Medicine and Health Sciences Commons^™

A Herpesvirus Encoded Deubiquitinase Is A Novel Neuroinvasive Determinant, Joy I. Lee, Patricia J. Sollars, Scott B. Baver, Gary E. Pickard, Mindy Leelawong, Gregory A. Smith

School of Veterinary and Biomedical Sciences: Faculty Publications

The neuroinvasive property of several alpha-herpesviruses underlies an uncommon infectious process that includes the establishment of life-long latent infections in sensory neurons of the peripheral nervous system. Several herpesvirus proteins are required for replication and dissemination within the nervous system, indicating that exploiting the nervous system as a niche for productive infection requires a specialized set of functions encoded by the virus. Whether initial entry into the nervous system from peripheral tissues also requires specialized viral functions is not known. Here we show that a conserved deubiquitinase domain embedded within a pseudorabies virus structural protein, pUL36, is essential for initial …

Regulation Of Innate Immune Responses By Bovine Herpesvirus 1 And Infected Cell Protein 0 (Bicp0), Clinton Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine herpesvirus 1 (BoHV-1) infected cell protein 0 (bICP0) is an important transcriptional regulatory protein that stimulates productive infection. In transient transfection assays, bICP0 also inhibits interferon dependent transcription. bICP0 can induce degradation of interferon stimulatory factor 3 (IRF3), a cellular transcription factor that is crucial for activating beta interferon (IFN-β) promoter activity. Recent studies also concluded that interactions between bICP0 and IRF7 inhibit trans-activation of IFN-β promoter activity. The C3HC4 zinc RING (really important new gene) finger located near the amino terminus of bICP0 is important for all known functions of bICP0. A recombinant virus that contains a single …

Synergistic Inhibition Of Bovine Leukemia Virus Replication In Vitro By Ribavirin And Alpha-Interferon [Abstract Only], Jeffrey Isaacson, Charles Wood, Jay Reddy

Jay Reddy Publications

Bovine leukemia virus (BLV) is an oncogenic retrovirus that infects cattle. It is classified in the human T-cell leukemia virus (HTLV) group, although BLV mainly infects B cells rather than T cells. Most BLV-infected cattle remain asymptomatic, but about 30% develop persistent lymphocytosis, and perhaps 5% eventually acquire B-cell lymphoma. Mainly as a result of the latter condition, BLV is a significant economic problem for cattle producers worldwide. Moreover, because of the close genetic similarities between the two viruses, BLV may also be a useful model for investigating HTLV-associated diseases in humans. The prognosis of HTLV-I-associated disease is generally poor …

What Is The Point: Will Screening Mammography Save My Life?, James E. Keen, John Keen

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: We analyzed the claim "mammography saves lives" by calculating the life-saving absolute benefit of screening mammography in reducing breast cancer mortality in women ages 40 to 65.
Methods: To calculate the absolute benefit, we first estimated the screen-free absolute death risk from breast cancer by adjusting the Surveillance, Epidemiology and End Results Program 15-year cumulative breast cancer mortality to account for the separate effects of screening mammography and improved therapy. We calculated the absolute risk reduction (reduction in absolute death risk), the number needed to screen assuming repeated screening, and the survival percentages without and with screening. We varied …

Mouse × Pig Chimeric Antibodies Expressed In Baculovirus Retain The Same Properties Of Their Parent Antibodies, Ana M. Jar, Fernando A. Osorio, Osvaldo J. López

School of Veterinary and Biomedical Sciences: Faculty Publications

The development of hybridoma and recombinant DNA technologies has made it possible to use antibodies against cancer, autoimmune disorders, and infectious diseases in humans. These advances in therapy, as well as immunoprophylaxis, could also make it possible to use these technologies in agricultural species of economic importance such as pigs. Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus causing very important economic losses to the industry. Passive transfer of antibodies obtained by biotechnology could be used in the future to complement or replace vaccination against this and other pig pathogens. To this end, we constructed and studied the …

Spontaneous Idiopathic Arteritis Of The Testicular Artery In Raccoons (Procyon Lotor), A. N. Hamir, M. V. Palmer, H. Li, J. Stasko, D. G. Rogers

School of Veterinary and Biomedical Sciences: Faculty Publications

The testes and the spermatic cord of raccoons (Procyon lotor, kits to adult breeders; n = 48) were examined. Segmental arteritis confined to the extratesticular portions of the testicular artery was present in raccoons of all ages. The arterial changes were seen in laboratory-confined experimental and control animals as well as in wild-caught raccoons. The lesions consisted of proliferative endarteritis with presence of inflammatory cells within the intima, media, and the adventitial regions of most affected vessels. Some aspects of the proliferative arterial lesions were reminiscent of systemic necrotizing vasculitis (polyarteritis nodosa), an immunologically mediated condition of animals and humans. …

Gene–Environment Interactions Across Development: Exploring Drd2 Genotype And Prenatal Smoking Effects On Self-Regulation, Sandra A. Wiebe, Kimberly Andrews Espy, Christian Stopp, Jennifer Respass, Peter Stewart, Travis R. Jameson, David G. Gilbert, Jodi I. Huggenvik

Department of Psychology: Faculty Publications

Genetic factors dynamically interact with both pre- and postnatal environmental influences to shape development. Considerable attention has been devoted to gene–environment interactions (G × E) on important outcomes (A. Caspi & T. E. Moffitt, 2006). It is also important to consider the possibility that these G × E effects may vary across development, particularly for constructs like self-regulation that emerge slowly, depend on brain regions that change qualitatively in different developmental periods, and thus may be manifested differently. To illustrate one approach to exploring such developmental patterns, the relation between variation in the TaqIA polymorphism, related to D2 dopamine receptor …

Daily Negative Mood Affects Fasting Glucose In Type 2 Diabetes, Marilyn M. Skaff, Joseph T. Mullan, David M. Almeida, Lesa Hoffman, Umesh Masharani, David Mohr, Lawrence Fisher

Department of Psychology: Faculty Publications

Objective: To examine the relationship between mood and blood glucose in a 21-day daily diary study.
Design: During a home visit, information was gathered from 206 persons with Type 2 diabetes regarding demographics, disease characteristics and treatment, and depressive symptoms. They had blood drawn at a laboratory, yielding HbA1C. The participants were then telephoned each evening for 21 days and were asked about their positive and negative mood during the past 24 hours. They also tested their blood glucose upon rising in the morning.
Main Outcome Measures: The main outcomes measures were positive and negative affect and fasting glucose.
Results: …

Responding To Societal Devaluation: Effects Of Perceived Personal And Group Discrimination On The Ethnic Group Identification And Personal Self-Esteem Of Latino/Latina Adolescents, Brian E. Armenta, Jennifer S. Hunt

Department of Psychology: Faculty Publications

The Rejection-Identification model (Branscombe, Schmitt, & Harvey, 1999) posits that perceived discrimination may lead to increased ingroup identification, which can help maintain psychological well-being in the face of societal devaluation. To address unknown aspects of this model, we examined the effects of perceived per¬sonal and group discrimination on the group identification and personal self-esteem of Latino/Latina adolescents. Results showed that perceived group discrimination was related to higher personal self-esteem via direct and indirect routes (i.e. through group identification). However, perceived personal discrimination was directly and indirectly associated with lower personal self-esteem. Moreover, these two levels of discrimination showed interactive effects …

Epistatic Interaction Between Comt And Dat1 Genes On Eating Behavior: A Pilot Study, Samantha L. Hersrud, Scott F. Stoltenberg

Department of Psychology: Faculty Publications

Problems related to food and weight in women may be influenced by the (DA) dopamine system. Catechol-o-methyl transferase (COMT) and the dopamine transporter (DAT) exert control on concentrations of extracellular DA. High and low functioning alleles of the COMT Val158Met and DAT1 3’ UTR VNTR polymorphisms have been identified, and their associations with reward and cognition suggest a role in the modulation of eating behavior. A sample of undergraduate college women (N = 71) was characterized for binge eating and eating psychopathology and genotyped for the COMT and DAT1 markers. Results revealed a significant epistatic interaction between COMT and DAT1 …

What’S Fair In Foul Weather And Fair? Distributive Justice Across Different Allocation Contexts And Goods, John T. Scott, Brian H. Bornstein

Department of Psychology: Faculty Publications

The Gulf coast hurricanes of a few years ago vividly highlighted important questions concerning the fair distribution of resources that are of continual concern in the more mundane distributive policies of the modern state. We present an experimental study of allocation decisions across two allocation contexts—nonemergency and emergency (flood) conditions—and with regard to qualitatively different goods—money, prescription medicine, and food. Distributive behavior is likely to vary across context and good depending on how individuals weigh distinct and competing allocation principles—merit, need, and equality here—in different circumstances. We find that allocation behavior is complex but structured, with context and good having …

Child Maltreatment History Among Newlywed Couples : A Longitudinal Study Of Marital Outcomes And Mediating Pathways, David Dilillo, James Peugh, Kate Walsh, Jillian Panuzio, Emily Trask, Sarah Evans

Department of Psychology: Faculty Publications

Participants included 202 newlywed couples who reported retrospectively about child maltreatment experiences (sexual abuse, physical abuse, psychological abuse, and neglect) and whose marital functioning was assessed 3 times over a 2-year period. Decreased marital satisfaction at T1 was predicted by childhood physical abuse, psychological abuse, and neglect for husbands; only neglect predicted lower satisfaction for wives. Increased maltreatment of various types was also related to T1 difficulties with marital trust and partner aggression. Dyadic growth curve analyses showed that the marital difficulties reported at T1 tended to remain over the course of the study. Further, in several instances, maltreatment exerted …

Severity Of Child Sexual Abuse And Revictimization: The Mediating Role Of Coping And Trauma Symptoms, Michelle A. Fortier, David Dilillo, Terri L. Messman-Moore, James Peugh, Kathleen A. Denardi, Kathryn J. Gaffey

Department of Psychology: Faculty Publications

Child sexual abuse (CSA) has consistently been associated with the use of avoidant coping; these coping methods have been associated with increased trauma symptoms, which have, in turn, been linked to increased risk for adult sexual revictimization. Given these previous findings, the purpose of the current study was to test a model that conceptualized the relationships among these variables. Specifically, CSA severity was conceptualized as leading to the use of avoidant coping, which was proposed to lead to maintenance of trauma symptoms, which would, in turn, impact severity of revictimization indirectly. This comprehensive model was tested in a cross-sectional study …

Impulsivity And Cigarette Craving: Differences Across Subtypes, Neal Doran, Jessica Werth Cook, Dennis E. Mcchargue, Bonnie Spring

Department of Psychology: Faculty Publications

Rationale: Cigarette smoking has been linked to a number of personality characteristics, including impulsivity. Smokers tend to endorse high levels of impulsivity, and more impulsive smokers have greater difficulty quitting, but little is known about potential explanatory mechanisms. Although indirect evidence suggests craving as a candidate mechanism, direct evidence has been mixed.
Materials and methods: This study assessed whether specific aspects of impulsivity (sensation seeking, lack of premeditation, lack of perseverance, and urgency) were associated with cue-induced craving. Regular smokers (n= 60; 50% female) were exposed to a smoking cue and a neutral cue in a repeated measure …

Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Clinical obervations indicate that antipsychotic action starts early and increases in magnitude with repeated treatment. Animal models that faithfully capture this time course of action are few. Inhibition of hyperlocomotion induced by amphetamine or phencyclidine has been widely used as a screening tool for the antipsychotic activity of a drug. We thus investigated whether repeated antipsychotic treatment could produce an early-onset and progressively increased antagonistic effect on amphetamine or phencyclidine-induced hyperlocomotion as a way of assessing the validity of such models in capturing time course of antipsychotic action. One each of the five consecutive test days, different groups of rats …

Sedation And Disruption Of Maternal Motivation Underlie The Disruptive Effects Of Antipsychotic Treatment On Rat Maternal Behavior, Changjiu Zhao, Ming Li

Department of Psychology: Faculty Publications

The behavioral mechanisms underlying antipsychotic-induced maternal behavior deficits were examined in the present study. Different groups of postpartum rats were treated with haloperidol (0.1 mg/kg), clozapine (10.0 mg/kg), chlordiazepoxide (5.0 mg/kg, an anxiolytic) or vehicle (0.9% saline) on Days 4 and 6 postpartum and their maternal behaviors were tested under either pup-separation (e.g. pups were removed from their mothers for 4 h before testing) or no-pup-separation condition. Maternal behavior and drug-induced sedation were further tested for 3 days from Day 8 to 12 postpartum. Results show that pup-separation, which putatively increases maternal motivation, did significantly shorten clozapine-elongated pup approach latency, …

Persons As Contexts: Evaluating Between-Person And Within-Person Effects In Longitudinal Analysis, Lesa Hoffman, Robert S. Stawski

Department of Psychology: Faculty Publications

Relationships among multiple variables over time are of interest in many developmental areas and are frequently examined using time-varying predictors in multilevel models. Yet an incomplete specification of time-varying predictors will usually result in biased model effects. Specifically, the impact of constant, between-person sources of variation must be differentiated from the impact of time-specific, within-person sources of variation -that is, persons should be modeled as contexts. The current didactic article expands upon previous work to address why and how to model persons as contexts in longitudinal analysis. An electronic appendix of syntax for estimating these models is also provided.

Daily Negative Mood Affects Fasting Glucose In Type 2 Diabetes, Marilyn M. Skaff, Joseph T. Mullan, David M. Almeida, Lesa Hoffman, Umesh Masharani, David C. Mohr, Lawrence Fisher

Department of Psychology: Faculty Publications

Objective—To examine the relationship between mood and blood glucose in a 21 day daily diary study.

Design—During a home visit, information was gathered from two hundred six persons with type 2 diabetes regarding demographics, disease characteristics and treatment, and depressive symptoms. They had blood drawn at a laboratory, yielding HbA1C. The participants were then telephoned each evening for 21 days and were asked about their positive and negative mood during the past 24 hours. They also tested their blood glucose upon rising in the morning.

Main Outcome Measures—The main outcomes measures were positive and negative affect and fasting glucose.

Results—Multilevel …

Rational Decisions: The Adaptive Nature Of Context-Dependent Choice, Alexandra G. Rosati, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Although classical economic theory hinges on the assumption that rational actors should seek to maximize gains, psychologists and behavioral economists have recently collected a wealth of evidence challenging this premise. In violation of the principles of rational choice, context appears to dramatically influence human decision making. Like humans, numerous nonhuman animals, ranging from honeybees to primates, are sensitive to context, suggesting deep evolutionary roots for seemingly irrational decision-making. Many psychologists have suggested that such choices may stem from cognitive biases that result in errors. We contend, however, that labeling context-dependent choices as errors obscures the real issue. Natural selection does …

The Dynamics Of Development: Challenges For Bayesian Rationality, Nils Straubinger, Edward T. Cokely, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Commentary on Oaksford & Chater, Precis of Bayesian Rationality

Oaksford & Chater draw a rather static picture of human reasoning by focusing on typical patterns of responses from adults. We propose a more dynamic perspective, which considers that reasoning systematically varies within individuals over the lifespan (Howe & Rabinowitz 1996; Markovits & Barrouillet 2002) and between individuals with different levels of knowledge and expertise (Ericsson et al. 2006).

The original articles, the full set of commentaries, and the authors' response are attached (below) as an "Additional file."

Social Interaction Effects On Reward And Cognitive Abilities In Monkeys, Jeffrey R. Stevens, Marc D. Hauser

Department of Psychology: Faculty Publications

When given a choice between receiving $100 in 30 days and $110 in 31 days, most people wait for the larger, more delayed reward. However, when the choice is between $100 today and $110 tomorrow, many people shift their preferences to the smaller, immediate reward despite the same difference of $10 and one day. Reward properties—such as time to receipt—play a crucial role in our processing of rewards. However, reward processing does not only occur for individual decisions but also for social interactions; we must decide to either cooperate or compete with others for rewards. Humans stand out in the …

Content Validity Of Nutrition Diagnostic Term Involuntary Weight Loss, Paula K. Ritter-Gooder, Nancy M. Lewis

Department of Nutrition and Health Sciences: Faculty Publications

Objective The purpose of this study was to validate content of the Nutrition Diagnostic Term NC- 3.2 Involuntary Weight Loss using expert raters.

Design/Subjects This descriptive survey invited all Board Certified Specialists in Gerontological Nutrition (CSG) to participate by mail. An instrument was developed that included the definition, etiologies, and signs and symptoms (s/s) of the diagnosis with items added from literature review. CSG rated how common or characteristic each item is to the diagnosis using a 5 point Likert scale. A weighted response for each item was used to calculate a Diagnostic Content Validity (DCV) score. DCV scores of …

Reducing The Public Health Impact Of Bovine Tuberculosis By Controlling Disease Transmission Between Cattle And White-Tailed Deer In Northwestern Minnesota, Barbara Knust

Michigan Bovine Tuberculosis Bibliography and Database

Bovine tuberculosis, caused by infection with Mycobacterium bovis, is a re-emerging zoonotic disease. It has staged a comeback by establishing infections in wildlife and cattle, creating the potential for human disease in locations where it was thought to be under control. In northwestern Minnesota, infected cattle and white-tailed deer were first discovered in 2005. A major bovine tuberculosis eradication campaign is underway in the state, with multiple efforts employed to control M. bovis infection in both cattle and deer populations. In order to effectively eradicate bovine tuberculosis in Minnesota, there is a need for better understanding of the …

Effects Of Shielding Adenoviral Vectors With Polyethylene Glycol On Vector-Specific And Vaccine-Mediated Immune Responses, Eric A. Weaver, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Many individuals have been previously exposed to human adenovirus serotype 5 (Ad5). This prior immunity has long been known to hinder its use for gene therapy and as a gene-based vaccine. Given these immunogenicity problems, we have tested whether polyethylene glycol (PEG) can blunt immune effects against Ad5 during systemic and mucosal vaccination. Ad5 vectors were covalently modified with 5-, 20-, and 35-kDa linear PEG polymers and evaluated for their ability to produce immune responses against transgene antigen products and the vector itself. We show that shielding Ad5 with different-sized PEGs generally reduces transduction and primary antibody responses by the …

Ecological Niche Of The 2003 West Nile Virus Epidemic In The Northern Great Plains Of The United States, Michael Wimberly, Michael B. Hildreth, Stephen P. Boyte, Erik Lindquist, Lon Kightlinger

United States Public Health Resources

Background: The incidence of West Nile virus (WNv) has remained high in the northern Great Plains compared to the rest of the United States. However, the reasons for the sustained high risk of WNv transmission in this region have not been determined. To assess the environmental drivers of WNv in the northern Great Plains, we analyzed the county-level spatial pattern of human cases during the 2003 epidemic across a seven-state region.
Methodology/Principal Findings: County-level data on WNv cases were examined using spatial cluster analysis, and were used to fit statistical models with weather, climate, and land use variables as predictors. …

How Does A Riverine Setting Affect The Lifestyle Of Shellmound Builders In Brazil?, Sabine Eggers, C. C. Petronilho, K. Brandt, C. Jericó-Daminello, J. Filippini, Karl Reinhard

Karl Reinhard Publications

The contact of inland and coastal prehistoric groups in Brazil is believed to have been restricted to regions with no geographical barrier, as is the case in the Ribeira de Iguape valley. The inland osteological collection from the riverine shellmound Moraes (5800–4500 BP) represents a unique opportunity to test this assumption for this region. Despite cultural similarities between riverine and coastal shellmounds, important ecological and site distribution differences are expected to impact on lifestyle. The purpose of this study is thus to document and interpret health and lifestyle indicators in Moraes in comparison to coastal shellmound groups. Specifically we test …

Toward Using National Cancer Surveillance Data For Preventing And Controlling Cervical And Other Human Papillomavirus-Associated Cancers In The Us, Mona Saraiya, Faruque Ahmed, Mary White, Herschel Lawson, Elizabeth R. Unger, Christie Eheman

United States Public Health Resources

This supplement, known as the ABHACUS (Assessing the Burden of HPV-Associated Cancers in the United States) supplement, contains 22 articles. Together, these articles provide a comprehensive snapshot of data related to the occurrence and control of multiple cancers that have been associated with the human papillomavirus (HPV). These analyses highlight the burden of HPV associated cancers in the US population as a whole and among vulnerable population subgroups. We anticipate that these findings will be an important resource for enhancing existing strategies for the prevention and control of HPV associated cancers.

HPV is estimated to be responsible for 5.2% of …

Antibody Responses Of Cervids (Cervus Elaphus) Following Experimental Mycobacterium Bovis Infection And The Implications For Immunodiagnosis, Noel P. Harrington, Om P. Surujballi, John F. Prescott, J. Robert Duncan, W. Ray Waters, Konstantin Lyashchenko, Rena Greenwald

Michigan Bovine Tuberculosis Bibliography and Database

Captive and free-ranging wildlife animals are implicated in the maintenance and transmission of bovine tuberculosis and therefore pose a significant obstacle to eradication of the disease from domestic livestock. The current antemortem diagnostic method, the intradermal tuberculin skin test, is impractical for routine use with many wild animals. Antibody-based assays are particularly attractive because the animals are handled only once and immediate processing of the sample is not required. This report characterizes the antibody responses of red deer-elk hybrids (Cervus elaphus) against Mycobacterium bovis and subsequently evaluates the diagnostic performance of select antigens in a rapid-test format. Sequential …

Short-Term Memory, Working Memory, And Executive Functioning In Preschoolers: Longitudinal Predictors Of Mathematical Achievement At Age 7 Years, Rebecca Bull, Kimberly A. Espy, Sandra A. Wiebe

Developmental Cognitive Neuroscience Laboratory: Faculty Publications

This study examined whether measures of short-term memory, working memory, and executive functioning in preschool children predict later proficiency in academic achievement at 7 years of age (third year of primary school). Children were tested in preschool (M age = 4 years, 6 months) on a battery of cognitive measures, and mathematics and reading outcomes (from standardized, norm-referenced school-based assessments) were taken on entry to primary school, and at the end of the first adn third year of primary school. Growth curve analyses examined predictors of math and reading achievement across the duration of the study and revealed that better …

Intraretinal Signaling By Ganglion Cell Photoreceptors To Dopaminergic Amacrine Neurons, Dao-Qi Zhang, Kwoon Y. Wong, Patricia J. Sollars, David M. Berson, Gary E. Pickard, Douglas G. Mcmahon

School of Veterinary and Biomedical Sciences: Faculty Publications

Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak …