission, Northeastern United States, Heidi E. Brown, James E. Childs, Maria A. Diuk-Wasser, Durland Fish Jan 2008

Ecological Factors Associated With West Nile Virus Transmission, Northeastern United States, Heidi E. Brown, James E. Childs, Maria A. Diuk-Wasser, Durland Fish

Zoonotics and Wildlife Disease: Publications

Since 1999, West Nile virus (WNV) disease has affected the northeastern United States. To describe the spatial epidemiology and identify risk factors for disease incidence, we analyzed 8 years (1999–2006) of county-based human WNV disease surveillance data. Among the 56.6 million residents in 8 northeastern states sharing primary enzootic vectors, we found 977 cases. We controlled for population density and potential bias from surveillance and spatial proximity. Analyses demonstrated significant spatial spreading from 1999 through 2004 (p2 = 0.16). A significant trend was apparent among increasingly urban counties; county quartiles with the least (0.75 cases/100,000 residents) than counties with the …

Go to article

Myenteric Neurons Of The Ileum That Express Somatostatin Are A Target Of Prion Neuroinvasion In An Alimentary Model Of Sheep Scrapie, David A. Schneider, Huijun Yan, Lindsay M. Fry, Janet Alverson, Stephen N. White, Katherine I. O'Rourke Jan 2008

Myenteric Neurons Of The Ileum That Express Somatostatin Are A Target Of Prion Neuroinvasion In An Alimentary Model Of Sheep Scrapie, David A. Schneider, Huijun Yan, Lindsay M. Fry, Janet Alverson, Stephen N. White, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Neuroinvasion of the enteric nervous system by prions is an important step in dissemination to the brain, yet very little is known about the basic process of enteric neuroinvasion. Using an alimentary model of neonatal disease transmission, neuroinvasion by scrapie prions in the ileum of lambs was detected by immunohistochemical staining for the disease-associated form of the prion protein, PrPSc. Odds ratios (OR) were determined for the frequency of PrPSc staining within enteric somata categorized by plexus location (myenteric, submucosal) and neurochemical staining (PGP 9.5, neural nitric oxide synthase, somatostatin, substance P, and vasoactive intestinal polypeptide). PrP …

Go to article

Prion Gene (Prnp) Haplotype Variation In United States Goat Breeds, Stephen N. White, Lynn Herrmann-Hoesing, Katherine I. O'Rourke, Daniel Waldron, Joan Rowe, Janet Alverson Jan 2008

Prion Gene (Prnp) Haplotype Variation In United States Goat Breeds, Stephen N. White, Lynn Herrmann-Hoesing, Katherine I. O'Rourke, Daniel Waldron, Joan Rowe, Janet Alverson

Zoonotics and Wildlife Disease: Publications

Scrapie eradication efforts cost 18 million dollars annually in the United States and rely heavily upon PRNP genotyping of sheep. Genetic resistance might reduce goat scrapie and limit the risk of goats serving as a scrapie reservoir, so PRNP coding sequences were examined from 446 goats of 10 breeds, 8 of which had not been previously examined at PRNP. The 10 observed alleles were all related to one of two central haplotypes by a single amino acid substitution. At least five of these alleles (M142, R143, S146, H154, and K222) have been associated with increased incubation time or decreased …

Go to article

A Species Barrier Limits Transmission Of Chronic Wasting Disease To Mink (Mustela Vison), Robert D. Harrington, Timothy V. Baszler, Katherine I. O'Rourke, David A. Schneider, Terry R. Spraker, H. Denny Liggitt, Donald P. Knowles Jan 2008

A Species Barrier Limits Transmission Of Chronic Wasting Disease To Mink (Mustela Vison), Robert D. Harrington, Timothy V. Baszler, Katherine I. O'Rourke, David A. Schneider, Terry R. Spraker, H. Denny Liggitt, Donald P. Knowles

Zoonotics and Wildlife Disease: Publications

Transmissible mink encephalopathy (TME) occurs as sporadic outbreaks associated with ingestion of feed presumably contaminated with some type of prion disease. Mink lack a species barrier to primary oral challenge with bovine spongiform encephalopathy, whereas they have a barrier to such challenge with scrapie. We investigated whether mink have a species barrier to chronic wasting disease (CWD) by performing primary intracerebral (IC) and primary oral challenge with CWD-positive elk brain. Primary IC challenge resulted in clinical disease in two of eight mink at 31–33 months incubation. Affected mink had spongiform vacuolation and astrocytosis within the central nervous system and immunoreactivity …

Go to article

Scrapie Resistance In Arq Sheep, W. W. Laegreid, M. L. Clawson, M. P. Heaton, B. T. Green, Katherine I. O'Rourke, D. P. Knowles Jan 2008

Scrapie Resistance In Arq Sheep, W. W. Laegreid, M. L. Clawson, M. P. Heaton, B. T. Green, Katherine I. O'Rourke, D. P. Knowles

Zoonotics and Wildlife Disease: Publications

Variation in the ovine prion protein amino acid sequence influences scrapie progression, with sheep homozygous for A136R154Q171 considered susceptible. This study examined the association of survival time of scrapie-exposed ARQ sheep with variation elsewhere in the ovine prion gene. Four single nucleotide polymorphism alleles were associated with prolonged survival. One nonsynonymous allele (T112) was associated with an additional 687 days of survival for scrapie-exposed sheep compared to M112 sheep (odds ratio, 42.5; P = 0.00014). The only two sheep homozygous for T112 (TARQ) did not develop scrapie, suggesting that the allelic effect may be additive. …

Go to article

A Collaborative Canadian–United Kingdom Evaluation Of An Immunohistochemistry Protocol To Diagnose Bovine Spongiform Encephalopathy, Lisa Manning, Katherine I. O'Rourke, Donald P. Knowles, Sarah A. Marsh, Yvonne I. Spencer, Estella Moffat, Gerald A. H. Wells, Stefanie Czub Jan 2008

A Collaborative Canadian–United Kingdom Evaluation Of An Immunohistochemistry Protocol To Diagnose Bovine Spongiform Encephalopathy, Lisa Manning, Katherine I. O'Rourke, Donald P. Knowles, Sarah A. Marsh, Yvonne I. Spencer, Estella Moffat, Gerald A. H. Wells, Stefanie Czub

Zoonotics and Wildlife Disease: Publications

Collaboration was established in 2001 to evaluate a commercially available immunohistochemistry assay kit for the detection of bovine spongiform encephalopathy (BSE) disease–associated prion protein in formic acid–treated formalin-fixed samples of bovine brain. The kit protocol was evaluated at the National Centre for Foreign Animal Diseases (Winnipeg, Canada) and the Veterinary Laboratories Agency (Weybridge, U.K.). The U.K. laboratory provided paraffin-embedded blocks of brainstem (medulla oblongata at the level of the obex) from 100 positive cases defined by clinical signs and histopathology, and 100 clinically suspect but BSE-negative samples defined by histopathology and immunohistochemistry with anti-PrP monoclonal antibody R145. The Canadian laboratory …

Go to article

Experimental Transmission Of Chronic Wasting Disease (Cwd) Of Elk (Cervus Elaphus Nelsoni), White-Tailed Deer (Odocoileus Virginianus), And Mule Deer (Odocoileus Hemionus Hemionus) To White-Tailed Deer By Intracerebral Route, A. N. Hamir, J. A. Richt, J. M. Miller, R. A. Kunkle, S. M. Hall, E. M. Nicholson, Katherine I. O'Rourke, J. J. Greenlee, E. S. Williams Jan 2008

Experimental Transmission Of Chronic Wasting Disease (Cwd) Of Elk (Cervus Elaphus Nelsoni), White-Tailed Deer (Odocoileus Virginianus), And Mule Deer (Odocoileus Hemionus Hemionus) To White-Tailed Deer By Intracerebral Route, A. N. Hamir, J. A. Richt, J. M. Miller, R. A. Kunkle, S. M. Hall, E. M. Nicholson, Katherine I. O'Rourke, J. J. Greenlee, E. S. Williams

Zoonotics and Wildlife Disease: Publications

To compare clinical and pathologic findings of chronic wasting disease (CWD) in a natural host, 3 groups (n = 5) of white-tailed deer (WTD) fawns were intracerebrally inoculated with a CWD prion of WTD, mule deer, or elk origin. Three other uninoculated fawns served as controls. Approximately 10 months postinoculation (MPI), 1 deer from each of the 3 inoculated groups was necropsied and their tissues were examined for lesions of spongiform encephalopathy (SE) and for the presence of abnormal prion protein (PrPd) by immunohistochemistry (IHC) and Western blot (WB). The remaining deer were allowed to live until …

Go to article

Rigid Thinking About Deformables: Do Children Sometimes Overgeneralize The Shape Bias?, Larissa K. Samuelson, Jessica S. Horst, Anne R. Schutte, Brandi N. Dobbertin Jan 2008

Rigid Thinking About Deformables: Do Children Sometimes Overgeneralize The Shape Bias?, Larissa K. Samuelson, Jessica S. Horst, Anne R. Schutte, Brandi N. Dobbertin

Department of Psychology: Faculty Publications

Young children learning English are biased to attend to the shape of solid rigid objects when learning novel names. This study seeks further understanding of the processes that support this behavior by examining a previous finding that three-year-old children are also biased to generalize novel names for objects made from deformable materials by shape, even after the materials are made salient. In two experiments, we examined the noun generalizations of 72 two-, three- and four-year- old children with rigid and deformable stimuli. Data reveal that three-year-old, but not two- or four-year-old, children generalize names for deformable things by shape, and …

Go to article

Chronic Wasting Disease In A Wisconsin White-Tailed Deer Farm, Delwyn P. Keane, Daniel J. Barr, Phillip N. Bochsler, S. Mark Hall, Thomas Gidlewski, Katherine I. O'Rourke, Terry R. Spraker, Michael D. Samuel Jan 2008

Chronic Wasting Disease In A Wisconsin White-Tailed Deer Farm, Delwyn P. Keane, Daniel J. Barr, Phillip N. Bochsler, S. Mark Hall, Thomas Gidlewski, Katherine I. O'Rourke, Terry R. Spraker, Michael D. Samuel

Zoonotics and Wildlife Disease: Publications

In September 2002, chronic wasting disease (CWD), a prion disorder of captive and wild cervids, was diagnosed in a white-tailed deer (Odocoileus virginianus) from a captive farm in Wisconsin. The facility was subsequently quarantined, and in January 2006 the remaining 76 deer were depopulated. Sixty animals (79%) were found to be positive by immunohistochemical staining for the abnormal prion protein (PrPCWD) in at least one tissue; the prevalence of positive staining was high even in young deer. Although none of the deer displayed clinical signs suggestive of CWD at depopulation, 49 deer had considerable accumulation of …

Go to article

Evaluation And Management Of Peripheral Nerve Injury, William W. Campbell Jan 2008

Evaluation And Management Of Peripheral Nerve Injury, William W. Campbell

Uniformed Services University of the Health Sciences

Common etiologies of acute traumatic peripheral nerve injury (TPNI) include penetrating injury, crush, stretch, and ischemia. Management of TPNI requires familiarity with the relevant anatomy, pathology, pathophysiology, and the surgical principles, approaches and concerns. Surgical repair of TPNI is done at varying time intervals after the injury, and there are a number of considerations in deciding whether and when to operate. In neurapraxia, the compound muscle and nerve action potentials on stimulating distal to the lesion are maintained indefinitely; stimulation above the lesion reveals partial or complete conduction block. The picture in axonotmesis and neurotmesis depends on the time since …

Go to article

Association Between Alcohol Consumption And Both Osteoporotic Fracture And Bone Density, Karina M. Berg, Hillary V. Kunins, Jeffrey L. Jackson, Shadi Nahvi, Amina Chaudhry, Kenneth A. Harris Jr., Rubina Malik, Julia H. Arnsten Jan 2008

Association Between Alcohol Consumption And Both Osteoporotic Fracture And Bone Density, Karina M. Berg, Hillary V. Kunins, Jeffrey L. Jackson, Shadi Nahvi, Amina Chaudhry, Kenneth A. Harris Jr., Rubina Malik, Julia H. Arnsten

Uniformed Services University of the Health Sciences

OBJECTIVE: Alcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and metaanalysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling.
METHODS: MEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force.
RESULTS: We pooled effect sizes for 2 specific outcomes (hip fracture …

Go to article

Chlorothalonil Exposure And Cancer Incidence Among Pesticideapplicator Participants In The Agricultural Health Study, Alicia M. Mozzachio, Jennifer A. Rusiecki, Jane A. Hoppin, Rajeev Mahajan, Rahulkumar Patel, Laura Beane-Freeman, Michael Cr Alavanja Jan 2008

Chlorothalonil Exposure And Cancer Incidence Among Pesticideapplicator Participants In The Agricultural Health Study, Alicia M. Mozzachio, Jennifer A. Rusiecki, Jane A. Hoppin, Rajeev Mahajan, Rahulkumar Patel, Laura Beane-Freeman, Michael Cr Alavanja

Uniformed Services University of the Health Sciences

Background: Chlorothalonil is a broad spectrum, non-systemic fungicide widely used to control diseases affecting over 50 fruit, vegetable, and agricultural crops. Despite its extensive use for over 30 years, little is known about the potential human carcinogenicity associated with the routine application of chlorothalonil. Rodent studies have shown evidence of renal tubular carcinomas and adenomas. We explored cancer incidence with chlorothalonil exposure using data from the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina.
Methods: Licensed private and commercial pesticide applicators were recruited into this study from 1993 to 1997. Detailed information regarding …

Go to article

Aortic Valve Disease In Turner Syndrome, Vandana Sachdev, Lea Ann Matura, Stanislav Sidenko, Vincent B. Ho, Andrew E. Arai, Douglas R. Rosing, Carolyn A. Bondy Jan 2008

Aortic Valve Disease In Turner Syndrome, Vandana Sachdev, Lea Ann Matura, Stanislav Sidenko, Vincent B. Ho, Andrew E. Arai, Douglas R. Rosing, Carolyn A. Bondy

Uniformed Services University of the Health Sciences

Objective: Our goal was to determine the prevalence and characteristics of aortic valve disease in girls and women with monosomy for the X chromosome, or Turner syndrome (TS).

Background: Complications from congenital aortic valve disease are a major source of premature mortality in TS, but accurate data on the prevalence of aortic valve abnormalities and their association with aortic root dilation are not available.

Methods: This prospective study characterized the aortic valve and proximal aorta in 253 individuals with TS age 7 to 67 years using transthoracic echocardiography as our primary screening tool, supplemented with magnetic resonance imaging.

Results: Transthoracic …

Go to article

Conformational Changes And Flexibility In T-Cell Receptor Recognition Of Peptide–Mhc Complexes, Kathryn M. Armstrong, Kurt H. Piepenbrink, Brian M. Baker Jan 2008

Conformational Changes And Flexibility In T-Cell Receptor Recognition Of Peptide–Mhc Complexes, Kathryn M. Armstrong, Kurt H. Piepenbrink, Brian M. Baker

Food for Health: Publications

A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been implicated in numerous autoimmune pathologies and is an underlying cause of transplant rejection. Early studies of the interactions of αβ TCRs (T-cell receptors) with their peptide–MHC ligands suggested that conformational plasticity in the TCR CDR (complementarity determining region) loops is a dominant contributor to T-cell cross-reactivity. Since these initial studies, the database of TCRs whose structures have been solved both bound and free is now large enough to permit general conclusions to be drawn about the extent of TCR plasticity and the types and locations of motion …

Go to article

Review Of Animal Noroviruses, A. Scipioni, A. Mauroy, J. Vinje, E. Thiry Jan 2008

Review Of Animal Noroviruses, A. Scipioni, A. Mauroy, J. Vinje, E. Thiry

United States Public Health Resources

Among enteric caliciviruses, noroviruses belong to the genus Norovirus, one of the four accepted genera in the family Caliciviridae. These single-stranded, positive-sense RNA viruses are highly variable both genetically and antigenically. Several animal enteric caliciviruses that are morphologically indistinguishable and genetically closely related to human noroviruses have been identified. The first bovine enteric noroviruses were described in Great Britain and are known as Newbury Agent 2. At least three genetic clusters of porcine noroviruses join together within genogroup II noroviruses. Human noroviruses are the most important cause of acute gastroenteritis illness in people of all ages. In the …

Go to article

Changes In Exposure To Secondhand Smoke Among Youth In Nebraska, 2002–2006, Lazarous Mbulo Jan 2008

Changes In Exposure To Secondhand Smoke Among Youth In Nebraska, 2002–2006, Lazarous Mbulo

United States Public Health Resources

Secondhand smoke is a major cause of morbidity and mortality. It has been associated with serious health problems in both children and adults. Efforts to reduce exposure to secondhand smoke in Nebraska have included programs to prevent tobacco use among young people and campaigns for smoke-free workplaces and homes. Despite these interventions, young people continue to be exposed to secondhand smoke at an unacceptably high rate. The objective of this study was to examine the extent to which Nebraska public middle and high school students were exposed to secondhand smoke in 2002 and 2006, to evaluate factors associated with this …

Go to article

Tick [Genome Mapping], Amy J. Ullmann, Jeffrey J. Stuart, Catherine A. Hill Jan 2008

Tick [Genome Mapping], Amy J. Ullmann, Jeffrey J. Stuart, Catherine A. Hill

United States Public Health Resources

Ticks (subphylum Chelicerata: class Arachnida: subclass Acari: superorder Parasitiformes: order Ixodidae) are obligate blood-feeding ectoparasites of global medical and veterinary importance. Ticks live on all continents of the world (Steen et al. 2006). There are approximately 899 species of ticks; the majority are ectoparasites of wildlife and approximately 10% of these are recognized as disease vectors or for their ability to cause direct damage through blood feeding (Jongejan and Uilenberg 2004). Ticks transmit a greater variety of viruses, bacteria, and protozoa than any other blood-feeding arthropod (Dennis and Piesman 2005) and are second only to mosquitoes in terms of their …

Go to article

Prostaglandin F2Α Increases Endothelial Nitric Oxide Synthase In The Periphery Of The Bovine Corpus Luteum: The Possible Regulation Of Blood Flow At An Early Stage Of Luteolysis, Koumei Shirasuna, Sho Watanabe, Takayuki Asahi, Missaka P. B. Wijayagunawardane, Kiemi Sasahara, Chao Jiang, Motozumi Matsui, Motoki Sasaki, Takashi Shimizu, John S. Davis, Akio Miyamoto Jan 2008

Prostaglandin F2Α Increases Endothelial Nitric Oxide Synthase In The Periphery Of The Bovine Corpus Luteum: The Possible Regulation Of Blood Flow At An Early Stage Of Luteolysis, Koumei Shirasuna, Sho Watanabe, Takayuki Asahi, Missaka P. B. Wijayagunawardane, Kiemi Sasahara, Chao Jiang, Motozumi Matsui, Motoki Sasaki, Takashi Shimizu, John S. Davis, Akio Miyamoto

United States Public Health Resources

Prostaglandin F2α (PGF2α) released from the uterus causes alterations in luteal blood flow, reduces progesterone secretion, and induces luteolysis in the bovine corpus luteum (CL).We have recently discovered that luteal blood flow in the periphery of the mature CL acutely increases coincidently with pulsatile increases in a metabolite of PGF2α (PGFM). In this study, we characterized changes in regional luteal blood flow together with regional alterations in endothelial nitric oxide synthase (eNOS) expression during spontaneous luteolysis and in response to PGF2α. Smooth muscle actin-positive blood vessels larger than 20 μm were observed mainly in …

Go to article

Prediction Of Clinical Outcomes In Primary Biliary Cirrhosis By Serum Enhanced Liver Fibrosis Assay, Marlyn J. Mayo, Julie Parkes, Beverley Adams-Huet, Burton Combes, A. Mills, Rodney Markin, Raphael Rubin, Donald Wheeler, Melissa Contos, A B. West, Sandra Saldana, Yonas Getachew, Robert Butsch, Velimir Luketic, Adrian Di Bisceglie, Nathan Bass, John Lake, Thomas Boyer, Enrique Martinez, James Boyer, Guadalupe Garcia-Tsao, David Barnes, William Rosenberg Jan 2008

Prediction Of Clinical Outcomes In Primary Biliary Cirrhosis By Serum Enhanced Liver Fibrosis Assay, Marlyn J. Mayo, Julie Parkes, Beverley Adams-Huet, Burton Combes, A. Mills, Rodney Markin, Raphael Rubin, Donald Wheeler, Melissa Contos, A B. West, Sandra Saldana, Yonas Getachew, Robert Butsch, Velimir Luketic, Adrian Di Bisceglie, Nathan Bass, John Lake, Thomas Boyer, Enrique Martinez, James Boyer, Guadalupe Garcia-Tsao, David Barnes, William Rosenberg

United States Public Health Resources

Primary biliary cirrhosis (PBC) is sometimes diagnosed based on a positive antimitochondrial antibody in the appropriate clinical setting without a liver biopsy. Although a liver biopsy can assess the extent of liver fibrosis and provide prognostic information, serum fibrosis markers avoid biopsy complications and sampling error and provide results as a continuous variable, which may be more precise than categorical histological stages. The current study was undertaken to evaluate serum fibrosis markers as predictors of clinical progression in a large cohort of PBCpatients. Serial liver biopsy specimens and serum samples were collected every 2 years in 161 PBC subjects for …

Go to article

First Prev Next Last